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Topic Review
Triple-Negative Breast Cancer and COVID-19
he Coronavirus disease (COVID-19) pandemic has resulted in challenges to cancer management, exacerbated by limited clinical resources and caution in preventing COVID-19 transmission between patients and healthcare professionals. The neglect of breast cancer (in particular, triple-negative breast cancer (TNBC)) patients during the outbreak could negatively impact their overall survival, as delays in treatment and consultations provide vital time for tumor progression and metastasis. Herein, we review the shifting clinical management of TNBCs during the COVID-19 outbreak. The suggested treatment recommendations can hopefully minimize virus exposure without sacrificing patient care during times when healthcare systems are overburdened. Further, we review published RNA-seq data to assess the theoretical infectability of metastatic TNBCs to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. 
  • 1.5K
  • 01 Feb 2021
Topic Review
C-,N- and S-Doped TiO2 Photocatalysts
This entry describes the basics of photocatalysis. It also presents properties and applications of C-,N- and S-Doped TiO2 as a photocatalyst.
  • 1.5K
  • 28 May 2021
Topic Review
Neurofibromatosis and Schwannomatosis
Neurofibromatosis (NF) is a neurocutaneous syndrome characterized by the development of tumors of the central or peripheral nervous system including the brain, spinal cord, organs, skin, and bones. There are three types of NF: NF1 accounting for 96% of all cases, NF2 in 3%, and schwannomatosis (SWN) in <1%. The NF1 gene is located on chromosome 17q11.2, which encodes for a tumor suppressor protein, neurofibromin, that functions as a negative regulator of Ras/MAPK and PI3K/mTOR signaling pathways. The NF2 gene is identified on chromosome 22q12, which encodes for merlin, a tumor suppressor protein related to ezrin-radixin-moesin that modulates the activity of PI3K/AKT, Raf/MEK/ERK, and mTOR signaling pathways. In contrast, molecular insights on the different forms of SWN remain unclear. Inactivating mutations in the tumor suppressor genes SMARCB1 and LZTR1 are considered responsible for a majority of cases.
  • 1.5K
  • 08 Jun 2021
Topic Review
Rare Genetic Syndromes and Oral Anomalies
Rare genetic syndromes, conditions with a global average prevalence of 40 cases/100,000 people, are associated with anatomical, physiological, and neurological anomalies that may affect different body districts, including the oral district.
  • 1.5K
  • 10 Jan 2022
Topic Review
Type 1 Fimbriae (Pili)
Type 1 fimbriae (pili) are an important colonization factor that can contribute to diseases such as urinary tract infections and neonatal meningitis.
  • 1.5K
  • 10 Jan 2022
Topic Review
Blockchain for Smart Mobility
The concept of a smart city aims to help cities to address these challenges by adapting modern information and communication technology. Smart mobility and transportation form one important aspect of smart cities. Inefficient mobility in cities can lead to problems such as traffic congestion, which results in frustration for residents and a decrease in the quality of life. In the context of smart mobility, blockchain can be used for transactions relating to ridesharing and electric charging, handling of interactions of platoon members, or serving as a foundation for communication between vehicles.
  • 1.5K
  • 17 Jan 2022
Topic Review
Lipids and Gut Microbiota Alterations
Advances in sequencing technologies over the past 15 years have led to a substantially greater appreciation of the importance of the gut microbiome to the health of the host. Recent outcomes indicate that aspects of nutrition, especially lipids (exogenous or endogenous), can influence the gut microbiota composition and consequently, play an important role in the metabolic health of the host. Thus, there is an increasing interest in applying holistic analytical approaches, such as lipidomics, metabolomics, (meta)transcriptomics, (meta)genomics, and (meta)proteomics, to thoroughly study the gut microbiota and any possible interplay with nutritional or endogenous components.
  • 1.5K
  • 21 Apr 2022
Topic Review
Thermochemical Cycle
Thermochemical cycles combine solely heat sources (thermo) with chemical reactions to split water into its hydrogen and oxygen components. The term cycle is used because aside of water, hydrogen and oxygen, the chemical compounds used in these processes are continuously recycled. If work is partially used as an input, the resulting thermochemical cycle is defined as a hybrid one.
  • 1.5K
  • 14 Oct 2022
Topic Review
Medical Entomology
The discipline of medical entomology, or public health entomology, and also veterinary entomology is focused upon insects and arthropods that impact human health. Veterinary entomology is included in this category, because many animal diseases can "jump species" and become a human health threat, for example, bovine encephalitis. Medical entomology also includes scientific research on the behavior, ecology, and epidemiology of arthropod disease vectors, and involves a tremendous outreach to the public, including local and state officials and other stake holders in the interest of public safety. Public health entomology has seen a huge surge in interest since 2005, due to the resurgence of the bed bug, Cimex lectularius.
  • 1.5K
  • 04 Nov 2022
Topic Review
Poly Drug Use
Poly drug use or polysubstance use refers to the use of combined psychoactive substances for recreational purposes. In many cases one drug is used as a base or primary drug, with additional drugs to leaven or compensate for the side effects of the primary drug and make the experience more enjoyable with drug synergy effects, or to supplement for primary drug when supply is low.
  • 1.5K
  • 17 Nov 2022
Topic Review
History of Passive Sliding Base Isolation Systems
Base isolation techniques have emerged as the most effective seismic damage mitigation strategies. Several types of aseismic devices for base isolation have been invented, studied, and used. Out of several isolation systems, sliding isolation systems are popular due to their operational simplicity and ease of manufacturing. These isolators behave passively i.e. their properties of independent of frequency of earthquake excitation. Herein, the historical development of passive sliding isolators based on the number of sliding surfaces is discussed.
  • 1.5K
  • 25 Nov 2022
Biography
Will Provine
William Ball Provine (February 19, 1942 – September 1, 2015) was an American historian of science and of evolutionary biology and population genetics. He was the Andrew H. and James S. Tisch Distinguished University Professor at Cornell University and was a professor in the Departments of History, Science and Technology Studies, and Ecology and Evolutionary Biology. Provine was born in Tenn
  • 1.5K
  • 02 Dec 2022
Topic Review
Relationship of Human Endogenous Retroviruses and Human Cancers
Human endogenous retroviruses (HERVs), once external pathogens, now occupy more than 8% of the human genome and represent the merge of genomic and external factors leading to the development of cancers. Certain HERVs have perfectly assimilated into the cellular environment preventing oncogenesis, while others maintain their pathogenic potential and remain undercover until a time of cellular dysregulation. In particular, HERV genes such as gag, env, pol, np9, and rec have been discovered to carry central roles in immune regulation, checkpoint blockade, cell differentiation, cell fusion, proliferation, metastasis, and cell transformation in tumor environments. In addition, HERV long terminal repeat (LTR) regions have been shown to be involved in transcriptional regulation, creation of fusion proteins, expression of long non-coding RNAs (lncRNAs), and promotion of genome instability through recombination influencing oncogenesis.
  • 1.5K
  • 27 Mar 2023
Topic Review
Discovery, Synthesis and Structural Characterization of Gomesin
Gomesin is a cationic antimicrobial peptide which is isolated from the haemocytes of the Brazilian tarantula Acanthoscurria gomesiana and can be produced chemically by Fmoc solid-phase peptide synthesis. Gomesin exhibits a range of biological activities, as demonstrated by its toxicity against therapeutically relevant pathogens such as Gram-positive or Gram-negative bacteria, fungi, cancer cells, and parasites.
  • 1.5K
  • 04 Apr 2023
Topic Review
Adaptive Learning Framework in UAE Public Schools
Educational systems are under intense pressure from the technological revolution, which demands graduates who can use new technologies to tackle critical societal issues in innovative and crucial ways. The Adaptive Learning Framework (Alef) is a smart learning program that is mandated in United Arab Emirates (UAE) public schools to promote student-centered, interactive, and differentiated learning and personalized experiences. 
  • 1.5K
  • 22 May 2023
Topic Review
Left Ventricle Unloading in VA ECMO
Impressively increasing availability of mechanical circulatory/cardiac support systems (MCSs) worldwide, together with the deepening of the knowledge of critical care medical practitioners, has inevitably led to the discussion about further improvements of intensive care associated to MCS. An appealing topic of the left ventricle (LV) overload related to VA ECMO support endangering myocardial recovery is being widely discussed within the scientific community. Unloading of LV leads to the reduction in LV end-diastolic pressure, reduction in pressure in the left atrium, and decrease in the LV thrombus formation risk. Consequently, better conditions for myocardial recovery, with comfortable filling pressures and a better oxygen delivery/demand ratio, are achieved. The combination of VA ECMO and Impella device, also called ECPELLA, seems to be a promising strategy that may bring the improvement of CS mortality rates.
  • 1.5K
  • 07 Oct 2023
Topic Review
Role of Riboflavin in Poultry Nutrition
Riboflavin, an essential B-vitamin, plays a crucial role in poultry metabolism, impacting energy production, growth, and immune regulation. Its role in redox reactions and energy metabolism is vital for optimal growth and development. Riboflavin is essential for adenosine triphosphate (ATP) production and the conversion of tryptophan into niacin. Deficiency can lead to skeletal deformities, impaired growth, and compromised immune function. Dietary riboflavin supplementation is necessary due to variable bioavailability in plant-derived sources. The vitamin is absorbed through specialized transport proteins, and its cellular uptake is facilitated by specific receptors. Riboflavin’s role in protein synthesis and its antioxidant properties influence poultry growth and defense against oxidative stress. Its impact on reproductive performance, hatchability, and overall poultry health underscores its significance in poultry nutrition.
  • 1.5K
  • 22 Nov 2023
Topic Review
Steroidogenesis, Oxidative Stress and Male Hypogonadism
Steroid sex hormones are classified as androgens, estrogens, and progestogens. Although all three classes are important in male and female physiology, androgens are associated with "musculisation" effects and are considered primarily male sex hormones. Androgens have diverse functions in muscle physiology, lean body mass, the regulation of adipose tissue, bone density, neurocognitive regulation, and spermatogenesis, male reproductive and sexual function.
  • 1.5K
  • 29 Mar 2022
Topic Review
Developing Edible Starch Film Used for Packaging Seasonings
Edible starch-based film was developed for packaging seasoning applied in instant noodles. The edible film can quickly dissolve into hot water so that the seasoning bag can mix in the soup of instant noodles during preparation.
  • 1.5K
  • 11 Jan 2022
Topic Review
Colorectal Cancer Treatment Based on Nanomaterials
Colorectal cancer (CRC) is a global health problem responsible for 10% of all cancer incidences and 9.4% of all cancer deaths worldwide. The number of new cases increases per annum, whereas the lack of effective therapies highlights the need for novel therapeutic approaches. Conventional treatment methods, such as surgery, chemotherapy and radiotherapy, are widely applied in oncology practice. Their therapeutic success is little, and therefore, the search for novel technologies is ongoing. Many efforts have focused recently on the development of safe and efficient cancer nanomedicines. Nanoparticles are among them. They are unique with their properties on a nanoscale and hold the potential to exploit intrinsic metabolic differences between cancer and healthy cells. This feature allows them to induce high levels of toxicity in cancer cells with little damage to the surrounding healthy tissues.
  • 1.5K
  • 21 Jul 2022
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