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Topic Review
Epigenetics for Forest Trees
Epigenetics refers to a scientific domain studying all the processes affecting the expression of genes and/or the activity of transposable elements (TEs) without altering the DNA sequence that may be heritable by mitosis (during development) and/or meiosis (across generations). Forest trees are sessile, perennial, and modular organisms with complex life cycles that are often challenged by environmental variations such as actual climate changes during their long-lifespan. Surviving tree populations can respond to these environmental changes through complex and interacting mechanisms and notably using epigenetics. 
  • 1.5K
  • 21 Sep 2020
Topic Review
E3 Ligases in Muscle Atrophy
Skeletal muscle loss is a detrimental side-effect of numerous chronic diseases that dramatically increases mortality and morbidity. The alteration of protein homeostasis is generally due to increased protein breakdown while, protein synthesis may also be down-regulated. The ubiquitin proteasome system (UPS) is a master regulator of skeletal muscle that impacts muscle contractile properties and metabolism through multiple levers like signaling pathways, contractile apparatus degradation, etc. Among the different actors of the UPS, the E3 ubiquitin ligases specifically target key proteins for either degradation or activity modulation, thus controlling both pro-anabolic or pro-catabolic factors. The atrogenes MuRF1/TRIM63 and MAFbx/Atrogin-1 encode for key E3 ligases that target contractile proteins and key actors of protein synthesis respectively. However, several other E3 ligases are involved upstream in the atrophy program, from signal transduction control to modulation of energy balance. Controlling E3 ligases activity is thus a tempting approach for preserving muscle mass.
  • 1.5K
  • 31 May 2021
Topic Review
DNA-Dependent Protein Kinase
The DNA-dependent protein kinase (DNA-PK) is composed of a DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Ku70/Ku80 heterodimer. DNA-PK is thought to act as the “sensor” for DNA double-stranded breaks (DSB), which are considered the most deleterious type of DNA damage. In particular, DNA-PKcs and Ku are shown to be essential for DSB repair through nonhomologous end joining (NHEJ). The phenotypes of animals and human individuals with defective DNA-PKcs or Ku functions indicate their essential roles in these developments, especially in neuronal and immune systems. DNA-PKcs are structurally related to Ataxia–telangiectasia mutated (ATM), which is also implicated in the cellular responses to DSBs. DNA-PKcs and ATM constitute the phosphatidylinositol 3-kinase-like kinases (PIKKs) family with several other molecules.
  • 1.5K
  • 11 Oct 2021
Topic Review
UBR Box-Containing E3 Ligases
UBR box E3 ligases, also called N-recognins, are integral components of the N-degron pathway. Representative N-recognins include UBR1, UBR2, UBR4, and UBR5, and they bind destabilizing N-terminal residues, termed N-degrons. Understanding the molecular bases of their substrate recognition and the biological impact of the clearance of their substrates on cellular signaling pathways can provide valuable insights into the regulation of these pathways.
  • 1.5K
  • 13 Aug 2021
Topic Review
Forensic Applications of Markers Present on X Chromosome
The X chromosome is considered one of the most stable nuclear chromosomes, presenting a size length of approximately 155 million base pairs (Mb), accounting for nearly 5% of the human genome. The X chromosome has many characteristics that are not shared by its counterpart, the Y chromosome. In males, the heterogametic sex, there is a single copy of the X chromosome and a single Y chromosome, while in females, there are two copies of the X chromosome. These mammalian sex chromosomes are believed to have evolved from an ordinary pair of autosomes, referred to as the ancestral protosex chromosomes. The proto-X and proto-Y underwent a series of deletion/addition events during evolution and became the modern X and Y. Additionally, it is believed that a mutation in a sex-determining locus (SRY) is responsible for triggering an evolutionary process of stepwise loss of recombination between the ancestral autosome pair, creating an X-specific region and a Y-specific region in the proto-Y (MSY).
  • 1.5K
  • 22 Sep 2022
Topic Review
Shadow of the Beast
Shadow of the Beast is a platform game developed by Reflections and published by Psygnosis in 1989. The original version was released for the Amiga, and was later ported to many other systems. The game was known for its graphics, with many colours on screen and up to twelve levels of parallax scrolling backdrops, and for its atmospheric score composed by David Whittaker that used high-quality instrument samples. It was followed by two sequels, Shadow of the Beast II in 1990 and Shadow of the Beast III in 1993. A remake was released for the PlayStation 4 in May 2016, and included the Amiga original.
  • 1.5K
  • 14 Oct 2022
Topic Review
High-Energy Methods for Pretreatment of Mineral Complexes
Pulsed power technologies have been proposed based on the conversion of energy into a short-pulsed form and exposing geomaterials (minerals, rocks, and ores) to strictly dosed high-power pulsed electric and magnetic fields, beams of charged particles, microwave radiation, neutrons and X-ray quanta, and low-temperature plasma flows. Such pulsed energy impacts are promising methods for the pretreatment of refractory mineral feeds (refractory ores and concentration products) to increase the disintegration, softening, and liberation performance of finely disseminated mineral complexes, as well as the contrast between the physicochemical and process properties of mineral components. The most important research and practical developments in the application of high-energy effects in the beneficiation and deep processing of complex ores are described. Examples are given of the implementation of various methods for processing minerals, ores, and concentrates, including accelerated electron flow, microwave (UHF) and laser treatment, high-intensity magnetic and electric (HVP) fields, high-power nanosecond electromagnetic pulses, and low-temperature plasma of dielectric barrier discharge, enabling a higher performance of the concentration processes for refractory mineral feeds.
  • 1.5K
  • 17 Oct 2022
Topic Review
Multi-Omics Approaches and Resources in the Plant Kingdom
In higher plants, the complexity of a system and the components within and among species are rapidly dissected by omics technologies. Multi-omics datasets are integrated to infer and enable a comprehensive understanding of the life processes of organisms of interest. Further, growing open-source datasets coupled with the emergence of high-performance computing and development of computational tools for biological sciences have assisted in silico functional prediction of unknown genes, proteins and metabolites, otherwise known as uncharacterized.
  • 1.5K
  • 25 Oct 2022
Topic Review
GRACE-FO
The Gravity Recovery and Climate Experiment (GRACE) was a joint mission of NASA and the German Aerospace Center (DLR). Twin satellites took detailed measurements of Earth's gravity field anomalies from its launch in March 2002 to the end of its science mission in October 2017. The Gravity Recovery and Climate Experiment Follow-On (GRACE-FO) is a continuation of the mission on near-identical hardware, launched in May 2018. By measuring gravity anomalies, GRACE showed how mass is distributed around the planet and how it varies over time. Data from the GRACE satellites is an important tool for studying Earth's ocean, geology, and climate. GRACE was a collaborative endeavor involving the Center for Space Research at the University of Texas at Austin, NASA's Jet Propulsion Laboratory, the German Aerospace Center and Germany's National Research Center for Geosciences, Potsdam. The Jet Propulsion Laboratory was responsible for the overall mission management under the NASA ESSP (Earth System Science Pathfinder) program. The principal investigator is Byron Tapley of the University of Texas Center for Space Research, and the co-principal investigator is Christoph Reigber of the GeoForschungsZentrum (GFZ) Potsdam. The two GRACE satellites (GRACE-1 and GRACE-2) were launched from Plesetsk Cosmodrome, Russia, on a Rockot (SS-19 + Breeze upper stage) launch vehicle on 17 March 2002. The spacecraft were launched to an initial altitude of approximately 500 km at a near-polar inclination of 89°. During normal operations, the satellites were separated by 220 km along their orbit track. This system was able to gather global coverage every 30 days. GRACE far exceeded its 5-year design lifespan, operating for 15 years until the decommissioning of GRACE-2 on 27 October 2017. Its successor, GRACE-FO, was successfully launched on 22 May 2018. In 2019, a glacier in West Antarctica was named after the GRACE mission.
  • 1.5K
  • 07 Nov 2022
Topic Review
Concurrent Estate
A concurrent estate or co-tenancy is a concept in property law which describes the various ways in which property is owned by more than one person at a time. If more than one person owns the same property, they are commonly referred to as co-owners. Legal terminology for co-owners of real estate is either co-tenants or joint tenants, with the latter phrase signifying a right of survivorship. Most common law jurisdictions recognize tenancies in common and joint tenancies, and some also recognize tenancies by the entirety, which is a joint tenancy between married persons. Many jurisdictions refer to a joint tenancy as a joint tenancy with right of survivorship, but they are the same, as every joint tenancy includes a right of survivorship. In contrast, a tenancy in common does not include a right of survivorship. The type of co-ownership does not affect the right of co-owners to sell their fractional interest in the property to others during their lifetimes, but it does affect their power to will the property upon death to their devisees in the case of joint tenants. However, any joint tenant can change this by severing the joint tenancy. This occurs whenever a joint tenant transfers his or her fractional interest in the property. Law can vary from place to place, and the following general discussion will not be applicable in its entirety to all jurisdictions.
  • 1.5K
  • 08 Nov 2022
Topic Review
Fusil Automatique Modèle 1917
The Fusil Automatique Modèle 1917 (English: Model 1917 Automatic Rifle) (also called the RSC M1917 ) was a gas-operated, semi-automatic rifle that the French Army placed in service during the latter part (1917) of World War I. It was chambered in then-standard 8mm Lebel, the rimmed cartridge used in other French Army infantry weapons of the time. Altogether, the French National Armories (primarily MAS (Manufacture d'Armes de St Etienne) and MAT (Manufacture d'Armes de Tulle) had manufactured 86,000 RSC M1917 rifles when their production run ended in late November 1918. However very few have survived in fully functional, semi-automatic condition and those have become highly sought-after collectibles.
  • 1.5K
  • 15 Nov 2022
Topic Review
The Seven Principles for Making Marriage Work
The Seven Principles for Making Marriage Work, by John Gottman is a book that sets forth what it describes as seven principles that can guide toward a harmonious and long-lasting relationship. The book attempts to debunk a number of what it describes as myths about marriages and why they fail. The seven principles Gottman sets out are for the partners to enhance their love maps; nurture fondness and admiration; turn toward each other instead of away; let their partner influence them; solve their solvable problems; overcome gridlock; and create shared meaning. The book was included in the Comprehensive Soldier fitness program. A follow-up to this book was the 2013 What Makes Love Last?
  • 1.5K
  • 21 Nov 2022
Topic Review
Mk F3 155mm
The 155 mm self-propelled gun Mk F3, or the Canon de 155 mm Mle F3 Automoteur (Cn-155-F3-Am), was developed in the early 1950s by the French Army to replace their American M41 Gorilla 155mm self-propelled guns. The Mk F3 is the smallest and lightest 155 mm motorized gun carriage ever produced, and because of its size and low cost it has found considerable success on the export market. Constructed on a modified AMX-13 light tank chassis, the Mk F3 is novel in incorporating room inside for only two of the eight required crewmen (the others riding in support vehicles). This allows the 155 mm gun to be placed on a smaller chassis than that employed by other armies, but exposes the outside crew members to enemy fire and other hazards.
  • 1.5K
  • 25 Nov 2022
Topic Review
SERS-Based Plasmonic Sensors for Biosensing Applications
Surface-enhanced Raman spectroscopy/scattering (SERS) has evolved into a popular tool for applications in biology and medicine owing to its ease-of-use, non-destructive, and label-free approach. Advances in plasmonics and instrumentation have enabled the realization of SERS’s full potential for the trace detection of biomolecules, disease diagnostics, and monitoring.
  • 1.5K
  • 07 Mar 2023
Topic Review
Bank Capital Structure and Its Determinants
Financial institutions, particularly banks, have long grappled with the dilemma of structuring their capital optimally. This process, commonly referred to as capital structure decision-making, is of paramount importance, especially within the financial services sector, where strict regulations are imposed by reserve and central banks in alignment with global Basel guidelines. 
  • 1.5K
  • 10 Nov 2023
Topic Review
Zinc Oxide Nanoparticles Seed Priming against Environmental Stresses
Drastic climate changes over the years have triggered environmental challenges for wild plants and crops due to fluctuating weather patterns worldwide. This has caused different types of stressors, responsible for a decrease in plant life and biological productivity, with consequent food shortages, especially in areas under threat of desertification. Nanotechnology-based approaches have great potential in mitigating environmental stressors, thus fostering a sustainable agriculture. Zinc oxide nanoparticles (ZnO NPs) have demonstrated to be biostimulants as well as remedies to both environmental and biotic stresses. Their administration in the early sowing stages, i.e., seed priming, proved to be effective in improving germination rate, seedling and plant growth and in ameliorating the indicators of plants’ well-being. Seed nano-priming acts through several mechanisms such as enhanced nutrients uptake, improved antioxidant properties, ROS accumulation and lipid peroxidation. The target for seed priming by ZnO NPs is mostly crops of large consumption or staple food, in order to meet the increased needs of a growing population and the net drop of global crop frequency, due to climate changes and soil contaminations. 
  • 1.5K
  • 11 Jan 2024
Topic Review Peer Reviewed
Optimisation of Small-Scale Aquaponics Systems Using Artificial Intelligence and the IoT: Current Status, Challenges, and Opportunities
Environment changes, water scarcity, soil depletion, and urbanisation are making it harder to produce food using traditional methods in various regions and countries. Aquaponics is emerging as a sustainable food production system that produces fish and plants in a closed-loop system. Aquaponics is not dependent on soil or external environmental factors. It uses fish waste to fertilise plants and can save up to 90–95% water. Aquaponics is an innovative system for growing food and is expected to be very promising, but it has its challenges. It is a complex ecosystem that requires multidisciplinary knowledge, proper monitoring of all crucial parameters, and high maintenance and initial investment costs to build the system. Artificial intelligence (AI) and the Internet of Things (IoT) are key technologies that can overcome these challenges. Numerous recent studies focus on the use of AI and the IoT to automate the process, improve efficiency and reliability, provide better management, and reduce operating costs. However, these studies often focus on limited aspects of the system, each considering different domains and parameters of the aquaponics system. This paper aims to consolidate the existing work, identify the state-of-the-art use of the IoT and AI, explore the key parameters affecting growth, analyse the sensing and communication technologies employed, highlight the research gaps in this field, and suggest future research directions. Based on the reviewed research, energy efficiency and economic viability were found to be a major bottleneck of current systems. Moreover, inconsistencies in sensor selection, lack of publicly available data, and the reproducibility of existing work were common issues among the studies.
  • 1.5K
  • 19 Feb 2024
Topic Review
Artificial Intelligence in CORONA Virus
AI is the most demanding field of the world. It is playing a vital role in many aspects like prediction of any pandemic or making any vaccine faster.
  • 1.5K
  • 11 Feb 2021
Topic Review
MT-ND5 Gene
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
  • 1.5K
  • 23 Dec 2020
Topic Review
Phosphorus Recovery from Sewage Sludge Ash
Phosphorus is an essential and limited element that cannot be replaced by any other. Phosphorus deposits in the world are rapidly depleting, so methods of recovering phosphorus from alternative sources and using it as a fertilizer in agriculture are becoming increasingly popular. Struvite from sewage sludge ash contains phosphorus, and also a significant amount of nitrogen and magnesium. It is considered an effective slow-release fertilizer that can be successfully applied to agricultural, vegetable, and ornamental crops. The slower leaching of nutrients and high fertilizer quality, and high phosphorus content can make struvite an environmentally friendly fertilizer. However, its production is not yet sustainable. The cradle-to-cradle (C2C) concept has made it possible to highlight the so-called critical points in the production of such fertilizer. Limitations are environmental  (concerns about heavy metals content in sewage sludge ash), legal (standard testing, product certification, quality control), economic (cost of energy, supply-chain), legal aspects (still not implemented as a mineral fertilizer under general EU regulations) and looses during P fertilizer production. 
  • 1.5K
  • 18 Apr 2022
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