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Topic Review
Digital Banking Implementation Indicators in Industry 4.0
Extensive technological changes brought about by Industry 4.0 have changed the behaviors and attitudes of customers and created new needs for them. The digital transformation of banking encompasses a wide range of services, such as document digitization, electronic signatures for transactions, e-learning, teleconferencing, online trading platforms, digital stores, e-statements, and mobile payments. Adopting new business models through the digital transformation of banking operations is the most appropriate approach for banking institutions in today’s economic environment.
  • 1.5K
  • 31 May 2023
Topic Review
Uric Acid Electroanalysis
Uric acid is a metabolic product that results from degradation of purines in the liver. Usually, uric acid is identified from biological fluids, human serum and urine through conventional methods, such as spectroscopy, chromatography, electrochemistry, membrane capillary electrophoresis and spectrophotometric methods, including uricase enzymatic reactions. Importantly, uric acid determination opens the possibility of early intervention in cases of hyperuricemia and preventing the degradation of renal function.
  • 1.5K
  • 25 Jun 2023
Topic Review
Impact of Transformational Leadership on Hospitality Employees
Transformational leadership is important to the hotel industry where employees play a critical role in delivering the service. Transformational leadership is a leadership style that causes changes in employees by sharing the organization’s vision and goals, providing necessary resources, promoting intellectual stimulation, and expecting high performance. 
  • 1.5K
  • 11 Sep 2023
Topic Review
Status Quo of 17 UN SDGs in Vietnam
The United Nations cautions that the Sustainable Development Goals may not be met by 2030, as COVID-19, the financial and energy crises continue to take a toll. Developing nations are grappling with many challenges, including sluggish economic growth, surging inflation, widespread supply chain disruptions, mounting debt, and declining job prospects. Governments, policymakers, and businesses need to develop specific strategies to address these issues.
  • 1.5K
  • 28 Feb 2024
Topic Review
Wound Healing Material
Dermal wound healing describes the progressive repair and recalcitrant mechanism of damaged skin, and eventually, reformatting and reshaping the skin. Many probiotics, nutritional supplements, metal nanoparticles, composites, skin constructs, polymers, and so forth have been associated with the improved healing process of wounds. The exact mechanism of material-cellular interaction is a point of immense importance, particularly in pathological conditions such as diabetes. Bioengineered alternative agents will likely continue to dominate the outpatient and perioperative management of chronic, recalcitrant wounds as new products continue to cut costs and improve the wound healing process. 
  • 1.5K
  • 22 Sep 2021
Topic Review
Gut Microbiota and Sex Hormones
Gut microbiota (GM) is the set of microbe strains colonizing the intestinal tract. Through its genetic heritage, known as the gut microbiome, this complex ecosystem generates bioactive metabolites that impact various physiological processes, far beyond food digestion. Able to communicate with distal districts through multiple pathways, GM is therefore considered the largest endocrine organ of the body and one of the major determinants of humans’ health from infancy through adulthood. Indeed, while a balanced GM facilitates beneficial effects including digestion of macronutrients, synthesis of some vitamins, maintenance of immune homeostasis, and protection against pathogens, detrimental changes in GM composition lead to adverse remodeling of the host phenotype, which predispose to several pathological conditions, such as insulin resistance, atherosclerosis, obesity, and associated disorders, ultimately leading to cardiovascular disease (CVD). Dietary habit and sex hormones (SH) are considered major regulators of the GM variability (6, 7).
  • 1.5K
  • 07 Jul 2022
Topic Review
George C. Marshall Institute
The George C. Marshall Institute (GMI) was a nonprofit conservative think tank in the United States. It was established in 1984 with a focus on science and public policy issues and was initially active mostly in the area of defense policy. Since the late 1980s, the Institute put forward environmental skepticism views, and in particular has promoted fringe views regarding the scientific consensus on climate change. The think tank received extensive financial support from oil companies. It closed in 2015, morphing somewhat into the CO2 Coalition.
  • 1.5K
  • 01 Dec 2022
Topic Review
Vincristine-Induced Pediatric Peripheral Neuropathy
Vincristine-induced peripheral neurotoxicity (VIPN) is a very common side effect of vincristine chemotherapy among pediatric patients with cancer. 
  • 1.5K
  • 21 May 2021
Topic Review
Character Amnesia
Character amnesia is a phenomenon whereby experienced speakers of some East Asian languages forget how to write Chinese characters previously well known to them. The phenomenon is specifically tied to prolonged and extensive use of input methods, such as those that use romanizations of characters, and is documented to be a significant issue in China and Japan. Modern technology, such as mobile phones and computers, allows users to enter Chinese characters using their phonetic transcription without knowing how to write them by hand. Whether or not the phenomenon is as widespread or troubling as some have claimed is the subject of debate.
  • 1.5K
  • 29 Sep 2022
Topic Review
Assembly Theory
Assembly theory is a framework for quantifying evolution and complexity. It, therefore, spans various scientific disciplines, including physics, chemistry, biology, and information theory. Assembly theory is rooted in the assembly of an object from a set of basic building units, forming an initial assembly pool and from subunits that entered the assembly pool in previous assembly steps. Hence, the object is defined not as a set of point particles but by the history of its assembly, where the assembly index is the smallest number of steps required to assemble the object.
  • 1.5K
  • 22 Aug 2026
Topic Review
Magnetic Nanoparticles
Technological development is in constant progress in the oncological field. The search for new concepts and strategies for improving cancer diagnosis, treatment and outcomes constitutes a necessary and continuous process, aiming at more specificity, efficiency, safety and better quality of life of the patients throughout the treatment. Nanotechnology embraces these purposes, offering a wide armamentarium of nanosized systems with the potential to incorporate both diagnosis and therapeutic features, towards real-time monitoring of cancer treatment. Within the nanotechnology field, magnetic nanosystems stand out as complex and promising nanoparticles with magnetic properties, that enable the use of these constructs for magnetic resonance imaging and thermal therapy purposes. Additionally, magnetic nanoparticles can be tailored for increased specificity and reduced toxicity, and functionalized with contrast, targeting and therapeutic agents, revealing great potential as multifunctional nanoplatforms for application in cancer theranostics. This review aims at providing a comprehensive description of the current designs, characterization techniques, synthesis methods, and the role of magnetic nanoparticles as promising nanotheranostic agents. A critical appraisal of the impact, potentialities and challenges associated with each technology is also presented.
  • 1.5K
  • 23 Oct 2020
Topic Review
Cr-free High-Temperature Water-Gas Shift Catalysts
Replacement of toxic Cr in the industrial Fe-oxide based High-Temperature Water-Gas Shift (HT-WGS) catalysts has been the focus of intense research in the past decades. In the current manuscript, we examine the promotion effect of Ca, Ni, Co and Ge as possible Cr substituents, and Ca and Ni are found to improve catalysts performance relative to Cr promotion. The current study, besides finding two promising Cr substitutes (Ca and Ni) for the HT-WGS reaction catalyst, also emphasizes on the qualities a promoter must possess to become a suitable substitution of Cr. The remarkable performance of Ca and Ni promoters are related to their ability to stabilize the surface area of the respective catalysts by making partial or complete solid solution with the bulk Fe-oxide phase and by promoting highly redox Cu0-FeOx interfacial sites on the catalyst surface. The poorer performance exhibited by Co and Ge promoters is related to the lack of their ability to promote the highly active Cu0-FeOx interfacial sites along with inability of Co to stabilize the surface area. All the promoters follow a redox type mechanism for the HT-WGS reaction.
  • 1.5K
  • 09 Nov 2020
Topic Review
Pedestrian–Vehicle Interaction at Unsignalized Crosswalks
A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), to generate a document that supports the development of future research, compiling the various studies focused on the analysis of the pedestrian-vehicle interaction at unsignalized crosswalks. Firstly, 381 studies were identified by applying the search protocol in the database sources; however, only nine studies were included in this review because most of the studies are not focused on this type of crosswalks or have not considered the micro-simulation perspective. For each study, an analysis of the used methodology for data collection was carried out, in addition to what type of model it was applied, including the variables that represent the PVI (Pedestrian-Vehicle Interaction). The outcomes obtained by this systematic review show that although the video camera observation technique is the most used, it is possible to complement them with other tools to add specific field information. Additionally, variables such as the adjacent yields, speed variables vehicles, pedestrian attitude, and the number of pedestrians waiting at the crossing were those most used in the cellular automata model or micro-simulation, which are the commonly developed models to simulate this interaction.
  • 1.5K
  • 25 Apr 2020
Topic Review
Autosomal Dominant Polycystic Kidney Disease
Autosomal dominant polycystic kidney disease (ADPKD) is a complex monogenic kidney disease which progressively leads to kidney failure. A brief description of the main characteristics and known causes of ADPKD pathology, as well as the current pharmacological treatment is presented. Numerous research tools have been developed over the last decades to study this pathology and have allowed significant progress in understanding ADPKD specific disease mechanisms, even though the precise pathophysiological mechanisms of this pathology still remain elusive. As no perfect model of ADPKD currently exists, a broad overview of available and emerging in vitro and in vivo research models used to study this disease is given. Finally, a multimodal approach, combining different and carefully selected in vitro and in vivo research tools is suggested, in order to produce reliable results relevant to the human disease.
  • 1.5K
  • 06 Jul 2020
Topic Review
Crohn’s Disease
Crohn’s disease is increasing in incidence and prevalence in younger people and is of a particularly aggressive nature. One emerging treatment targets Mycobacterium avium paratuberculosis (MAP), an organism implicated in the causation of Crohn’s disease. This study reviewed a cohort of paediatric patients with active Crohn’s disease treated with Anti-Mycobacterial Antibiotic Therapy (AMAT). Sixteen paediatric patients, the majority of whom had failed conventional immunosuppressive therapy, were treated with AMAT. Endoscopic remission was scored using the Simple Endoscopic Score for Crohn’s Disease and clinical remission was assessed using the Weighted Paediatric Crohn’s Disease Activity Index (wPCDAI). Inflammatory blood markers were also routinely recorded. Patients were followed up clinically and endoscopically during treatment after an average of two months (range 1–6) and 17 months (range 2–49), respectively. A significant reduction in both scores assessing clinical improvement (p < 0.001) and mucosal healing (p < 0.0078) was observed at these timepoints; 47% of patients had achieved clinical remission and 63% endoscopic remission. Haemoglobin and serum inflammatory markers normalised for more than 50% of the cohort by six months of treatment. No adverse effects were reported throughout treatment.
  • 1.5K
  • 10 Dec 2020
Topic Review
Mesoporous Silica Nanoparticles therapy potential
Nanoparticles have become a powerful tool in oncology not only as carrier of the highly toxic chemotherapeutic drugs but also as imaging contrast agents that provide valuable information about the state of the disease and its progression. The enhanced permeation and retention effect for loaded nanocarriers in tumors allow substantial improvement of selectivity and safety of anticancer nanomedicines. Additionally, the possibility to design stimuli-responsive nanocarriers able to release their payload in response to specific stimuli provide an excellent control on the administered dosage.
  • 1.5K
  • 15 Oct 2020
Topic Review
Graphene Nanomaterials as Biocompatible/Conductive Scaffolds
The unique properties of graphene make graphene (and its derivatives) a valuable nanomaterial for 2D or 3D stem cells culture maintenance and differentiation. To the best of our knowledge, this is the first review worldwide that besides provide clues and insights on the way we can much better manage and study stem cells especially for tissue engineering, regenerative medicine, transplantation, orthopedic surgery.
  • 1.5K
  • 10 Nov 2020
Topic Review
Parkinson’s Disease
Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting 1% of the population over 60 years of age. Clinically, PD is characterized mainly by the presence of motor symptoms, but a wide range of non-motor symptoms not only accompany the disease, but many of them even prevent the occurrence of motor symptoms. Despite many efforts, current medicine fails, not only in the treatment of PD, but in the early diagnosis of the disease. Current treatment is mainly based on symptomatic treatment or treatment with levodopa (L-DOPA) but does not focus on the pathogenesis of the disease itself. The presence of non-motor symptoms such as gastrointestinal dysfunction, which occurs up to 20 years before the onset of motor symptoms themselves, provides a sufficiently wide window of early diagnosis and thus potential early therapy for these patients. α-synuclein (α-Syn) is one of the candidates for a biomarker of PD. Mutations in its gene are associated with the familial form of PD as well as conformational changes in the protein and with its ability to oligomerize and fibrillate and form Lewy bodies (LB) and Lewy neurites (LN). It is LB and LN that are considered to be one of the most important pathological features of the disease, where α-Syn is the major component of these pathological structures. Its direct association with the pathogenesis of the disease together with the fact that in addition to brain structures, α-Syn is present in body fluids as well as in peripheral tissues such as gastrointestinal (GIT) tissues even enhances its potential use in early diagnosis of the disease. The diagnosis of the disease is also complicated by the similarity of clinical, cognitive, and neuropathological features of PD with other neurodegenerative diseases. In this context, various α-Syn strains have been identified based on the ability of α-Syn to form several types of fibrillar structures (strains) with different conformational, biological, and biochemical properties. And it is these differences that may be key to the correct early diagnosis of PD.
  • 1.5K
  • 16 Sep 2023
Topic Review
Stress-Induced Epstein-Barr Virus Reactivation
Epstein-Barr virus (EBV) is typically found in a latent, asymptomatic state in immunocompetent individuals. Perturbations of the host immune system can stimulate viral reactivation. Furthermore, there are a myriad of EBV-associated illnesses including various cancers, post-transplant lymphoproliferative disease, and autoimmune conditions. A thorough understanding of this virus, and the interplay between stress and the immune system, is essential to establish effective treatment.
  • 1.5K
  • 07 Oct 2021
Topic Review
Marine Plastic Litter Reduction in Manila
Without coordinated intervention, the annual flow of plastics into the ocean is expected to nearly triple by 2040, from 11 million tons today to 29 million metric tons, globally. Manila Bay, situated in Manila, is where the challenges related to plastic pollution are of great importance nationally and, thus, make headlines globally, as plastic waste that is not properly managed has increased the economic and environmental effects of marine plastics. At the global governance forum on 2 March 2022, at the UN Environment Assembly in Nairobi, 175 countries endorsed a historic resolution to end plastic pollution and forge an international, legally binding agreement by the end of 2024. With this global and binding agreement, cities like Manila could properly enforce measures to end this plastic pollution—which needs the political will of the administrators and the participation of the relevant constituents. 
  • 1.5K
  • 26 May 2022
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