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Topic Review
The Effects of Diets on the “Gut–Brain” Pathways
With depression becoming increasingly prevalent, being closely associated with stress, and many patients exhibiting resistance to current treatments, depression pathophysiology requires further elucidation. Recent research has shown complex bidirectional links between the brain and the gut, and the gut microbiota and the influence of diet is beginning to provide new clues to the complex nature of this disorder. It is well known that diet is a key modulator of gut microbial composition. In humans, good quality plant-based diets such as the Mediterranean diet have been shown to reduce pathogenic bacteria in the gut, increase Bifidobacterium and Clostridium, as well as lower the risk of depression, while poorer quality diets such as the Western diet have been shown to reduce Lactobacillus in the gut, reduce overall gut microbial diversity and have been associated with increased depression risk. Evaluating the effects of diets on the brain-to-gut and gut-to-brain mechanisms in animal models of stress and depression may aid in the elucidation of the pathophysiology of depression and may provide novel therapeutic approaches. 
  • 1.5K
  • 21 Feb 2022
Topic Review
Application of Biostimulants in Ornamental Horticulture
The biostimulant segment is becoming increasingly important worldwide. One of the reasons for this is that fewer plant protection products are placed on the market in the European Union, and environmental sustainability also plays an important role in their use. Biostimulants are often used in several horticultural sectors, including ornamentals, to strengthen plants, achieve commercial standards, produce quality goods, increase plant vitality, and aid harvesting.
  • 1.5K
  • 01 Jul 2022
Topic Review
Biological and Chemical Diversity of Angelica archangelica L.
Garden angelica (Angelica archangelica L.), native to the northern temperate region, is widespread in Europe and Asia. Since the middle ages, it has been used for healing and as a vegetable in traditional dishes. In the modern era, it has been proven that A. archangelica has a complex chemical composition. The main derivatives that contribute to the plant’s biological activities are essential oil and coumarins. 
  • 1.5K
  • 26 Jul 2022
Topic Review
Incidents in the Life of Madame Blavatsky
Incidents in the Life of Madame Blavatsky: compiled from information supplied by her relatives and friends is a book originally published in 1886 in London; it was compiled by a member of the Theosophical Society A. P. Sinnett, the first biographer of H. P. Blavatsky (née Hahn). He describes the many unusual incidents in her life, beginning from her childhood in Russia and asserts that she has been with "an early connection with the supernatural world;" he says about her short unlucky marriage and "decade of extensive global travels," about her period of learning in Tibet, and the "criticism she received about some of her 'phenomena' and practices."
  • 1.5K
  • 06 Oct 2022
Topic Review
Situational Factors Affecting Tic Severity
Much of the research regarding Tourette’s syndrome (TS) has focused on why certain individuals develop tics while others do not. However, a separate line of research focuses on the momentary influences that cause tics to increase or decrease in patients who are already known to have TS or another chronic tic disorder (CTD). Environmental and internal variables such as fatigue, anxiety, and certain types of thoughts all have been shown to worsen tic severity and may even overcome the positive effects of treatment. Other influences such as stress, distraction, and being observed have had mixed effects in the various studies that have examined them. Still, other variables such as social media exposure and dietary habits have received only minimal research attention and would benefit from additional study. Understanding the impact of these environmental and internal influences provides an opportunity to improve behavioral treatments for TS/CTD and to improve the lives of those living with these conditions. 
  • 1.5K
  • 12 Oct 2022
Topic Review
UAVCAN
UAVCAN (Uncomplicated Application-level Vehicular Computing and Networking) is a lightweight protocol designed for reliable intra-vehicle communications using various communications transports, originally destined for CAN bus but targeting various network types in subsequent revisions.
  • 1.5K
  • 01 Nov 2022
Topic Review
Clinical Trials Registry
A clinical trials registry is an official platform and catalog for registering a clinical trial. Some countries require clinical trials being conducted in that country to be registered; others do not require it, but often strongly encourage it. ClinicalTrials.gov, run by the United States National Library of Medicine (NLM) was the first online registry for clinical trials and is the largest and most widely used today. Clinical trials are conducted to allow safety and efficacy data to be collected for health interventions (e.g., drugs, diagnostics, devices, therapy protocols). The goal of a clinical trials registry is to provide increased transparency and access to clinical trials, made available to the public. Clinical trials registries are often searchable (for example, trials can be searchable by disease/indication, drug, location, etc.). Trials are registered by the pharmaceutical, biotech or medical device company (Sponsor) or by the hospital or foundation which is sponsoring the study, or by another organization, such as a contract research organization (CRO) which is running the study. There has been a push from governments and international organizations, especially since 2005, to make clinical trial information more widely available and to standardize registries and processes of registering. The World Health Organization is working toward "achieving consensus on both the minimal and the optimal operating standards for trial registration".
  • 1.5K
  • 02 Nov 2022
Topic Review
Distance Geometry Problem
The distance geometry problem is that of characterization and study of sets of points based only on given values of the distances between member pairs. Therefore distance geometry has immediate relevance where distance values are determined or considered, such as biology, sensor network, surveying, cartography, and physics.
  • 1.5K
  • 03 Nov 2022
Biography
Leopold Infeld
Leopold Infeld (20 August 1898 – 15 January 1968) was a Poland physicist who worked mainly in Poland and Canada (1938–1950). He was a Rockefeller fellow at Cambridge University (1933–1934) and a member of the Polish Academy of Sciences.[1] Leopold Infeld was born into a family of Polish Jews in Kraków, then part of the Austro-Hungarian Empire (it rejoined an independent Poland in 1918)
  • 1.5K
  • 02 Dec 2022
Topic Review
Biological Properties of Lignans
Lignans are, phenolic compounds and, as such, have a strong antioxidant capacity, which inextricably links them to beneficial effects on human health. Flax (Linum usitatissimum) is an annual herbaceous plant with blue flowers, widespread in various parts of the world. Flaxseeds are one of the plant matrices richest in lignans.
  • 1.5K
  • 17 Jan 2023
Topic Review
Antibody–Drug Conjugates Approved in Breast Cancer
Antibody–drug conjugates (ADCs), with antibodies targeted against specific antigens linked to cytotoxic payloads, offer the opportunity for a more specific delivery of chemotherapy and other bioactive payloads to minimize side effects. First approved in the setting of HER2+ breast cancer, more recent ADCs have been developed for triple-negative breast cancer (TNBC) and hormone receptor-positive (HR+) breast cancer.
  • 1.5K
  • 28 Feb 2023
Topic Review
Autism and Emotional Intelligence
Emotional intelligence is important within the workplace, as indicated by the multitude of positive workplace outcomes associated with heightened emotional intelligence. Research has demonstrated that many autistic individuals exhibit lower levels of trait emotional intelligence, potentially putting them at a disadvantage within the workplace. Examining emotional intelligence via its separate components, however, suggests autistic adults may not fare as poorly as trait-level research may indicate.
  • 1.5K
  • 17 May 2023
Topic Review
Photon-Counting CT Technology
Photon-counting computed tomography (PCCT) is an emerging technology that can potentially transform clinical CT imaging. The improved diagnostic performance of PCCT over conventional CT in the diagnosis and characterization of cardiovascular diseases has been demonstrated in several phantom, animal, and even human studies. 
  • 1.5K
  • 01 Sep 2023
Topic Review
Extracellular Vesicles in Blood
Extracellular vesicles (EVs) are important players for intercellular communication. EVs are secreted by almost all cell types; they can transfer information between nearby or distant cells, and they are highly abundant in body fluids. The present work provides an overview of the components, effects, and applications of EVs in blood.
  • 1.5K
  • 26 Aug 2021
Topic Review
Dendrimers in Personalized Medicine
Dendrimers are a special class of synthetic macromolecules, constituted of branches built, step by step, around a central multifunctional core. Each layer of branching points creates a new “generation”. Most of the properties of dendrimers depend on the type of their terminal functions. Dendrimers are often considered as 3-dimensional soft nanoparticles, in opposition to hard metal nanoparticles. Despite the fact that nature has favored branching structures at all levels, from galaxies to trees and to dendritic cells, examples of branching at the molecular level are extremely rare. One can cite glycogen, a branched polymer of glucose, and also some cases of branched lignin, but none of them have a precisely highly branched structure, as do dendrimers. Such unusual structure has generated a many expectations for dendrimers: a huge number of publications and patents exist in relation to medicine, including in relation to personalized medicine but have resulted in very poor clinical translation up to now. This entry focusses on some of the clinical trials carried out with dendrimers.
  • 1.5K
  • 14 Sep 2022
Topic Review
Pexophagy in Plants
Autophagy, or self-eating, is a conservative process that occurs in yeast, animal, and plant cells, and primarily involves the degradation of cytoplasmic fragments along with organelles, protein complexes, and other macromolecules. In plants, autophagy participates in the circulation of cell components and acts as a quality control mechanism. 
  • 1.5K
  • 30 Oct 2020
Topic Review
Osteoclasts
There are sexually dimorphic differences in osteoclast formation and function that may have significant importance for understanding why females are prone to have a lower bone mass than males at any given age and are at increased risk for osteoporosis. Osteoclasts are the principal mediators of bone resorption. They form through the fusion of mononuclear precursor cells under the principal influence of the cytokines macrophage colony stimulating factor (M-CSF, aka CSF-1) and receptor activator of NF-κB ligand (RANKL, aka TNFSF11).
  • 1.5K
  • 04 Nov 2020
Topic Review
Wind Turbine Blades: End-of-Life Scenarios
Large expansion of wind energy is expected in next decades. At the same time, a significant proportion of the installed wind turbines, the generation installed in 2000s, will come to the end of their lifetime between 2020 and 2030. Many parts of wind turbines can be recycled, however, this is seldom the case for the composite wind blades. Wind turbine blades are developed and designed to sustain challenging service conditions and extraordinary mechanical and ennvironmental loads for several decades. Therefore, their afterlife destruction and separation into re-usable elements represents a challenge. In this review, strategies of end-of-life management of wind turbine blades are discussed. Various scenarios of end-of-life management of wind turbine blades are considered. “Reactive” strategies, designed to deal with ageing turbines, installed in 2000s, include improved maintenance and repair technologies, reuse, refurbishment and recycling.  “Pro-active strategies”, applicable to f new generations of wind turbines, include wind turbine blades with thermoplastic and recyclable thermoset composite matrices, as well as wood, bamboo and natural fiber based composites. 
  • 1.5K
  • 23 Mar 2021
Topic Review
3D Graphene-Based Toxic Gas Sensors
Air pollution is becoming an increasingly important global issue. Toxic gases such as ammonia, nitrogen dioxide, and volatile organic compounds (VOCs) like phenol are very common air pollutants. To date, various sensing methods have been proposed to detect these toxic gases. Researchers are trying their best to build sensors with the lowest detection limit, the highest sensitivity, and the best selectivity. As a 2D material, graphene is very sensitive to many gases and so can be used for gas sensors. Recent studies have shown that graphene with a 3D structure can increase the gas sensitivity of the sensors. The limit of detection (LOD) of the sensors can be upgraded from ppm level to several ppb level.
  • 1.5K
  • 25 Aug 2021
Topic Review
Cr and Plants
Extensive industrial activities resulted in an increase in chromium (Cr) contamination in the environment. The toxicity of Cr severely affects plant growth and development. Cr is also recognized as a human carcinogen that enters the human body via inhalation or by consuming Cr-contaminated food products.
  • 1.5K
  • 28 May 2021
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