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Topic Review
Transcriptional Regulation of the Hippo Pathway
Hippo signaling pathway is a key modulator of tissue growth with widespread implications in organ development, cell growth, regeneration, and stem cell function.
  • 1.5K
  • 15 Aug 2022
Topic Review
Adaptation to Climate Change in Jordan
Adaptation to climate change in Jordan describes measures with the objective to prepare the country for the impacts of climate change. Water resources in Jordan are scarce. Besides the rapid population growth, the impacts of climate change are likely to further exacerbate the problem. Temperatures will increase and the total annual precipitation is likely to decrease, however with a fair share of uncertainty. Hence, existing and new activities with the objective to minimize the gap between water supply and demand contribute to adapt Jordan to tomorrow's climate. This might be accompanied by activities improving Jordan's capacity to monitor and project meteorological and hydrological data and assess its own vulnerability to climate change. This article focuses on the impacts of climate change on the Jordanian water sector.
  • 1.5K
  • 17 Oct 2022
Topic Review
Cognitive Neuroscience of Visual Object Recognition
Visual object recognition refers to the ability to identify the objects in view based on visual input. One important signature of visual object recognition is "object invariance", or the ability to identify objects across changes in the detailed context in which objects are viewed, including changes in illumination, object pose, and background context..
  • 1.5K
  • 19 Oct 2022
Topic Review
Celtic Animism
According to classical sources, the ancient Celts were animists. They honoured the forces of nature, saw the world as inhabited by many spirits, and saw the Divine manifesting in aspects of the natural world.
  • 1.5K
  • 08 Nov 2022
Topic Review
Blue Ribbon Study Panel on Biodefense
The Blue Ribbon Study Panel on Biodefense (BRSPB) is a panel of former high-ranking government officials and academic experts that analyzes the United States' defense capabilities against biological threats. According to BRSPB's mission statement, the organization was formed to "provide for a comprehensive assessment of the state of U.S. biodefense efforts, and to issue recommendations that will foster change." BRSPB is supported by donor organizations. Hudson Institute serves as the Panel's fiscal sponsor. Current donors include Open Philanthropy.
  • 1.5K
  • 11 Nov 2022
Topic Review
β-Lactam Resistance Genes in Wastewater Treatment Plants
Antimicrobial resistance (AMR) is one of the largest global concerns due to its influence in multiple areas, which is consistent with One Health’s concept of close interconnections between people, animals, plants, and their shared environments. Antibiotic-resistant bacteria (ARB) and antibiotic-resistance genes (ARGs) circulate constantly in various niches, sediments, water sources, soil, and wastes of the animal and plant sectors, and is linked to human activities. Sewage of different origins gets to the wastewater treatment plants (WWTPs), where ARB and ARG removal efficiency is still insufficient, leading to their transmission to discharge points and further dissemination. Thus, WWTPs are believed to be reservoirs of ARGs and the source of spreading AMR. According to a World Health Organization report, the most critical pathogens for public health include Gram-negative bacteria resistant to third-generation cephalosporins and carbapenems (last-choice drugs), which represent β-lactams, the most widely used antibiotics. Therefore, this research presents the available research data for ARGs in WWTPs that confer resistance to β-lactam antibiotics, with a particular emphasis on clinically important life-threatening mechanisms of resistance, including extended-spectrum β-lactamases (ESBLs) and carbapenemases (KPC, NDM).
  • 1.5K
  • 17 Nov 2022
Topic Review
Mechanism of Remediation of Contaminated Soil by Nanoparticles
The varied sources of soil pollution include the application of chemical fertilizers and pesticides, industrial discharge, and transformed products of these accumulated chemical residues. These processes may hamper the composition and soil ecosystem. Different types of methodologies ranging from physical, chemical, and biological approaches have been exploited to tackle this challenge. Nanomaterials (NMs) research has contributed to a new dimension for the remediation of polluted soils.
  • 1.5K
  • 12 Dec 2022
Topic Review
Intelligent Tutoring for Student-Athletes Based on Self-Determination Theory
Student-athletes frequently struggle to strike a balance between their academic and athletic responsibilities. Various factors, such as age and competitive level, contribute to differences in their academic motivation and identity, showcasing the multifaceted needs they possess. While self-determination theory (SDT) has been proven effective for explaining student-athletes academic needs, its integration into learning design for this group remains limited. The developing AI technology, especially the Intelligent Tutoring System (ITS), offers the potential for creating personalized learning environments that can cater to the varying levels of motivation among student-athletes within the framework of SDT.
  • 1.5K
  • 20 Oct 2023
Topic Review
Types and General Role of Organic Amendments
Salinity and metal stress are significant abiotic factors that negatively influence plant growth and development. These factors lead to diminished agricultural yields on a global scale. Organic amendments have emerged as a potential solution for mitigating the adverse effects of salinity and metal stress on plants. When plants experience these stresses, they produce reactive oxygen species, which can impair protein synthesis and damage cellular membranes. Organic amendments, including biochar, vermicompost, green manure, and farmyard manure, have been shown to facilitate soil nitrogen uptake, an essential component for protein synthesis, and enhance various plant processes such as metabolism, protein accumulation, and antioxidant activities. Researchers have observed that the application of organic amendments improves plant stress tolerance, plant growth, and yield.
  • 1.5K
  • 19 Mar 2024
Topic Review
Effect of Probiotics on Glucose Metabolism and Homeostasis
The maintenance of a healthy status depends on the coexistence between the host organism and the microbiota. Early studies have already focused on the nutritional properties of probiotics, which may also contribute to the structural changes in the gut microbiota, thereby affecting host metabolism and homeostasis. Maintaining homeostasis in the body is therefore crucial and is reflected at all levels, including that of glucose, a simple sugar molecule that is an essential fuel for normal cellular function. Despite numerous clinical studies that have shown the effect of various probiotics on glucose and its homeostasis, knowledge about the exact function of their mechanism is still scarce. 
  • 1.5K
  • 12 Aug 2022
Topic Review
Hematopoietic Stem Cells (HSCs)
Hematopoietic stem cells (HSCs) and their offspring, the hematopoietic progenitor cells (HPCs), are highly sociable. Their capacity to interact with bone marrow niche cells and respond to environmental cytokines orchestrates the generation of the different types of blood and immune cells. 
  • 1.5K
  • 28 May 2021
Topic Review
Silica Pervaporation Membranes
Solvents are very critical not only to produce lifesaving drugs, but also to manufacture many household products. Hence, they are widely used in the pharmaceutical industry, petroleum refineries, paints and coatings, adhesives, printing inks, industrial cleaning and research essential to the fields of medicine and disease diagnosis. Conventional technologies such as distillation which are used to recover those solvents, are energy-intensive, inefficient and suffer from high operating and maintenance costs. Pervaporation based membrane separation overcomes these challenges and in conjunction with the utilization of inorganic membranes derived from non-toxic, sufficiently abundant and hence expendable, silica, allows for high operating temperatures and enhanced chemical and structural integrity, raw material abundance and easy disposability. However, silica membranes possess some disadvantages, such as an inadequacy in the complete understanding of the governing mechanism as well as compromised structural integrity towards dilute aqueous organic mixtures.  Membrane-based separation is predicted to dominate the industry in the coming decades, as the process is being understood at a deeper level, leading to the fabrication of tailored membranes for niche applications. The current review aims to compile and present the extensive and often dispersive scientific investigations to the reader and highlight the current scenario as well as the limitations suffered by this mature field. In addition, viable alternative to the conventional methodologies, as well as other rival materials in existence to achieve membrane-based pervaporation are highlighted.
  • 1.5K
  • 13 Aug 2020
Topic Review
Centromere Flexibility
Centromeres are the complex structures responsible for the proper segregation of chromosomes during cell division. Structural or functional alterations of the centromere cause aneuploidies and other chromosomal aberrations that can induce cell death with consequences on health and survival of the organism as a whole. Because of their essential function in the cell, centromeres have evolved high flexibility and mechanisms of tolerance to preserve their function following stress, whether it is originating from within or outside the cell.Despite the differences in DNA sequences, protein composition and centromere size, all of these diverse centromere structures promote efficient chromosome segregation, balancing genome stability and adaptability, and ensuring faithful genome inheritance at each cellular generation.
  • 1.5K
  • 03 Aug 2020
Topic Review
Endocrine-Disrupting Compounds
The continual detection of endocrine-disrupting chemicals (EDCs) (ng/L or µg/L) in water and wastewater has attracted critical concerns among the regulatory authorities and general public, due to its associated public health, ecological risks, and a threat to global water quality. Presently, there is a lack of stringent discharge standards regulating the emerging multiclass contaminants to obviate its possible undesirable impacts.
  • 1.5K
  • 18 Feb 2021
Topic Review
Antimicrobial Properties of Lignocellulosic Materials
Pathogenic microbes are a major source of health and environmental problems, mostly due to their easy proliferation on most surfaces. Currently, new classes of antimicrobial agents are under development to prevent microbial adhesion and biofilm formation. However, they are mostly from synthetic origin and present several disadvantages. The use of natural biopolymers such as cellulose, hemicellulose, and lignin, derived from lignocellulosic materials as antimicrobial agents has a promising potential. Lignocellulosic materials are one of the most abundant natural materials from renewable sources, and they present attractive characteristics, such as low density and biodegradability, are low-cost, high availability, and environmentally friendly.
  • 1.5K
  • 08 Apr 2021
Topic Review
Schizochytrium.: Game-Changer in Rumen Bacteriome
The inclusion of microalgae on ruminants' diets appears to be a promising feeding strategy to enrich milk with beneficial biomolecules such as ω3 fatty acids. However, radical alterations could occur in both structure and biochemistry potential of the rumen microbiome.
  • 1.5K
  • 16 Oct 2021
Topic Review
HDL in Familial Hypercholesterolemia
HDL are the first defensive barrier against the burden of high LDL cholesterol levels owing to their contribution to reverse cholesterol transport as well as their antioxidant and anti-inflammatory properties, among others. 
  • 1.5K
  • 28 Jul 2021
Topic Review Peer Reviewed
L-Asparaginase-Based Biosensors
L-asparaginase (ASNase) is an aminohydrolase enzyme widely used in the pharmaceutical and food industries. Although currently its main applications are focused on the treatment of lymphoproliferative disorders such as acute lymphoblastic leukemia (ALL) and acrylamide reduction in starch-rich foods cooked at temperatures above 100 °C, its use as a biosensor in the detection and monitoring of L-asparagine levels is of high relevance. ASNase-based biosensors are a promising and innovative technology, mostly based on colorimetric detection since the mechanism of action of ASNase is the catalysis of the L-asparagine hydrolysis, which releases L-aspartic acid and ammonium ions, promoting a medium pH value change followed by color variation. ASNase biosensing systems prove their potential for L-asparagine monitoring in ALL patients, along with L-asparagine concentration analysis in foods, due to their simplicity and fast response. 
  • 1.5K
  • 13 Apr 2022
Topic Review
Mathematics Problems Solving
Mathematics problems solving (MPS) has been considered for decades as the centre of mathematics teaching, as it demonstrates the ability to analyse, understand, reason and apply. At the same time, it is also considered to be specific content when highlighting it as a basic competence that students should acquire.
  • 1.5K
  • 12 Nov 2021
Topic Review
Bird Displacement by Wind Turbines
Wind turbines can affect bird populations by causing mortality when birds collide with turbine blades or displacement when the individuals move permanently to other areas. While mortality is well documented, displacement has only been studied more extensively in the last decade, and it is important to summarise the current knowledge and research trends. 
  • 1.5K
  • 22 Dec 2021
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