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Topic Review
Fundamentals of Chlorine Disinfection
Chlorine first reacts with organic and inorganic matters before pathogens inactivation. The amount of chlorine consumed in this process is termed chlorine demand. The combined chlorine that forms together with any free available chlorine in the water is called the chlorine residual. This is the component of the added chlorine that disinfects the water. Free available chlorine is formed by differences in the concentrations of hypochlorous and hypochlorite ions, a process that depends on the pH of the water. Even though the chlorination procedure is well-researched, establishing an appropriate chlorine dose remains a difficult task for many field applications. Nevertheless, the effective chlorine dose should be sufficient to destroy pathogens and oxidize the organic contaminants as well as maintain sufficient free available chlorine in the water distribution system, post-chlorination.
  • 6.6K
  • 06 Jun 2022
Topic Review
Central Nervous System in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined, neurodevelopmental disorder that has been modeled as a brain-based disease.
  • 6.6K
  • 20 Jan 2022
Topic Review
Pharmacological Activities of Indian Camphorweed (Pluchea indica)
Pluchea indica (L.) Less. (Asteraceae) commonly-known as Indian camphorweed, pluchea, or marsh fleabane has gained great importance in various traditional medicines for its nutritional and medicinal benefits. It is utilized to cure several illnesses such as lumbago, kidney stones, leucorrhea, inflammation, gangrenous and atonic ulcer, hemorrhoids, dysentery, eye diseases, itchy skin, acid stomach, dysuria, abdominal pain, scabies, fever, sore muscles, dysentery, diabetes, rheumatism, etc. The plant or its leaves in the form of tea are commonly used for treating diabetes and rheumatism. 
  • 6.6K
  • 25 May 2022
Topic Review
Dukkha
Dukkha (/ˈduːkə/; Pāli; Sanskrit: duḥkha; Tibetan: སྡུག་བསྔལ་ sdug bsngal, pr. "duk-ngel") is an important Buddhist concept, commonly translated as "suffering", "pain", "unsatisfactoriness" or "stress". It refers to the fundamental unsatisfactoriness and painfulness of mundane life. It is the first of the Four Noble Truths. The term is also found in scriptures of Hinduism, such as the Upanishads, in discussions of moksha (spiritual liberation).
  • 6.6K
  • 24 Oct 2022
Topic Review
76 Mm Gun M1
The 76 mm gun M1 was an American World War II–era tank gun developed by the U.S Ordnance Department in 1942 to supplement the 75 mm gun on the basic Medium tank M4. It was also used to arm the 76 mm Gun Motor Carriage M18 tank destroyer. Although the gun was tested in early August 1942 and classified on August 17, 1942, it was not until August 1943 that the Ordnance Department developed a mounting for the M4 tank that the tank forces would accept. It was not accepted for combat until July 1944. In January 1943, the decision was made to mount the 76 mm on the vehicle that would become the M18. By May 1944, it was being combat tested as the T70.
  • 6.6K
  • 11 Nov 2022
Topic Review
Visual Appearance of Oil
The visual appearance of oil spills at sea is often used as an indicator of spilled oil properties, state and slick thickness. These appearances and the oil properties that are associated with them are reviewed in this entry. The appearance of oil spills is an estimator of thickness of thin oil slicks, thinner than a rainbow sheen (<3 µm). Rainbow sheens have a strong physical explanation. Thicker oil slicks (e.g., >3 µm) are not correlated with a given oil appearance. At one time, the appearance of surface discharges from ships was thought to be correlated with discharge rate and vessel speed; however, this approach is now known to be incorrect. Oil on the sea can sometimes form water-in-oil emulsions, dependent on the properties of the oil, and these are often reddish in color. These can be detected visually, providing useful information on the state of the oil. Oil-in-water emulsions can be seen as a coffee-colored cloud below the water surface. Other information gleaned from the oil appearance includes coverage and distribution on the surface.
  • 6.6K
  • 27 Jan 2021
Topic Review
Lithium-Ion Battery Fire Suppression
Lithium-ion Batteries (LiBs) hazards, techniques for mitigating risks, the suppression of LiB fires and identification of shortcomings for future improvement were thoroughly reviewed. Water is identified as an efficient cooling and suppressing agent and water mist is considered the most promising technique to extinguish LiBs fire. 
  • 6.6K
  • 29 Apr 2021
Topic Review
Varna Necropolis
The so-called Varna Necropolis (Bulgarian: Варненски некропол) (also Varna Cemetery) is a burial site from 4569–4340 BC in the western industrial zone of Varna (approximately half a kilometre from Lake Varna and 4 km from the city centre), internationally considered one of the key archaeological sites in world prehistory. There were other necropoles dating from later Greek and Roman periods around the ancient city. The oldest gold treasure in the world, dating from this period, was discovered at the site.
  • 6.6K
  • 28 Oct 2022
Topic Review
Cost–Benefit Analysis for Road Infrastructure Projects
Cost–benefit analysis (CBA) is considered an effective evaluation method for fostering optimal decision-making and ranking of road infrastructures over decades. Eight distinct modelling categories used for CBA implementation were determined, each encompassing three different modelling approaches for capturing the data risk assessment (deterministic or probabilistic), CBA’s parameters interactive behavior (static or dynamic) and the considered economies (microeconomic or macroeconomic). In-depth content analysis led to the interpretation of the current status of extant models and the identification of three main knowledge gaps: the absence of the CBA’s inputs updating into a probabilistic environment, the deficiency of a dynamic interdependent framework and the necessity of homogenous cost datasets for road projects. Future research directions and a conceptual framework for modelling CBA into a microeconomic, probabilistic and dynamic environment are proposed providing decision-makers with new avenues for more reliable CBA modelling.
  • 6.6K
  • 29 Jan 2023
Topic Review
Brassicaceae Family
Brassicaceae family vegetables have an ample worldwide distribution, which can be found in all continents except Antarctica. One of the most striking features of this botanical family is the presence of several kinds of secondary metabolites with a distinctive taste, and also interesting bioactivities. The most deeply studied are the glucosinolates (GSL) and from their bioactive breakdown products, the isothiocyanates and the indoles. Moreover, these species are also rich and possess unique profiles of phenolic compounds, carotenoids, and other groups of less studied compounds such as phytoalexins, terpenes, phytosteroids, and tocopherols, here reviewed.
  • 6.6K
  • 29 Oct 2020
Topic Review
Non-Ionic Surfactants
Surfactants are essential in the manufacture of polymeric nanoparticles by emulsion formation methods and to preserve the stability of carriers in liquid media. The deposition of non-ionic surfactants at the interface allows a considerable reduction of the globule of the emulsion with high biocompatibility and the possibility of oscillating the final sizes in a wide nanometric range.
  • 6.6K
  • 29 Jun 2021
Topic Review
Mathematical Modeling and Computational Tools in Drug Design
The conventional drug discovery approach is an expensive and time-consuming process, but its limitations have been overcome with the help of mathematical modeling and computational drug design approaches. Previously, finding a small molecular candidate as a drug against a disease was very costly and required a long time to screen a compound against a specific target. The development of novel targets and small molecular candidates against different diseases including emerging and reemerging diseases remains a major concern and necessitates the development of novel therapeutic targets as well as drug candidates as early as possible. In this regard, computational and mathematical modeling approaches for drug development are advantageous due to their fastest predictive ability and cost-effectiveness features. Computer-aided drug design (CADD) techniques utilize different computer programs as well as mathematics formulas to comprehend the interaction of a target and drugs. Traditional methods to determine small-molecule candidates as a drug have several limitations, but CADD utilizes novel methods that require little time and accurately predict a compound against a specific disease with minimal cost.
  • 6.6K
  • 01 Aug 2022
Topic Review
Human Immunodeficiency Virus (HIV) Biology
The genomic RNA of HIV-1 enables employing complex splicing patterns the encryption of multiple proteins within a limited coding capacity. The viral RNA and related proteins mediate toxicity via multiple different pathways. The circumvention of the host cell immune system and the progressing elimination of T helper cells leads to AIDS and opportunistic infections. The aberrant interaction of viral RNA-binding proteins can result in cellular transcriptional deregulations, tumor formation and apoptosis.
  • 6.6K
  • 02 Mar 2022
Topic Review Peer Reviewed
Solar Chimney Applications in Buildings
A solar chimney is a renewable energy system used to enhance the natural ventilation in a building based on solar and wind energy. It is one of the most representative solar-assisted passive ventilation systems attached to the building envelope. It performs exceptionally in enhancing natural ventilation and improving thermal comfort under certain climate conditions. The ventilation enhancement of solar chimneys has been widely studied numerically and experimentally. The assessment of solar chimney systems based on buoyancy ventilation relies heavily on the natural environment, experimental environment, and performance prediction methods, bringing great difficulties to quantitative analysis and parameterization research. With the increase in volume and complexity of modern building structures, current studies of solar chimneys have not yet obtained a unified design strategy and corresponding guidance. Meanwhile, combining a solar chimney with other passive ventilation systems has attracted much attention. The solar chimney-based integrated passive-assisted ventilation systems prolong the service life of an independent system and strengthen the ventilation ability for indoor cooling and heating. However, the progress is still slow regarding expanded applications and related research of solar chimneys in large volume and multi-layer buildings, and contradictory conclusions appear due to the inherent complexity of the system.
  • 6.6K
  • 13 Apr 2022
Topic Review Peer Reviewed
Cuteness and Its Emotional Responses
Cuteness is commonly associated with visual features such as large eyes, a disproportionately large head, round body shapes, and small size. While these traits are most often observed in infants and young animals, they also appear in inanimate objects and digital representations intentionally designed to evoke emotional appeal. Drawing on developmental psychology, behavioral science, neuroscience, and cultural studies, this paper examines five core emotional responses to cute stimuli: caretaking, socializing, whimsical, cute aggression, and kama muta (the feeling of being emotionally moved). These responses emerge from an interplay between evolutionary mechanisms, such as caregiving instincts, and cultural frameworks that shape how cuteness is perceived, expressed, and valued. The analysis highlights not only biological foundations but also cultural moderators, with particular attention to gender differences and the pervasive role of kawaii aesthetics in Japan’s popular culture, communication, and everyday life. This paper provides an overview of these emotional responses, situates them within their theoretical foundations and broader psychological and social implications, and proposes a framework for future research.
  • 6.6K
  • 17 Sep 2025
Topic Review
Mini-LED and Micro-LED
The mini-LEDs with chip sizes ranging from 100 to 200 μm have already been commercialized for backlight sources in consumer electronics applications. The realized local diming can greatly improve the contrast ratio at relatively low energy consumptions. The micro-LEDs with chip size less than 100 μm, still remain in the laboratory.
  • 6.6K
  • 24 Jun 2021
Topic Review
Pine Ridge Indian Reservation
The Pine Ridge Indian Reservation (Template:Lang-lkt), also called Pine Ridge Agency, is an Oglala Lakota Native American reservation located in the U.S. state of South Dakota. Originally included within the territory of the Great Sioux Reservation, Pine Ridge was created by the Act of March 2, 1889, 25 Stat. 888. in the southwest corner of South Dakota on the Nebraska border. Today it consists of 3,468.85 sq mi (8,984.3 km2) of land area and is the eighth-largest reservation in the United States, larger than Delaware and Rhode Island combined. The reservation encompasses the entirety of Oglala Lakota County and Bennett County, the southern half of Jackson County, and a small section of Sheridan County added by Executive Order No. 2980 of February 20, 1904. Of the 3,142 counties in the United States, these are among the poorest. Only 84,000 acres (340 km2) of land are suitable for agriculture. The 2000 census population of the reservation was 15,521; but a study conducted by Colorado State University and accepted by the United States Department of Housing and Urban Development has estimated the resident population to reach 28,787. Pine Ridge is the site of several events that mark milestones in the history between the Sioux of the area and the United States (U.S.) government. Stronghold Table—a mesa in what is today the Oglala-administered portion of Badlands National Park—was the location of the last of the Ghost Dances. The U.S. authorities' attempt to repress this movement eventually led to the Wounded Knee Massacre on December 29, 1890. A mixed band of Miniconjou Lakota and Hunkpapa Sioux, led by Chief Spotted Elk, sought sanctuary at Pine Ridge after fleeing the Standing Rock Agency, where Sitting Bull had been killed during efforts to arrest him. The families were intercepted by a heavily armed detachment of the Seventh Cavalry, which attacked them, killing many women and children as well as warriors. This was the last large engagement between U.S. forces and Native Americans and marked the end of the western frontier. Changes accumulated in the last quarter of the 20th century; in 1971 the Oglala Sioux Tribe (OST) started Oglala Lakota College, a tribal college, which offers 4-year degrees. In 1973 decades of discontent at the Pine Ridge Reservation resulted in a grassroots protest that escalated into the Wounded Knee Incident, gaining national attention. Members of the Oglala Lakota, the American Indian Movement and supporters occupied the town in defiance of federal and state law enforcement in a protest that turned into an armed standoff lasting 71 days. This event inspired American Indians across the country and gradually led to changes at the reservation, with a revival of some cultural traditions. In 1981 the Lakota Tim Giago started the Lakota Times at Pine Ridge, the first independent Native American newspaper in the nation; he published it until selling it in 1998. Located at the southern end of the Badlands, the reservation is part of the mixed grass prairie, an ecological transition zone between the short-grass and tall-grass prairies; all are part of the Great Plains. A great variety of plant and animal life flourishes on and adjacent to the reservation, including the endangered black-footed ferret. The area is also important in the field of paleontology; it contains deposits of Pierre Shale formed on the seafloor of the Western Interior Seaway, evidence of the marine Cretaceous–Paleogene boundary, and one of the largest deposits of fossils of extinct mammals from the Oligocene epoch.
  • 6.6K
  • 07 Oct 2022
Topic Review
Antioxidants
There are established links between free radicals and more than sixty different human health conditions, including ageing, cancer, diabetes, Alzheimer’s disease, strokes, heart attacks, and atherosclerosis. Consumption of higher levels of dietary antioxidant enzymes and antioxidant molecules-enriched food or antioxidant supplements has been found to reduce the risk of free radical-related health issues. The green halotolerant microalgae Dunaliella can grow in a wide range of saline environments and is a  potential natural source for antioxidant production.
  • 6.6K
  • 10 May 2021
Topic Review
Modern Stoicism
Modern Stoicism is an intellectual and popular movement that began at the end of the 20th century aimed at reviving the practice of Stoicism. It is not to be confused with neostoicism, an analogous phenomenon in the 17th century. The term "modern Stoicism" covers both the revival of interest in the Stoic philosophy and the philosophical efforts to adjust ancient Stoicism to the language and conceptual framework of the present. The rise of modern Stoicism has received attention in the international media since around November 2012 when the first Annual Stoic Week event was organized.
  • 6.6K
  • 04 Nov 2022
Topic Review
Transcription
Transcription is the process of copying a segment of DNA into RNA. The segments of DNA transcribed into RNA molecules that can encode proteins are said to produce messenger RNA (mRNA). Other segments of DNA are copied into RNA molecules called non-coding RNAs (ncRNAs). Averaged over multiple cell types in a given tissue, the quantity of mRNA is more than 10 times the quantity of ncRNA (though in particular single cell types ncRNAs may exceed mRNAs). The general preponderance of mRNA in cells is valid even though less than 2% of the human genome can be transcribed into mRNA (Human genome), while at least 80% of mammalian genomic DNA can be actively transcribed (in one or more types of cells), with the majority of this 80% considered to be ncRNA. Both DNA and RNA are nucleic acids, which use base pairs of nucleotides as a complementary language. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, antiparallel RNA strand called a primary transcript. Transcription proceeds in the following general steps: If the stretch of DNA is transcribed into an RNA molecule that encodes a protein, the RNA is termed messenger RNA (mRNA); the mRNA, in turn, serves as a template for the protein's synthesis through translation. Other stretches of DNA may be transcribed into small non-coding RNAs such as microRNA, transfer RNA (tRNA), small nucleolar RNA (snoRNA), small nuclear RNA (snRNA), or enzymatic RNA molecules called ribozymes as well as larger non-coding RNAs such as ribosomal RNA (rRNA), and long non-coding RNA (lncRNA). Overall, RNA helps synthesize, regulate, and process proteins; it therefore plays a fundamental role in performing functions within a cell. In virology, the term transcription may also be used when referring to mRNA synthesis from an RNA molecule (i.e., equivalent to RNA replication). For instance, the genome of a negative-sense single-stranded RNA (ssRNA -) virus may be a template for a positive-sense single-stranded RNA (ssRNA +)[clarification needed]. This is because the positive-sense strand contains the sequence information needed to translate the viral proteins needed for viral replication. This process is catalyzed by a viral RNA replicase.[clarification needed]
  • 6.6K
  • 14 Apr 2023
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