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Topic Review
Infrared Thermography in Wildlife Animals under Human Care
Ensuring the welfare of wildlife under human care requires tools to monitor their health and well-being. Infrared thermography is a non-invasive technique for assessing thermal states that measure the radiation emitted from the skin in distinct anatomical areas, known as thermal windows—anatomical regions with abundant capillaries and arteriovenous anastomosis that facilitate heat exchange with the environment.
  • 1.6K
  • 03 Jan 2023
Topic Review
Irinotecan
Irinotecan has been used in the treatment of various malignancies for many years. Still, the knowledge regarding this drug is expanding. The pharmacogenetics of the drug is the crucial component of response to irinotecan. Furthermore, new formulations of the drug are introduced for it enhanced delivery. Novel formulations of drugs (e.g., liposomal formulations, dendrimers, and nanoparticles) have a huge potential to avoid potentially life-threatening side effects of the iriniotecan. 
  • 1.6K
  • 14 Jul 2020
Topic Review
Ocular Cystinosis
Cystinosis is a rare autosomal recessive disease that affects about 1 in 100,000–200,000 people among the general population, characterized by high levels of cystine within the lysosomes in cells of certain types of tissues. The accumulation of this substance is caused by mutations in the CTNS gene which codes for cystinosin, the carrier that transports cystine out of the lysosome. The presence of cystine crystals in different tissues leads to the progressive impairment and dysfunction of multiple organs, such as kidneys, pancreas, brain, thyroid and eyes.
  • 1.6K
  • 16 Dec 2020
Topic Review
Microglia
Microglia, the innate immune cells of the brain, are commonly perceived as resident macrophages of the central nervous system (CNS). This definition, however, requires further specification, as under healthy homeostatic conditions, neither morphological nor functional properties of microglia mirror those of classical macrophages.
  • 1.6K
  • 04 Feb 2021
Topic Review
Flecainide in Ventricular Arrhythmias
Flecainide is an IC antiarrhythmic drug (AAD) that received in 1984 Food and Drug Administration approval for the treatment of sustained ventricular tachycardia (VT) and subsequently for rhythm control of atrial fibrillation (AF). Currently, flecainide is mainly employed for sinus rhythm maintenance in AF and the treatment of idiopathic ventricular arrhythmias (IVA) in absence of ischaemic and structural heart disease on the basis of CAST data. Recent studies enrolling patients with different structural heart diseases demonstrated good effectiveness and safety profile of flecainide.
  • 1.6K
  • 10 Sep 2021
Topic Review
Antiphospholipid Syndrome (APS)
Antiphospholipid syndrome (APS) is considered an autoimmune, thrombo-inflammatory disease characterized by vascular thrombosis in the setting of one or more antiphospholipid antibodies (aPLs) such as lupus anticoagulant (AL), anticardiolipin antibodies (aCL) and anti-β2-glycoprotein1 antibodies (aβ2GPI).
  • 1.6K
  • 07 Dec 2021
Topic Review
Vehicle-to-Everything and Machine Learning Applications
The fifth-generation (5G) network is the current emerging technology that meets the increasing need for higher throughputs and greater system capacities. It is expected that 5G technology will enable many new applications and services. Vehicle-to-everything (V2X) communication is an example of an application that is supported by 5G technology and beyond. A V2X communication system allows a vehicle to be connected to an entity, such as a pedestrian, another vehicle, infrastructure, and a network, to provide a robust transportation solution.
  • 1.6K
  • 07 May 2022
Topic Review
Fetal Hemoglobin in Sickle Hemoglobinopathies
Fetal hemoglobin (HbF; α2γ2), encoded by two nearly identical γ-globin genes (HBG2, HBG1) that are part of the β-globin gene (HBB) cluster (11p15.4), comprises 70 to 90% of the hemolysate in newborns, falling to <1% after 12 months. HbF usually consists of 4 to 10% of total hemoglobin in adults of African descent with sickle cell anemia. Rarely, their HbF levels reach more than 30%. High HbF levels are sometimes a result of β-globin gene deletions or point mutations in the promoters of the HbF genes. 
  • 1.6K
  • 01 Aug 2022
Topic Review
Shambhala Training
Shambhala Training is a secular approach to meditation developed by Tibetan Buddhist teacher Chogyam Trungpa and his students. It is based on what Trungpa calls Shambhala Vision, which sees enlightened society as not purely mythical, but as realizable by people of all faiths through practices of mindfulness/awareness, non-aggression, and sacred outlook. He writes: The Shambhala Training teachings cover art, society, and politics and the goal of creating an enlightened society. That goal is presented as not solely a social and political process, but one requiring individuals to develop an awareness of the basic goodness and inherent dignity of themselves, of others, and of the everyday details of the world around them. This is facilitated by cultivating gentleness and bravery. Shambhala Training is currently administered worldwide by Shambhala International. The Satdharma community offers a comparable "Shambhala Education" course of training in Ojai, California.
  • 1.6K
  • 01 Nov 2022
Topic Review
Mining Effects on the Karst
Karst develops on soluble rocks (limestone, dolomite, and evaporite). The infiltrating water with carbonic acid creates cavities (caves), fills them, and flows towards the mountain margin (karst water), where it emerges in springs. The infiltrated water constitutes a three-dimensional system whose surface is the karst water level, which undergoes fluctuation of various degrees and periods due to natural and artificial effects, at another time a one-way rise or subsidence. Since karst rocks drain water, neither a surface water network nor valleys develop (they are only formed at sites where the valley is inherited from the non-karstic cover or when the karst water level is situated at the valley floor). The dissolved material is transported into the karst with the infiltrating waters; therefore, surface karst features are closed. These are karren, dolines, ponors with blind valleys, and poljes. The material transported in the solution precipitates as freshwater limestone.
  • 1.6K
  • 05 Dec 2022
Topic Review
Types of Solution Cocrystallization
Solution crystallization has been used in both batch and continuous modes for industrial crystallization for several decades. Solution cocrystallization is often used on a laboratory scale due to its familiarity, simple design, ease of operation, process monitoring, and control. Solvent selection and the mode of supersaturation generation are the two factors that are crucial at the early stages of solution crystallization. For cocrystallization, the solubility of coformers in a given solvent is key factor in solvent selection. Additionally, other operational parameters such as the crystallizer design, mode of agitation, cooling rate/antisolvent addition rate, seeding, or nucleation control can impact final crystal properties such as shape, size, and desired polymorphic.
  • 1.6K
  • 25 Jun 2023
Topic Review Peer Reviewed
Morphometric Characterization of Bacteria Associated with Bacteremia
Among the leading causes of bacteremia are Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus. E. coli and K. pneumoniae are increasingly exhibiting resistance to last-resort antibiotics, such as carbapenems. Rapid and accurate identification of these pathogens is critical for timely treatment and infection control. This paper aimed to develop a computer-aided bacterial morphometric technique for identifying and classifying wild-type E. coli, K. pneumoniae, and S. aureus in a field guide fashion. A 3D laser scanning confocal microscope was used to gather key parameters of each organism: length (L, µm), circular diameter (CD, µm), volume (V, µm3), surface area-to-cross-sectional area ratio (SA/CSA, unitless), surface uniformity ratio (Str), and surface texture ratio (Sdr). Microscope images and measurement results showed that S. aureus was spherical with the shortest length (1.08 µm) and smallest volume (0.52 µm3). E. coli and K. pneumoniae were rod-shaped with lengths >2.0 µm and volumes >1.0 µm3. Carbapenem-resistant (CR) strains exhibited larger volumes than their wild-type counterparts. Surface parameters further differentiated strains: wild-type E. coli had a greater surface texture or a less smooth surface (larger Sdr) than K. pneumoniae (lower Sdr) did. CR E. coli had more surface uniformity (lower Str) than CR K. pneumoniae did. A dichotomous key based on shape, circular diameter, volume, length, and surface characteristics was developed to classify the species using a series of paired, contrasting features. This morphometric analysis can aid researchers in quickly identifying bacteria, leading to faster diagnosis of life-threatening diseases and improved treatment decisions.
  • 1.6K
  • 28 Aug 2025
Topic Review
ESKAPE Bacteria in the Dog
ESKAPE bacteria (i.e., Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are a group of common opportunistic pathogens associated mainly with nosocomial infections.
  • 1.6K
  • 30 Oct 2020
Topic Review
Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements
Inherited retinal dystrophies and optic neuropathies cause chronic disabling loss of visual function. The development of recombinant adeno-associated viral vectors (rAAV) gene therapies in all disease fields have been promising, but the translation to the clinic has been slow. The safety and efficacy profiles of rAAV are linked to the dose of applied vectors. DNA changes in the rAAV gene cassette affect potency, the expression pattern (cell-specificity), and the production yield. Here, we present a library of rAAV vectors and elements that provide a workflow to design novel vectors. We first performed a meta-analysis on recombinant rAAV elements in clinical trials (2007-2020) for ocular gene therapies. We analyzed 33 unique rAAV gene cassettes used in 57 ocular clinical trials. The rAAV gene therapy vectors used six unique capsid variants, 16 different promoters, and six unique polyadenylation sequences. Further, we compiled a list of promoters, enhancers, and other sequences used in current rAAV gene cassettes in preclinical studies. Then, we give an update on pro-viral plasmid backbones used to produce the gene therapy vectors, inverted terminal repeats, production yield, and rAAV safety considerations. Finally, we assess rAAV transgene and bioactivity assays applied to cells or organoids in vitro, explants ex vivo, and clinical studies.
  • 1.6K
  • 22 Jun 2020
Topic Review
Osteoclast Multinucleation
       Osteoclasts  are derived from hemopoietic progenitors of the monocyte-macrophage lineage. They differentiate upon exposure to macrophage colony stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL), which are presented by osteoblasts and osteocytesare. Multinucleation in a late phase of osteoclastogenesis is a hallmark of osteoclast maturation. The unique and dynamic multinucleation process not only increases cell size but causes functional alterations through reconstruction of the cytoskeleton, creating the actin ring and ruffled border that enable efficient bone resorption.  The process of osteoclast multinucleation is dynamic, complicated and finely controlled by multiple entangled factors. At the beginning of the 21st century, two master fusogens, DC-STAMP and OC-STAMP, had been identified that directly regulate osteoclast multinucleation.
  • 1.6K
  • 17 Aug 2020
Topic Review
Legacy Effect in Cardiovascular Disease
The "legacy effect" describes the long-term benefits that may persist for many years after the end of an intervention period, involving different biological processes. The legacy effect in cardiovascular disease (CVD) prevention has been evaluated by a limited number of studies, mostly based on pharmacological interventions, while few manuscripts on dietary interventions have been published. Most of these studies are focused on intensive treatment regimens, whose main goal is to achieve tight control of one or more cardiovascular risk factors. 
  • 1.6K
  • 16 Nov 2020
Topic Review
Rabbit Sperm Cryopreservation
Sperm cryopreservation is one of the most efficient ways to preserve rabbit strains because it is easy to collect ejaculate repeatedly from a single male and inseminate artificially into multiple females. During the cooling, freezing and thawing process of sperms, the plasma membrane, cytoplasm and genome structures could be damaged by osmotic stress, cold shock, intracellular ice crystal formation, and excessive production of reactive oxygen species.
  • 1.6K
  • 07 May 2021
Topic Review
Abdominal Aortic Aneurysm
Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects, mostly, the elder population, with a high mortality rate (>80%) upon rupture. It features a dilation of the aortic diameter to larger than 30 mm or more than 50%. Diverse pathological processes are involved in the development of AAA, including aortic wall inflammation, elastin breakdown, oxidative stress, smooth muscle cell (SMC) phenotypic switching and dysfunction, and extracellular matrix degradation. 
  • 1.6K
  • 21 Feb 2022
Topic Review
LaGaO3-Based Solid Oxide Fuel Cell Electrolytes
Solid oxide fuel cells (SOFCs) are efficient electrochemical devices that allow for the direct conversion of fuels (their chemical energy) into electricity. Although conventional SOFCs based on YSZ electrolytes are widely used from laboratory to commercial scales, the development of alternative ion-conducting electrolytes is of great importance for improving SOFC performance at reduced operation temperatures. The basic information has been studied on representative family of oxygen-conducting electrolytes, such as doped lanthanum gallates (LaGaO3). Complex oxides based on LaGaO3 offer a convenient basis for the design of oxygen-conducting electrolytes that can be employed in intermediate-temperature solid oxide fuel cells. A rational combination of appropriate dopants incorporated at various sublattices of LaGaO3 allows superior transport properties to be achieved for co-doped derivatives (La1−xSrxGa1−yMgyO3−δ, LSGM).
  • 1.6K
  • 20 Jun 2022
Topic Review
Optimization Approaches and Techniques for Automotive Alternators
Optimization and improvement of the electrical system are applied to cope with the increased demand for electrical power in the vehicular system; they must be carried out in many ways to ensure that the vehicles are provided with the necessary electricity for their performance work electrical equipment.
  • 1.6K
  • 28 Jun 2022
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