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Topic Review
Urban Land Expansion
At the county level, this entry investigated the relationship between urban land and regional economic development in Beijing-Tianjin-Hebei Region in China. The interaction effects were quantitatively investigated. The spatial effects decomposition was used to analyze the influence of socioeconomic factors on the scales of urban land through direct effect, spillover effect and total effect. It is an important finding that average wages are the most prominent among the spatial spillovers.
  • 1.6K
  • 01 Dec 2020
Topic Review
Skin Photoprotection by Polyphenols
Polyphenols are phytochemicals with proven antioxidant and antiinflammatory properties. Premature aging and UV-induced skin conditions could be better overcome by topical polyphenols nanoformulations. Further, polyphenols nanoformulations can be of great interest for the cosmetic industries and any individuals who want to improve their skin appearance. Examples in this regard are provided and the potential toxicity issues related to the use of nanomaterials are highlighted.
  • 1.6K
  • 26 Nov 2020
Topic Review
Unrecognizable Memory Phenotype CD8+ T-cells
Virtual memory T (TVM) cells are a recently described population of conventional CD8+ T cells that, in spite of their antigen inexperience, express markers of T cell activation. TVM cells exhibit rapid responsiveness to both antigen-specific and innate stimuli in youth but acquire intrinsic antigen-specific response defects in the elderly.
  • 1.6K
  • 09 Dec 2020
Topic Review
Colon Fibroblasts and Inflammation
Colorectal cancer (CRC) is the third most common cause of cancer-related death. Patients suffering inflammatory bowel disease have an increased risk of CRC. It is admitted that CRC found its origin within crypts of the colon mucosa, which host the intestinal stem cells (ISCs) responsible of the tissue renewal. ISC behavior is controlled by the fibroblasts that surround the crypt. During inflammation, the signals delivered by fibroblasts are altered, leading to stem cells’ dysregulation, possibly turning them into cancer-initiating cells.
  • 1.6K
  • 23 Jun 2021
Topic Review
Low/Medium-Carbon Advanced Martensitic Steels
Advanced martensitic steels (AMSs) developed for sheet and wire rod products have a tensile strength higher than 1.5 GPa, good cold-formability, superior toughness and fatigue strength, and delayed fracture strength due to a mixture of martensite and retained austenite, compared with the conventional martensitic steels. 
  • 1.6K
  • 09 Oct 2021
Topic Review
Fruitflow® as Dietary Antiplatelets
Fruitflow® is derived from ripe tomatoes using a process that removes pomace, seeds, and fats while operating at low processing temperatures (~40 °C) to control the production of artefacts such as Maillard/Amadori products or Strecker aldehydes. Fruitflow® is standardised regarding representatives of its three main classes of antiplatelet compounds—nucleosides, phenolic derivatives, and flavonoid derivatives—and the total amount of ‘bioactive extract’ present.
  • 1.6K
  • 27 Jul 2021
Topic Review
Nutritional Value of Insects in Pet Food
Due to the increasing global population, the world cannot currently support the well-known techniques of food production due to their harmful effects on land use, water consumption, and greenhouse gas emissions. The key answer is a solution based on the use of edible insects. They have always been present in the diet of animals. They are characterized by a very good nutritional value (e.g., high protein content and contents of essential amino acids and fatty acids, including lauric acid), and products with them receive positive results in palatability tests. 
  • 1.6K
  • 15 Jun 2022
Topic Review
Pneumocystis Pneumonia
Pneumocystis pneumonia (PCP), also known as Pneumocystis jirovecii pneumonia (PJP), is a form of pneumonia that is caused by the yeast-like fungus Pneumocystis jirovecii. Pneumocystis specimens are commonly found in the lungs of healthy people although it is usually not a cause for disease. However, they are a source of opportunistic infection and can cause lung infections in people with a weak immune system or other predisposing health conditions. PCP is seen in people with HIV/AIDS (who account for 30-40% of PCP cases), those using medications that suppress the immune system, and people with cancer, autoimmune or inflammatory conditions, and chronic lung disease.
  • 1.6K
  • 17 Oct 2022
Topic Review
Cygnus CRS Orb-3
Cygnus CRS Orb-3, also known as Orbital Sciences CRS Flight 3 or Orbital 3, was an attempted flight of Cygnus, an automated cargo spacecraft developed by United States-based company Orbital Sciences, on 28 October 2014. The mission was intended to launch at 6:22 PM that evening. This flight, which would have been its fourth to the International Space Station and the fifth of an Antares launch vehicle, resulted in the Antares rocket exploding seconds after liftoff.
  • 1.6K
  • 24 Oct 2022
Biography
Hans-Peter Dürr
Hans-Peter Dürr (7 October 1929 – 18 May 2014) was a German physicist. He worked on nuclear and quantum physics, elementary particles and gravitation, epistemology, and philosophy, and he has advocated responsible scientific and energy policies.[1] In 1987, he was awarded the Right Livelihood Award for "his profound critique of the Strategic Defense Initiative (SDI) and his work to convert hi
  • 1.6K
  • 17 Nov 2022
Topic Review
Evolving Networks
Evolving Networks are networks that change as a function of time. They are a natural extension of network science since almost all real world networks evolve over time, either by adding or removing nodes or links over time. Often all of these processes occur simultaneously, such as in social networks where people make and lose friends over time, thereby creating and destroying edges, and some people become part of new social networks or leave their networks, changing the nodes in the network. Evolving network concepts build on established network theory and are now being introduced into studying networks in many diverse fields.
  • 1.6K
  • 21 Nov 2022
Topic Review
Yeast-Based Biosensors
Composed of a sensor part made up of live yeast cells coupled to a transducer/reporter technological element, yeast-based biosensors are  powerful tools to detect and monitor environmental contaminants, toxins and generally organic or chemical markers of potential threat to human health. Yeasts are eukaryotic microorganisms very resistant to adverse environmental conditions but also able to sense and respond to a wide variety of stimuli. As eukaryotes, they constitute excellent cellular models to detect organic contaminants and chemicals  harmful to animals. For these reasons, combined with their ease of culture and genetic modification, yeasts have often been chosen as biological elements of biosensors since the 1970s. Numerous different types of yeast-based biosensors have been developed for the environmental and medical domains, some of which are able to detect pathogens and viruses. The present technological developments of Synthesis Biology and Nanotechnologies further drive yeasts based biosensors into a new era where the biological element is optimized in a tailor-made fashion by in silico design and where the output signals can be recorded or followed on a smartphone.
  • 1.6K
  • 02 Nov 2020
Topic Review
Antibacterial Peptides
Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are produced by all living matter as a critical part of the innate immune system [1,2,3]. Their existence was discovered in 1939, the year gramicidin was isolated from the bacteria, Bacillus brevis; some resources, however, claim that the discovery of lysozyme in the 1920s should be treated as the first AMP instance, due to lysozyme’s non enzymatic, bactericidal second mode of action [2].
  • 1.6K
  • 20 Oct 2020
Topic Review
Muscular Dystrophies
Muscle dystrophy is a muscle disease that leads to a progressive loss of muscle mass and a weakened musculoskeletal system in accordance with age of onset, severity, and the group of muscles affected.
  • 1.6K
  • 21 Jan 2021
Topic Review
Neural Stem Cell
Stem cells have extensive proliferative potential and the ability to differentiate into one or more mature cell types. The mechanisms by which stem cells accomplish self-renewal provide fundamental insight into the origin and design of multicellular organisms. These pathways allow the repair of damage and extend organismal life beyond that of component cells, and they probably preceded the evolution of complex metazoans.
  • 1.6K
  • 11 Mar 2021
Topic Review
Alloplastic Bone Substitutes
Various bone graft products are commercially available worldwide. However, there is no clear consensus regarding the appropriate bone graft products in different clinical situations. This study is intended to summarize bone graft products, especially alloplastic bone substitutes that are available in multiple countries. It also provides dental clinicians with detailed and accurate information concerning these products. Furthermore, it discusses the prospects of alloplastic bone substitutes based on an analysis of the current market status, as well as a comparison of trends among countries. 
  • 1.6K
  • 17 Mar 2021
Topic Review
Exosomal-based Drug Delivery
Exosomes are membrane-bound nanovesicles that are typically 30–150 nm in size with various bioactive molecules. They are typically generated by first endocytosing various transmembrane proteins into endosomes within the cell, which are then sorted and form intraluminal vesicles. These vesicles are then released as the endosome merges with the cell membrane and releases its contents outside of the cell. Tetraspanins (CD9, CD63, CD81) are one of the most common proteins expressed on the surface of exosomes and are often used as exosome-specific markers. These proteins have been shown to interact with different proteins such as integrins and major histocompatibility complexes (MHC). Exosomes commonly act as carriers of genetic and proteomic information, and are therefore vital in intercellular communication. In its role as a cellular messenger, exosomes have been implicated in promoting cancer; because of this, they are also being investigated as potential therapeutic targets and delivery vehicles. 
  • 1.6K
  • 06 Jun 2021
Topic Review
Geochemical Modeling Applications
The geochemical computer model is an important innovation that exponentially evolved in the last decades, and that now plays a vital role in several areas of study, ranging from developing new models for surface complexation, reactive transport models, or the generation of thermodynamic data used to simulate or predict solubility reactions. An important application of geochemical modeling involves supporting the explanation or characterization of engineering systems related to waste management, wastewater reuse, evaluation of water quality from a landfill, metal speciation within soils in industrial areas, new technologies or process for waste treatment, and even the evaluation of the potential to use solid wastes in carbon sequestering processes.
  • 1.6K
  • 03 Aug 2021
Topic Review
Bioaccumulation of Fluoride and Its Microbially Assisted Remediation
Fluoride is widely found in soil–water systems due to anthropogenic and geogenic activities that affect millions worldwide. Fluoride ingestion results in chronic and acute toxicity, including skeletal and dental fluorosis, neurological damage, and bone softening in humans. 
  • 1.6K
  • 17 Dec 2021
Topic Review
Electromagnetic Microrobotic Platforms for Biomedical Applications
Magnetic microrobotics is a promising technology for improving minimally invasive surgery (MIS) with the ambition of enhancing patient care and comfort. The potential benefits include limited incisions, less hemorrhaging and postoperative pain, and faster recovery time. To achieve this, a key issue relies on the design of a proper electromagnetic actuation (EMA) setup which is based on the use of magnetic sources. The magnetic field and its gradient generated by the EMA platform is then used to induce magnetic torque and force for microrobot manipulations inside the human body. Like any control systems, the EMA system must be adapted to the given controlled microrobot and customized for the application. 
  • 1.6K
  • 24 Jan 2022
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