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Topic Review
Clinical Applications of CT Body Composition
CT body composition analysis has been shown to play an important role in predicting health and has the potential to improve patient outcomes if implemented clinically. 
  • 399
  • 17 Mar 2023
Topic Review
Recurrent Prostate Cancer after Radical Prostatectomy
The main prostate cancer (PCa) treatments include surgery or radiotherapy (with or without ADT). None of the suggested treatments eliminates the risk of lymph node metastases. Conventional imaging methods, including MRI and CT scanning, are not sensitive enough for the diagnosis of lymph node metastases; the novel imaging method, PSMA PET/CT scanning, has provided valuable information about the pelvic LN involvement in patients with recurrent PCa (RPCa) after radical prostatectomy.
  • 382
  • 30 Dec 2022
Topic Review
Post-Translational Modifications in DNA Damage Response
DNA damage in astronauts induced by cosmic radiation poses a major barrier to human space exploration. Cellular responses and repair of the most lethal DNA double-strand breaks (DSBs) are crucial for genomic integrity and cell survival. Post-translational modifications (PTMs), including phosphorylation, ubiquitylation, and SUMOylation, are among the regulatory factors modulating a delicate balance and choice between predominant DSB repair pathways, such as non-homologous end joining (NHEJ) and homologous recombination (HR). Researchers focused on the engagement of proteins in the DNA damage response (DDR) modulated by phosphorylation and ubiquitylation, including ATM, DNA-PKcs, CtIP, MDM2, and ubiquitin ligases. The involvement and function of acetylation, methylation, PARylation, and their essential proteins were also investigated, providing a repository of candidate targets for DDR regulators. However, there is a lack of radioprotectors in spite of their consideration in the discovery of radiosensitizers. 
  • 381
  • 06 May 2023
Topic Review
Amyloid-Targeting Positron Emission Tomography Imaging
Cardiac amyloidosis (CA) is characterized by extracellular infiltration and deposition of amyloid fibrils primarily derived from the circulating transthyretin protein (TTR) or immunoglobulin light chain (AL). Bone-seeking single-photon emission tomography/computed tomography (SPECT/CT) quantification and amyloid-targeting positron emission tomography (PET) imaging could be useful as a new strategy for disease burden and therapy monitoring to provide more insights into therapy response assessed by quantifying the amyloid burden in CA.
  • 375
  • 13 Oct 2022
Topic Review
Upfront Chemotherapy Followed by SBRT in Pancreatic Cancer
Multimodality therapy involving stereotactic body radiation therapy (SBRT) is safe and feasible in older patients with localized pancreatic cancer. Surgical resection was associated with improved clinical outcomes. As such, older patients who complete chemotherapy should not be excluded from aggressive local therapy when possible.
  • 373
  • 14 Jan 2022
Topic Review
Ultrasound-Guided Ethanol Ablation for Thyroglossal Duct Cyst
The thyroglossal duct cyst (TGDC) is the most common congenital neck mass, accounting for 70–75% of all congenital neck masses. Although the Sistrunk operation has been used as a standard of treatment, it is accompanied by a considerable surgical burden, including the need for general anesthesia, a visible surgical scar on the neck surface, and postoperative complications. Ultrasound-guided ethanol ablation (US-EA) is a minimally invasive and office-based technique that is widely used as a non-surgical treatment for several benign cystic lesions, particularly benign thyroid cysts. US-EA has also been gaining popularity as a good alternative for TGDC treatment, which is associated with high feasibility, a high safety profile, and favorable treatment outcomes. 
  • 369
  • 26 Oct 2023
Topic Review
Radiomics Applications in Spleen Imaging
The spleen plays numerous important roles in various diseases. There has been a growing interest in developing radiomic models for implementation in clinical practice, and spleen imaging has not been exempted from this trend. 
  • 365
  • 24 Aug 2023
Topic Review
Imaging Features of Plantar Vein Thrombosis
Plantar vein thrombosis is a venous disorder affecting deep plantar veins that can manifest with non-specific localized pain, plantar foot pain, swelling, and sensation of fullness. Plantar veins are not routinely assessed during sonographic scans for deep venous thrombosis, which makes plantar venous thrombosis a commonly missed diagnosis. 
  • 365
  • 09 Jan 2024
Topic Review
Breast Imaging Physics in Mammography (Part II)
Mammography is the gold standard for breast cancer diagnosis, as it is low cost, low administered radiation dose, and high sensitivity.
  • 363
  • 13 Dec 2023
Topic Review
Non-Invasive Diagnosis of Chronic Coronary Syndrome
Coronary artery disease is still a major cause of death and morbidity worldwide. In the setting of chronic coronary disease, demonstration of inducible ischemia is mandatory to address treatment. Consequently, scientific and technological efforts were made in response to the request for non-invasive diagnostic tools with better sensitivity and specificity. Clinicians have at their disposal a wide range of stress-imaging techniques. Among others, stress cardiac magnetic resonance (S-CMR) and computed tomography perfusion (CTP) techniques both demonstrated their diagnostic efficacy and prognostic value in clinical trials when compared to other non-invasive ischemia-assessing techniques and invasive fractional flow reserve measurement techniques. 
  • 362
  • 12 Jun 2023
Topic Review
Computed Tomography-Guided Bone Biopsies
Computed tomography (CT)-guided bone biopsies are currently the diagnostic tool of choice for histopathological (and microbiological) diagnoses of skeletal lesions. Several research works have well-demonstrated their safety and feasibility in almost all skeletal regions. 
  • 357
  • 18 Jul 2023
Topic Review
Magnetic Resonance Imaging Approach in Renal Tumors
Ultrasound and computed tomography (CT) have been the mainstay of renal mass screening and diagnosis but advances in magnetic resonance (MR) technology have made this the optimal choice when diagnosing and staging renal tumors. 
  • 354
  • 31 May 2023
Topic Review
Photon-Counting Computed Tomography Technology
Photon-counting computed tomography (PCCT) is an emerging technology that is expected to radically change clinical CT imaging. PCCT offers several advantages over conventional CT, which can be combined to improve and expand the diagnostic possibilities of CT angiography. 
  • 354
  • 07 Jun 2023
Topic Review
Differential Diagnosis of Acute Pelvic Pain
In female patients, acute pelvic pain can be caused by gynaecological, gastrointestinal, and urinary tract pathologies. Due to the variety of diagnostic possibilities, the correct assessment of these patients may be challenging. The most frequent gynaecological causes of acute pelvic pain in non-pregnant women are pelvic inflammatory disease, ruptured ovarian cysts, ovarian torsion, and degeneration or torsion of uterine leiomyomas. On the other hand, spontaneous abortion, ectopic pregnancy, and placental disorders are the most frequent gynaecological entities to cause acute pelvic pain in pregnant patients.
  • 352
  • 26 Oct 2023
Topic Review
Non-Contrast and Contrast-Enhanced Cardiac Computed Tomography
Cardiac computed tomography (CT) has emerged as a powerful non-invasive tool for risk stratification, as well as the detection and characterization of coronary artery disease (CAD), which remains the main cause of morbidity and mortality in the world. Advances in technology have favored the increasing use of cardiac CT by allowing better performance with lower radiation doses.
  • 351
  • 21 Jun 2023
Topic Review
Treatment of Pancreatic Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) accounts for the majority of pancreatic cancers and is associated with poor prognosis, a high mortality rate, and a substantial number of healthy life years lost. Surgical resection is the primary treatment option for patients with resectable disease; however, only 10–20% of all patients with PDAC are eligible for resection at the time of diagnosis.
  • 349
  • 01 Dec 2023
Topic Review
Photon-Counting Detector
Photon-counting detector (PCD) is a novel computed tomography detector technology (photon-counting computed tomography—PCCT) that bears several advantages in many fields of imaging, namely: cardiac, cardiovascular, neurovascular, oncological, body, musculoskeletal, neurostructural, traumatologic, and so forth. This is because of the much higher spatial resolution, reduced radiation exposure, and optimization of the use of contrast agents and material decomposition.
  • 342
  • 01 Jun 2023
Topic Review
Endoscopic Ultrasound-Guided Biliary Drainage
Endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic biliary drainage (PTBD) are currently first- and second-line therapeutic options, respectively, for the relief of biliary obstruction. However, endoscopic ultrasound-guided biliary drainage (EUS-BD) has become an established alternative therapy for biliary obstruction. There are multiple different techniques for EUS-BD, which can be distinguished based on the access point within the biliary tree (intrahepatic versus extrahepatic) and the location of stent placement (transenteric versus transpapillary). The clinical and technical success rates of biliary drainage for EUS-BD are similar to both ERCP and PTBD, and complication rates are favorable for EUS-BD relative to PTBD.
  • 341
  • 28 Jun 2023
Topic Review
The Sentinel Lymph Node in Treatment Planning
The sentinel lymph node is a surgical technique developed in oncological surgery to identify and analyze fewer lymph nodes than a conventional lymph node dissection in order to limit the morbidity and mortality of such an extensive procedure without compromising the patients’ outcomes. This concept seems to also be useful in radiation oncology that treats lymph node areas. This may help radiation oncologists to treat their patients more precisely by targeting more accurately pathological sites and sparing healthy tissues.
  • 339
  • 13 Jun 2023
Topic Review
Radiological Aspects of Sacroiliitis
Sacroiliitis is the inflammation of the sacroiliac joint, the largest axial joint in the human body, contributing to 25% of lower back pain cases. It can be detected using various imaging techniques like radiography, Magnetic Resonance Imaging (MRI), and Computed Tomography (CT) scans. Treatments range from conservative methods to invasive procedures. Recent advancements in artificial intelligence offer precise detection of this condition through imaging. Treatment options range from physical therapy and medications to invasive methods like joint injections and surgery. 
  • 339
  • 19 Mar 2024
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