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Topic Review
Pyrido[2,3-d], [3,2-d], [3,4-d] and [4,3-d]pyrimidine Derivatives
The structures composed of a pyridopyrimidine moiety which have shown a therapeutic interest or have already been approved for use as therapeutics, including pyrido[2,3-d]pyrimidines, pyrido[3,4-d]pyrimidines, pyrido[4,3-d]pyrimidines and pyrido[3,2-d]pyrimidines.
  • 6.8K
  • 06 Apr 2022
Topic Review
Grand Duchy
A grand duchy is a country or territory whose official head of state or ruler is a monarch bearing the title of grand duke or grand duchess. Relatively rare until the abolition of the Holy Roman Empire in 1806, the term was often used in the official name of countries smaller than most continental kingdoms of modern Europe (e.g., Denmark, Spain, United Kingdom) yet larger than most of the sovereign duchies in the Holy Roman Empire, Italy or Scandinavia (e.g. Anhalt, Lorraine, Modena, Schleswig-Holstein). During the 19th century there were as many as 14 grand duchies in Europe at once (a few of which were first created as exclaves of the Napoleonic empire but later re-created, usually with different borders, under another dynasty). Some of these were sovereign and nominally independent (Baden, Hesse and by Rhine, Mecklenburg-Schwerin, Mecklenburg-Strelitz, Oldenburg, Saxe-Weimar and Tuscany), some sovereign but held in personal union with larger realms by a monarch whose grand-dukedom was borne as a subsidiary title (Finland, Luxembourg, Transylvania), some of which were client states of a more powerful realm (Cleves and Berg), and some whose territorial boundaries were nominal and the position purely titular (Frankfurt). In the 21st century, only Luxembourg remains a grand duchy.
  • 6.8K
  • 17 Oct 2022
Topic Review
Smart Waste Management and Classification Systems
Waste management requires necessary processes and activities to dominate from its inception to demolition. Waste comes in solid, liquid, or gaseous form, and every type of waste demands a different method of classification, disposal, and management. Waste management deals with every waste category, including household, organic, industrial, municipal, biomedical, organic, biological, and radioactive waste. Any unnecessary substance or substance with no use is called “waste”. Waste management involves the collection of the waste and its transport and disposal to appropriate locations. In the European Union (EUROPA), 423 million tons or 56% of domestic waste was recycled in 2016. Reports reflect the need for proper household waste management for the recycling process. Most of the Earth’s population will emigrate from rural to urban areas in the coming years. Therefore, bigger cities will require a highly sustainable infrastructure and smart waste management system to fulfill the fundamental needs of its citizens and provide them with a good service for the future.
  • 6.8K
  • 06 Sep 2022
Topic Review
The Fibrosis-4 (FIB-4) Index
The fibrosis-4 (FIB-4) index is the first triaging tool for excluding advanced fibrosis because of its accuracy, simplicity, and cheapness, especially for general physicians or endocrinologists, although the FIB-4 index has several drawbacks. Accumulating evidence has suggested that vibration-controlled transient elastography (VCTE) and the enhanced liver fibrosis (ELF) test may become useful as the second step after triaging by the FIB-4 index. The leading cause of mortality in MAFLD is cardiovascular disease (CVD), extrahepatic malignancy, and liver-related diseases. MAFLD often complicates chronic kidney disease (CKD), resulting in increased simultaneous liver kidney transplantation. The FIB-4 index could be a predictor of not only liver-related mortality and incident hepatocellular carcinoma, but also prevalent and incident CKD, CVD, and extrahepatic malignancy.
  • 6.8K
  • 25 May 2021
Topic Review
Bṛhaspati
Bṛhaspati (Sanskrit: बृहस्पति; meaning spati of briha, the spirit of vastness of the universe written as Brihaspati) is an Indian name, and refers to different mythical figures depending on the age of the text. In ancient Hindu literature Brihaspati is a Vedic era sage who counsels the gods, while in some medieval texts the word refers to the largest planet of the solar system, Jupiter. He taught Bhishma the duties of a king which he later taught it to Vidura.
  • 6.8K
  • 18 Oct 2022
Topic Review
Sea Urchin
Sea urchins (/ˈɜːrtʃɪnz/) are spiny, globular echinoderms in the class Echinoidea. About 950 species of sea urchin live on the seabed of every ocean and inhabit every depth zone — from the intertidal seashore down to 5,000 metres (16,000 ft; 2,700 fathoms). The spherical, hard shells (tests) of sea urchins are round and spiny, ranging in diameter from 3 to 10 cm (1 to 4 in). Sea urchins move slowly, crawling with tube feet, and also propel themselves with their spines. Although algae are the primary diet, sea urchins also eat slow-moving (sessile) animals. In the food chain, the predators who eat sea urchins are the sea otter and the starfish, the wolf eel, the triggerfish, and human beings. Adult sea urchins have fivefold symmetry, but their pluteus larvae feature bilateral (mirror) symmetry, indicating that the sea urchin belongs to the Bilateria group of animal phyla, which also comprises the chordates and the arthropods, the annelids and the molluscs, and are found in every ocean and in every climate, from the tropics to the polar regions, and inhabit marine benthic (sea bed) habitats, from rocky shores to hadal zone depths. The fossil record of the Echinoids dates from the Ordovician period, some 450 million years ago; the closest echinoderm relatives of the sea urchin are the sea cucumbers (Holothuroidea); both are deuterostomes, a clade that includes the chordates. The animals have been studied since the 19th century as model organisms in developmental biology, as their embryos were easy to observe; this has continued with studies of their genomes because of their unusual fivefold symmetry and relationship to chordates. Species such as the slate pencil urchin are popular in aquariums, where they are useful for controlling algae. Fossil urchins have been used as protective amulets.
  • 6.7K
  • 19 Oct 2022
Topic Review
Social Construction of Disability
The social construction of disability comes from a paradigm of ideas that suggest that society's beliefs about a particular community, group or population are grounded in the power structures inherent in a society at any given time. These are often steeped in historical representations of the issue and social expectations surrounding concepts such as disability, thereby enabling a social construct around what society deems disabled and healthy. Ideas surrounding disability stem from societal attitudes, often connected to who is deserving or undeserving, and deemed productive to society at any given time. For example, in the medieval period, a person's moral behavior established disability. Disability was a divine punishment or side effect of a moral failing; being physically or biologically different was not enough to be considered disabled. Only during the European Enlightenment did society change its definition of disability to be more related to biology. However, what most Western Europeans considered to be healthy determined the new biological definition of health.
  • 6.7K
  • 11 Nov 2022
Topic Review
Muesli
Muesli (/ˈmjuːzli/ MEWZ-lee; Template:Lang-gsw Template:IPA-gsw, non-Swiss Standard German: Müsli [ˈmyːsli] (listen)) is a cold oatmeal dish based on rolled oats and ingredients like grains, nuts, seeds and fresh or dried fruits. This mix may be combined with one or more liquids like milk, almond milk, other plant milks, yogurt, or fruit juice and left for a time to soften the oats before being consumed. Developed around 1900 by Swiss physician Maximilian Bircher-Benner for patients in his hospital, it is now eaten as a standard breakfast dish, and also in Switzerland as a supper called Birchermüesli complet: muesli with Café complet (milk coffee, accompanied with bread, butter, and jam. (Butterbrot)).
  • 6.7K
  • 15 Nov 2022
Topic Review
Carbon fiber-reinforced Thermoplastic polymers
Carbon fiber-reinforced thermoplastic polymers are considered a promising composite for many industrial applications including in the automation, renewable energy, and aerospace industries. They exhibit exceptional properties such as a high strength-to-weight ratio and high wear resistance and stiffness, which give them an advantage over other conventional materials such as metals.
  • 6.7K
  • 17 Aug 2021
Topic Review
Fresh Fruit and Vegetable Waste in Human Health
Food supply disruption and shortage verified during the current pandemic events are a scenario that many anticipate for the near future. The impact of climate changes on food production, the continuous decrease in arable land, and the exponential growth of the human population are important drivers for this problem. 
  • 6.7K
  • 19 Jan 2023
Topic Review
Small and Medium Enterprises (SMEs) Performance
SMEs are one of the business entities that make a significant contribution to economic conditions in Indonesia. This is the reason why information about the condition and presence of SMEs is important data for the government as an indicator for Indonesia’s economic conditions, especially during the COVID-19 pandemic. 
  • 6.7K
  • 23 May 2022
Topic Review
List of Mergers and Acquisitions by IBM
IBM has undergone a large number of mergers and acquisitions during a corporate history lasting over a century; the company has also produced a number of spinoffs during that time. The acquisition date listed is the date of the agreement between IBM and the subject of the acquisition. The value of each acquisition is listed in USD because IBM is based in the United States . If the value of an acquisition is not listed, then it is undisclosed. Many of the companies listed in this article had subsidiaries of their own who had subsidiaries who ... For examples, see Pugh's book Building IBM, page 26.
  • 6.7K
  • 17 Oct 2022
Topic Review
Cathode Ray Tube
The cathode ray tube (CRT) is a vacuum tube that contains one or more electron guns and a phosphorescent screen, and is used to display images. It modulates, accelerates, and deflects electron beam(s) onto the screen to create the images. The images may represent electrical waveforms (oscilloscope), pictures (television, computer monitor), radar targets, or other phenomena. CRTs have also been used as memory devices, in which case the visible light emitted from the fluorescent material (if any) is not intended to have significant meaning to a visual observer (though the visible pattern on the tube face may cryptically represent the stored data). In television sets and computer monitors, the entire front area of the tube is scanned repetitively and systematically in a fixed pattern called a raster. An image is produced by controlling the intensity of each of the three electron beams, one for each additive primary color (red, green, and blue) with a video signal as a reference. In all modern CRT monitors and televisions, the beams are bent by magnetic deflection, a varying magnetic field generated by coils and driven by electronic circuits around the neck of the tube, although electrostatic deflection is commonly used in oscilloscopes, a type of electronic test instrument. A CRT is constructed from a glass envelope which is large, deep (i.e., long from front screen face to rear end), fairly heavy, and relatively fragile. The interior of a CRT is evacuated to approximately 0.01 pascals (9.9×10−8 atm) to 133 nanopascals (1.31×10−12 atm), evacuation being necessary to facilitate the free flight of electrons from the gun(s) to the tube's face. The fact that it is evacuated makes handling an intact CRT potentially dangerous due to the risk of breaking the tube and causing a violent implosion that can hurl shards of glass at great velocity. As a matter of safety, the face is typically made of thick lead glass so as to be highly shatter-resistant and to block most X-ray emissions, particularly if the CRT is used in a consumer product. Since the late 2000s, CRTs have been largely superseded by newer "flat panel" display technologies such as LCD, plasma display, and especially OLED displays, which in the case of LCD and OLED displays have lower manufacturing costs and power consumption, as well as significantly less weight and bulk. Flat panel displays can also be made in very large sizes; whereas 38 to 40 in (97 to 102 cm) was about the largest size of a CRT television, flat panels are available in 60 in (150 cm) and larger sizes.
  • 6.7K
  • 02 Dec 2022
Topic Review
Royal Marriages Act 1772
The Royal Marriages Act 1772 was an act of the Parliament of Great Britain which prescribed the conditions under which members of the British royal family could contract a valid marriage, in order to guard against marriages that could diminish the status of the royal house. The right of veto vested in the sovereign by this act provoked severe adverse criticism at the time of its passage. It was repealed as a result of the 2011 Perth Agreement, which came into force on 26 March 2015. Under the Succession to the Crown Act 2013, the first six people in the line of succession need permission to marry if they and their descendants are to remain in the line of succession.
  • 6.7K
  • 02 Nov 2022
Topic Review
Nanotechnology in Warfare
Nanotechnology in Warfare is a branch of nano-science in which molecular systems are designed, produced and created to fit a nano-scale (1-100nm). The application of such technology, specifically in the area of warfare and defence, has paved the way for future research in the context of weaponisation. Nanotechnology unites a variety of scientific fields including material science, chemistry, physics, biology and engineering. Advancements in this area, have led to categorised development of such nano-weapons with classifications varying from; small robotic machines, hyper-reactive explosives, and electromagnetic super-materials. With this technological growth, has emerged implications of associated risks and repercussions, as well as regulation to combat these effects. These impacts give rise to issues concerning global security, safety of society, and the environment. Legislation may need to be constantly monitored to keep up with the dynamic growth and development of nano-science, due to the potential benefits or dangers of its use. Anticipation of such impacts through regulation, would 'prevent irreversible damages' of implementing defence related nanotechnology in warfare.
  • 6.7K
  • 02 Nov 2022
Topic Review
Burnside-Butler Syndrome Genotype-Phenotype Associations
The 15q11.2 BP1-BP2 deletion (Burnside-Butler) syndrome is emerging as the most common cytogenetic finding in patients with neurodevelopmental or autism spectrum disorders (ASD) presenting for microarray genetic testing. Clinical findings in Burnside-Butler syndrome include developmental and motor delays, congenital abnormalities, learning and behavioral problems, and abnormal brain findings. To better define symptom presentation, we performed comprehensive cognitive and behavioral testing, collected medical and family histories, and conducted clinical genetic evaluations. The 15q11.2 BP1-BP2 region includes the TUBGCP5, CYFIP1, NIPA1, and NIPA2 genes. To determine if additional genomic variation outside of the 15q11.2 region influences expression of symptoms in Burnside-Butler syndrome, whole-exome sequencing was performed on the parents and affected children for the first time in five families with at least one parent and child with the 15q1l.2 BP1-BP2 deletion. In total, there were 453 genes with possibly damaging variants identified across all of the affected children. Of these, 99 genes had exclusively de novo variants and 107 had variants inherited exclusively from the parent without the deletion. There were three genes (APBB1, GOLGA2, and MEOX1) with de novo variants that encode proteins evidenced to interact with CYFIP1. In addition, one other gene of interest (FAT3) had variants inherited from the parent without the deletion and encoded a protein interacting with CYFIP1. The affected individuals commonly displayed a neurodevelopmental phenotype including ASD, speech delay, abnormal reflexes, and coordination issues along with craniofacial findings and orthopedic-related connective tissue problems. Of the 453 genes with variants, 35 were associated with ASD. On average, each affected child had variants in 6 distinct ASD-associated genes (x¯ = 6.33, sd = 3.01). In addition, 32 genes with variants were included on clinical testing panels from Clinical Laboratory Improvement Amendments (CLIA) approved and accredited commercial laboratories reflecting other observed phenotypes. Notably, the dataset analyzed in this study was small and reported results will require validation in larger samples as well as functional follow-up. Regardless, we anticipate that results from our study will inform future research into the genetic factors influencing diverse symptoms in patients with Burnside-Butler syndrome, an emerging disorder with a neurodevelopmental behavioral phenotype.
  • 6.7K
  • 25 Mar 2021
Topic Review
Glass–Ceramics
Owing to their combinations of unique properties of sintered ceramics and the distinctive characteristics of glasses, glass-ceramics have attracted great interest from both academia and industry worldwide since their accidental discovery in 1953.
  • 6.7K
  • 27 Oct 2020
Topic Review
Uterosacral Ligament
The uterosacral ligaments (USLs) are extraperitoneal structures that extend backward from the posterior surface of the cervix and upper vagina to the second-to-fourth sacral vertebrae, forming the lateral boundaries of the rectouterine and rectovaginal spaces. They are composed mainly of connective tissue along with vessels and splanchnic nerve fibers.
  • 6.7K
  • 08 Feb 2021
Topic Review
Starship (Spacecraft)
Starship is the fully reusable second stage and space vehicle of the SpaceX BFR "Super Heavy" rocket currently under development by SpaceX. It is a long-duration cargo- and passenger-carrying spacecraft that also serves as the BFR launch vehicle second stage and integrated payload section. Three 9-meter (30 ft)-diameter stainless steel Starship test articles are being built, and one had already begun integrated system testing by March 2019. The Starship test flight rocket—Starhopper—will be used for initial integrated testing of the Raptor rocket engine with a flight-capable propellant structure as well as for low-altitude, low-velocity flight testing of launches and landings. It began hotfire testing in April 2019. Two additional test articles, Starship orbital prototypes, are being built by competing teams in South Texas and along the space coast of Florida. They are planned to be used after mid-2019 for high-altitude, high-velocity testing. Integrated system testing of Starhopper, including the first flight test, began in April 2019. SpaceX is planning to launch commercial payloads using Starship no earlier than 2021.
  • 6.7K
  • 21 Oct 2022
Topic Review
Eurostar
Eurostar is an international high-speed rail service connecting the United Kingdom with France , Belgium and the Netherlands. Most Eurostar trains travel through the Channel Tunnel between the United Kingdom and France, owned and operated separately by Getlink. The London terminus is London St Pancras International; the other British calling points are Ebbsfleet International and Ashford International in Kent. Intermediate calling points in France are Calais-Fréthun and Lille-Europe. Trains to Paris terminate at Gare du Nord. Trains to Belgium and the Netherlands serve Brussels-South and Rotterdam Centraal, before terminating at Amsterdam Centraal. Additionally, in France there are direct services from London to Marne-la-Vallée–Chessy (Disneyland Paris) and seasonal direct services to southern France (Lyon, Avignon and Marseille) in summer, and to the French Alps in winter. The service is operated by 11 Class 373/1 trainsets, each with 18 coaches, and 17 Class 374 trainsets, each with 16 coaches. The trains run at up to 320 kilometers per hour (200 mph) on high-speed lines. The LGV Nord high-speed line in France opened before Eurostar services began in 1994, and newer lines enabling faster journeys were added later: HSL 1 in Belgium and High Speed 1 in south-east England. The French and Belgian parts of the network are shared with Paris–Brussels Thalys services and TGV trains. Eurostar is operated by Eurostar International Limited (EIL), jointly owned by SNCF, the national railway of France (55%), investment firms (40%), and the National Railway Company of Belgium (5%).
  • 6.7K
  • 20 Nov 2022
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