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Topic Review
Intrusive Thought
An intrusive thought is an unwelcome, involuntary thought, image, or unpleasant idea that may become an obsession, is upsetting or distressing, and can feel difficult to manage or eliminate. When such thoughts are associated with obsessive-compulsive disorder (OCD), depression, body dysmorphic disorder (BDD), and sometimes attention-deficit hyperactivity disorder (ADHD), the thoughts may become paralyzing, anxiety-provoking, or persistent. Intrusive thoughts may also be associated with episodic memory, unwanted worries or memories from OCD, post-traumatic stress disorder, other anxiety disorders, eating disorders, or psychosis. Intrusive thoughts, urges, and images are of inappropriate things at inappropriate times, and generally have aggressive, sexual, or blasphemous themes.
  • 1.7K
  • 10 Nov 2022
Topic Review
International Monetary Systems
An international monetary system is a set of internationally agreed rules, conventions and supporting institutions that facilitate international trade, cross border investment and generally the reallocation of capital between nation states. It should provide means of payment acceptable to buyers and sellers of different nationalities, including deferred payment. To operate successfully, it needs to inspire confidence, to provide sufficient liquidity for fluctuating levels of trade, and to provide means by which global imbalances can be corrected. The system can grow organically as the collective result of numerous individual agreements between international economic factors spread over several decades. Alternatively, it can arise from a single architectural vision, as happened at Bretton Woods in 1944.
  • 1.7K
  • 02 Dec 2022
Topic Review
The Production of Rare Earth Elements
Rare earth elements (REE) are less than 20% of all elements naturally occurring in the environment. They are defined as a group of 17 elements comprising scandium (Sc), yttrium (Y), and lanthanum (La) elements of group 3B of Periodic Table, and the 14 elements of the lanthanides series, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu.
  • 1.7K
  • 23 Feb 2022
Topic Review
CAD Algorithms for Adjusting Contours
In patients with atrophy of the temporalis muscle or flattened skin flaps (trephined syndrome), CAD/CAM (customized computer-assisted design/manufacturing)-fabricated implants with modified reconstructed curvature is crucial for cranioplasty. For the aforementioned clinical conditions, adequate scalp adaptation is significant for either the maintenance of soft tissue bulk or the prevention of the dead space between the dura and implant. This can thoroughly be achieved by adjusting CAD algorithms for the contouring of skull defects with outwardly elevation or inwardly depression, respectively. We herein demonstrate operative details involving modified contours for the reconstruction of skull defects in CAD Modeling.
  • 1.7K
  • 29 Oct 2020
Topic Review
PTEN in different TME compartments
Mounting preclinical and clinical evidence indicates that rewiring the host immune system in favor of an antitumor microenvironment achieves remarkable clinical efficacy in the treatment of many hematological and solid cancer patients. Nevertheless, despite the promising development of many new and interesting therapeutic strategies, many of these still fail from a clinical point of view, probably due to the lack of prognostic and predictive biomarkers. In that respect, several data shed new light on the role of the tumor suppressor phosphatase and tensin homolog on chromosome 10 (PTEN) in affecting the composition and function of the tumor microenvironment (TME) as well as resistance/sensitivity to immunotherapy. In this review, we summarize current knowledge on PTEN functions in different TME compartments (immune and stromal cells) and how they can modulate sensitivity/resistance to different immunological manipulations and ultimately influence clinical response to cancer immunotherapy
  • 1.7K
  • 04 Aug 2020
Topic Review
Pain
The phenomenon of pain sensation is defined differently, depending on the specialty. From the point of view of psychology or psychiatry, pain is a difficult to define and a subjective experience. Being a result of awareness of nerve impulses reaching the brain and caused by noxious stimuli of adequate strength, pain can be also defined as a psychic factor, triggering defensive reflexes. From a biological point of view, pain is a warning signal about a danger or tissue injury. Pain is a sensory impression, formed by the action of various stimuli that damage tissues; therefore, pain provides information about the action site of the harmful factor (stressor). Pain can be experienced as a local sensation or as widespread pain when the response to stimulus is intense and the effect of the damage lasts for an extended duration. Controversies still exist regarding nomenclature and definitions specifying the phenomenon of pain. According to the Taxonomy Committee of the International Association for the Study of Pain (IASP), pain is defined as an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage.
  • 1.7K
  • 02 Mar 2023
Topic Review
Graphene Quantum Dots (GQDs)
Graphene quantum dots (GQDs) are small fragments of graphene with lateral dimensions less than 100 nm, with properties deriving from both graphene and carbon points.
  • 1.7K
  • 11 May 2021
Topic Review
Ransomware Detection, Avoidance, and Mitigation Scheme
Ransomware attacks have emerged as a major cyber-security threat wherein user data is encrypted upon system infection. Latest Ransomware strands using advanced obfuscation techniques along with offline C2 Server capabilities are hitting Individual users and big corporations alike. This problem has caused business disruption and, of course, financial loss. 
  • 1.7K
  • 13 Jan 2022
Topic Review
Clinical Indications to Germectomy in Pediatric Dentistry
Germectomy is a procedure often required in patients at developmental age. It is defined as the surgical removal of the third molar at a very specific stage of development. 
  • 1.7K
  • 25 Jan 2022
Topic Review
L-Dopa Extraction and Analytical Determination in Plant Matrices
L-dopa is a precursor of dopamine used as the most effective symptomatic drug treatment for Parkinson’s disease. Most of the L-dopa isolated is either synthesized chemically or from natural sources, but only some plants belonging to the Fabaceae family contain significant amounts of L-dopa. Due to its low stability, the unambiguous determination of L-dopa in plant matrices requires appropriate technologies. Several analytical methods have been developed for the determination of L-dopa in different plants. The most used for quantification of L-dopa are mainly based on capillary electrophoresis or chromatographic methods, i.e., high-performance liquid chromatography (HPLC), coupled to ultraviolet-visible or mass spectrometric detection. HPLC is most often used. 
  • 1.7K
  • 01 Sep 2022
Topic Review
Ailanthus altissima as a Source of Natural Pesticides
The extensive use of pesticides may negatively affect human health. Additionally, it is one of the main reasons for the decline of pollinators and is thus a hazard for most crops and biodiversity as a whole. Good candidates for the replacement of pesticides with ones less toxic to humans and pollinators are natural products (bioactive compounds extracted from plants), even though it should be kept in mind that some of them can be toxic too. Ailanthus altissima (Mill.), swingle, known also as tree of heaven, (Simaroubaceae) is one of the most aggressive alien invasive plants. It demonstrates a high tolerance to various habitat conditions and a potent propagation ability. This plant has a prominent ability to suppress the seed development of local vegetation.
  • 1.7K
  • 06 Sep 2022
Topic Review
Human Diseases with Mutations in the BRPF1-KAT6A/KAT6B Complex
The bromodomain and PHD finger–containing protein1 (BRPF1) is a member of family IV of the bromodomain-containing proteins that participate in the post-translational modification of histones. Patients with BRPF1 mutations often display intellectual disability or suffer from leukemia or medulloblastoma. BRPF1 is an activator and a scaffold protein of a multiunit complex, with other members being KAT6A/KAT6B, the inhibitor of growth 5 (ING5) or ING4 and MYST/Esa1-associated factor 6 (MEAF6). 
  • 1.7K
  • 09 Sep 2022
Topic Review
Pathogenesis and Treatment of Neuropsychiatric Lupus Erythematosus
Neuropsychiatric systemic lupus erythematosus (NPSLE) has a broad spectrum of sub-types with diverse severities and prognoses. Ischemic and inflammatory mechanisms, including autoantibodies and cytokine-mediated pathological processes, are key components of the pathogenesis of NPSLE. Additional brain-intrinsic elements (such as the brain barrier and resident microglia) are also important facilitators of NPSLE. An improved understanding of NPSLE may provide further options for managing this disease. The attenuation of neuropsychiatric disease in mouse models demonstrates the potential for novel targeted therapies. Conventional therapeutic algorithms include symptomatic, anti-thrombotic, and immunosuppressive agents that are only supported by observational cohort studies, therefore performing controlled clinical trials to guide further management is essential and urgent. The latest pathogenetic mechanisms of NPSLE are presented, and the progress in its management is discussed.
  • 1.7K
  • 09 Sep 2022
Topic Review
Syslog
In computing, syslog /ˈsɪslɒɡ/ is a standard for message logging. It allows separation of the software that generates messages, the system that stores them, and the software that reports and analyzes them. Each message is labeled with a facility code, indicating the type of system generating the message, and is assigned a severity level. Computer system designers may use syslog for system management and security auditing as well as general informational, analysis, and debugging messages. A wide variety of devices, such as printers, routers, and message receivers across many platforms use the syslog standard. This permits the consolidation of logging data from different types of systems in a central repository. Implementations of syslog exist for many operating systems. When operating over a network, syslog uses a client-server architecture where a syslog server listens for and logs messages coming from clients.
  • 1.7K
  • 19 Oct 2022
Biography
Birutė Galdikas
Birutė Marija Filomena Galdikas or Birutė Mary Galdikas, OC (born 10 May 1946), is a Lithuanian-Canadian[1] anthropologist, primatologist, conservationist, ethologist, and author. She is a professor at Simon Fraser University. In the field of primatology, Galdikas is recognized as a leading authority on orangutans.[2] Prior to her field study of orangutans, scientists knew little about the spe
  • 1.7K
  • 16 Nov 2022
Topic Review
Secondary Metabolites from Trichoderma harzianum
The biocontrol fungus Trichoderma harzianum, from both marine and terrestrial environments, has attracted considerable attention. T. harzianum has a tremendous potential to produce a variety of bioactive secondary metabolites (SMs), which are an important source of new herbicides and antibiotics.
  • 1.7K
  • 05 Dec 2022
Topic Review
Relationship between Ferroptosis and Alzheimer’s Disease
Alzheimer’s disease (AD), which was first identified more than a century ago, has become a pandemic that exacts enormous social burden and economic tolls as no measure of combating devastated AD is currently available. Growing etiopathological, genetic, and biochemical data indicate that AD is a heterogeneous, polygenic, multifactorial, and complex disease. However, its exact etiopathology remains to be determined. Numerous experimental data show that cerebral iron and copper dyshomeostasis contribute to Aβ amyloidosis and tauopathy, two neuropathological hallmarks of AD. Increasing experimental evidence suggests ferroptosis, an iron-dependent and nonapoptotic form of cell death, may be involved in the neurodegenerative process in the AD brain. Thus, the anti-ferroptosis approach may be an efficacious therapeutic strategy for AD patients.
  • 1.7K
  • 23 May 2023
Topic Review
Maintenance Management Systems Integration with Industry 4.0 Technologies
Industry 4.0 is the latest technological age, in which recent technological developments are being integrated within industrial systems. Consequently, maintenance management of current industrial manufacturing systems is affected by the emergence of the technologies and features of Industry 4.0 which need to be integrated efficiently. 
  • 1.7K
  • 11 Aug 2023
Topic Review
COVID-19 and Sleep Disturbances
The need for adequate good quality sleep to optimally function is well known. Various physical, psychological, biological, and social factors have been investigated to understand their impact on sleep. However, understanding the etiological processes that are involved in causing sleep disturbances (SD) as impacted by stressful phases such as pandemics has not been well studied. Many such etiological and management strategies have surfaced during the “coronavirus disease of 2019 (COVID-19) pandemic. The occurrence of these SD in the infected and uninfected individuals poses a need to investigate factors linked to such occurrence during this phase. Some of such factors include stressful practices such as social distancing, masking, vaccines, and medications availability, changes in routines, and lifestyles. As the status of infection improved, a collective term for all the prolonged effects of COVID-19 after the resolution of the primary infection called the post-COVID-19 syndrome (PCS) surfaced. Apart from impacting sleep during the infectious phase, the aftereffects of this virus left an even greater impact during the PCS.
  • 1.7K
  • 05 Sep 2023
Topic Review
CRISPR/Cas-Based Cell Therapy for Type 1 Diabetes
Type 1 diabetes mellitus (T1D) is an autoimmune disease caused by the destruction of insulin-producing β-cells in the pancreas by cytotoxic T-cells. To date, there are no drugs that can prevent the development of T1D. Insulin replacement therapy is the standard care for patients with T1D. This treatment is life-saving, but is expensive, can lead to acute and long-term complications, and results in reduced overall life expectancy. This has stimulated the research and development of alternative treatments for T1D. In this research, potential therapies for T1D are considered using cellular regenerative medicine approaches with a focus on CRISPR/Cas-engineered cellular products. However, CRISPR/Cas as a genome editing tool has several drawbacks that should be considered for safe and efficient cell engineering. In addition, cellular engineering approaches themselves pose a hidden threat. The purpose of this research is to critically discuss novel strategies for the treatment of T1D using genome editing technology. 
  • 1.7K
  • 26 Dec 2023
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