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Topic Review
Creativity as an Intervention
Creativity is defined as the ability to produce novel and useful ideas. Being creative influences our achievements in various domains, from the invention of new technologies that facilitate our everyday life to the development of artistic output for our pleasure and entertainment. Given that creativity involves the ability to create original, useful, remote, and unusual associations between ideas, it may possibly trigger a broad style of thinking that is not stereotypical in its attitude toward outgroups. Thus, creative cognition may offer a new avenue for interventions aimed at diminishing group-related biases.
  • 1.7K
  • 30 Nov 2022
Biography
Patrice Engle
Patrice Lee Engle (December 1, 1944–Sept 22, 2012) was a developmental psychologist known as a pioneer in the field of global early childhood development and for her international work advocating for children's education and healthcare.[1] She was Professor of Psychology and Child Development at California Polytechnic State University, San Luis Obispo. Engle was senior advisor for early child
  • 1.7K
  • 29 Dec 2022
Topic Review
Mechanisms of Microbial Biostimulant Action
Sustainable farming of horticultural plants has been the focus of research during the last decade, paying significant attention to alarming weather extremities and climate change, as well as the pressure of biotic stressors on crops. Microbial biostimulants, including plant growth-promoting bacteria (PGPB) and arbuscular mycorrhizal fungi (AMF), have been proven to increase plant growth via both direct and indirect processes, as well as to increase the availability and uptake of nutrients, boosting soil quality, increasing plants’ tolerance to abiotic stress and increasing the overall quality attributes of various horticultural crops (e.g., vegetables, fruit, herbs). The positive effects of microbial biostimulants have been confirmed so far, mostly through symbiotic interactions in the plant–soil–microbes ecosystem, which are considered a biological tool to increase quality parameters of various horticultural crops as well as to decrease soil degradation. 
  • 1.7K
  • 21 Feb 2023
Topic Review
Attitudes towards Plastic Pollution
Plastic pollution has received unprecedented attention globally, and there are increasing calls to control it. Despite this, the uptrends of plastic consumption and mismanaged plastic waste show little sign of reversal. It is imperative to understand the attitudes of various societal groups towards plastics to identify the barriers to behavioral changes to reduce plastic pollution and synthesize effective countermeasures. Generally, there are negative attitudes towards plastic pollution and people are willing to act against it by supporting campaigns, paying for environmentally friendly alternatives, and supporting solution-based interventions from governments including policies, regulations and guidelines. Inconvenience due to limited options for plastic items and habits are two main barriers to behavioral changes. Governments play crucial roles to tap into these attitudes to lead and intensify control plastic pollution through a multi-pronged approach that facilitates systematic substitution of conventional plastics with environmentally friendly alternatives as well as the stepping-up of the circular plastic economy and industrial symbiosis. Progressively regulated capping of conventional plastic production and consumption could help the transition, and the public could complement government endeavors through education, mutual influence and awareness-raising which could also be driven by governmental policies and programs.
  • 1.7K
  • 21 Jun 2023
Topic Review
Application of Hydrogels for Bone Regeneration
Hydrogels are versatile biomaterials characterized by three-dimensional, cross-linked, highly hydrated polymeric networks. These polymers exhibit a great variety of biochemical and biophysical properties, which allow for the diffusion of diverse molecules, such as drugs, active ingredients, growth factors, and nanoparticles. Meanwhile, these polymers can control chemical and molecular interactions at the cellular level. The polymeric network can be molded into different structures, imitating the structural characteristics of surrounding tissues and bone defects. Interestingly, the application of hydrogels in bone tissue engineering (BTE) has been gathering significant attention due to the beneficial bone improvement results that have been achieved.
  • 1.7K
  • 29 Jun 2023
Topic Review
Application of Membrane Technology in the Pharmaceutical Industry
With the advancement in membrane technology, membrane separation technology has been found increasingly widespread applications in the pharmaceutical industry. It is utilized in drug separation and purification, wastewater treatment, and the recycling of wastewater resources. 
  • 1.7K
  • 23 Jan 2024
Topic Review
Cascade Lake (Microarchitecture)
Cascade Lake is an Intel codename for a 14 nanometer server, workstation and enthusiast processor microarchitecture, launched in April 2019. In Intel's Process-Architecture-Optimization model, Cascade Lake is an optimization of Skylake. Intel states that this will be their first microarchitecture to support 3D XPoint-based memory modules. It also features Deep Learning Boost instructions and mitigations for Meltdown and Spectre. Intel officially launched new Xeon Scalable SKUs on February 24, 2020.
  • 1.7K
  • 23 Nov 2022
Topic Review
Necroptosis in Intestinal Inflammation
Necroptosis is a caspases-independent programmed cell death displaying intermediate features between necrosis and apoptosis. Albeit some physiological roles during embryonic development such tissue homeostasis and innate immune response are documented, necroptosis is mainly considered a pro-inflammatory cell death. Key actors of necroptosis are the receptor-interacting-protein-kinases, RIPK1 and RIPK3, and their target, the mixed-lineage-kinase-domain-like protein, MLKL. The intestinal epithelium has one of the highest rates of cellular turnover in a process that is tightly regulated. Altered necroptosis at the intestinal epithelium leads to uncontrolled microbial translocation and deleterious inflammation. Indeed, necroptosis plays a role in many disease conditions and inhibiting necroptosis is currently considered a promising therapeutic strategy.
  • 1.7K
  • 20 Oct 2020
Topic Review
CCL21/CCR7 in Breast Cancer
Breast cancer is a leading cause of cancer-related deaths worldwide, predominantly caused by metastasis. It is generally accepted that the pattern of breast cancer metastasis is largely determined by the interaction between the chemokine receptors on cancer cells and the chemokines expressed at the sites of metastatic disease. Chemokine receptors belong to the G-protein-coupled receptors (GPCRs) family that appear to be implicated in inflammatory diseases, tumor growth and metastasis. One of its members, C-C Chemokine receptor 7 (CCR7), binds chemokines CCL19 and CCL21, which are important for tissue homeostasis, immune surveillance and tumorigenesis. These receptors have been shown to induce the pathobiology of breast cancer due to their ability to induce cellular proliferation and migration upon the binding of the cognate chemokine receptors. The underlying signaling pathways and exact cellular interactions within this biological system are not fully understood and need further insights.
  • 1.7K
  • 25 May 2021
Topic Review
Cell Cycle and Its Regulation
A decisive characteristic of life is the reproductive capacity of cells, which it does through a collection of highly complex and ordered regulatory process commonly known as the cell cycle. The cell cycle combines DNA replication with chromosomal segregation in an oscillatory manner. In this way, the cell cycle coordinates the precise replication of the genome through specific events to ensure that the duplicated genetic material is distributed equally to each daughter cell. The repetition of this process leads to the exponential proliferation of cells. This process is classically described as interphase and mitosis (M) phase. Most of the cell cycle is in interphase, which encompasses Gap 1 (G1), synthesis (S), and Gap 2 (G2) phases. During the interphase, the cell grows, replicates genetic materials, and repairs DNA damage and replication errors. M phase, a relatively short period, consists of prophase, metaphase, anaphase, and telophase, which completes the equal distribution of genome and cytoplasmic components. Following interphase, most nondividing cells exit the cell cycle at G1 into G0 phase (quiescence). G0 was originally used to describe cells that are not in the cell cycle but with the potential for division. The rate of cell cycling varies with the developmental stage and cell type. In general, the cell cycle is most active during development, as cells in early embryos can proliferate and differentiate to form tissues and organs. The cell cycle involves numerous life processes, and it is closely related to the growth and proliferation of eukaryotic cells, development of organisms, regulation of DNA damage repair, and occurrence of diseases.
  • 1.7K
  • 25 Jun 2021
Topic Review
Foraminiferal EcoQS Assessment, Transitional Waters
Transitional waters straddle the interface between marine and terrestrial biomes and, among others, include fjords, bays, lagoons, and estuaries. These coastal systems are essential for transport and manufacturing industries and suffer extensive anthropogenic exploitation of their ecosystem services for aquaculture and recreational activities. These activities can have negative effects on the local biota, necessitating investigation and regulation. As a result of this, EcoQS (ecological quality status) assessment has garnered great attention as an essential aspect of governmental bodies’ legislative decision-making process. Assessing EcoQS in transitional water ecosystems is problematic because these systems experience high natural variability and organic enrichment and often lack information about their pre-human impact, baseline, or “pristine” reference conditions, knowledge of which is essential to many commonly used assessment methods. Here, foraminifera can be used as environmental sentinels, providing ecological data such as diversity and sensitivity, which can be used as the basis for EcoQS assessment indices. Fossil shells of foraminifera can also provide a temporal aspect to ecosystem assessment, making it possible to obtain reference conditions from the study site itself. These foraminifera-based indices have been shown to correlate not only with various environmental stressors but also with the most common macrofaunal-based indices currently employed by bodies such as the Water Framework Directive (WFD).
  • 1.7K
  • 28 Jul 2021
Topic Review
GSH/NO in Skeletal Muscle Physiology
Glutathione (GSH) is the main non-enzymatic antioxidant playing an important role in detoxification and signal transduction by modulation of protein thiols redox status and direct scavenging of radicals. The latter function is not only performed against reactive oxygen species (ROS) but GSH also has a fundamental role in buffering nitric oxide (NO), a physiologically-produced molecule having multifaceted functions. The efficient rate of GSH synthesis and high levels of GSH-dependent enzymes are characteristic features of healthy skeletal muscle where, besides the canonical functions, it is also involved in muscle contraction regulation. 
  • 1.7K
  • 03 Sep 2021
Topic Review
AI-Assisted Design-on-Simulation for Life Prediction
Many researchers have adopted the finite-element-based design-on-simulation (DoS) technology for the reliability assessment of electronic packaging. DoS technology can effectively shorten the design cycle, reduce costs, and effectively optimize the packaging structure. However, the simulation analysis results are highly dependent on the individual researcher and are usually inconsistent between them. Artificial intelligence (AI) can help researchers avoid the shortcomings of the human factor. 
  • 1.7K
  • 28 Sep 2021
Topic Review
Biomedical Effects of Oregano
The term oregano refers to a group of several plant genera, including Thymbra, Thymus, Coridothymus, Satureja, and Origanum, containing a high amount of the phytochemicals carvacrol and thymol in their essential oils.
  • 1.7K
  • 03 Nov 2021
Topic Review
E-Learning and iLearn2.0
E-learning refers to using computer technology in a learning experience that has led to many changes in traditional learning. In the beginning, people who originally studied psychology talked about the use of artificial intelligence (AI) as a teaching assistant but were unable or afraid to implement it. iLearn is an online assistant first launched in 2000. It was used in university courses to integrate technology with education in line with the SLE approach. In 2015, the iLearn system was upgraded and migrated to the iLearn 2.0 version. 
  • 1.7K
  • 23 Nov 2021
Topic Review
Marine Collagen
Marine organisms harbor numerous bioactive substances that can be utilized in the pharmaceutical and cosmetic industries. Scientific research on various applications of collagen extracted from these organisms has become increasingly prevalent. Marine collagen can be used as a biomaterial because it is water-soluble, metabolically compatible, and highly accessible. 
  • 1.7K
  • 29 Mar 2022
Topic Review
Cohesive Sediment Transport in River Systems
Mathematical modelling of cohesive sediment transport is a challenge because of the large number of governing parameters controlling the transport processes. These parameters have to be determined using a rotating circular flume for site specific sediments. The parameters that that need to be determined using a rotating circular flume during the application of the RIVFLOC model to different river systems include the critical shear stress for erosion of the cohesive sediment, critical shear stress for deposition according to the definition of Partheniades, critical shear stress for deposition according to the definition of Krone, the cohesion parameter governing the flocculation of cohesive sediment and a set of empirical parameters that define the density of the floc in terms of the size of the flocs. An examination of the variability of these parameters shows the need for testing site-specific sediments using a rotating circular flume to achieve a reliable prediction of the RIVFLOC model. Application of the model to various river systems has highlighted the need for including the entrapment process in a cohesive sediment transport model.
  • 1.7K
  • 28 Jan 2022
Topic Review
A Lean-Led Design Approach
Lean-led Design is a  user-empowering approach that gained popularity in some countries such as the USA. It is proposed to be used during the project definition of healthcare projects in order to enhance quality of healthcare and optimize pathways that patients could follow.
  • 1.7K
  • 06 Apr 2022
Topic Review
Orion's Arm
Orion's Arm (also called the Orion's Arm Universe Project, OAUP, or simply OA and formerly known as the Orion's Arm Worldbuilding Group) is a multi-authored online science fiction world-building project, first established in 2000 by M. Alan Kazlev, Donna Malcolm Hirsekorn, Bernd Helfert and Anders Sandberg and further co-authored by many people since. Anyone can contribute articles, stories, artwork, or music to the website. A large mailing list exists, in which members debate aspects of the world they are creating, discussing additions, modifications, issues arising, and work to be done. A computer game and a tabletop role-playing game are being developed by the community, within the OA milieu. There is an ezine for Orion's Arm fiction, art, and commentary, called Voices: Future Tense, add-ons for the Celestia program to displaying Orion's Arm planets, spacecraft and other objects, and additional transhumanist flavored SF illustrations. The first published Orion's Arm book, a collection of five novellas set within the OA universe, called Against a Diamond Sky, was released in September 2009 by Outskirts Press. The second published Orion's Arm book, called After Tranquility, was released in February 2014.
  • 1.7K
  • 14 Oct 2022
Topic Review
Reactive Species on Innate Immunity
The role of reactive species RS (of oxygen ROS, nitrogen RNS and halogen RHS) on innate immunity is examined. The importance of these species in innate immunity was first recognized in phagocytes that underwent a “respiratory burst” after activation. The anion superoxide •O2− and hydrogen peroxide H2O2 are detrimental to the microbial population. NADPH oxidase NOx, as an •O2− producer is essential for microbial destruction, and patients lacking this functional oxidase are more susceptible to microbial infections. Reactive nitrogen species RNS (the most important are nitric oxide radical -•NO, peroxynitrite ONOO— and its derivatives), are also harmful to microorganisms, including bacteria, viruses, and parasites. Hypochlorous acid HOCl and hypothiocyanous acid HOSCN synthesized through the enzyme myeloperoxidase MPO, which catalyzes the reaction between H2O2 and Cl− or SCN−, are important inorganic bactericidal molecules, effective against a wide range of microbes. 
  • 1.7K
  • 26 Oct 2022
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