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Shaik, L.; Boike, S.; Ramar, K.; Subramanian, S.; Surani, S. COVID-19 and Sleep Disturbances. Encyclopedia. Available online: https://encyclopedia.pub/entry/48801 (accessed on 03 May 2024).
Shaik L, Boike S, Ramar K, Subramanian S, Surani S. COVID-19 and Sleep Disturbances. Encyclopedia. Available at: https://encyclopedia.pub/entry/48801. Accessed May 03, 2024.
Shaik, Likhita, Sydney Boike, Kannan Ramar, Shyam Subramanian, Salim Surani. "COVID-19 and Sleep Disturbances" Encyclopedia, https://encyclopedia.pub/entry/48801 (accessed May 03, 2024).
Shaik, L., Boike, S., Ramar, K., Subramanian, S., & Surani, S. (2023, September 05). COVID-19 and Sleep Disturbances. In Encyclopedia. https://encyclopedia.pub/entry/48801
Shaik, Likhita, et al. "COVID-19 and Sleep Disturbances." Encyclopedia. Web. 05 September, 2023.
COVID-19 and Sleep Disturbances
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This entry is adapted from the peer-reviewed paper 10.3390/medicina59050818

The need for adequate good quality sleep to optimally function is well known. Various physical, psychological, biological, and social factors have been investigated to understand their impact on sleep. However, understanding the etiological processes that are involved in causing sleep disturbances (SD) as impacted by stressful phases such as pandemics has not been well studied. Many such etiological and management strategies have surfaced during the “coronavirus disease of 2019 (COVID-19) pandemic. The occurrence of these SD in the infected and uninfected individuals poses a need to investigate factors linked to such occurrence during this phase. Some of such factors include stressful practices such as social distancing, masking, vaccines, and medications availability, changes in routines, and lifestyles. As the status of infection improved, a collective term for all the prolonged effects of COVID-19 after the resolution of the primary infection called the post-COVID-19 syndrome (PCS) surfaced. Apart from impacting sleep during the infectious phase, the aftereffects of this virus left an even greater impact during the PCS.

sleep disorders post-COVID-19 syndrome coronasomnia sleep cycle COVID-19 pandemic

1. Introduction

The initial outbreak of “coronavirus disease of 2019. (COVID-19), which would cause a devastating pandemic worldwide, occurred in late 2019. On March 11th, 2020, the World Health Organization (WHO) announced the COVID-19 global pandemic outbreak [1]. The World Health Organization has reported that this pandemic has surpassed the number of deaths due to respiratory diseases from prior years, amounting to nearly 6.5 million deaths worldwide [2]. The incubation period of 5–14 days made it difficult to recognize infected individuals during the asymptomatic phase of the infection, making it challenging to isolate patients while they are contagious [3], further complicating the management of the disease. The underestimation of the effects of this new virus aided in its further spread and provided an unguarded environment for multiplying the contagious state exponentially, making the task of virus containment extremely challenging. The increased morbidity and mortality associated with the virus speeded actions toward curbing the further spread [4]. These included track-and-tracing, self-isolation, quarantine, social distancing, and community containment, and nationwide lockdowns were among the public health measures to prevent the further spread [5]. The sudden climb in awareness regarding the gravity of the situation created monumental havoc among the masses. In addition to facing the direct effects of COVID-19 infection, people’s health was additionally affected by the guidelines put in place in an attempt to slow the spread. Many perceived isolation as confinement, causing worries about livelihood and social distancing from loved ones, directly and indirectly affecting the health and well-being of patients and their families [6]. The additional media updates regularly made on the statistics of COVID-19 significantly affected mental health and sleep, causing distress among many [7].
Sleep is vital for the optimal functioning of organ systems and the mind. Poor sleep is associated with unfavorable clinical outcomes. Such outcomes are undesirable at any point in time, especially amidst a raging pandemic [8]. Research studies indicate the link between infectious disease outbreaks and sleep dysfunction [9][10][11][12]. Similarly, associations between infectious outbreaks and sleep dysfunction can be applied during this COVID-19 pandemic in the setting of physical illness, separation from family and friends, environmental stresses, social isolation, and prior poor mental health [13][14][15][16][17]. Jaharmi et al., describe sleep changes as a common symptom among COVID-19-infected individuals [8]. As per a meta-analysis, the global prevalence of COVID-19-related sleep disturbances was 40.49% [18]. However, it remains a scarcely studied entity in the realm of COVID-19 research [19]. The psychological or psychiatric repercussions of such measures have been well-researched. However, the effects on sleep are not well understood due to the lack of consistency between study results [20][21][22].

2. Sleep Disturbances: Definition and Instruments

Sleep disturbances refer to a group of disturbances described as trouble falling/staying asleep, which can cause excessive drowsiness during the daytime as a result of an inadequate amount of sleep, or change in sleep quantity, quality, or timing [23][24][25]. However, the sleep disturbances that were focused on in the majority of the studies were poor sleep quality and insomnia. Sleep quality that was poor in nature was assessed using the Pittsburgh sleep quality index (PSQI), and insomnia was assessed using the insomnia severity index (ISI) and the Athens insomnia scale (AIS). Many other measures were also used to report sleep disturbances. The BEARS questionnaire described bedtime problems, increased daytime sleepiness, awakening throughout the night, regularity and duration of sleep, and finally snoring. Adequate sleep, somnolence, amount of sleep obtained, snoring, and waking up with shortness of breath or with a headache were reported using the medical outcomes study sleep scale (MOS-SS). Patient’s own perceptions of sleep quality, the depth of their sleep, and restoration associated with sleep were assessed by the patient-reported outcomes measurement information system-sleep disturbance (PROMIS) questionnaire. In children, the Sleep Disturbance Scale for Children (SDSC) and the youth self-rating insomnia scale were valuable tools to measure these sleep changes [18].

3. Prevalence of Sleep Disturbances in COVID-19 Patients

Sleep’s vital role in everyday life is well known [23]. Sleep dysfunction has been linked to deleterious effects on mood, health, and various motor vehicle accidents [24]. Self-reported data from various sections of society indicate high amounts of the burden of this dysfunction during the COVID-19 pandemic [25]. The prevalence of sleep changes during the COVID-19 pandemic was estimated to be about 36% [8][25], with higher impact on patients infected with the COVID-19 virus [8][25][26][27][28]. However, these numbers are variable based on several factors, as discussed below.
  • Age and gender: Among COVID-19 patients, the elderly and male gender exhibited a higher prevalence of sleep problems [8][25]. The study conducted in 51,625 participants indicated a 29% worsening of sleep changes (subjective deterioration in sleep quality) in individuals > 50 years of age during the COVID pandemic with a greater predilection toward the male gender. Their questionnaire also assessed sleep changes to “more or less trouble sleeping since the outbreak,” and this was recoded as a binary variable to compare “more trouble sleeping since the outbreak” versus “less trouble sleeping since the outbreak” or “no changes in sleep”. Participants who felt lonelier since after the COVID outbreak had more trouble sleeping than those who did not complain of loneliness (Odds Ratio (OR)  =  1.21; p  =  0.002; CI, 1.07–1.37 and OR  =  4.06; p  =  0.000; CI, 2.75–5.99, respectively). They also concluded that age and gender were independent predictors of sleep changes in their population [29].
Studies by Ara et al. [30], Wang et al. [31], Czeisler et al. [32] and Kim et al. [33] reported that sleep disturbances are either more likely among patients more than 30 years of age or increase with age. On the contrary, studies by Beck et al. [34], Romero-Blanco et al. [35], Mareli et al. [36], and Kaparounaki et al. [37] indicate a higher prevalence of sleep disturbances among younger ages (18–34 years). It can be argued that even though sleep structure and circadian rhythm alter with age, the variability in stress related to financial, social, and emotional burdens heavily impacts various age groups differently [17]. Moreover, as the above factors change with geographical location, cultural backgrounds and other comorbidities, inconsistency in results is expected [17][18].

4. How Did COVID-19 Affect Sleep: Related Mechanisms

The impact of the COVID-19 pandemic has affected sleep in various ways through cytokine release, neuro-inflammation, and other ways discussed later in this research. The psycho-sociological effects of social distancing, isolation, and quarantine measures manifested as loneliness, detachment, boredom, and loss of freedom [7][13][14][15][16][17]. This diminished coping mechanisms, which likely contributed to new mental health issues. As is already known, any amount of mental health concerns is an obvious link to sleep disturbances and vice-versa [7][13][14][15][16][17]. The increased morbidity and mortality in society further aggravated stress and led to sleep disorders.

5. Various Sleep Disorders Associated with COVID-19 Infection

Prior epidemics and pandemics have exposed the world population to stress, social confinement, limited daylight exposure, step back from normalcy, and induced sleep disturbances, which during the coronavirus period was termed the coronasomnia phenomenon. These sleep disturbances include insufficient sleep, insomnia, poor sleep quality, sleep apnea, and circadian rhythm disorders [38]. Confinement from quarantine measures played a vital role in causing insomnia, as evidenced by studies in Europe [6]. In Italy, anxiety from COVID-19 was associated with sleep problems [39][40][41]. REM sleep disorders could be directly linked to the COVID-19 infection itself [42].
The prevalence of insomnia was as high as 60% among COVID-19 survivors, although variable rates were noted in China (2%) [43], Italy (40%) [44], and Mexico (77%) [44][45]. These results are attributable to the neuroinflammatory changes or the stress around the pandemic. These results may be related to the duration of illness, as explained by Pedrozo-Pop et al., where insomnia was more likely in patients who experienced illness for more than 3 weeks. Moreover, insomnia was associated with increased post-traumatic stress disorder (PTSD) risk as encountered in clinical practice [43][46][47].
Obstructive sleep apnea (OSA) was present in 8–21% of patients hospitalized with COVID-19 infection [48][49][50][51][52][53]. The results of the association between the two have been contradictory. However, the majority of studies suggest OSA as a risk factor for a complicated hospital course. The underlying inflammatory state of COVID provides a plausible explanation for this association. The hypoxemic state in OSA affects the cytokine storm, further worsening it [43]. Hence, owing to its antioxidant, anti-inflammatory, and pro-immunity actions, melatonin can be used in the treatment of COVID-19 pneumonia, especially in OSA patients [54][55]. Various studies thus indicate the relationship between COVID and OSA as bidirectional and synergistic [48][56][57]. However, minimal literature is available confirming this relationship and the prevalence of other sleep disorders during the COVID pandemic.

6. Poor Sleep and COVID-19

Sleep is a known factor that impacts the immune response, and evidence suggests that sleep disturbances alter the immunity to feasibly cause immunosuppression [58][59]. This may be from the changes in cytokine production, release, and associated cell count variability. Similarly, as studied by previous research, the COVID-19 virus alters sleep quality in hospitalized patients. However, the effect from the direct impact of the virus is ambiguous. It is hypothesized to be a result of anxiety, pain, physical discomfort, prolonged hospitalization, or polypharmacy [60][61]. Several studies indicate the link between poor sleep quality and slow improvement of lymphopenia in hospitalized patients and further need for ICU admissions, indicating the association between the two [62]. Research indicates that reduced sleep duration and coexisting comorbidities are significant indicators of disease severity. Hence, while studying the impact of COVID-19 on sleep, it should be borne in mind that sleep affects COVID-19 severity, alters the clinical course of events, and impacts the clinical outcomes of COVID-19. Outpatient and hospitalized patients suffering from this infection should be notified about the importance of sleep in the recovery from infection [63]. A particular study showed poor sleep and high-stress levels in hospitalized schizophrenic patients suspected of developing a COVID-19 infection. This indicates that treating sleep problems is imperative for recovering from mental illnesses and possibly strengthening immunity to prevent infections [64].
Sleep manifestations such as insomnia can impose prolonged problems. Insomnia can become chronic, worsen pain syndromes and gastrointestinal disorders, and increase the risk of hypertension and heart diseases if left untreated [28]. Recent evidence suggests that sleep loss is a potential biomarker of blood–brain barrier (BBB) leak. Possible mechanisms implicated in this process are neuroinflammation from causing loss of BBB integrity [65] and possibly inducing infection or other mental illnesses. Sleep stands as an often-ignored entity during the other deleterious impact of COVID-19 infection. However, it remains a silent component that can cause long-term effects, making early management vital to prevent such an outcome.

7. Management Modalities

Sleep is affected by and, in turn, also affects health and mood. Hence, it is imperative to recognize and address sleep disturbances in various population groups during the early phase of impact. This starts with identifying individual, interpersonal, professional, and community risk factors [66]. Basic principles of sleep hygiene should be reinforced. As COVID-19 infection has been correlated to sleep disturbances, mental health problems, and stress in general, special focus on this subset of patients is much needed to reduce the burden of the already disastrous disease impact and improve prognosis [16][54][61]. Often, hospitalization causes delirium and can disturb the sleep cycle. Hence, delirium management strategies such as frequent re-orientation, maintaining the sleep–wake cycle through adequate light settings, adequate pain control, and through use of circadian rhythm-maintaining medications such as melatonin [54][55]. The effects of ICU stay and associated trauma from mechanical ventilation can induce PTSD and aggravate sleep problems [43][44][45][46][47]. The use of prophylactic melatonin and melatonin receptor agonists such as Ramelteon for sleep–wake cycle disorders improved the sleep of ICU patients, decreasing the delirium occurrence and duration of ICU stay [55]. Other sleep dysfunction treatment modalities have been discussed below (Figure 1).
Figure 1. Treatment modalities for pandemic related sleep dysfunction.

8. Novel vs. Existing Therapeutics

This research has important biomedical applications, as it provides a review on the literature surrounding actions providers can take in treating sleep disturbances. Some of these examples, as previously mentioned, include good sleep hygiene, strategies of minimizing delirium in the inpatient setting, and utilizing melatonin agonists when indicated. Other nonpharmacologic treatments classically discussed in the sleep literature include sleep diaries, sleep restriction, and other cognitive and relaxing techniques (122). Other pharmacologic therapies include benzodiazepines, non-benzodiazepine hypnotics, antihistamines, and antidepressants (122). Comparatively, the therapies discussed offer many benefits, including ease of administration (i.e., minimizing delirium via maintaining schedules, opening window blinds) and accessibility to patients (i.e., sleep hygiene is a factor patients can directly address themself). More research needs to be conducted regarding use of these alternate therapies in sleep disturbances.

References

  1. WHO. Director-General’s Opening Remarks at the Media Briefing on COVID-19. Available online: https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020 (accessed on 11 March 2020).
  2. Available online: https://covid19.who.int (accessed on 25 October 2022).
  3. Parasher, A. COVID-19: Current understanding of its pathophysiology, clinical presentation and treatment. Postgrad Med. J. 2021, 97, 312–320.
  4. Available online: https://www.washingtonpost.com/health/2021/03/09/coronavirus-spread-world (accessed on 29 December 2022).
  5. Wilder-Smith, A.; Freedman, D.O. Isolation, quarantine, social distancing and community containment: Pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak. J. Travel Med. 2020, 27, taaa020.
  6. Altena, E.; Baglioni, C.; Espie, C.A.; Ellis, J.; Gavriloff, D.; Holzinger, B.; Schlarb, A.; Frase, L.; Jernelöv, S.; Riemann, D. Dealing with sleep problems during home confinement due to the COVID-19 outbreak: Practical recommendations from a task force of the European CBT-I Academy. J. Sleep Res. 2020, 29, e13052.
  7. Available online: https://www.sleepfoundation.org/covid-19-and-sleep (accessed on 23 March 2023).
  8. Jahrami, H.; BaHammam, A.S.; Bragazzi, N.L.; Saif, M.Z.; Faris, M.; Vitiello, M.V. Sleep problems during the COVID-19 pandemic by population: A systematic review and meta-analysis. J. Clin. Sleep Med. 2021, 17, 299–313.
  9. Ji, D.; Ji, Y.-J.; Duan, X.-Z.; Li, W.-G.; Sun, Z.-Q.; Song, X.-A.; Meng, Y.-H.; Tang, H.-M.; Chu, F.; Niu, X.-X.; et al. Prevalence of psychological symptoms among Ebola survivors and healthcare workers during the 2014–2015 Ebola outbreak in Sierra Leone: A cross-sectional study. Oncotarget 2017, 8, 12784–12791.
  10. Lin, C.-Y.; Peng, Y.-C.; Wu, Y.-H.; Chang, J.; Chan, C.-H.; Yang, D.-Y. The psychological effect of severe acute respiratory syndrome on emergency department staff. Emerg. Med. J. 2007, 24, 12–17.
  11. Mohammed, A.; Sheikh, T.L.; Gidado, S.; Poggensee, G.; Nguku, P.; Olayinka, A.; Ohuabunwo, C.; Waziri, N.E.; Shuaib, F.; Adeyemi, J.; et al. An evaluation of psychological distress and social support of survivors and contacts of Ebola virus disease infection and their relatives in Lagos, Nigeria: A cross sectional study—2014. BMC Public Health 2015, 15, 824.
  12. Jiang, Z.; Zhu, P.; Wang, L.; Hu, Y.; Pang, M.; Ma, S.; Tang, X. Psychological distress and sleep quality of COVID-19 patients in Wuhan, a lockdown city as the epicenter of COVID-19. J. Psychiatr. Res. 2021, 136, 595–602.
  13. Pang, J.C.Y.; Chan, E.L.S.; Lau, H.M.C.; Reeves, K.K.L.; Chung, T.H.Y.; Hui, H.W.L.; Leung, A.H.L.; Fu, A.C.L. The impacts of physical activity on psychological and behavioral problems, and changes in physical activity, sleep and quality of life during the COVID-19 pandemic in preschoolers, children, and adolescents: A systematic review and meta-analysis. Front. Pediatr. 2023, 11, 1015943.
  14. Xin, J.; Zhang, Y.; Tang, Y.; Yang, Y. Brain Differences Between Men and Women: Evidence from Deep Learning. Front. Neurosci. 2019, 13, 185.
  15. Bo, H.-X.; Li, W.; Yang, Y.; Wang, Y.; Zhang, Q.; Cheung, T.; Wu, X.; Xiang, Y.-T. Posttraumatic stress symptoms and attitude toward crisis mental health services among clinically stable patients with COVID-19 in China. Psychol. Med. 2021, 51, 1052–1053.
  16. Zhang, J.; Lu, H.; Zeng, H.; Zhang, S.; Du, Q.; Jiang, T.; Du, B. The differential psychological distress of populations affected by the COVID-19 pandemic. Brain Behav. Immun. 2020, 87, 49–50.
  17. Lin, C.-Y.; Li, Y.-P.; Lin, S.-I.; Chen, C.-H. Measurement equivalence across gender and education in the WHOQOL-BREF for community-dwelling elderly Taiwanese. Int. Psychogeriatrics 2016, 28, 1375–1382.
  18. Jahrami, H.A.; Alhaj, O.A.; Humood, A.M.; Alenezi, A.F.; Fekih-Romdhane, F.; AlRasheed, M.M.; Saif, Z.Q.; Bragazzi, N.L.; Pandi-Perumal, S.R.; BaHammam, A.S.; et al. Sleep disturbances during the COVID-19 pandemic: A systematic review, meta-analysis, and meta-regression. Sleep Med. Rev. 2022, 62, 101591.
  19. Choudhry, A.A.; Shahzeen, F.; Choudhry, S.A.; Batool, N.; Murtaza, F.; Dilip, A.; Rani, M.; Chandnani, A. Impact of COVID-19 Infection on Quality of Sleep. Cureus 2021, 13, e18182.
  20. Jeong, H.; Yim, H.W.; Song, Y.-J.; Ki, M.; Min, J.-A.; Cho, J.; Chae, J.-H. Mental health status of people isolated due to Middle East Respiratory Syndrome. Epidemiol. Health 2016, 38, e2016048.
  21. Brooks, S.K.; Webster, R.K.; Smith, L.E.; Woodland, L.; Wessely, S.; Greenberg, N.; Rubin, G.J. The psychological impact of quarantine and how to reduce it: Rapid review of the evidence. Lancet 2020, 395, 912–920.
  22. Su, C.-T.; Wang, J.-D.; Lin, C.-Y. Child-rated versus parent-rated quality of life of community-based obese children across gender and grade. Health Qual. Life Outcomes 2013, 11, 206.
  23. Kowall, S.M.; Sommer, J.L.; Reynolds, K.A.; Mota, N.; El-Gabalawy, R. Sleep disturbance during COVID-19: Correlates and predictive ability for mental health symptomatology in a Canadian online sample. Gen. Hosp. Psychiatry 2023, 80, 48–53.
  24. Mazza, M.G.; De Lorenzo, R.; Conte, C.; Poletti, S.; Vai, B.; Bollettini, I.; Melloni, E.M.T.; Furlan, R.; Ciceri, F.; Rovere-Querini, P.; et al. Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors. Brain Behav. Immun. 2020, 89, 594–600.
  25. Alimoradi, Z.; Broström, A.; Tsang, H.W.H.; Griffiths, M.D.; Haghayegh, S.; Ohayon, M.M.; Lin, C.-Y.; Pakpour, A.H. Sleep problems during COVID-19 pandemic and its’ association to psychological distress: A systematic review and meta-analysis. Eclin. Med. 2021, 36, 100916.
  26. Salari, N.; Khazaie, H.; Hosseinian-Far, A.; Ghasemi, H.; Mohammadi, M.; Shohaimi, S.; Daneshkhah, A.; Khaledi-Paveh, B.; Hosseinian-Far, M. The prevalence of sleep disturbances among physicians and nurses facing the COVID-19 patients: A systematic review and meta-analysis. Glob. Health 2020, 16, 92.
  27. Serrano-Ripoll, M.J.; Zamanillo-Campos, R.; Castro, A.; Fiol-de Roque, M.A.; Ricci-Cabello, I. Insomnia and sleep quality in healthcare workers fighting against COVID-19: A systematic review of the literature and meta-analysis. Actas Esp. Psiquiatr. 2021, 49, 155–179.
  28. Al Maqbali, M.; Al Sinani, M.; Al-Lenjawi, B. Prevalence of stress, depression, anxiety and sleep disturbance among nurses during the COVID-19 pandemic: A systematic review and meta-analysis. J. Psychosom. Res. 2021, 141, 110343.
  29. Cordeiro, C.R.; Pestana, P.C.; Côrte-Real, B.; Novais, F. Long Time, No Sleep. Prim. Care Companion J. Clin. Psychiatry 2022, 24, 41259.
  30. Ara, T.; Rahman, M.; Hossain, A.; Ahmed, A. Identifying the Associated Risk Factors of Sleep Disturbance During the COVID-19 Lockdown in Bangladesh: A Web-Based Survey. Front. Psychiatry 2020, 11, 580268.
  31. Wang, S.; Ungvari, G.S.; Forester, B.P.; Chiu, H.F.; Wu, Y.; Kou, C.; Fu, Y.; Qi, Y.; Liu, Y.; Tao, Y.; et al. Gender differences in general mental health, smoking, drinking and chronic diseases in older adults in Jilin province, China. Psychiatry Res. 2017, 251, 58–62.
  32. Czeisler, C.; Dumont, M.; Duffy, J.; Steinberg, J.; Richardson, G.; Brown, E.; Sánchez, R.; Ríos, C.; Ronda, J. Association of sleep-wake habits in older people with changes in output of circadian pacemaker. Lancet 1992, 340, 933–936.
  33. Kim, H.J.; Kim, R.E.; Kim, S.; Kim, B.S.A.; Kim, S.E.; Lee, S.K.; Lee, H.W.; Shin, C. Sex differences in deterioration of sleep properties associated with aging: A 12-year longitudinal cohort study. J. Clin. Sleep Med. 2021, 17, 964–972.
  34. Beck, F.; Léger, D.; Fressard, L.; Peretti-Watel, P.; Verger, P. The Coconel Group Covid-19 health crisis and lockdown associated with high level of sleep complaints and hypnotic uptake at the population level. J. Sleep Res. 2020, 30, e13119.
  35. Romero-Blanco, C.; Rodríguez-Almagro, J.; Onieva-Zafra, M.D.; Parra-Fernández, M.L.; Prado-Laguna, M.D.C.; Hernández-Martínez, A. Sleep Pattern Changes in Nursing Students during the COVID-19 Lockdown. Int. J. Environ. Res. Public Health 2020, 17, 5222.
  36. Marelli, S.; Castelnuovo, A.; Somma, A.; Castronovo, V.; Mombelli, S.; Bottoni, D.; Leitner, C.; Fossati, A.; Ferini-Strambi, L. Impact of COVID-19 lockdown on sleep quality in university students and administration staff. J. Neurol. 2021, 268, 8–15.
  37. Kaparounaki, C.K.; Patsali, M.E.; Mousa, D.-P.V.; Papadopoulou, E.V.; Papadopoulou, K.K.; Fountoulakis, K.N. University students’ mental health amidst the COVID-19 quarantine in Greece. Psychiatry Res. 2020, 290, 113111.
  38. Campos, E.V.R.; Pereira, A.E.S.; De Oliveira, J.L.; Carvalho, L.B.; Guilger-Casagrande, M.; De Lima, R.; Fraceto, L.F. How can nanotechnology help to combat COVID-19? Opportunities and urgent need. J. Nanobiotechnology 2020, 18, 125.
  39. Rossi, R.; Socci, V.; Talevi, D.; Mensi, S.; Niolu, C.; Pacitti, F.; Di Marco, A.; Rossi, A.; Siracusano, A.; Di Lorenzo, G. COVID-19 Pandemic and Lockdown Measures Impact on Mental Health Among the General Population in Italy. Front. Psychiatry 2020, 11, 790.
  40. Gualano, M.R.; Lo Moro, G.; Voglino, G.; Bert, F.; Siliquini, R. Effects of Covid-19 Lockdown on Mental Health and Sleep Disturbances in Italy. Int. J. Environ. Res. Public Health 2020, 17, 4779.
  41. Belleville, G.; Ouellet, M.-C.; Morin, C.M. Post-Traumatic Stress among Evacuees from the 2016 Fort McMurray Wildfires: Exploration of Psychological and Sleep Symptoms Three Months after the Evacuation. Int. J. Environ. Res. Public Health 2019, 16, 1604.
  42. Pedrozo-Pupo, J.C.; Caballero-Domínguez, C.C.; Campo-Arias, A. Prevalence and variables associated with insomnia among COVID-19 survivors in Colombia. Acta Biomed. 2022, 93, e2022019.
  43. Xu, F.; Wang, X.; Yang, Y.; Zhang, K.; Shi, Y.; Xia, L.; Hu, X.; Liu, H. Depression and insomnia in COVID-19 survivors: A cross-sectional survey from Chinese rehabilitation centers in Anhui province. Sleep Med. 2021, 91, 161–165.
  44. Innocenti, P.; Puzella, A.; Mogavero, M.P.; Bruni, O.; Ferri, R. Letter to editor: CoVID-19 pandemic and sleep disorders: A web survey in Italy. Neurol Sci. 2020, 41, 2021–2022.
  45. Mahmoudi, H.; Saffari, M.; Movahedi, M.; Sanaeinasab, H.; Rashidi-Jahan, H.; Pourgholami, M.; Poorebrahim, A.; Barshan, J.; Chiami, M.; Khoshmanesh, S.; et al. A mediating role for mental health in associations between COVID-19-related self-stigma, PTSD, quality of life, and insomnia among patients recovered from COVID-19. Brain Behav. 2021, 11, e02138.
  46. Khurshid, K.A. Comorbid Insomnia and Psychiatric Disorders: An Update. Innov. Clin. Neurosci. 2018, 15, 28–32.
  47. Goldstein, C.A.; Rizvydeen, B.M.; Conroy, D.A.; O’Brien, L.M.; Gupta, G.; Somers, E.C.; Sharma, P.; Golob, J.L.; Troost, J.P.; Burgess, H.J. The prevalence and impact of pre-existing sleep disorder diagnoses and objective sleep parameters in patients hospitalized for COVID-19. J. Clin. Sleep Med. 2021, 17, 1039–1050.
  48. Pazarlı, A.C.; Ekiz, T.; Ilik, F. Coronavirus disease 2019 and obstructive sleep apnea syndrome. Sleep Breath. 2021, 25, 371.
  49. Maas, M.B.; Kim, M.; Malkani, R.G.; Abbott, S.M.; Zee, P.C. Obstructive Sleep Apnea and Risk of COVID-19 Infection, Hospitalization and Respiratory Failure. Sleep Breath. 2020, 25, 1155–1157.
  50. Strausz, S.; Kiiskinen, T.; Broberg, M.; Ruotsalainen, S.; Koskela, J.; Bachour, A.; Palotie, A.; Palotie, T.; Ripatti, S.; Ollila, H.M.; et al. Sleep apnoea is a risk factor for severe COVID-19. BMJ Open Respir. Res. 2021, 8, e000845.
  51. Bhatraju, P.K.; Ghassemieh, B.J.; Nichols, M.; Kim, R.; Jerome, K.R.; Nalla, A.K.; Mikacenic, C. Covid-19 in critically ill patients in the Seattle region—Case series. N. Engl. J. Med. 2020, 382, 2012–2022.
  52. Najafi, A.; Sadeghniiat-Haghighi, K.; Akbarpour, S.; Samadi, S.; Rahimi, B.; Alemohammad, Z.B. The effect of apnea management on novel coronavirus infection: A study on patients with obstructive sleep apnea. Sleep Health 2021, 7, 14–18.
  53. Krueger, J. The role of cytokines in sleep regulation. Curr. Pharm. Des. 2008, 14, 3408–3416.
  54. Zhang, Q.; Gao, F.; Zhang, S.; Sun, W.; Li, Z. Prophylactic use of exogenous melatonin and melatonin receptor agonists to improve sleep and delirium in the intensive care units: A systematic review and meta-analysis of randomized controlled trials. Sleep Breath. 2019, 23, 1059–1070.
  55. Miller, M.A.; Cappuccio, F.P. A systematic review of COVID-19 and obstructive sleep apnoea. Sleep Med. Rev. 2021, 55, 101382.
  56. Bezner, T.L.; Sivaraman, M. COVID-19 Pandemic and Its Impact on Sleep Health: A Rapid Review. Mol. Med. 2022, 119, 385–389.
  57. Irwin, M.R. Why sleep is important for health: A psychoneuroimmunology perspective. Annu. Rev. Psychol. 2015, 66, 143–172.
  58. Besedovsky, L.; Lange, T.; Born, J. Sleep and immune function. Pflugers Arch. 2012, 463, 121–137.
  59. Zambrelli, E.; Canevini, M.; Gambini, O.; D’Agostino, A. Delirium and sleep disturbances in COVID–19: A possible role for melatonin in hospitalized patients? Sleep Med. 2020, 70, 111.
  60. Vitale, J.A.; Perazzo, P.; Silingardi, M.; Biffi, M.; Banfi, G.; Negrini, F. Is disruption of sleep quality a consequence of severe Covid-19 infection? A case-series examination. Chronobiol. Int. 2020, 37, 1110–1114.
  61. Zhang, J.; Xu, D.; Xie, B.; Zhang, Y.; Huang, H.; Liu, H.; Chen, H.; Sun, Y.; Shang, Y.; Hashimoto, K.; et al. Poor-sleep is associated with slow recovery from lymphopenia and an increased need for ICU care in hospitalized patients with COVID-19: A retrospective cohort study. Brain Behav. Immun. 2020, 88, 50–58.
  62. Huang, B.; Niu, Y.; Zhao, W.; Bao, P.; Li, D. Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19. Nat. Sci. Sleep 2020, 12, 999–1007.
  63. Liu, X.; Lin, H.; Jiang, H.; Li, R.; Zhong, N.; Su, H.; Li, Y.; Zhao, M. Clinical characteristics of hospitalised patients with schizophrenia who were suspected to have coronavirus disease (COVID-19) in Hubei Province, China. Gen. Psychiatry 2020, 33, e100222.
  64. Medina-Flores, F.; Hurtado-Alvarado, G.; de Oca, A.C.-M.; López-Cervantes, S.P.; Konigsberg, M.; Deli, M.A.; Gómez-González, B. Sleep loss disrupts pericyte-brain endothelial cell interactions impairing blood-brain barrier function. Brain Behav. Immun. 2020, 89, 118–132.
  65. Becker, P.M. Overview of sleep management during COVID-19. Sleep Med. 2021, 91, 211–218.
  66. Casagrande, M.; Forte, G.; Tambelli, R.; Favieri, F. The Coronavirus Pandemic: A Possible Model of the Direct and Indirect Impact of the Pandemic on Sleep Quality in Italians. Nat. Sci. Sleep 2021, 13, 191–199.
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Subjects: Primary Health Care
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
Likhita Shaik
,
Sydney Boike
,
Kannan Ramar
,
Shyam Subramanian
,
Salim Surani
View Times: 740
Entry Collection: COVID-19
Revisions: 2 times (View History)
Update Date: 05 Sep 2023
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