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Topic Review
Rotational Thromboelastometry (ROTEM®)
Rotational thromboelastometry (ROTEM) is a viscoelastic method, which provides a graphical and numerical representation of induced hemostasis in whole blood samples. Its ability to quickly assess the state of hemostasis is used in the management of bleeding from a variety of causes. 
  • 1.6K
  • 01 Nov 2023
Topic Review
Kit Fox
The Kit Fox (Vulpes macrotis) is a small and elusive member of the Canidae family, native to the arid regions of North America. Renowned for its diminutive size and distinctive large ears, the Kit Fox is supremely adapted to its desert habitat, where it hunts primarily at night for rodents, insects, and small reptiles. Despite its small stature, the Kit Fox plays a vital role in ecosystem dynamics, regulating prey populations and contributing to desert ecosystem health.
  • 1.6K
  • 08 Mar 2024
Topic Review
The Catalytic Interface Layer for Bipolar Membrane
Bipolar membranes, a new type of composite ion exchange membrane, contain an anion exchange layer, a cation exchange layer and an interface layer. The interface layer or junction is the connection between the anion and cation exchange layers. Water is dissociated into protons and hydroxide ions at the junction, which provides solutions to many challenges in the chemical, environmental and energy fields. By combining bipolar membranes with electrodialysis technology, acids and bases could be produced with low cost and high efficiency. The interface layer or junction of bipolar membranes (BPMs) is the connection between the anion and cation exchange layers, which the membrane and interface layer modification are vital for improving the performance of BPMs.
  • 1.6K
  • 02 Sep 2022
Topic Review
Electrical Contacts
An electrical contact is an electrical circuit component found in electrical switches, relays, connectors and circuit breakers. Each contact is a piece of electrically conductive material, typically metal. When a pair of contacts touch, they can pass an electrical current with a certain contact resistance, dependent on surface structure, surface chemistry and contact time; when the pair is separated by an insulating gap, then the pair does not pass a current. When the contacts touch, the switch is closed; when the contacts are separated, the switch is open. The gap must be an insulating medium, such as air, vacuum, oil, SF6. Contacts may be operated by humans in push-buttons and switches, by mechanical pressure in sensors or machine cams, and electromechanically in relays. The surfaces where contacts touch are usually composed of metals such as silver or gold alloys that have high electrical conductivity, wear resistance, oxidation resistance and other properties.
  • 1.6K
  • 04 Nov 2022
Topic Review
Immune Checkpoint Inhibitor-Related Myositis
Immune checkpoint inhibitor (ICI)-related inflammatory diseases, including polymyositis (PM) and dermatomyositis (DM), in patients suffering from neoplastic disorders represent a medical challenge. The treatment of these conditions has taken on new urgency due to the successful and broad development of cancer-directed immunological-based therapeutic strategies. While primary and secondary PM/DM phenotypes have been pathophysiologically characterized, a rational, stepwise approach to the treatment of patients with ICI-related disease is lacking. In the absence of high-quality evidence to guide clinical judgment, the available data must be critically assessed. In this literature review, we examine partially neglected immunological and clinical findings to obtain insights into the biological profiles of ICI-related PM/DM and potential treatment options. We show that differential diagnosis is essential to stratifying patients according to prognosis and therapeutic impact. Finally, we provide a comprehensive assessment of druggable targets and suggest a stepwise patient-oriented approach for the treatment of ICI-related PM/DM.
  • 1.6K
  • 28 Oct 2020
Topic Review
Targeting PI3K/Akt/mTOR in AML
Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy, characterized by excessive proliferation and accumulation of immature myeloid blasts in the bone marrow. While reductions of bulk malignant cells can be achieved in the majority of patients by standard chemotherapy consisting of cell cycle active drugs, such as cytarabine and anthracyclines, approximately two-thirds of patients relapse after the induction therapy, highlighting an unmet need for a more targeted therapeutic approach. A rare population of therapy-resistant cells are believed to be the origin of relapse, termed leukemia stem cells (LSCs), also referred to as leukemia-initiating cells (LICs). These cells acquire enhanced self-renewal capacity and exhibit a block in differentiation.
  • 1.6K
  • 23 Sep 2020
Topic Review
Jasmonic Acid in Plant Responses
As sessile organisms, plants must tolerate various environmental stresses. Plant hormones play vital roles in plant responses to biotic and abiotic stresses. Among these hormones, jasmonic acid (JA) and its precursors and derivatives (jasmonates, JAs) play important roles in the mediation of plant responses and defenses to biotic and abiotic stresses and have received extensive research attention. 
  • 1.6K
  • 17 Aug 2021
Topic Review
Physiological Function of Alpha-Synuclein
Synucleinopathy underlies a wide spectrum of clinical syndromes, including Parkinson's disease (PD), Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and pure autonomic failure (PAF). A common feature of these syndromes is alpha-synuclein (aS) aggregation and cellular inclusions.  In synucleinopathies, the formation of the distinct αS species is determined by the nature of the self-assembly processes, which is influenced by many factors including the SNCA mutation or multiplication, epigenetic regulation, post-translational modification, micro-environments, etc.  Both the oligomeric and fibrillar forms of αS are toxic to cells.  The detrimental effects of αS continue to grow as αS fibrils start to form LBs, which can cause mitochondrial disassembly, mitophagy, mitochondrial depolarization, and synaptic dysfunction that result in progressive neurodegeneration.  
  • 1.6K
  • 16 Sep 2023
Topic Review
Nuclear Envelope
The formation of the nuclear envelope and the subsequent compartmentalization of the genome is a defining feature of eukaryotes. Traditionally, the nuclear envelope was purely viewed as a physical barrier to preserve genetic material in eukaryotic cells.
  • 1.6K
  • 07 Jan 2022
Topic Review
Nomenclature for Hydrogeological Instability Risks
The nomenclature for hydrogeological instability risks includes four main risks, which are distinguished according to the risk causes : 1) hydrogeological risk, that is slowly caused by natural factors (e.g. collapse landslides in a calcareous cliff in uninhabited areas and erosion along a marly-calcareous slope) in environments where human activities are minimal, i.e. woods, forests and mountain pastures; 2) hydraulic-pedological farming risk, that implies the occurrence of landslides in every winter and is caused by incorrect crop selection, not suitable for the soil and climate parameters (e.g. on a hilly slope with a clay vertisol type with a landslide having different fronts, when the arable land is cultivated with a cereal-legume crop rotation), or the presence of springs with missing drainage in clay soils with a high gradient;3) hydraulic-infrastructural risk, that is caused by the building up of infrastructures not suitable for the surrounding environment, as they change the downflow of shallow water; 4) hydraulic-infrastructural-pedological-management risk, that is caused by crop operations not suitable for soil and crop parameters, where the selected cultivated plant species are suitable for the environment and field improvements change water downflow (e.g. in soils along hilly calcarenite slopes cultivated with olive orchards, where up-down soil tillage causes shallow water erosion).
  • 1.6K
  • 25 Jan 2022
Topic Review
Non-equilibrium Thermodynamic Foundations of the Origin of Life
There is little doubt that life’s origin followed from the known physical and chemical laws of Nature. The most general scientific framework incorporating the laws of Nature and applicable to most known processes to good approximation, is that of thermodynamics and its extensions to treat out-of-equilibrium phenomena. The event of the origin of life should therefore also be amenable to such an analysis. The Thermodynamic Dissipation Theory of the Origin and Evolution of Life postulates that the first molecules of life (the fundamental molecules) were, at their origin, pigments dissipatively structured through photochemical and chemical reactions on the surface of the oceans from simpler and more common precursor molecules in water under the solar long-wavelength UVC (205–285 nm) light of the Archean. They were “designed” by Nature to carry out this thermodynamic imperative of absorbing light in this UVC region and then to dissipate it into heat (longer wavelength photons) released into the environment. 
  • 1.6K
  • 13 Apr 2022
Topic Review
STEAP1–4 and Prostate Cancer
Six-Transmembrane Epithelial Antigen of the Prostate 1–4 (STEAP1–4) compose a family of metalloproteinases involved in iron and copper homeostasis and other cellular processes. In prostate cancer, STEAP1, STEAP2, and STEAP4 are overexpressed, while STEAP3 expression is downregulated. STEAP1–4 can be used as a biomarker and therapeutic target for prostate cancer.
  • 1.6K
  • 24 Aug 2022
Topic Review
Polyphenols from Red and White Grape Pomace
Grape pomace (GP) represents a very reliable source of polyphenols because it could be found globally as a remnant of the wine industry. During the winemaking process, two types of GP are generated: red GP and white GP, according to the produced wine, red or white. Grape pomace represents a viable source of polyphenols, mainly flavanols, procyanidins anthocyanins, and resveratrol which possess antioxidant and anti-inflammatory activities. Multiple differences were observed between red and white GP in terms of their antioxidant and anti-inflammatory activity in both in vitro and in vivo studies. Although most studies are focused on the antioxidant and anti-inflammatory effect of red grape pomace, there are still many variables that need to be taken into consideration, as well as extensive study of the white GP. It was observed that in both in vitro and in vivo studies, the GP polyphenols have a direct antioxidant activity by acting as a free radical scavenger or donating a hydrogen atom. It also possesses an indirect antioxidant and anti-inflammatory activity by reducing mitochondrial reactive oxygen species (ROS) generation, malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), interleukin-1-beta (IL-1β), interleukin-6 (IL-6), nuclear factor kappa-light-chain-enhancer of activated B cells (NF- κβ), and inhibitor of nuclear factor kappa-B kinase subunit beta (Iκκβ) levels or nitrate oxide-4 (NOX4) expression and by increasing the levels of antioxidants enzymes like superoxide dismutase (SOD), catalase (CAT) glutathione reductase (GRx) and glutathione peroxidase(GPx). Besides these activities, many beneficial effects in ischemic heart diseases were also observed, such as the maintenance of the ventricular function as close as possible to normal, and the prevention of infarcted area extension.
  • 1.6K
  • 29 Sep 2022
Topic Review
List of Countries by Wealth Equality
This is a list of countries by distribution of wealth, including Gini coefficients. Wealth distribution can vary greatly from income distribution in a country (see List of countries by income equality). Higher Gini coefficients signify greater inequality in wealth distribution, with 0 being complete equality, whereas a value near 1 can arise in a situation where everybody has zero wealth except a very small minority. It is a common misconception that Scandinavian countries have low wealth inequality. This is not true. These countries have low income inequality, meaning that the income is relatively equal for everyone. However, their wealth inequality is very high, meaning that a small minority of the people owns the vast majority of wealth.
  • 1.6K
  • 14 Oct 2022
Topic Review
Technologies for Attaining Doubled Haploid Plants In Vivo
Haploid plants with a doubled set of chromosomes (doubled haploid (DH)) significantly speed up the selection process by the fixation of genetic traits in each locus in the homozygous state within one generation. Doubled haploids are mainly attained by the formation of plants from the cultured gametophytic (haploid) tissues and cells in vitro, or by targeted reduction in the parent chromosome during intra- or interspecific hybridization. Since then, DH has become one of the most powerful tools to support various basic research studies, as well as applied research.
  • 1.6K
  • 20 Oct 2022
Topic Review
Obstacle Detection Systems of Autonomous Underwater Vehicles
The high efficiency of obstacle detection system (ODS) is essential to obtain the high performance of autonomous underwater vehicles (AUVs) carrying out a mission in a complex underwater environment. ODSs being improved and provide greater detection accuracy that results in better AUV response time. Almost all analysed methods are based on the conventional approach to obstacle detection. In the future, even better ODSs parameters could be achieved by using artificial intelligence (AI) methods. 
  • 1.6K
  • 11 Nov 2022
Topic Review
Behavioral Addiction
Behavioral addiction is a form of addiction that involves a compulsion to engage in a rewarding non-substance-related behavior – sometimes called a natural reward – despite any negative consequences to the person's physical, mental, social or financial well-being. Addiction canonically refers to substance abuse; however, the term's connotation has been expanded to include behaviors that may lead to a reward (e.g., gambling, eating, or shopping) since the 1990s. A gene transcription factor known as ΔFosB has been identified as a necessary common factor involved in both behavioral and drug addictions, which are associated with the same set of neural adaptations in the reward system.
  • 1.6K
  • 23 Nov 2022
Topic Review
Agency (LDS Church)
Agency (also referred to as free agency or moral agency), in the theology of The Church of Jesus Christ of Latter-day Saints (LDS Church), is "the privilege of choice which was introduced by God the Eternal Father to all of his spirit children in the premortal state". Mortal life is viewed as a test of faith, where our choices are central to the plan of salvation in Latter-day Saint teaching. "It was essential for their eternal progression that they be subjected to the influences of both good and evil". LDS Church members believe that Lucifer rebelled against the God's plan, which resulted in a war in heaven, and Lucifer being cast out of heaven and becoming Satan. Church members believe that all individuals have the ability to differentiate between good and evil and that Satan and his followers are not able to tempt people beyond the point where they can resist. This implies that mortals can be held accountable for their actions; mortals will be judged by God based on a combination of one's faith and works (with salvation coming only through the power, mercy, and grace of Jesus Christ).
  • 1.6K
  • 01 Dec 2022
Topic Review Peer Reviewed
Pathogenesis of Glaucoma
Glaucoma, a neurodegenerative disease, has a varied pathogenesis scenario, including elevated intraocular pressure (IOP), and hypoxic conditions in the retina. Consequently, degenerating optic axons at the optic nerve head are observed clinically when extensive damage has already occurred. Following elevated IOP, changes in retinal ganglion cells lead to apoptosis immediately followed by degeneration of their optic axons. Degradation of axons leads to cupping of the optic nerve head and visual field losses. Here we emphasize that it is the retinal ganglion cells that are initial targets of elevated IOP, and, together with hyperactivity of retinal astrocytes, create the ischemic conditions which represent the earliest sign in the pathogenesis of glaucoma.
  • 1.6K
  • 10 Mar 2023
Topic Review
Smart Irrigation for Improving Water Productivity in Drylands
By using several factors, including soil and climate variation, soil properties, plant responses to water deficits, and changes in weather factors, smart irrigation can drive better irrigation decisions that can help save water and increase yields. Various smart irrigation approaches, such as artificial intelligence and deep learning (artificial neural network, fuzzy logic, expert system, hybrid intelligent system, and deep learning), model predictive irrigation systems, variable rate irrigation (VRI) technology, and unmanned aerial vehicles (UAVs) could ensure high water use efficiency in water-scarce regions. These smart irrigation technologies can improve water management and accelerate the progress in achieving multiple Sustainable Development Goals (SDGs), where no one gets left behind.
  • 1.6K
  • 26 Oct 2023
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