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Topic Review
Sustainable Manufacturing Practices
Sustainable manufacturing was defined as "the creation of manufactured products that use processes that minimize negative environmental impacts, conserve energy and natural resources, are safe for employees, communities, and consumers and are economically sound".
  • 1.7K
  • 12 Sep 2021
Topic Review
Nature Time and Pro-environmental Attitudes/Behaviors
Urbanization, screen dependency, and the changing nature of childhood and parenting have led to increased time indoors, creating physical and emotional distancing from nature and time spent in natural environments. Substantial evidence from observational and intervention studies indicates that overall time spent in nature leads to increased perceived value for connectedness to nature and, subsequently, greater pro-environmental attitudes and behaviors (PEAB).
  • 1.7K
  • 30 Sep 2021
Topic Review
Skeletal Muscle Uncoupling Proteins in Obesity Mice Models
Obesity and accompanying type 2 diabetes are among major and increasing worldwide problems that occur fundamentally due to excessive energy intake during its expenditure. Endotherms continuously consume a certain amount of energy to maintain core body temperature via thermogenic processes, mainly in brown adipose tissue and skeletal muscle. Skeletal muscle glucose utilization and heat production are significant and directly linked to body glucose homeostasis at rest, and especially during physical activity. However, this glucose balance is impaired in diabetic and obese states in humans and mice, and manifests as glucose resistance and altered muscle cell metabolism. Uncoupling proteins have a significant role in converting electrochemical energy into thermal energy without ATP generation. Different homologs of uncoupling proteins were identified, and their roles were linked to antioxidative activity and boosting glucose and lipid metabolism. From this perspective, uncoupling proteins were studied in correlation to the pathogenesis of diabetes and obesity and their possible treatments. Mice were extensively used as model organisms to study the physiology and pathophysiology of energy homeostasis. However, researchers should be aware of interstrain differences in mice models of obesity regarding thermogenesis and insulin resistance in skeletal muscles. 
  • 1.7K
  • 05 May 2022
Topic Review
Assessment of Computer Vision-Based Construction Progress Monitoring Process
The progress monitoring (PM) of construction projects is an essential aspect of project control that enables the stakeholders to make timely decisions to ensure successful project delivery, but ongoing practices are largely manual and document-centric. However, the integration of technologically advanced tools into construction practices has shown the potential to automate construction PM (CPM) using real-time data collection, analysis, and visualization for effective and timely decision making. CPM entails periodically measuring the on-site progress and comparing the data with a planned schedule to get the actual status of a construction project. Traditional CPM practices involve manual data collection, which requires human intervention and hence are slow, error-prone, and labor-intensive. To overcome these issues, various automated CPM processes have been proposed. These processes include but are not limited to the use of enhanced information, geospatial, and imaging technologies. The imaging technologies comprise photogrammetry, videogrammetry, laser scanning, and range imaging. Laser scanning is a promising tool for as-built DAQ due to its accuracy; however, it requires expensive equipment, is technically complex, and requires experts to capture, model, and manipulate data for meaningful interpretations. An alternate technique is CV-based technology, which comprises photogrammetry, videogrammetry, and range images. The CV-based CPM comprises four sub-processes: data acquisition (DAQ), information retrieval, progress estimation, and output visualization. Each process involves various methods and techniques to achieve the desired output posing several benefits and limitations.
  • 1.7K
  • 05 Aug 2022
Topic Review
Nanostructured Antibiotics
Bacterial strains resistant to antimicrobial treatments, such as antibiotics, have emerged as serious clinical problems, necessitating the development of novel bactericidal materials. Nanostructures with particle sizes ranging from 1 to 100 nanometers have appeared recently as novel antibacterial agents, which are also known as “nanoantibiotics”. Nanomaterials have been shown to exert greater antibacterial effects on Gram-positive and Gram-negative bacteria across several studies. Antibacterial nanofilms for medical implants and restorative matters to prevent bacterial harm and antibacterial vaccinations to control bacterial infections are examples of nanoparticle applications in the biomedical sectors. The development of unique nanostructures, such as nanocrystals and nanostructured materials, is an exciting step in alternative efforts to manage microorganisms because these materials provide disrupted antibacterial effects, including better biocompatibility, as opposed to minor molecular antimicrobial systems, which have short-term functions and are poisonous.
  • 1.7K
  • 10 Nov 2022
Topic Review
M4 Cannon
The 37 mm Automatic Gun, M4, known as the T9 during development, was a 37 mm (1.46 in) recoil-operated autocannon designed by Browning Arms Company. The weapon, which was built by Colt, entered service in 1942. It was used in the Bell P-39 Airacobra and P-63 Kingcobra.
  • 1.7K
  • 10 Oct 2022
Biography
Janet Pierrehumbert
Janet Pierrehumbert /pɪərˈhʌmbərt/ is Professor of Language Modeling in the Oxford e-Research Centre at the University of Oxford and a senior research fellow of Trinity College, Oxford.[1] She developed an intonational model which includes a grammar of intonation patterns and an explicit algorithm for calculating pitch contours in speech, as well as an account of intonational meaning.[2][3]
  • 1.7K
  • 24 Nov 2022
Biography
Alan Lloyd Hodgkin
Sir Alan Lloyd Hodgkin OM KBE PRS[1] (5 February 1914 – 20 December 1998) was an English physiologist and biophysicist, who shared the 1963 Nobel Prize in Physiology or Medicine with Andrew Huxley and John Eccles. Hodgkin was born in Banbury, Oxfordshire, to George Hodgkin and Mary Wilson Hodgkin. His father died of dysentery in Baghdad in 1918. His mother was remarried to Lionel Smith, wit
  • 1.7K
  • 09 Dec 2022
Topic Review
Synthesis of TiO2 at the Industrial Level
Among a diverse range of dense mineral reserves found across the world, only ilmenite and rutile ores are capable of yielding titanium compounds, specifically titanium dioxide, through industrial processes. Although ilmenite and rutile are extensively used to extract TiO2 at the industrial level, through the sulphate and chloride processes, they can also be recognized to possess the potential to be employed as the raw material to synthesize other titanium compounds as well. Since titanium containing compounds possess the capability to be applied in numerous applications, such as environmental remediation, energy technologies, the pharmaceutical industry, paint industry and textile industry, exploration of the ability of these ore materials to yield titanium species is highly significant in the field of research as well as the industrial sector.
  • 1.7K
  • 17 May 2023
Topic Review
Potential Application of Fungal Pigments
Fungal pigments are produced as secondary metabolites when essential nutrients in the culture medium are depleted or the environment is unfavorable for growth. Since natural pigments have benefits over synthetic pigments, their popularity has grown considerably. It has been demonstrated that fungi are a reliable, accessible, alternative supply of natural pigments. Applications for fungal pigments include food coloring, antimicrobial defense, antioxidant agents, cancer prevention, and so on.
  • 1.7K
  • 11 Apr 2023
Topic Review
Epithelial
Respiratory diseases are frequently characterised by epithelial injury, airway inflammation, de-fective tissue repair, and airway remodelling. This may occur in a subacute or chronic context, such as asthma and chronic obstructive pulmonary disease, or occur acutely as in pathogen challenge or acute respiratory distress syndrome (ARDS). Despite the frequent challenge of lung homeostasis, not all pulmonary insults lead to disease. Traditionally thought of as a quiescent organ, emerging evidence highlights that the lung has significant capacity to respond to injury by repairing and replacing damaged cells. This occurs with the appropriate and timely resolution of inflammation and concurrent initiation of tissue repair programmes. Airway epithelial cells are key effectors in lung homeostasis and host defence; continual exposure to pathogens, toxins, and particulate matter challenge homeostasis, requiring robust defence and repair mechanisms. As such, the epithelium is critically involved in the return to homeostasis, orchestrating the resolution of inflammation and initiating tissue repair. 
  • 1.7K
  • 04 Mar 2021
Topic Review
TiO2 Microscale Structures
TiO2 microscale structures can be prepared from both TiO2 precursors and TiO2 nanoparticles (NPs). TiO2 microscale structures have many advantages compared to TiO2 NPs powders, such as tunable structure, higher photocatalytic activity, and ease of recovery. For TiO2 microscale structures, solid spheres and hollow spheres share some similar synthesis methods. However, microscale TiO2 microscale structures are not easily mass-produced due to the complexity of the synthesis process.
  • 1.7K
  • 26 Oct 2020
Topic Review
ZEB Family
Molecular signaling pathways involved in cancer have been intensively studied due to their crucial role in cancer cell growth and dissemination. Among them, zinc finger E-box binding homeobox-1 (ZEB1) and -2 (ZEB2) are molecules that play vital roles in signaling pathways to ensure the survival of tumor cells, particularly through enhancing cell proliferation, promoting cell migration and invasion, and triggering drug resistance. Importantly, ZEB proteins are regulated by microRNAs (miRs). In this review, we demonstrate the impact that miRs have on cancer therapy, through their targeting of ZEB proteins. MiRs are able to act as onco-suppressor factors and inhibit the malignancy of tumor cells through ZEB1/2 down-regulation. This can lead to an inhibition of EMT mechanism, therefore reducing metastasis. Also, miRs are able to inhibit ZEB1/2-mediated drug resistance and immunosuppression. Additionally, we explore the upstream modulators of miRs such as long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), as these regulators can influence the inhibitory effect of miRs on ZEB proteins and cancer progression.
  • 1.7K
  • 19 Jul 2020
Topic Review
Post-Traumatic Stress Disorder in Caregivers
Post-traumatic stress disorder (PTSD) is a mental disorder typically occurring after the exposure, both direct and indirect, to a traumatic event, and is characterized by the onset and persistence of a series of clinical symptoms that can often be profoundly incapacitating and tendentially chronic. In the past decades, increasing attention has been deserved to PTSD among caregivers of patients affected by severe medical conditions characterized by a risk for life, a severe impairment or a chronic course (e.g. cancer, severe injuries, type 1 diabetes and neurologic disorders) highlighting the potential traumatic role of such experiences.
  • 1.7K
  • 22 Sep 2020
Topic Review
Ammonia Fuel Cells
Ammonia use in maritime applications is considered promising, due to its high energy density, low flammability, easy storage and low production cost. Moreover, ammonia can be used as fuel in a variety of propulsors such as fuel cells and can be produced from renewable sources. 
  • 1.7K
  • 07 Jun 2021
Topic Review
Deubiquitinases in Breast Cancer
Deubiquitinase (DUB) is an essential component in the ubiquitin-proteasome system (UPS) by removing ubiquitin chains from substrates, thus modulating the expression, activity, and localization of many proteins that contribute to tumor development and progression. DUBs have emerged as promising prognostic indicators and drug targets. DUBs have shown significant roles in regulating breast cancer growth, metastasis, resistance to current therapies, and several canonical oncogenic signaling pathways. In addition, specific DUB inhibitors have been identified and are expected to benefit breast cancer patients in the future. 
  • 1.7K
  • 09 Nov 2021
Topic Review
Digitally Enabled Person Centred Health and Care
Digitally enabled Person Centred Health and Care [DePCHaC] is term applicable to activities aimed at addressing health or providing care that use digital tools and functionality that has been specifically targeted to objectives and outcomes of the person.
  • 1.7K
  • 28 Jan 2022
Topic Review
Millet-Based Diet Improves the Growth of Children
Millets (defined broadly to include sorghum) are traditional staple foods, and climate smart nutritious crops, which are grown across Africa and Asia, they have not been mainstreamed globally like rice, wheat, and maize. Diversifying staples with millets can potentially provide more macro and micro nutrients, compared to the mainstream staples that are also often refined. However, there had been little known scientific evidence to prove millets’ efficacy on growth. 
  • 1.7K
  • 09 Mar 2022
Topic Review
Nitrate–Nitrite–Nitric Oxide Pathway in Plants
Oxygen (O2) is the most crucial substrate for numerous biochemical processes in plants. Its deprivation is a critical factor that affects plant growth and may lead to death if it lasts for a long time. However, various biotic and abiotic factors cause O2 deprivation, leading to hypoxia and anoxia in plant tissues. To survive under hypoxia and/or anoxia, plants deploy various mechanisms such as fermentation paths, reactive oxygen species (ROS), reactive nitrogen species (RNS), antioxidant enzymes, aerenchyma, and adventitious root formation, while nitrate (NO3−), nitrite (NO2−), and nitric oxide (NO) have shown numerous beneficial roles through modulating these mechanisms. However, the end product of nitrate-nitrite-nitric oxide pathway, the NO is toxic if accumulated. Thus, its scavenging or inhibition is equally important for plant survival.
  • 1.7K
  • 14 Oct 2022
Topic Review
AI-Control Problem
In artificial intelligence (AI) and philosophy, the AI-control problem is the hypothetical puzzle of how to build a superintelligent agent that will aid its creators, and avoid inadvertently building a superintelligence that will harm its creators. Its study is motivated by the claim that the human race will have to get the control problem right "the first time", as a misprogrammed superintelligence might rationally decide to "take over the world" and refuse to permit its programmers to modify it after launch. In addition, some scholars argue that solutions to the control problem, alongside other advances in "AI safety engineering", might also find applications in existing non-superintelligent AI. Potential strategies include "capability control" (preventing an AI from being able to pursue harmful plans), and "motivational control" (building an AI that wants to be helpful).
  • 1.7K
  • 15 Nov 2022
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