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Topic Review
Open Diary
Open Diary (often abbreviated as "OD") is an online diary community, an early example of social networking software. It was founded on October 22, 1998. Open Diary went offline on February 7, 2014, but was re-launched on January 26, 2018. The site was owned and operated by Bruce Ableson and Susan Ableson, known on the Open Diary website by the title of their diaries, The DiaryMaster and The DiaryMistress. Ableson has described Open Diary as "the first web site that brought online diary writers together into a community." Open Diary has hosted more than five million diaries since it was founded, and was home to over half a million diaries. As of October 2008, there were over 561,000 diaries on OpenDiary.com, including diaries from 77 different countries and all 7 continents. The site innovated some key features that later became central to the architecture of other social networking and blogging sites, including reader comments and friends-only privacy.
  • 1.7K
  • 11 Oct 2022
Topic Review
The Short-Chain Fatty Acids
Through fermentation, the gut microbiota can produce several types of metabolites, including short-chain fatty acids (SCFAs). SCFAs play an important role in maintaining epithelial barrier functions and intestinal homeostasis. 
  • 1.7K
  • 27 Oct 2022
Topic Review
Prism Fusion Range
The prism fusion range (PFR) or fusional vergence amplitude is a clinical eye test performed by orthoptists, optometrists, and ophthalmologists to assess motor fusion, specifically the extent to which a patient can maintain binocular single vision (BSV) in the presence of increasing vergence demands. Motor fusion is largely accounted to amplitudes of fusional vergences and relative fusional vergences. Fusional vergence is the maximum vergence movement enabling BSV and the limit is at the point of diplopia (double vision). Relative fusional vergence is the maximum vergence movement enabling a patient to see a comfortable clear image and the limit is represented by the first point of blur. These motor fusion functions should fall within average values so that BSV can be comfortably achieved. Excessive stress on the vergence system or inability to converge or diverge adequately can lead to asthenopic symptoms, which generally result from decompensation of latent deviations (heterophoria) or loss of control of ocular misalignments. Motor anomalies can be managed in various ways, however, in order to commence treatment, motor fusion testing such as the PFR is required. The PFR involves placing a prism bar in front of an eye. In a patient with BSV, a natural shift of the eye occurs. When measuring horizontal fusion ranges, base in prisms assess fusional divergence while base out prisms assess fusional convergence. The vertical fusional vergence amplitude can also be measured with base up and base down prisms although the horizontal PFR is typically the main focus when testing. When performing the PFR, prism strengths are increased, placing greater demand on the vergence system, eventually resulting in a break point accompanying diplopia. Break point, recovery and blur are key aspects of this assessment. The break point occurs at the loss of BSV, recovery point when BSV is regained from break and blur point is at the loss of comfortable BSV. These stops can be subjectively indicated when the patient notices a double or blurred image. Both subjective and objective measurements can be considered however the examiner's objective observation is the gold standard.
  • 1.7K
  • 02 Dec 2022
Topic Review
Biological Control of Fall Armyworm
The fall armyworm (FAW), Spodoptera frugiperda, is one of the most important invasive pests worldwide, resulting in considerable losses in host crops. FAW comprises two genetic strains, such as the “rice strain”, which prefers rice and other grass species, and the “maize strain”, which feeds upon maize and sorghum. Potential control measures are generally more applicable to the farmers who lack financial assets to buy chemical insecticides or costly pure seeds. The adverse effects of pesticides on the ecosystem and human’s health and the development of resistance to insect pests have exaggerated efforts to find an alternative strategy that is cost-effective, low-risk and target-specific. Therefore, biological control is widely considered as one of the most important options for insect pest management. 
  • 1.7K
  • 09 Dec 2022
Topic Review
The Gel-State Electrolytes in Zinc-Ion Batteries
Zinc-ion batteries (ZIBs) are receiving increasing research attention due to their high energy density, resource abundance, low-cost, intrinsic high-safety properties, and the appropriate plating/stripping voltage. Gel-state electrolytes possess merits of having a wide electrochemical window, good flexibility, superior water retainability, and excellent compatibility with aqueous electrolytes, which makes them potential candidates for flexible batteries. However, the practical applications of ZIBs with gel-state electrolytes still have some issues of water content easily dropping, poor mechanical stability, and the interface problem. 
  • 1.7K
  • 08 Dec 2022
Topic Review
Nanomaterials in Cosmetic
Skin aging is described as dermatologic changes either naturally occurring over the course of years or as the result of the exposure to environmental factors (e.g., chemical products, pollution, infrared and ultraviolet radiations). The production of collagen and elastin, the main structural proteins responsible for skin strength and elasticity, is reduced during aging, while their role in skin rejuvenation can trigger a wrinkle reversing effect. Elasticity loss, wrinkles, dry skin, and thinning are some of the signs that can be associated with skin aging. To overcome skin aging, many strategies using natural and synthetic ingredients are being developed aiming to reduce the signs of aging and/or to treat age-related skin problems (e.g., spots, hyper- or hypopigmentation). Among the different approaches in tissue regeneration, the use of nanomaterials loaded with cosmeceuticals (e.g., phytochemicals, vitamins, hyaluronic acid, and growth factors) has become an interesting alternative. Based on their bioactivities and using different nanoformulations as efficient delivery systems, several cosmeceutical and pharmaceutical products are now available on the market aiming to mitigate the signs of aged skin.
  • 1.7K
  • 30 Oct 2020
Topic Review
Genomics in Personalized Nutrition
Genome-wide single nucleotide polymorphism (SNP) data are now quickly and inexpensively acquired, raising the prospect of creating personalized dietary recommendations based on an individual's genetic variability at multiple SNPs. In this review, we discuss the current potential for precision nutrition based on an individual's genetic data. We also review complicating issues and their impact on our ability to predict responses to dietary interventions. 
  • 1.7K
  • 30 Oct 2020
Topic Review
EphA2 Signaling in tumors
The Eph receptors represent the largest group among Receptor Tyrosine kinase (RTK) families. The Eph/ephrin signaling axis plays center stage during development, and the deep perturbation of signaling consequent to its dysregulation in cancer reveals the multiplicity and complexity underlying its function. In the last decades, they have emerged as key players in solid tumors, including colorectal cancer (CRC). EphA2 is involved in tumor progression and resistance to therapy.
  • 1.7K
  • 18 Mar 2021
Topic Review
Google Earth Application
Released in 2005 by Google, Google Earth (GE) has become the most popular and successful virtual globe tool. GE has demonstrated its capacity for 3D global representation and visualization of geospatial data from local to global scales.
  • 1.7K
  • 11 Oct 2021
Topic Review
Rotary Desiccant-Based Air-Conditioning Systems
A rotary desiccant-based air-conditioning system is a heat-driven hybrid system which combines different technologies such as desiccant dehumidification, evaporative cooling, refrigeration, and regeneration. This system has an opportunity to utilize low-grade thermal energy obtained from the sun or other sources.
  • 1.7K
  • 03 Nov 2021
Topic Review
Drought Stress in Grain Legumes
Grain legumes are important sources of proteins, essential micronutrients and vitamins and for human nutrition. Climate change, including drought, is a severe threat to grain legume production throughout the world. The yield loss of grain legumes varies from species to species, even variety to variety within a species, depending upon the severity of drought stress and several other factors, such as phenology, soil textures and agro-climatic conditions. Closure of stomata leads to an increase in leaf temperature by reducing the transpiration rate, and, so, the legume plant faces another stress under drought stress. The biosynthesis of reactive oxygen species (ROS) is the most detrimental effect of drought stress. Legumes can adapt to the drought stress by changing their morphology, physiology and molecular mechanism. Improved root system architecture (RSA), reduced number and size of leaves, stress-induced phytohormone, stomatal closure, antioxidant defense system, solute accumulation (e.g., proline) and altered gene expression play a crucial role in drought tolerance. 
  • 1.7K
  • 30 Nov 2021
Topic Review
G Protein-Coupled Receptors
GPCRs arguably represent the most effective current therapeutic targets for a plethora of diseases. GPCRs also possess a pivotal role in the regulation of the physiological balance between healthy and pathological conditions; thus, their importance in systems biology cannot be underestimated. The molecular diversity of GPCR signaling systems is likely to be closely associated with disease-associated changes in organismal tissue complexity and compartmentalization, thus enabling a nuanced GPCR-based capacity to interdict multiple disease pathomechanisms at a systemic level. GPCRs have been long considered as controllers of communication between tissues and cells. This communication involves the ligand-mediated control of cell surface receptors that then direct their stimuli to impact cell physiology.
  • 1.7K
  • 28 Feb 2022
Topic Review
Fluorescence Microscopy
Fluorescence microscopy has become a critical tool for researchers to understand biological processes at the cellular level. Micrographs from fixed and live-cell imaging procedures feature in a plethora of scientific articles for the field of cell biology.
  • 1.7K
  • 10 Feb 2022
Topic Review
Wind Farms and Humidity
Several investigations have shown that enhanced mixing brought about by wind turbines alters near-surface meteorological conditions within and downstream of a wind farm. When scalar meteorological parameters have been considered, the focus has most often centered on temperature changes. A subset of these works has also considered humidity to various extents. These limited investigations are complemented by just a few studies dedicated to analyzing humidity changes. With onshore wind turbines often sited in agricultural areas, any changes to the microclimate surrounding a turbine can impact plant health and the length of the growing season; any changes to the environment around an offshore wind farm can change cloud and fog formation and dissipation, among other impacts. This article provides a review of observational field campaigns and numerical investigations examining changes to humidity within wind turbine array boundary layers. Across the range of empirical observations and numerical simulations, changes to humidity were observed in stably stratified conditions. In addition to the role of atmospheric stability, this review reveals that the nature of the change depends on the upstream moisture profile; robustness of the mixing; turbine array layout; distance from the turbine, in all three directions; and vertical temperature profile.
  • 1.7K
  • 15 Apr 2022
Topic Review
Effects of Genocide on Youth
The effects of genocide on youth include psychological and demographic effects that affect the transition into adulthood. These effects are also seen in future generations of youth. Demographic effects involve the transfer of children during genocides. In cases of transfer, children are moved or displaced from their homes into boarding schools, adoptive families, or to new countries with or without their families. There are significant shifts in populations in the countries that experience these genocides. Often, children are then stripped of their cultural identity and assimilated into the culture that they have been placed into. Unresolved trauma of genocide affects future generations of youth. Intergenerational effects help explain the background of these children and analyze how these experiences shape their futures. Effects include the atmosphere of the household they grew up in, pressures to succeed or act in specific ways, and how they view the world in which they live. The passing down of narratives and stories are what form present day perceptions of the past. Narratives are what form future generations' ideas of the people who were either victimized or carried out the genocide. As youth of future generations process the stories they hear they create their own perception of it and begin to identify with a specific group in the story. Youth of future generations begin to form their identity through the narratives they hear as they begin to relate to it and see how the genocide affects them. As stories are passed down, children also begin to understand what their parents or grandparents went through. They use narratives as explanation of why their parents talk about it in the way they do or do not talk about it all. Psychological effects of genocide are also relevant in youth. Youth who experience an extreme trauma at an early age are often incapable of fully understanding the event that took place. As this generation of children transition into adulthood, they sort out the event and recognize the psychological effects of the genocide. It is typical for these young survivors to experience symptoms of posttraumatic stress disorder (PTSD) as well as other psychological disorders. Transitioning out of youth and into adulthood is an important development marker in the lives of all people. Youth who transition into adulthood during a genocide have a different experience than those who do not transition during a genocide. Some youth transition earlier as means of survival. Others are unable to fully transition, remaining in a youth state longer.
  • 1.7K
  • 19 Oct 2022
Topic Review
Asynchronous Transfer Mode
Asynchronous Transfer Mode (ATM) is a telecommunications standard defined by ANSI and ITU (formerly CCITT) for digital transmission of multiple types of traffic, including telephony (voice), data, and video signals in one network without the use of separate overlay networks. ATM was developed to meet the needs of the Broadband Integrated Services Digital Network, as defined in the late 1980s, and designed to integrate telecommunication networks. It can handle both traditional high-throughput data traffic and real-time, low-latency content such as voice and video. ATM provides functionality that uses features of circuit switching and packet switching networks. It uses asynchronous time-division multiplexing, and encodes data into small, fixed-sized network packets. In the ISO-OSI reference model data link layer (layer 2), the basic transfer units are generically called frames. In ATM these frames are of a fixed (53 octets or bytes) length and specifically called cells. This differs from approaches such as IP or Ethernet that use variable sized packets or frames. ATM uses a connection-oriented model in which a virtual circuit must be established between two endpoints before the data exchange begins. These virtual circuits may be either permanent, i.e. dedicated connections that are usually preconfigured by the service provider, or switched, i.e. set up on a per-call basis using signaling and disconnected when the call is terminated. The ATM network reference model approximately maps to the three lowest layers of the OSI model: physical layer, data link layer, and network layer. ATM is a core protocol used in the SONET/SDH backbone of the public switched telephone network (PSTN) and in the Integrated Services Digital Network (ISDN), but has largely been superseded in favor of next-generation networks based in Internet Protocol (IP) technology, while wireless and mobile ATM never established a significant foothold.
  • 1.7K
  • 27 Oct 2022
Topic Review
Compaq Portable
The Compaq Portable is an early portable computer which was one of the first IBM PC compatible systems. It was Compaq Computer Corporation's first product, to be followed by others in the Compaq Portable series and later Compaq Deskpro series. It was not simply an 8088-CPU computer that ran a Microsoft DOS as a PC "work-alike", but contained a reverse-engineered BIOS, and a version of MS-DOS that was so similar to IBM's PC DOS that it ran nearly all its application software. The computer was also an early variation on the idea of an "all-in-one". It became available two years after the similar, but CP/M-based, Osborne 1 and Kaypro II. Columbia Data Products' MPC 1600 "Multi Personal Computer" had come out in June 1982. Other "work-alikes" included the MS-DOS and 8088-based, but not entirely IBM PC software compatible, Dynalogic Hyperion, and Eagle Computer's Eagle 1600 series, including the Eagle Spirit portable, and the Corona personal computer The latter two companies were threatened by IBM for BIOS copyright infringement, and settled out of court, agreeing to re-implement their BIOS There was also the Seequa Chameleon, which had both 8088 and Z80 CPUs to run with MS-DOS or CP/M OSes. Unlike Compaq, many of these companies had previously released computers based on Zilog's Z80 and Digital Research's CP/M operating system. Like Compaq, they recognized the replicability of the IBM PC's off-the-shelf parts, and saw that Microsoft retained the right to license MS-DOS. Only Compaq was able to fully capitalize, by aiming for complete IBM PC and PC DOS compatibility, while reverse-engineering the BIOS to head off copyright claims. Other contemporary systems include the portable Commodore SX-64, also known as the Executive 64, or VIP-64 in Europe, is a briefcase/suitcase-size "luggable" version of the popular Commodore 64 home computer built with an 8-bit MOS 6510 (6502-based) CPU microprocessor, and the first full-color portable computer. Like the Z80 and "work-alike" portables, its sales fell into insignificance in the face of the Compaq Portable series.
  • 1.7K
  • 31 Oct 2022
Topic Review
Biological and Hydrobiological Background of Pond Carp Breeding
In the Central European region, there is a long tradition of breeding fish in artificially constructed ponds. As the area belongs to the temperate zone, farmed fish need to survive cold winter periods. Common carp (Cyprinus carpio L.), which is an omnivorous, bioturbating species, is well adapted to warm and cold periods and the alluvial water environment. Since the Middle Ages, a large scale, efficient carp farming methodology has been developed in the region, where production is based on natural resources (protein and fatty acid sources) of renewable water ecosystems.
  • 1.7K
  • 03 Nov 2022
Topic Review
Late Glacial
The Late Glacial climate warming (c. 13,000–10,000 years ago), or Tardiglacial ("Late Glacial"), is defined primarily by the beginning of the modern warm period, in which temperatures in the Northern Hemisphere rose substantially, causing a process of accelerated deglaciation following the Last Glacial Maximum (c. 25,000–13,000 years ago). At this time, human populations, previously forced into refuge areas as a result of Last Glacial Maximum (LGM) climatic conditions, gradually begin to repopulate the Northern Hemisphere's Eurasian landmass and eventually populate North America via Beringia for the first time. The Late Glacial Interstadial c.14,670 to c.12,890 BP represents the first pronounced warming since the end of the LGM. Evidence for its occurrence stems from two main types of analysis. The first is the use of oxygen isotope stages (OIS) gathered from stratified deep-sea sediment cores. Samples are gathered and measured for change in isotope levels to determine temperature fluctuation for given periods of time. The second is a proxy measurement, the observation of certain reappearing fauna and flora fossils that can survive only in temperate climates, thus indicating warming trends for a given geographic area. Archaeological evidence of settlement and resettlement in certain areas by humans also serve as proxy measurements. Towards the end of OIS 2 in which the Late Glacial Maximum occurs, the deep-sea sediment cores indicate a gradually warming climate, and the reappearance of certain warm-weather flora and fauna remains throughout the Northern Hemisphere correlate with that trend. The Late Glacial was interrupted by a severe decline in temperatures during the Younger Dryas from c.12,890 to c.11,650 BP.
  • 1.7K
  • 17 Nov 2022
Topic Review
Compensation Methods
Compensation methods (remuneration), are pricing models and business models used for the different types of Internet marketing, including affiliate marketing, contextual advertising, search engine marketing (including vertical comparison shopping search engines and local search engines) and display advertising.
  • 1.7K
  • 21 Nov 2022
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