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Topic Review
Polycyclic Aromatic Hydrocarbon Occurrence and Formation
The chemical group comprising polycyclic aromatic hydrocarbons (PAHs) has received prolonged evaluation and scrutiny in the past several decades. PAHs are ubiquitous carcinogenic pollutants and pose a significant threat to human health through their environmental prevalence and distribution. Regardless of their origin, natural or anthropogenic, PAHs generally stem from the incomplete combustion of organic materials. Dietary intake, one of the main routes of human exposure to PAHs, is modulated by pre-existing food contamination (air, water, soil) and their formation and accumulation during food processing. To this end, processing techniques and cooking options entailing thermal treatment carry additional weight in determining the PAH levels in the final product.
  • 1.7K
  • 24 Jul 2023
Topic Review
Bifunctional Non-Canonical Amino Acids
Genetic code expansion is a powerful tool for the study of protein interactions, as it allows for the site-specific incorporation of a photoreactive group via non-canonical amino acids. Recently, several groups have published bifunctional amino acids that carry a handle for click chemistry in addition to the photo-crosslinker. This allows for the specific labeling of crosslinked proteins and therefore the pulldown of peptides for further analysis. This review describes the properties and advantages of different bifunctional amino acids, and gives an overview about current and future applications.
  • 1.7K
  • 17 Jun 2021
Topic Review
Fabrication Methods for Composite Films/Coatings
Chitin is made by joining N-acetyl glucosamine residues through β (1–4) glycosidic linkages and is the second-most prevalent natural polysaccharide after cellulose. Chitosan and its derivatives exhibit anti-hypoxic, adaptogenic, immunostimulant, antiviral, antibacterial, radioprotective, and hemostatic properties. In addition, they are nontoxic, biocompatible, and biodegradable.
  • 1.7K
  • 02 Aug 2023
Topic Review
Cellular Senescence in the Lung
Cellular senescence is a key process in physiological dysfunction developing upon aging or following diverse stressors including ionizing radiation. It describes the state of a permanent cell cycle arrest, in which proliferating cells become resistant to growth-stimulating factors. Senescent cells differ from quiescent cells, which can re-enter the cell cycle and from finally differentiated cells: morphological and metabolic changes, restructuring of chromatin, changes in gene expressions and the appropriation of an inflammation-promoting phenotype, called the senescence-associated secretory phenotype (SASP), characterize cellular senescence. The biological role of senescence is complex, since both protective and harmful effects have been described for senescent cells. While initially described as a mechanism to avoid malignant transformation of damaged cells, senescence can even contribute to many age-related diseases, including cancer, tissue degeneration, and inflammatory diseases, particularly when senescent cells persist in damaged tissues. Due to overwhelming evidence about the important contribution of cellular senescence to the pathogenesis of different lung diseases, specific targeting of senescent cells or of pathology-promoting SASP factors as potential therapeutic approach has been suggested. In this review, we summarize recent advances regarding the role of cellular (fibroblastic, endothelial, and epithelial) senescence in lung pathologies, with a focus on radiation-induced senescence. Among the different cells here, a central role of epithelial senescence is suggested.
  • 1.7K
  • 29 Oct 2020
Topic Review
DNA Polymerases
Recent studies on tumor genomes revealed that mutations in genes of replicative DNA polymerases cause a predisposition for cancer by increasing genome instability. The past 10 years have uncovered exciting details about the structure and function of replicative DNA polymerases and the replication fork organization. The principal idea of participation of different polymerases in specific transactions at the fork proposed by Morrison and coauthors 30 years ago and later named “division of labor,” remains standing, with an amendment of the broader role of polymerase δ in the replication of both the lagging and leading DNA strands. However, cancer-associated mutations predominantly affect the catalytic subunit of polymerase ε that participates in leading strand DNA synthesis. 
  • 1.7K
  • 14 Dec 2020
Topic Review
Autophagy during Herpesvirus Infections
Human herpesviruses are a ubiquitous family of viruses that infect individuals of all ages and are present at a high prevalence worldwide. Herpesviruses are responsible for a broad spectrum of diseases, ranging from skin and mucosal lesions to blindness and life-threatening encephalitis, and some of them, such as Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein–Barr virus (EBV), are known to be oncogenic. Furthermore, recent studies suggest that some herpesviruses may be associated with developing neurodegenerative diseases. These viruses can establish lifelong infections in the host and remain in a latent state with periodic reactivations. To achieve infection and yield new infectious viral particles, these viruses require and interact with molecular host determinants for supporting their replication and spread. Important sets of cellular factors involved in the lifecycle of herpesviruses are those participating in intracellular membrane trafficking pathways, as well as autophagic-based organelle recycling processes.
  • 1.7K
  • 24 Apr 2021
Topic Review
Academic Teachers about Their Productivity
The situation of the COVID-19 epidemic in the world, as well as in Poland, forced changes in the functioning of many professions, including academic teachers. Taking classes online has forced many of them to acquire new digital competencies. Competence of this type implies a construct related to the cognitive sphere that allows the use of the various tools of telecommunications technology to handle information that can be obtained from training in the use of electronic devices and the software used. For this reason, it can be said that a kind of experiment was undertaken. Currently, they were assigned to a specific social group, e.g., IT specialists, but along with their functioning in the information society, they have become one of the elements of social life.
  • 1.7K
  • 05 May 2022
Topic Review
Svabhava
Svabhava (Sanskrit: svabhāva; Pali: sabhāva; Chinese: 自性; pinyin: zìxìng; Tibetan: རང་བཞིན, Wylie: rang-bzhin) literally means "own-being" or "own-becoming". It is the intrinsic nature, essential nature or essence of beings. The corresponding concept in Western philosophy is substance theory. The concept and term svabhāva are frequently encountered in Hindu and Buddhist traditions such as Advaita Vedanta (e.g. in the Avadhūta Gītā), Mahayana Buddhism (e.g. in the Ratnagotravibhāga), Vaishnavism (e.g., the writings of Ramanuja) and Dzogchen (e.g. in the seventeen tantras). In the nondual Advaita Vedānta yoga text, Avadhūta Gītā, Brahman (in the Upanishadic denotation) is the svabhāva. In the Mahāyāna Buddhadharma tradition(s) it is one of a suite of terms employed to denote the Buddha-nature, such as "gotra".
  • 1.7K
  • 20 Oct 2022
Topic Review
Trace Minerals and Anxiety
Anxiety disorder is characterized by excessive fear or avoidance of perceived threats. Diet is a modifiable risk factor that may contribute to the pathogenesis or treatment of anxiety, depending on diet quality. Trace mineral treatments for the relief of anxiety have been investigated.
  • 1.7K
  • 12 Jun 2023
Topic Review
Sophorolipids—Bio-Based Antimicrobial Formulating Agents
Sophorolipids are well-known glycolipid biosurfactants, produced mainly by non-pathogenic yeast species such as Candida bombicola with high yield. Its unique environmental compatibility and high biodegradable properties have made them a focus in the present review for their promising applications in diverse areas.
  • 1.7K
  • 27 Sep 2022
Topic Review
Java Servlet
A Java servlet is a Java software component that extends the capabilities of a server. Although servlets can respond to many types of requests, they most commonly implement web containers for hosting web applications on web servers and thus qualify as a server-side servlet web API. Such web servlets are the Java counterpart to other dynamic web content technologies such as PHP and ASP.NET.
  • 1.7K
  • 25 Nov 2022
Topic Review
What are the Causes of Slough in Wound?
Learn what causes slough in a wound, how it affects healing, and effective ways to manage and treat it for better recovery outcomes.
  • 1.7K
  • 09 Apr 2025
Topic Review
Electroporation based treatments in Urology
The observation that an application of a pulsed electric field (PEF) resulted in an increased permeability of the cell membrane has led to the discovery of the phenomenon called electroporation (EP). Depending on the parameters of the electric current and cell features, electroporation can be either reversible or irreversible. The irreversible electroporation (IRE) found its use in urology as a non-thermal ablative method of prostate and renal cancer. As its mechanism is based on the permeabilization of cell membrane phospholipids, IRE (as well as other treatments based on EP) provides selectivity sparing extracellular proteins and matrix. Reversible EP enables the transfer of genes, drugs, and small exogenous proteins. In clinical practice, reversible EP can locally increase the uptake of cytotoxic drugs such as cisplatin and bleomycin. This approach is known as electrochemotherapy (ECT). Few in vivo and in vitro trials of ECT have been performed on urological cancers. EP provides the possibility of transmission of genes across the cell membrane. As the protocols of gene electrotransfer (GET) over the last few years have improved, EP has become a well-known technique for non-viral cell transfection. GET involves DNA transfection directly to the cancer or the host skin and muscle tissue. Among urological cancers, the GET of several plasmids encoding prostate cancer antigens has been investigated in clinical trials.
  • 1.7K
  • 25 Aug 2020
Topic Review
Inter-Organizational Relationship Performance
Inter-Organizational Relationship Performance (IORP) was directly affected by trust, commitment, coordination, and frequency of interaction directly, while simultaneously, communication and participation have indirect impacts on IORP. 
  • 1.7K
  • 17 Aug 2021
Topic Review
Sea Slug Elysia crispata
Some species of sacoglossan sea slugs are able to steal chloroplasts from the algae they feed on and maintain them functional for several months, a process termed “kleptoplasty”. One of these photosynthetic slugs is Elysia crispata, found in coral reefs of the Gulf of Mexico. This sacoglossan inhabits different depths (0–25 m), being exposed to different food sources and contrasting light conditions.
  • 1.7K
  • 19 Apr 2022
Topic Review
ERYX
ERYX is a short-range portable SACLOS-based wire-guided anti-tank missile (ATGM) produced by European company MBDA. It is used by several countries, including the Canadian Army, French, and Norwegian armies. The weapon can also be used against bunkers and pillboxes. It also has some capability in the anti aircraft role to bring down low flying helicopters, due to its wire guided system. An agreement was reached in 1989 between the French and Canadian governments to co-produce the ERYX missile system. It entered service in 1994.
  • 1.7K
  • 04 Nov 2022
Topic Review
AI-Control Problem
In artificial intelligence (AI) and philosophy, the AI-control problem is the hypothetical puzzle of how to build a superintelligent agent that will aid its creators, and avoid inadvertently building a superintelligence that will harm its creators. Its study is motivated by the claim that the human race will have to get the control problem right "the first time", as a misprogrammed superintelligence might rationally decide to "take over the world" and refuse to permit its programmers to modify it after launch. In addition, some scholars argue that solutions to the control problem, alongside other advances in "AI safety engineering", might also find applications in existing non-superintelligent AI. Potential strategies include "capability control" (preventing an AI from being able to pursue harmful plans), and "motivational control" (building an AI that wants to be helpful).
  • 1.7K
  • 15 Nov 2022
Topic Review
Communication-Based Control Strategies for Parallel Inverters
The communication-based control methods require a power management platform or supervisory control and data acquisition (SCADA) operation. These control methods are employed to provide power-sharing and voltage control, and their main advantage is eliminating the requirement for a secondary controller. The supervisory control receives information from all inverters and tries to maintain a balance in power-sharing between the inverters. 
  • 1.7K
  • 25 Nov 2022
Topic Review
Medicinally Viable Plants of the Genus Tylophora
Plants of the genus Tylophora have commonly been used in traditional medicine in various communities, especially in the tropical and subtropical regions of climatic zones. Of the nearly 300 species reported in the Tylophora genus, eight are primarily used in various forms to treat a variety of bodily disorders based on the symptoms. Certain plants from the genus have found use as anti-inflammatory, anti-tumor, anti-allergic, anti-microbial, hypoglycemic, hypolipidemic, anti-oxidant, smooth muscle relaxant, immunomodulatory, and anti-plasmodium agents, as well as free-radical scavengers. Pharmacologically, a few plant species from the genus have exhibited broad-spectrum anti-microbial and anti-cancer activity, which has been proven through experimental evaluations. Some of the plants in the genus have also helped in alcohol-induced anxiety amelioration and myocardial damage repair. The plants belonging to the genus have also shown diuretic, anti-asthmatic, and hepato-protective activities. Tylophora plants have afforded diverse structural bases for secondary metabolites, mainly belonging to phenanthroindolizidine alkaloids, which have been found to treat several diseases with promising pharmacological activity levels. 
  • 1.7K
  • 09 Mar 2023
Topic Review
Haloanisoles in Wine
Haloanisoles in wine have devastating effects on the aroma and quality of the wine. 2,4,6-trichloroanisole (TCA) was discovered and coined as “cork taint” in 1982. There are many more haloanisoles that contribute to these musty odors, including 2,4,6-Tribromoanisiole (TBA), 2,3,4,6-tetrachloroanisole (TeCA), and pentachloroanisole (PCA). While TCA, TeCA, and PCA can all be traced back to the cork, TBA’s phenol precursor is ubiquitous in building material as a fire retardant, making it a much larger vector. All haloanisoles have the ability to aerosolize and resettle onto surfaces in the winery, making this a very difficult problem to eliminate. 
  • 1.7K
  • 23 Mar 2023
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