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Topic Review
Time Regulated Dynamics
How parameters such as interaction, iteration, frequency of iteration and time can express in a simple manner a nonlinear dynamics? Considering a system with stationary PDF and ergodic properties, the mathematical framework reveals a constant oscillation of information flow in the system. Those parameters mentioned before can start chaotic process in the previous system generating infinite random sequences as Per Martin-Löf suggested in his work "Complexity oscillations in infinite binary sequences". In this way the non ergodic properties of system express observable oscillations in which time lengths regulations can be used as a tool for PDF constraint and  phase space formations.
  • 1.8K
  • 30 Oct 2020
Topic Review
O-Acetyl Sialylation
The recently emerged SARS-CoV-2 is the cause of the global health crisis of the coronavirus disease 2019 (COVID-19) pandemic. No evidence is yet available for CoV infection into hosts upon zoonotic disease outbreak, although the CoV epidemy resembles influenza viruses, which use sialic acid (SA). Currently, information on SARS-CoV-2 and its receptors is limited. O-acetylated SAs interact with the lectin-like spike glycoprotein of SARS CoV-2 for the initial attachment of viruses to enter into the host cells. SARS-CoV-2 hemagglutinin-esterase (HE) acts as the classical glycan-binding lectin and receptor-degrading enzyme. Most β-CoVs recognize 9-O-acetyl-SAs but switched to recognizing the 4-O-acetyl-SA form during evolution of CoVs. Type I HE is specific for the 9-O-Ac-SAs and type II HE is specific for 4-O-Ac-SAs. The SA-binding shift proceeds through quasi-synchronous adaptations of the SA-recognition sites of the lectin and esterase domains. The molecular switching of HE acquisition of 4-O-acetyl binding from 9-O-acetyl SA binding is caused by protein–carbohydrate interaction (PCI) or lectin–carbohydrate interaction (LCI). The HE gene was transmitted to a β-CoV lineage A progenitor by horizontal gene transfer from a 9-O-Ac-SA–specific HEF, as in influenza virus C/D. HE acquisition, and expansion takes place by cross-species transmission over HE evolution. This reflects viral evolutionary adaptation to host SA-containing glycans. Therefore, CoV HE receptor switching precedes virus evolution driven by the SA-glycan diversity of the hosts. The PCI or LCI stereochemistry potentiates the SA–ligand switch by a simple conformational …
  • 1.8K
  • 26 Oct 2020
Topic Review
Natural-Drugs-Based Low-Molecular-Weight Supramolecular Gels
The utilization of paclitaxel, camptothecin, rhein, curcumin, and other natural small molecular drugs with unique rigid backbone structures and modifiable multiple sites as building blocks to form gels by self-assembly has attracted widespread attention. The obtained low-molecular-weight supramolecular gel not only retains the general characteristics of the gel but also overcomes the shortcomings of natural drugs, such as poor water solubility and low bioavailability.
  • 1.8K
  • 12 Aug 2021
Topic Review
Building Information Modelling and Project-Lifecycle
The Architecture, Engineering, Construction and Operations (AECO) industry constitutes a cornerstone of a country’s economy and is predicted to account for circa 15% of the World’s Gross Domestic Product (GDP) by 2030. Construction outputs create critical infrastructure and buildings that cumulatively constitute the built environment which provides the basis for society and other industries to flourish; hence, the economic contribution is perhaps greater than the estimated “direction” contribution to the GDP. Annually, the AECO industry is responsible for nearly 40% of the total energy use, 32% of CO2 emissions and 25% of the generated waste in Europe. Furthermore, in many developing countries, the construction industry has undergone substantial fluctuations to accomplish its local economic objectives. As a result, many developing countries’ financial procedures are in the process of improvement. In these countries, construction projects frequently face several time-schedule delays. Furthermore, the industry is faced with numerous productivity issues stemming from the lack of adoption of emerging technologies or concepts such as Building Information Modelling (BIM), blockchain, Internet of Things (IoT) and Industry 4.0. As a result, the construction industry in developing countries does not achieve government goals for society and clients, and a need for developing “overall success construction projects” that are resource-efficient has been underlined in the literature.
  • 1.8K
  • 17 Aug 2021
Topic Review Video Peer Reviewed
Next Generation of AMR Network
Antimicrobial resistance (AMR) is one of the top 10 global public health threats facing humanity, especially in low-resource settings, and requires an interdisciplinary response across academia, government, countries, and societies. If unchecked, AMR will hamper progress towards reaching the United Nations Sustainable Development Goals (SDGs), including ending poverty and hunger, promoting healthy lives and well-being, and achieving sustained economic growth. There are many global initiatives to curb the effects of AMR, but significant gaps remain. New ways of thinking and operating in the context of the SDGs are essential to making progress. In this entry, we define the next generation of the AMR research network, its composition, and strategic activities that can help mitigate the threats due to AMR at the local, regional, and global levels. This is supported by a review of recent literature and bibliometric and network analyses to examine the current and future state of AMR research networks for global health and sustainable development. 
  • 1.8K
  • 13 Apr 2022
Topic Review
COVID-19 Pneumonia and Lung Cancer
Oncological patients are more prone to present severe forms of COVID-19 pneumonia and are subject to worse complications. Radiologists have the challenging role of suggesting a differential diagnosis with lung cancer and treatment-induced lung diseases or suggesting an overlap between these pathologies. Despite similarities or overlapping findings, the combination of clinics and some specific radiological findings, which are also identified by comparison with previous and follow-up CT scans, may guide differential diagnosis.
  • 1.8K
  • 01 Apr 2022
Topic Review
T-Cell Acute Lymphoblastic Leukemia
Thanks to the use of high-resolution genetic techniques to detect cryptic aberrations present in T-ALL, researchers now have a clearer view of the genetic landscape that explains the particular oncogenetic processes taking place in each T-ALL. They also have begun to understand relapse-specific mechanisms. To summarize the latest advances in the knowledge of the genome in T-ALL and highlight the areas where the research on this ALL subtype is progressing, thereby identifying the key issues that need to be addressed in the medium-to-long term to move forward in the applicability of this knowledge into clinics.
  • 1.8K
  • 02 Jun 2022
Topic Review
Recycling of Multilayer Waste Films
In a circular economy context with the dual problems of depletion of natural resources and the environmental impact of a growing volume of wastes, it is of great importance to focus on the recycling process of multilayered plastic films. First to the general concepts and summary of plastic waste management in general, making emphasis on the multilayer films recycling process. Then, in the second part, the focus is dealing with multilayer films manufacturing process, including the most common materials used for agricultural applications, their processing, and the challenges of their recycling, recyclability, and reuse. Hitherto, some prospects are discussed from eco-design to mechanical or chemical recycling approaches.
  • 1.8K
  • 20 Jun 2022
Topic Review
Organizational Self-Management
Organizational Self-management, also referred to as Workers' Self-management, Labor Management and Autogestión (see also workers' control, industrial democracy, democratic management and worker cooperative), is a form of organizational management based on self-directed work processes on the part of an organization's workforce. Self-management is a characteristic of many forms of socialism, with proposals for Self-management having appeared many times throughout the history of the socialist movement, advocated variously by libertarian and market socialists, communists and anarchists. There are many variations of Self-management. In some variants, all the worker-members manage the enterprise directly through assemblies while in other forms workers exercise management functions indirectly through the election of specialist managers. Self-management may include worker supervision and oversight of an organization by elected bodies, the election of specialized managers, or self-directed management without any specialized managers as such. The goals of self-management are to improve performance by granting workers greater autonomy in their day-to-day operations, boosting morale, reducing alienation and eliminating exploitation when paired with employee ownership. An enterprise that is self-managed is referred to as a labour-managed firm. Self-management refers to control rights within a productive organization, being distinct from the questions of ownership and what economic system the organization operates under. Self-management of an organization may coincide with employee ownership of that organization, but Self-management can also exist in the context of organizations under public ownership and to a limited extent within private companies in the form of co-determination and worker representation on the board of directors.
  • 1.8K
  • 09 Oct 2022
Topic Review
Caisson (Engineering)
In geotechnical engineering, a caisson (/ˈkeɪsən/ or /ˈkeɪsɒn/) is a watertight retaining structure used, for example, to work on the foundations of a bridge pier, for the construction of a concrete dam, or for the repair of ships. These are constructed such that the water can be pumped out, keeping the working environment dry. When piers are being built using an open caisson, and it is not practical to reach suitable soil, friction pilings may be driven to form a suitable sub-foundation. These piles are connected by a foundation pad upon which the column pier is erected.
  • 1.8K
  • 22 Nov 2022
Topic Review
Mechanisms of Bortezomib Resistance in Multiple Myeloma Cell
Bortezomib is the most effective chemotherapeutic drug used in the treatment of MM. This inhibitor is a dipeptide boronic acid analogue discovered in 1995 and is the premier in the class of chymotrypsin-like (CP) inhibitors. Bortezomib is a C-terminal boronic acid, and the boron atom is essential for inhibiting the proteasome activity because of its ability to specifically and tightly bind the β5 catalytic subunit. Boronates form tetrahedral adducts, which are further stabilized by a hydrogen bond between the N-terminal amino group of threonines and the hydroxyl groups of boronic acid. These bonds provide a higher influence for Bortezomib than other drugs developed for inhibition. It binds the proteasome with a high resolution, slowly dissociates, and provides a stable but reversible proteasome inhibition. Various mechanisms have been suggested to explain the multidrug resistance in cancer cells. Increased drug excretion, decreased drug uptake, activation of detoxification systems, inhibition of apoptosis, alterations in cell cycle regulation factors, and changes in drug targets are among the causes.
  • 1.8K
  • 17 Jan 2023
Topic Review
Domestication in the Neotropics
Charles Darwin used domestication as a metaphor for natural selection because everyone is familiar with the term. Since Darwin, domestication has become a major topic of research, both to help understand evolution, as Darwin did, and to understand how human societies came to dominate the world, which also interested Darwin. However, Darwin did not define the term, which has allowed students of domestication, such as geneticists, archaeologists and others, to tailor their definitions to their own objectives. Even our grammar influences the way we interpret simple phrases about domestication ( p. xiv), as we tend to put ourselves, as individuals or the human collective, in charge. As Darwin pointed out, however, the long history of human interaction with plants and animals that resulted in the domestication of some of them was influenced more by unconscious selection than conscious selection. Only when considering the latter type of selection, which Darwin called methodical selection, can we affirm that humans are in charge, and even then unintended consequences are common. Nonetheless, especially when used in studies to understand how humans came to dominate the world, definitions often assume that humans are in control, which is unlikely at the beginning of human interactions with plants and animals. As pointed out by Dolores Piperno and Deborah Pearsall ( p. 6), clear definitions of concepts are extremely important when discussing domestication and the food production systems in which many domesticates are grown or raised. Melinda Zeder reviewed a set of definitions to highlight their differences and theoretical frameworks, and emphasized that definitions for plants and animals are often quite different. Clement et al. prepared a short list of definitions for plant domestication since Zeder. Full definitions can help identify nuances that place human culture within Nature, as occurs in most Neotropical ontologies, rather than outside, which is typical of ideas of being in charge. We think that returning to a dictionary is also an appropriate exercise to explore definitions, especially as the definitions in Zeder and Clement et al. were designed by their authors to meet their own objectives, the majority of which are associated with identifying changes in morphology or genetics that prove that human selection resulted in a response. We will use the 1989 edition of the Oxford English Dictionary (OED), whose first edition was being researched and published at the same time that Darwin was writing. The verb domesticate comes from the Latin domesticäre – to dwell in a house, to accustom. The house is the center of the domus, the Latin root of domesticäre. The OED definitions include: “1.a. To make, or settle as, a member of a household; to cause to be at home; to naturalize. 1.b. To make to be or to feel ‘at home’; to familiarize. 2. To make domestic; to attach to home and its duties. 3. To accustom (an animal) to live under the care and near the habitations of man; to tame or bring under control; to civilize. 4. To live familiarly or at home (with); to take up one's abode.” It follows that the noun domestication is “the action of domesticating, or the condition of being domesticated” (OED), i.e., both the process itself and the results of the process. These definitions are about humans, who domesticate each other in their houses, with their associated gardens, orchards, pastures, woodlots, agroforests, and adjacent managed forests. Hence, the house and the surrounding landscape comprise the domus , until humans started living in cities or more recently in apartments. Animals are recognized in one of the definitions as being domesticated in the domus also, and it was Darwin who included plants. From these definitions, domestication is clearly anthropocentric, i.e., it is about us humans. Note that only one definition mentions control.  What are the human behaviors involved? Two are explicit in the definitions: care (of the occupants of the domus) and duty (the tasks of caring for the domus and its occupants). Two are implicit. Selection – since humans are selective about what is brought into the domus. The fact that selection is implicit, rather than explicit, may be why Darwin adopted domestication as his metaphor for natural selection. Accumulation – as people and animals are brought into the domus, both from nearby (familiarize) and far away (naturalize). As Darwin recognized, humans like variety, which can be seen in most gardens and even more clearly in swiddens. The definitions above are about both organisms (humans, animals, plants) and the domus. Most current definitions of domestication concentrate one behavior (selection), but care and accumulation are just as important.
  • 1.8K
  • 04 Mar 2021
Topic Review
DNA Loading Using Extracellular Vesicles
Gene therapy is a therapeutic strategy of delivering foreign genetic material (encoding for an important protein) into a patient’s target cell to replace a defective gene. Nucleic acids are embedded within the adeno-associated virus (AAVs) vectors; however, preexisting immunity to AAVs remains a significant concern that impairs their clinical application. Extracellular vesicles (EVs) hold great potential for therapeutic applications as vectors of nucleic acids due to their endogenous intercellular communication functions through their cargo delivery, including lipids and proteins. So far, small RNAs (siRNA and micro (mi)RNA) have been mainly loaded into EVs to treat several diseases, but the potential use of EVs to load and deliver exogenous plasmid DNA has not been thoroughly described.
  • 1.8K
  • 02 Sep 2020
Topic Review
Hydrogels
This entry briefly covers the existing knowledge on the lubrication mechanisms of hydrogels by discussing the main ideas, knowledge gaps and opportunities in the research area.
  • 1.8K
  • 21 Dec 2020
Topic Review
Tracking Methods for Autonomous Driving
Tracking: identifying traffic participants, i.e., cars, pedestrians, and obstacles from sequences of images, sensor data, or observations. It is assumed that some preprocessing of sensor data and/or input images has already been done. Trajectory prediction: anticipating the future trajectories and motion of other vehicles in order to facilitate navigating through various traffic conditions.
  • 1.8K
  • 27 Mar 2021
Topic Review
Microwave-Assisted Preparation of Luminescent Materials
Luminescent inorganic materials are used in several technological applications such as light-emitting displays, white LEDs for illumination, bioimaging, and photodynamic therapy. Usually, inorganic phosphors (e.g., complex oxides, silicates) need high temperatures and, in some cases, specific atmospheres to be formed or to obtain a homogeneous composition. Low ionic diffusion and high melting points of the precursors lead to long processing times in these solid-state syntheses with a cost in energy consumption when conventional heating methods are applied. Microwave-assisted synthesis relies on selective, volumetric heating attributed to the electromagnetic radiation interaction with the matter. The microwave heating allows for rapid heating rates and small temperature gradients yielding homogeneous, well-formed materials swiftly. Luminescent inorganic materials can benefit significantly from microwave-assisted synthesis for high homogeneity, diverse morphology, and rapid screening of different compositions. The rapid screening allows for fast material investigation, whereas the benefits of enhanced homogeneity include improvement in the optical properties such as quantum yields and storage capacity.
  • 1.8K
  • 23 Jun 2021
Topic Review
Advanced Glycation End Products
Diabetes mellitus (DM) is considered one of the most massive epidemics of the twenty-first century due to its high mortality rates caused mainly due to its complications; therefore, the early identification of such complications becomes a race against time to establish a prompt diagnosis. The research of complications of DM over the years has allowed the development of numerous alternatives for diagnosis. Among these emerge the quantification of advanced glycation end products (AGEs) given their increased levels due to chronic hyperglycemia, while also being related to the induction of different stress-associated cellular responses and proinflammatory mechanisms involved in the progression of chronic complications of DM. Additionally, the investigation for more valuable and safe techniques has led to developing a newer, noninvasive, and effective tool, termed skin fluorescence (SAF).
  • 1.8K
  • 10 Aug 2021
Topic Review
Green Tea Catechin EGCG-Sensing Receptor
The body is equipped with a “food factor-sensing system” that senses food factors, such as polyphenols, sulfur-containing compounds, and vitamins, taken into the body, and plays an essential role in manifesting their physiological effects. For example, (−)-epigallocatechin-3-O-gallate (EGCG), the representative catechin in green tea (Camellia sinensi L.), exerts various effects, including anti-cancer, anti-inflammatory, and anti-allergic effects, when sensed by the cell surficial protein 67-kDa laminin receptor (67LR). 
  • 1.8K
  • 19 Aug 2022
Topic Review
NewsRx
NewsRx is a media and technology company focusing on digital media, printed media, news services, and knowledge discovery through its BUTTER platform. In 1995 the company was the world's largest producer of health news. The company publishes 194 newsweeklies in health and other fields, which are distributed to subscribers and partners including Factiva, the Wall Street Journal Professional Edition, Thomson Reuters, ProQuest, and Cengage Learning. C W Henderson founded the company in 1984 and its first publication was AIDS Weekly. In the early 2000s, the firm added the imprint, VerticalNews to publish newsweeklies in non-health fields. Now based in Atlanta, Georgia, the company reports through its daily news service and publishes reference books through its partner, ScholarlyEditions. NewsRx launched its BUTTER platform in 2015, which is a knowledge discovery engine that delivers its content to academics, researchers, and professionals.
  • 1.8K
  • 26 Oct 2022
Topic Review
Texturing Methods of Abrasive Grinding Wheels
Creating textures on abrasive wheels is a strategy that allows a significant improvement in grinding operations. The reduction of the internal stresses in the workpiece and the temperature during the grinding operation generates an increase in the dimensional accuracy of the workpiece and a longer tool life. Textured abrasive wheels can be produced in many different ways. Depending on the processing method, the dimensional accuracy of the tool and its applicability is changed. 
  • 1.8K
  • 28 Nov 2022
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