Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Antibodies in HIV-infection and HIV-vaccine development
The structure of HIV-envelope changes as the infection progresses and is one of the biggest obstacles in developing of HIV-vaccine. HIV-infection can cause the production of various natural autoantibodies, including catalytic antibodies hydrolyzing DNA, myelin basic protein, histones, HIV-integrase, HIV-reverse transcriptase, β-casein, serum albumin, and some other natural substrates. Currently, there are various directions for the development of HIV vaccines: stimulation of the immune response on the mucous membranes; induction of cytotoxic T cells, which lyse infected cells and hold back HIV-infection; immunization with recombinant Env proteins or vectors encoding Env; mRNA-based vaccines and some others. 
  • 1.8K
  • 22 Mar 2022
Topic Review
Metal-Free Carbon-Based Supercapacitors-A Comprehensive Review
This state-of-the-art entry aims to highlight  advances in metal-free carbon-based supercapacitors over the last 20 years. Author discuss the various types of carbons (without metals) used (activated, nanoforms of carbon, and doped carbons) as well as key parameters in supercapacitor performance such as surface area, porosity, and functional groups.
  • 1.8K
  • 18 Jan 2021
Topic Review
Toothing
Toothing was originally a hoax claim that Bluetooth-enabled mobile phones or PDAs were being used to arrange random sexual encounters, perpetrated as a prank on the media who reported it. The hoax was created by Ste Curran, then Editor at Large at the gaming magazine Edge, and ex-journalist Simon Byron. They based it on the two concepts dogging and bluejacking that were popular at the time. The creators started a forum in March 2004 where they wrote fake news articles about toothing with other members and then sent them off to well-known Internet-based news services. The point of the hoax was to "highlight how journalists are happy to believe something is true without necessarily checking the facts". Dozens of news organizations, including BBC News, Wired News, and The Independent thought the toothing story was real and printed it. On April 4, 2005, Curran and Byron admitted that the whole thing was a hoax. There have, however, been real Bluetooth dating devices since.
  • 1.8K
  • 27 Oct 2022
Topic Review
Biomechanics Applied in Ergonomic Furniture Design
Furniture as a functional object must satisfy both artistic and scientific requirements. In particular, ergonomic factors are very important in furniture design in terms of human health and productivity. To make furniture designs at the ideal intersection of science and art, it is necessary to approach furniture design with a scientific systematic.
  • 1.8K
  • 29 Dec 2023
Topic Review
Spherical Nucleic Acids
Spherical nucleic acids (SNAs) are nanostructures consisting of nucleic acids in a spherical configuration, often around a nanoparticle core. SNAs are advantageous as gene-regulating agents compared to conventional gene therapy owing to their low toxicity, enhanced stability, uptake by virtually any cell, and ability to penetrate the epidermal barrier. 
  • 1.8K
  • 25 Nov 2020
Topic Review
Coastal Adaptation to Sea-Level Rise
The Earth’s climate is changing; ice sheets and glaciers are melting and coastal hazards and sea level are rising in response. With a total population of over 300 million people situated on coasts, including 20 of the planet’s 33 megacities (over 10 million people), low-lying coastal areas represent one of the most vulnerable areas to the impacts of climate change. The need to identify and implement adaptation solutions to the impacts of climate change in coastal zones is urgent. 
  • 1.8K
  • 17 Aug 2021
Topic Review
Audi E-tron
The Audi e-tron family is a series of electric and hybrid concept cars shown by Audi from 2009 onwards. In 2012 Audi unveiled a plug-in hybrid version, the Audi A3 Sportback e-tron, released to retail customers in Europe in August 2014, and slated for the U.S. in 2015.
  • 1.8K
  • 12 Aug 2023
Topic Review
Paging
In computer operating systems, paging is a memory management scheme by which a computer stores and retrieves data from secondary storage[lower-alpha 1] for use in main memory. In this scheme, the operating system retrieves data from secondary storage in same-size blocks called pages. Paging is an important part of virtual memory implementations in modern operating systems, using secondary storage to let programs exceed the size of available physical memory. For simplicity, main memory is called "RAM" (an acronym of "random-access memory") and secondary storage is called "disk" (a shorthand for "hard disk drive, drum memory or solid-state drive"), but the concepts do not depend on whether these terms apply literally to a specific computer system.
  • 1.8K
  • 17 Oct 2022
Topic Review
Poliomyelitis Eradication
Poliomyelitis eradication refers to a permanent elimination of all cases of poliomyelitis (polio) infection around the world. A public health effort to this end began in 1988, led by the World Health Organization (WHO), the United Nations Children's Fund (UNICEF) and the Rotary Foundation. These organizations, along with the U.S. Centers for Disease Control and Prevention (CDC) and The Gates Foundation, have spearheaded the campaign through the Global Polio Eradication Initiative (GPEI), which helps to coordinate vaccination campaigns, environmental monitoring, evaluation of possible polio cases and logistics. Successful eradication of infectious diseases has been achieved twice before, with smallpox and rinderpest. Prevention of disease spread is accomplished by vaccination. There are two kinds of polio vaccine—oral polio vaccine (OPV), which uses weakened poliovirus, and inactivated polio vaccine (IPV), which is injected. The OPV is less expensive and easier to administer, and can spread immunity beyond the person vaccinated, creating contact immunity. It has been the predominant vaccine used. However, under conditions of long-term vaccine virus circulation in under-vaccinated populations, mutations can reactivate the virus to produce a polio-inducing strain, while the OPV can also, in rare circumstances, induce polio or persistent asymptomatic infection in vaccinated individuals, particularly those that are immunodeficient. Being inactivated, the IPV is free of these risks but does not induce contact immunity. IPV is more costly and the logistics of delivery are more challenging. The 22 diagnosed wild polio virus (WPV) cases worldwide in 2017[needs update] represented a 97% reduction from the 719 diagnosed cases in 2000 and a 99.99% reduction from the estimated 350,000 cases when the eradication effort began in 1988. Of the three strains of polio virus, the last recorded wild case caused by type 2 (WPV2) was in 1999, and WPV2 was declared eradicated in 2015. Type 3 (WPV3) is last known to have caused polio on 11 November 2012, with all wild-virus cases since that date being due to type 1 (WPV1). All three types are represented among the periodic cases arising from mutated oral vaccine strains, so-called circulating vaccine-derived poliovirus (cVDPV). India is the latest country to have officially stopped endemic transmission of polio, with its last reported case in 2011. Three countries remain where the disease is endemic—Afghanistan, Pakistan and Nigeria.
  • 1.8K
  • 20 Oct 2022
Biography
Sylvester James Gates
Sylvester James Gates Jr. (born December 15, 1950), known as S. James Gates Jr. or Jim Gates, is an American theoretical physicist who works on supersymmetry, supergravity, and superstring theory. He retired from the physics department and Center for Fundamental Physics at the University of Maryland College of Computer, Mathematical, and Natural Sciences in 2017,[1] and he is now the Brown Theor
  • 1.8K
  • 24 Nov 2022
Topic Review
Configuration Space
In classical mechanics, the parameters that define the configuration of a system are called generalized coordinates, and the space defined by these coordinates is called the configuration space of the physical system. It is often the case that these parameters satisfy mathematical constraints, such that the set of actual configurations of the system is a manifold in the space of generalized coordinates. This manifold is called the configuration manifold of the system. Notice that this is a notion of "unrestricted" configuration space, i.e. in which different point particles may occupy the same position. In mathematics, in particular in topology, a notion of "restricted" configuration space is mostly used, in which the diagonals, representing "colliding" particles, are removed.
  • 1.8K
  • 25 Nov 2022
Topic Review
Meet the Flintstones
"Meet the Flintstones", also worded as "(Meet) The Flintstones", is the theme song of the 1960s animated television series The Flintstones. Composed in 1961 by Hoyt Curtin, Joseph Barbera and William Hanna, it is one of the most popular and best known of all theme songs, with its catchy lyrics "Flintstones, meet the Flintstones, they're the modern Stone Age family".
  • 1.8K
  • 01 Dec 2022
Topic Review
Iris Species
The genus Iris from the Iridaceae family consists of more than 262 recognized species. It is an ornamental and medicinal plant widely distributed in the Northern Hemisphere. Iris species convey a long history as valuable traditional drugs with a wide variety of applications in various cultures, having been recorded since medieval times. 
  • 1.8K
  • 29 Mar 2022
Topic Review
Crowdfunding
Crowdfunding is the practice of funding a newly created firm or project by raising funds from a large number of people. It is usually performed online. In 2009 the volume of funds raised using crowdfunding was negligeably small. Crowdfunding raised $34.4 billion in 2015. Some analysts predict that crowdfunding market size will grow at an annual rate of 27.8% and will surpass venture capital investments in the near future (Miglo and Miglo, 2019).
  • 1.8K
  • 29 Oct 2020
Topic Review
Ischemia and Reperfusion
Ischemia and reperfusion (I/R) causes a reduction in arterial blood supply to tissues, followed by the restoration of perfusion and consequent reoxygenation. The reestablishment of blood flow triggers further damage to the ischemic tissue through reactive oxygen species (ROS) accumulation, interference with cellular ion homeostasis, and inflammatory responses to cell death. In normal conditions, ROS mediate important beneficial responses. When their production is prolonged or elevated, harmful events are observed with peculiar cellular changes. In particular, during I/R, ROS stimulate tissue inflammation and induce NLRP3 inflammasome activation. The mechanisms underlying the activation of NLRP3 are several and not completely elucidated. It was recently shown that NLRP3 might sense directly the presence of ROS produced by normal or malfunctioning mitochondria or indirectly by other activators of NLRP3. Aim of the present review is to describe the current knowledge on the role of NLRP3 in some organs (brain, heart, kidney, and testis) after I/R injury, with particular regard to the role played by ROS in its activation. Furthermore, as no specific therapy for the prevention or treatment of the high mortality and morbidity associated with I/R is available, the state of the art of the development of novel therapeutic approaches is illustrated.
  • 1.8K
  • 03 Nov 2020
Topic Review
Glutamatergic Neurotransmission in Alzheimer’s Disease
Alzheimer’s disease (AD) is an age-related dementia and neurodegenerative disorder, characterized by Aβ and tau protein deposition impairing learning, memory, and suppressing synaptic plasticity of neurons. Increasing evidence suggests that there is a link between the glucose and glutamate alterations with age that down-regulates glucose utilization reducing glutamate levels in AD patients. Deviations in brain energy metabolism reinforce the development of AD by hampering glutamate levels in the brain. Glutamate is a nonessential amino acid and the major excitatory neurotransmitter synthesized from glucose. Alterations in cerebral glucose and glutamate levels precede the deposition of Aβ plaques. In the brain, over 40% of neuronal synapses are glutamatergic and disturbances in glutamatergic function have been implicated in the pathophysiology of AD. Nevertheless, targeting the glutamatergic system seems to be a promising strategy to develop novel, improved therapeutics for AD. Thus, the present review will extensively cover recent findings on the dysregulation of glutamatergic signaling in AD and will highlight the molecular mechanisms through which the modulation of glutamatergic receptors and transporters might exert beneficial effects in AD treatment.
  • 1.8K
  • 10 Nov 2020
Topic Review
Smart village
In this study, the level of progress of climate smart agriculture was examined, its ideas were employed to develop a framework for smart village development. This is essential because most agricultural activites are maximized in the rural communities, more so, its development can influence the increasing rural-urban migration. Also of importance is the tailoring of this framework towards sustainability. 
  • 1.8K
  • 31 Dec 2020
Topic Review
Cannabis
The landscape of attitudes, legal status and patterns of use of cannabis is rapidly changing in the United States and elsewhere. Therefore, the primary aim of this narrative review is to provide a concise overview of the literature on the comorbidity of cannabis use and cannabis use disorder (CUD) with other substance use and psychiatric disorders, and to use this information to accurately guide future directions for the field. A literature review of PubMed was conducted for studies relating to cannabis use, CUD, and a co-occurring psychiatric disorder. To provide an overview of representative data, the literature review focused on national-level, population-based work from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) and National Survey on Drug Use and Health (NSDUH) surveys. Considering rapidly changing cannabis laws, recent (past five-year) studies were addressed. A strong body of literature shows associations between cannabis use and CUD with other drug use, psychosis, mood disorders, anxiety disorders, and personality disorders. The strongest evidence of a potential causal relationship exists between cannabis use and psychotic disorders. While some evidence shows potential directionality between cannabis use and mood and anxiety disorders, results are inconsistent. Studies have established higher rates of CUD among those with personality disorders, but little about the specifics of this relationship is understood. Conclusions: Although the general population in the United States increasingly perceives cannabis to be a harmless substance, empirical evidence shows that cannabis use is associated both with CUD and comorbid psychiatric illness. However, there is mixed evidence regarding the role of cannabis in the etiology, course, and prognosis of a co-occurring disorder across all categories of psychiatric disorders. Future research should expand on the existing body of literature with representative, longitudinal data, in order to better understand the acute and long-term effects of cannabis on comorbid psychiatric illness. 
  • 1.8K
  • 19 May 2021
Topic Review
RGO-Loaded Metal-Oxide Nanofiber Gas Sensors
Reduced graphene oxide (rGO) is a reduced form of graphene oxide used extensively in gas sensing applications. However, in its pristine form, graphene has some shortages and thus, it is generally utilized in combination with other metal oxides to improve gas sensing capabilities. There are different ways of adding rGO to different metal oxides with various morphologies. This study focuses on rGO-loaded metal oxide nanofiber (NF) synthesized using an electrospinning method. Different amounts of rGO were added to the metal oxide precursors, and after electrospinning, the gas response is enhanced through different sensing mechanisms. 
  • 1.8K
  • 04 Mar 2021
Topic Review Peer Reviewed
β-Glucans
β-glucans are complex polysaccharides that are found in several plants and foods, including mushrooms. β-glucans display an array of potentially therapeutic properties.
  • 1.8K
  • 13 Apr 2022
  • Page
  • of
  • 2799
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback