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Topic Review
Probiotics in cosmetics
Probiotics, defined as “live microorganisms that, when administered in adequate amounts, confer a health benefit on the host,” are becoming increasingly popular and marketable. The cosmetic industry has harnessed this potential by producing products claiming to contain probiotics. However, not all products marketed as such comply with the requirements for this claim.  
  • 1.8K
  • 10 Mar 2021
Topic Review
Prognostic Biomarkers of CLL
Chronic lymphocytic leukemia (CLL) is an extremely heterogeneous disease. With the advent of oral targeted agents (Tas) the treatment of CLL has undergone a revolution, which has been accompanied by an improvement in patient’s survival and quality of life. 
  • 1.8K
  • 27 Apr 2021
Topic Review
Bioactive Phytochemicals
Bioactive phytochemicals, including natural compounds, secondary metabolites and their derivatives, have attracted significant attention for use in both medicinal products and cosmetic products. Our review highlights the pharmacological mode-of-action and current biomedical applications of key bioactive compounds applied as anti-inflammatory, bactericidal with antibiotics effects, and pain relief purposes in controlled clinical studies or preclinical studies.
  • 1.8K
  • 09 Jun 2021
Topic Review
Valorization of Grape by-products
The emergence of antibiotic-resistance in bacteria has limited the ability to treat bacterial infections, besides increasing their morbidity and mortality at the global scale. The need for alternative solutions to deal with this problem is urgent and has brought about a renewed interest in natural products as sources of potential antimicrobials. The wine industry is responsible for the production of vast amounts of waste and by-products, with associated environmental problems. These residues are rich in bioactive secondary metabolites, especially phenolic compounds. Some phenolics are bacteriostatic/bactericidal against several pathogenic bacteria and may have a synergistic action towards antibiotics, mitigating or reverting bacterial resistance to these drugs. Complex phenolic mixtures, such as those present in winemaking residues (pomace, skins, stalks, leaves, and especially seeds), are even more effective as antimicrobials and could be used in combined therapy, thereby contributing to management of the antibiotic resistance crisis. 
  • 1.8K
  • 14 Feb 2022
Topic Review
Antibiotic Hybrids
An emerging strategy in the fight against antimicrobial resistance is the development of antibiotic hybrids. The term “hybrid” suggests a two-component molecule with biological activity that retains the activity of the individual components after hybridization, acting synergistically. For example, hybrid drugs that incorporate two active compounds into a single molecule could be used to expand the biological activity and prevent the development of bacterial resistance.
  • 1.8K
  • 22 Sep 2022
Topic Review
Gain of Function Mutant p53 in Cancer
The tumor suppressor p53, encoded by the TP53 gene and known as “the guardian of the genome”, performs a variety of functions in cancer prevention.
  • 1.8K
  • 17 Nov 2022
Topic Review
Bread in Culture
Bread has a significance beyond mere nutrition in many cultures in the Western world and Greater Middle East because of its history and contemporary importance. Bread is also significant in Christianity as one of the elements (alongside wine) of the Eucharist; see sacramental bread. The word companion comes from Latin com- "with" + panis "bread". The political significance of bread is considerable. In 19th century Britain, the inflated price of bread due to the Corn Laws caused major political and social divisions, and was central to debates over free trade versus protectionism. The Assize of Bread and Ale in the 13th century demonstrated the importance of bread in medieval times by setting heavy punishments for short-changing bakers, and bread appeared in Magna Carta a half-century earlier. Like other foods, choosing the "right" kind of bread is used as a social signal, to let others know, for example, that the person buying expensive bread is financially secure, or the person buying whatever type of bread that the current fashions deem most healthful is a health-conscious consumer. As a simple, cheap, and adaptable type of food, bread is often used as a synecdoche for food in general in some languages and dialects, such as Greek and Punjabi. There are many variations on the basic recipe of bread worldwide, such as bagels, baguettes, biscuits, bocadillo, brioche, chapatis, Challah, lavash, naan, pitas, pizza, pretzels, puris, tortillas, and many others. There are various types of traditional "cheese breads" in many countries, including Brazil , Colombia, Italy, and Russia .
  • 1.8K
  • 28 Nov 2022
Topic Review
Transient Receptor Potential Channels in Migraine Pathophysiology
Migraine is a chronic neurological disorder that affects approximately 12% of the population. The cause of migraine headaches is not yet known, however, when the trigeminal system is activated, neuropeptides such as calcitonin gene-related peptide (CGRP) and substance P (SP) are released, which cause neurogenic inflammation and sensitization. Advances in the understanding of migraine pathophysiology have identified new potential pharmacological targets. Transient receptor potential (TRP) channels have been the focus of attention in the pathophysiology of various pain disorders, including primary headaches. Genetic and pharmacological data suggest the role of TRP channels in pain sensation and the activation and sensitization of dural afferents. TRP channels are widely expressed in the trigeminal system and brain regions which are associated with the pathophysiology of migraine and furthermore, co-localize several neuropeptides that are implicated in the development of migraine attacks. Moreover, there are several migraine trigger agents known to activate TRP channels. Based on these, TRP channels have an essential role in migraine pain and associated symptoms, such as hyperalgesia and allodynia. Mammalian TRP channels are divided into seven subfamilies based on their homology of amino acid sequences: canonical or classic (TRPC), vanilloid (TRPV), melastatin (TRPM), nonmechanoreceptor potential C (NOMP-like, TRPN1) polycystin (TRPP), mucolipin (TRPML), and ankyrin (TRPA). 
  • 1.8K
  • 10 Jan 2023
Topic Review
Kahweol and Cafestol on Several Cancer
Kahweol and cafestol are two diterpenes extracted from Coffea arabica beans that have distinct biological activities. Recent research describes their potential activities, which include anti-inflammatory, anti-diabetic, and anti-cancer properties, among others. The two diterpenes have been shown to have anticancer effects in various in vitro and in vivo cancer models.
  • 1.8K
  • 19 Jan 2023
Topic Review
Primordial Germ Cells
Primordial germ cells (PGCs) are precursor cells of sperm and eggs. The fate decisions of chicken PGCs in terms of their development, integrity, and sex determination have unique features, thereby providing insights into evolutionary developmental biology.
  • 1.8K
  • 21 Mar 2023
Topic Review
Properties and Biomedical Application of Chitosan-Based Hydrogels
The prospective applications of chitosan-based hydrogels (CBHs), a category of biocompatible and biodegradable materials, in biomedical disciplines such as tissue engineering, wound healing, drug delivery, and biosensing have garnered great interest. The synthesis and characterization processes used to create CBHs play a significant role in determining their characteristics and effectiveness. 
  • 1.8K
  • 13 Jun 2023
Topic Review
Interactions of Gibberellins with Phytohormones
Gibberellins are amongst the main plant growth regulators. Discovered over a century ago, the interest in gibberellins research is growing due to their current and potential applications in crop production and their role in the responses to environmental stresses. The complex interrelations between gibberellins and other plant growth regulators are described, providing an intricate network of interactions that ultimately drives towards precise and specific gene expression. Thus, genes and proteins identified as being involved in gibberellin responses in model and non-model species are highlighted. Furthermore, the molecular mechanisms governing the gibberellins’ relation to stress responses are also depicted.
  • 1.8K
  • 21 Apr 2022
Topic Review
Biological Activities of Mucuna Pruriens
Mature fruits of M. pruriens were harvested from Fort Hare University’s Research Farm located in Alice, South Africa. The collected seeds were pulverized in a standard process and taken to the laboratory for crude extraction and further treatments. Cytotoxic, antimalarial, and trypanocidal effects of crude extracts obtained from ethanol and water were tested, while the total phenolic, proanthocyanidin, and flavonoid contents of the aqueous extracts as well as their pharmacological activities were determined in vitro using 2,2-diphenyl-1-picrylhydrazyl ethanol (DPPH), ferric reducing antioxidant power (FRAP), and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays. Although the extracts showed mild antiparasitic (antiplasmodial and trypanocidal) effects, results from the cytotoxic experiment revealed that M. pruriens is not toxic to human cervix adenocarcinoma (HeLa) cells when tested using 50 µg/mL of extracts. It was observed that the seeds were remarkably rich in phenol (3730.1 ± 15.52 mg gallic acid equivalent (GAE)/g) compared to flavonoids (63.03 ± 1.95 mg quercetin equivalent (QE)/g) and proanthocyanidin (18.92 ± 1.09 mg catechin equivalent (CE)/g). Also, the antioxidant activities of the extracts were comparable to those of the standard antioxidant drugs (rutin and gallic acid) used, in a concentration-dependent manner. There was a direct relationship between phenolic acid content and antioxidant effects. It is therefore suggested that M. pruriens seeds be incorporated into human diets as a supplement to promote healthy living. Pharmaceutical industries with a particular interest in natural phenolic acids should consider using seeds of M. pruriens as pharmaceutical precursors. 
  • 1.8K
  • 09 Nov 2020
Topic Review
Cardiac Connexins
Connexins are a family of transmembrane proteins that play a key role in cardiac physiology. Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes, allowing the existence of electrical coupling. However, in addition to this fundamental role, connexins are also involved in cardiomyocyte death and survival. Thus, chemical coupling through gap junctions plays a key role in the spreading of injury between connected cells. Moreover, in addition to their involvement in cell-to-cell communication, mounting evidence indicates that connexins have additional gap junction-independent functions. Opening of unopposed hemichannels, located at the lateral surface of cardiomyocytes, may compromise cell homeostasis and may be involved in ischemia/reperfusion injury. In addition, connexins located at non-canonical cell structures, including mitochondria and the nucleus, have been demonstrated to be involved in cardioprotection and in regulation of cell growth and differentiation.
  • 1.8K
  • 13 May 2021
Topic Review
Aurora Kinase B in Cancer
Aurora kinase B (AURKB) is a mitotic serine/threonine protein kinase that belongs to the aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC). AURKB is a member of the chromosomal passenger protein complex and plays a role in cell cycle progression.
  • 1.8K
  • 23 Jun 2021
Topic Review
Human Endogenous Retrovirus in Neurodegeneration
Human endogenous retroviruses (HERVs) are ancient retroviral DNA sequences established into germline. They contain regulatory elements and encoded proteins few of which may provide benefits to hosts when co-opted as cellular genes. Their tight regulation is mainly achieved by epigenetic mechanisms, which can be altered by environmental factors, e.g., viral infections, leading to HERV activation. This review summarizes the recent advances on the epigenetic mechanisms controlling HERV expression and the pathogenic effects triggered by HERV de-repression leading to neurological diseases, inflammatory processes and neurodegeneration.
  • 1.8K
  • 04 Jun 2021
Topic Review
Firewall for Securing Smart Healthcare Environment
Firewalls today represent the first line of defense against major attacks, affecting both traditional and modern networks, and enforcing the protection of inside networks from external (and untrusted) networks. The application of an effective set of security practices and policies may indeed keep those systems safe and save entire businesses. Firewalls have a very important function of protecting, filtering, and controlling all traffic sent and received from the computer, Local Area Network (LAN), or Wide Local Area Network (WLAN) internal networks from unauthorized intrusions or external attacks.
  • 1.8K
  • 08 Oct 2021
Topic Review
Treatment of Endometriosis
Endometriosis is a gynecological condition characterized by the growth of endometrium-like tissues inside and outside the pelvic cavity. The evolution of the disease can lead to infertility in addition to high treatment costs. The available medications are only effective in treating endometriosis-related pain.   
  • 1.8K
  • 12 Jul 2022
Topic Review
Global Quality Management System in Systems of Systems
Quality Management in System of Systems (SoS) organizations are characterized by very complex products and organizational structures. Since SoS integrate multiple systems and technologies, the corresponding organizational systems are characterized by great complexity that includes sub-organizational substructures. 
  • 1.8K
  • 08 Aug 2022
Topic Review
Electrostatic Nuclear Accelerator
An electrostatic nuclear accelerator is one of the two main types of particle accelerators, where charged particles can be accelerated by subjection to a static high voltage potential. The static high voltage method is contrasted with the dynamic fields used in oscillating field particle accelerators. Owing to their simpler design, historically these accelerators were developed earlier. These machines are operated at lower energy than some larger oscillating field accelerators, and to the extent that the energy regime scales with the cost of these machines, in broad terms these machines are less expensive than higher energy machines, and as such they are much more common. Many universities worldwide have electrostatic accelerators for research purposes.
  • 1.8K
  • 25 Oct 2022
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