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Topic Review
Cultural Heritage in Catholic Church
The 2003 UNESCO Convention definition of intangible heritage also covers religious practices and rites. Catholic religious traditions constitute a significant part of the UNESCO intangible cultural heritage (ICH) of religious provenance. 
  • 1.8K
  • 18 Mar 2024
Topic Review
Five Hundred Meter Aperture Spherical Telescope
The Five-hundred-meter Aperture Spherical radio Telescope (FAST; Chinese: 五百米口径球面射电望远镜), nicknamed Tianyan (天眼, lit. "Heavenly Eye" or "The Eye of Heaven") is a radio telescope located in the Dawodang depression (大窝凼洼地), a natural basin in Pingtang County, Guizhou Province, southwest China. It consists of a fixed 500 m (1,600 ft) diameter dish constructed in a natural depression in the landscape. It is the world's largest filled-aperture radio telescope, and the second-largest single-dish aperture after the sparsely-filled RATAN-600 in Russia. It has a novel design, using an active surface made of metal panels that can be tilted by a computer to help change the focus to different areas of the sky. The cabin containing the feed antenna suspended on cables above the dish is also moved using a digitally-controlled winch by the computer control system to steer the instrument to receive from different directions. Construction on the FAST project began in 2011 and it achieved first light in September 2016. It is currently undergoing testing and commissioning. It observes at wavelengths of 10 cm to 4.3 m.:11 The telescope made its first discovery of two new pulsars in August 2017, barely one year after its first light. The new pulsars PSR J1859-01 and PSR J1931-02, which are also referred to as FAST pulsar #1 and #2 (FP1 and FP2), were detected on 22 and 25 August and are 16,000 and 4,100 light years away, respectively. They were independently confirmed by the Parkes Observatory in Australia on 10 September. The telescope had discovered 44 new pulsars by September, 2018.
  • 1.8K
  • 14 Oct 2022
Topic Review
Technologies for Crop Nitrogen Diagnosis
       Nitrogen (N) plays a key role in the growth of agricultural crops, efficient and precise tools for diagnosis of N status is key to improving crop productivity and reducing environmental pollution. Recent development of non-destructive optical techniques, such as spectroscopy and machine vision technologies, have laid a good foundation for real-time monitoring and precise management of crop N status. We mainly focused on the contribution of spectral and machine vision technology to the accurate diagnosis of crop N status from three aspects: system selection, data processing, and estimation methods. In order to provide useful information for readers.
  • 1.8K
  • 09 Feb 2021
Topic Review
CCL2
Factors secreted from adipose tissue may induce and/or maintain a local and systemic low-grade activation of the innate immune system. Attraction of macrophages into adipose tissue and altered crosstalk between macrophages, adipocytes, and other cells of adipose tissue are symptoms of metabolic inflammation. Among several secreted factors attracting immune cells to adipose tissue, chemotactic C-C motif chemokine ligand 2 (CCL2) (also described as monocyte chemoattractant protein-1 (MCP-1)) has been shown to play a crucial role in adipose tissue macrophage infiltration. 
  • 1.8K
  • 28 Sep 2021
Topic Review
The Complement System
The complement system is part of the innate immune response, where it provides immediate protection from infectious agents and it plays a fundamental role in homeostasis. Complement dysregulation occurs in several diseases, where the tightly regulated proteolytic cascade turns offensive. Prominent examples are atypical hemolytic uremic syndrome, paroxysmal nocturnal hemoglobinuria and Alzheimer’s disease. Therapeutic intervention targeting complement activation may allow treatment of such debilitating diseases.
  • 1.8K
  • 17 Mar 2021
Topic Review
Microbial Pyrrolnitrin
Pyrrolnitrin (PRN) is a microbial pyrrole halometabolite of immense antimicrobial significance for agricultural, pharmaceutical and industrial implications. The compound and its derivatives have been isolated from rhizospheric fluorescent or non-fluorescent pseudomonads, Serratia and Burkholderia. They are known to confer biological control against a wide range of phytopathogenic fungi, and thus offer strong plant protection prospects against soil and seed-borne phytopathogenic diseases. Although chemical synthesis of PRN has been obtained using different steps, microbial production is still the most useful option for producing this metabolite. In many of the plant-associated isolates of Serratia and Burkholderia, production of PRN is dependent on the quorum-sensing regulation that usually involves N-acylhomoserine lactone (AHL) autoinducer signals. When applied on the organisms as antimicrobial agent, the molecule impedes synthesis of key biomolecules (DNA, RNA and protein), uncouples with oxidative phosphorylation, inhibits mitotic division and hampers several biological mechanisms. 
  • 1.8K
  • 01 Sep 2021
Topic Review
Natural Biomolecules in Sperm Production
Poor semen quality and abnormal sperm structure or function by and large constitute a predominant presentation of male infertility and are among the major reasons why couples seek the services of assisted reproduction. Natural biomolecules, such as polyphenols or flavonoids have garnered substantial attention from the scientific community as well as public media. In the meantime, it has been suggested that administration of natural biomolecules has been shown to have a positive impact male infertility. A number of in vivo as well as in vitro studies have reported that active components isolated from natural resources could enhance blood circulation in the male reproductive system and support the synthesis and secretion of androgens. Animal and human reports also suggest that natural biomolecules may play important roles in the enhancement of semen quality, including sperm concentration, motility, vitality, and structural integrity. 
  • 1.8K
  • 23 Sep 2021
Topic Review
Dapsone Imine Derivatives
Dapsone (DDS) is an antibacterial drug with well-known antioxidant properties. However, the antioxidant behavior of its derivatives has not been well explored. In the present work, the antioxidant activity of 10 dapsone derivatives 4-substituted was determined by an evaluation in two in vitro models (DPPH radical scavenging assay and ferric reducing antioxidant power). These imine derivatives 1–10 were obtained through condensation between DDS and the corresponding aromatic aldehydes 4-substuited. Three derivatives presented better results than DDS in the determination of DPPH (2, 9, and 10). Likewise, we have three compounds with better reducing activity than dapsone (4, 9, and 10). In order to be more insight, the redox process, a conceptual DFT analysis was carried out. Molecular descriptors such as electronic distribution, the total charge accepting/donating capacity (I/A), and the partial charge accepting/donating capacity (ω+/ω−) were calculated to analyze the relative donor-acceptor capacity through employing a donor acceptor map (DAM). The DFT calculation allowed us to establish a relationship between GAPHOMO-LUMO and DAM with the observed antioxidant effects. According to the results, we concluded that compounds 2 and 3 have the lowest Ra values, representing a good antioxidant behavior observed experimentally in DPPH radical capturing. On the other hand, derivatives 4, 9, and 10 display the best reducing capacity activity with the highest ω− and Rd values. Consequently, we propose these compounds as the best antireductants in our DDS imine derivative series.
  • 1.8K
  • 08 Oct 2021
Topic Review
WNT Signaling
The WNT signaling pathway is an evolutionarily conserved signal transduction pathway that regulates a wide range of cellular functions during development and adulthood. It controls multiple aspects of development, including cell proliferation, cell fate determination, apoptosis, cell migration and cell polarity during development and stem cell maintenance in adults. Inappropriate activation of the WNT pathway is also a major factor in human oncogenesis.
  • 1.8K
  • 11 Mar 2022
Topic Review
Cleaning Technologies for Indoor Air Quality Improvement
If outdoor air is more polluted, or in certain situations where ventilation is not possible, other strategies need to be applied, such as source control and pollutants extraction. The latter incorporates air cleaning technologies, one of the emergent areas of indoor air quality. Various air treatment technologies can be used to control contaminants, including physicochemical technologies and biological technologies.
  • 1.8K
  • 28 Sep 2022
Topic Review
Soyot
The Soyot people live mainly in the Oka region in the Okinsky District in the Republic of Buryatia, Russia . According to the 2010 census, there were 3,608 Soyots in Russia. Their extinct language was of a Turkic type and basically similar to the Tuvans. Their language has been reconstructed and a textbook has been published. The language is currently taught in some schools in Oka. The Oka River, the largest river flowing down from the Western Sayans into the Angara is called the Ok-hem meaning "an arrow-river" by the Soyots of the Oka River basin. They live dispersed among the Buryats and now speak the Buryat language.
  • 1.8K
  • 04 Oct 2022
Topic Review
Desmosomal Genes
Desmosomes are mirroring, transmembrane protein chains that connect the intermediate filament networks of neighbouring cells. Each chain continuously (dis)assembles due to the turnover of five desmosomal protein types: desmoplakin, plakoglobin, plakophilins, desmocollins and desmogleins. The expression of two genes is critical to the formation of all desmosomes: namely DSP, encoding two differently spliced desmoplakin proteins (DPI and DPII) and JUP, encoding plakoglobin (PG). Meanwhile, plakophilins, desmocollins and desmogleins are expressed in a tissue-specific manner and are therefore encoded by multiple genes.
  • 1.8K
  • 20 Oct 2022
Topic Review
Private Equity Growth Capital Council
The American Investment Council (AIC), formerly the Private Equity Growth Capital Council (PEGCC), is a lobbying, advocacy, and research organization based in Washington, D.C., that was launched by a consortium of private equity firms in February 2007. It focuses on defending and promoting the private equity and growth capital investment industry to lawmakers and the public at large. Its members include some of the world's largest private equity firms.
  • 1.8K
  • 05 Nov 2022
Topic Review
Particulate Matter Generation and Mitigation in Poultry Houses
Poultry farming plays a key role in agricultural air emissions. Particulate matter (PM) level tends to be high in broiler and cage-free layer houses, that may impair health and welfare of animals and their caretakers. To protect public health and welfare, the occupational exposure limit for PM10 and PM2.5 (i.e., PM diameters that are generally ≤10 and 2.5 μm, respectively) are suggested not to exceed 150 µg m−3 and 35 µg m−3, respectively, based on 24-h concentrations thresholds as suggested by US. EPA. However, the levels of PM10 and PM2.5 in poultry houses could be 100 times higher than that limit. Generally, PM emissions are affected by various factors, including housing types, seasonal and diurnal variation, manure management, bedding materials, ventilation rates, and birds’ activities. High PM concentrations in poultry houses impair birds’ and caretakers’ liver, kidneys, and respiratory systems. Effective mitigation strategies include frequent house cleaning, optimum light intensity, liquid spraying, bedding management, and air filtration systems. However, mitigation strategies can be cost-prohibitive and have side effects. Therefore, poultry farms should select mitigation strategies based on farm location, climate conditions, environmental policies, and available resources (government assistance programs). 
  • 1.8K
  • 29 Nov 2022
Topic Review
Residency
Residency or postgraduate training is specifically a stage of graduate medical education. It refers to a qualified physician (one who holds the degree of MD, DO, MBBS, MBChB), dentist (DDS or DMD) or podiatrist (DPM) who practices medicine, dentistry, or podiatry, respectively, usually in a hospital or clinic, under the direct or indirect supervision of a senior medical clinician registered in that specialty such as an attending physician or consultant. In many jurisdictions, successful completion of such training is a requirement in order to obtain an unrestricted license to practice medicine, and in particular a license to practice a chosen specialty. In the meantime they practice "on" the license of their supervising physician. An individual engaged in such training may be referred to as a resident, registrar or trainee depending on the jurisdiction. Residency training may be followed by fellowship or sub-specialty training. Whereas medical school teaches physicians a broad range of medical knowledge, basic clinical skills, and supervised experience practicing medicine in a variety of fields, medical residency gives in-depth training within a specific branch of medicine.
  • 1.8K
  • 06 Dec 2022
Topic Review
The Useful Antiviral Properties of Lysozyme
Lysozyme, especially the one obtained from hen’s egg white, continues to show new pharmacological properties. Lysozyme can interact with nucleic acids and alter their function, but this effect is uncoupled from the catalytic activity that determines its antibacterial activity; it is present in intact lysozyme but is equally potent in a heat-degraded lysozyme or in a nonapeptide isolated by proteolytic digestion.
  • 1.8K
  • 08 Feb 2024
Topic Review
Fibrosis in Osteoarthritis
Osteoarthritis (OA) is a chronic degenerative joint disease where the main characteristics include cartilage degeneration and synovial membrane inflammation. 
  • 1.8K
  • 25 Jan 2021
Topic Review
Arch-Dams’ Building Risk Reduction
The are thousands of large dams over the globe. The importance of dams is rapidly increasing due to the impact of climate change on increasing hydrological process variability and on water planning and management need. This study tackles a review for the concrete arch-dams’ design process, from a dual sustainability/safety management approach. On one hand, Sustainability is evaluated through a design optimization for dams´ stability and deformation analysis. On the other hand, safety is directly related to the reduction and consequences of failure risk. For that, several scenarios about stability and deformation, identifying desirable and undesirable actions, were estimated. More than 100 specific parameters regarding dam-reservoir-foundation-sediments system and their interactions have been collected. Also, a summary of mathematical modelling was made, and more than 100 references were summarized. The following consecutive steps, required to design engineering (why act), maintenance (when to act) and operations activities (how to act), were evaluated: individuation of hazards, definition of failure potential and estimation of consequences (harm to people, assets and environment). Results show that the area to model the dam–foundation interaction is around 3.0 Hd2, the system-damping ratio and vibration period is 8.5% and 0.39 s. Also, maximum elastic and elasto-plastic displacements are ~0.10–0.20 m. The failure probability for stability is 34%, whereas for deformation it is 29%
  • 1.8K
  • 30 Oct 2020
Topic Review
Carbon Nanotubes
Carbon nanotubes are a quasi-one-dimensional nanomaterial having excellent compatibility with cementitious material. Recently several research carried out utilising different types of Carbon nanotubes (Single wall carbon nanotube, multiwall carbon nanotube, -COOH and -OH functionalised carbon nanotube etc.) to investigate its influences in terms of flowability, microstructure, mechanical, and durability properties. CNT is chemically inert material but addition of small doses of CNTs can significantly improve the mechanical and microstructural properties of concrete/cementitious composites. CNT act as nucleating agents and promote the higher growth of C-S-H. However, improvement of mechanical, microstructural  and durability properties depends on CNTs concentration, physical properties and type of CNTs. 
  • 1.8K
  • 27 Oct 2020
Topic Review
Particle-Bound Mercury Characterization
Particulate Bound Hg (PBM) consists of all airborne particulate containing Hg, including both stable condensed and gaseous forms adsorbed on atmospheric particulate matter (PM); it is operationally sampled and quantified by pulling air through a glass fiber or a quartz filter. PBM usually includes all those particles with a diameter <2.5 μm, even if its characterization depends on the pore size of the filter used for its collection. The accurate dimensional characterization is then essential to estimate the dry deposition of PBM, as well as any other particulate pollutant; the particles diameters directly influence gravitational sedimentation and the PBM residence time in the atmosphere. In addition, PBM chemical speciation, as well as for the other Hg forms, is fundamental to understand PBM bioavailability and therefore the effects on human .
  • 1.8K
  • 05 Jul 2021
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