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Topic Review
Dairy Buffalo Behavior: Calving, Imprinting and Allosuckling
Maternal behavior, in water buffalo and other ruminants, is a set of patterns of a determined species, including calving, imprinting, and suckling. Since the success of dairy farms depends on parturition, lactation, and the welfare of both the dam and the calf, calving behavior in water buffalo is a research area that could help researchers understand this process.
  • 1.8K
  • 18 Nov 2022
Topic Review
Modulation of NOS Isoforms by Dietary Polyphenols
Nitric oxide (NO) plays several key roles in the functionality of an organism, and it is usually released in numerous organs and tissues. There are mainly three isoforms of the enzyme that produce NO starting from the metabolism of arginine, namely endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), and neuronal nitric oxide synthase (nNOS). The expression and activity of these isoforms depends on the activation/deactivation of different signaling pathways at an intracellular level following different physiological and pathological stimuli. Compounds of natural origin such as polyphenols, which are obtainable through diet, have been widely studied in in vivo and in vitro investigations for their ability to induce or inhibit NO release, depending on the tissue. 
  • 1.8K
  • 28 Jan 2023
Topic Review
Application of Iron Nanoparticle-Based Materials in Food Production
Due to their different properties compared to other materials, nanoparticles of iron and iron oxides are increasingly used in the food industry. Food technologists have especially paid attention to their ease of separation by magnetic fields and biocompatibility. Compared to other metallic NPs, iron nanoparticles are widely used. This is determined by such properties as their small size, superparamagnetism and biocompatibility. Iron nanoparticles are used in bioprocessing, tissue engineering and other aspects of modern medicine. There are different oxide forms of iron, such as hematite (α-Fe2O3), maghemite (γ-Fe2O3), FeOH (OH) goethite and magnetite (Fe3O4). The most commonly used crystalline iron oxide structures are maghemite (γ-Fe2O3) and magnetite (Fe3O4). They are used in many fields, including magnetic data storage, pigment production for electrochemistry, contrast production and many others. 
  • 1.8K
  • 31 Jan 2023
Topic Review
MXenes as Electrode Materials for Supercapacitors
MXenes have been considered to be potential building blocks for composites for use in energy storage applications due to their distinctive 2D wafer structure and superior electrical conductivity. MXenes have been combined with multiple active ingredients, including metal oxides and conductive polymers, to produce a synergistic effect. The synthesis method of MXene shows various surface termini and topographies with different energy storage properties, and there have been multiple studies examining surface modification, stoichiometric ratio, and electrode composition control.
  • 1.8K
  • 09 Mar 2023
Topic Review
Extracellular Vesicles Mediated Regulation
Small noncoding RNAs (sRNA) appear to play a key role in extracellular vesicle (EV)-mediated information transfer. Within the vesicular envelope, RNAs are well protected from degradation and can be shuttled between individuals from one and the same species and beyond. Various communication routes have been discovered such as mother-infant-interaction via breast milk, diverse host-pathogen-relations, and dietary uptake of food derived EVs, proving that EV-mediated inter-kingdom regulation is more than a random event.
  • 1.8K
  • 23 Oct 2020
Topic Review
Quiescent Cancer Cells
Quiescent cancer cells (QCCs) are cancer cells that are reversibly suspended in G0 phase with the ability to re-enter the cell cycle and initiate tumor growth, and, ultimately, cancer recurrence and metastasis.
  • 1.8K
  • 23 Mar 2021
Topic Review
TNAP in Central Nervous System
Tissue-nonspecific alkaline phosphatase (TNAP) is an ectoenzyme bound to the plasma membranes of numerous cells via a glycosylphosphatidylinositol (GPI) moiety. TNAP is one of many proteins localized to Brain microvascular endothelial cells (BMECs), and is highly abundant in human and rodent cerebral microvessels [33]. There are four alkaline phosphatase (AP) isoenzymes in humans and they include: TNAP, germ cell alkaline phosphatase (GCAP), intestinal alkaline phosphatase (IAP), and placental alkaline phosphatase (PLAP). Although TNAP is ubiquitous in many tissue, it is most highly expressed in bone, liver, intestine, kidney, and brain, while the three other AP isoenzymes are expressed in the tissues for which they are named. TNAP is also highly expressed in cerebral microvessels.
  • 1.8K
  • 10 Jun 2021
Topic Review
Layer-by-Layer Deposition to Reduce Flammability of Textiles
Layer-by-layer (LbL) deposition is an emerging green technology to reduce flammability of the most widely used fibers (cotton, polyester, polyamide and their blends), which shows numerous advantages over current commercially available textile finishing processes due to the use of water as a solvent for a variety of active substances at very low concentrations. The LbL deposition includes immersing textiles into the solutions of oppositely charged polyelectrolytes or spraying textiles with charged solutions to build LbL assemblies with the desired number of bilayers (BLs), trilayers (TLs), or quadlayers (QLs) with different functionality. In conventional LbL deposition, layers are attracted by weak electrostatic forces of polyelectrolytes soluble in water, polyanions and polycations with one charged group per monomer unit, but polymers bearing hydrogen bond donors and acceptors are also able to form assemblies. 
  • 1.8K
  • 14 Jan 2022
Topic Review
Atlantic Multidecadal Oscillation
The Atlantic Multidecadal Oscillation (AMO), also known as Atlantic Multidecadal Variability (AMV), is a climate cycle that affects the sea surface temperature (SST) of the North Atlantic Ocean based on different modes on multidecadal timescales. While there is some support for this mode in models and in historical observations, controversy exists with regard to its amplitude, and in particular, the attribution of sea surface temperature change to natural or anthropogenic causes, especially in tropical Atlantic areas important for hurricane development. The Atlantic multidecadal oscillation is also connected with shifts in hurricane activity, rainfall patterns and intensity, and changes in fish populations.
  • 1.8K
  • 27 Sep 2022
Topic Review
Uturunku
Uturunku (Quechua for jaguar, Hispanicized spellings Uturunco, Uturuncu) is a dormant volcano in the Cordillera de Lípez in Potosí Department, Bolivia. It is located in the Sur Lípez Province, San Pablo de Lípez Municipality. It is in the Central Volcanic Zone of the Andes, and its highest summit is 6,008 metres (19,711 ft) above sea level. The volcano has two summits, with a fumarole field between them. The volcano's landforms include lava domes and lava flows. The volcano was sporadically active during the Pleistocene, with the most recent eruption dated at 271,000 years ago. Since then, Uturunku has displayed fumarolic activity. Starting in 1992, satellite observations have indicated a large area of regional uplift centered on Uturunku, which has been interpreted as an indication of large-scale magma intrusion under the volcano. This might be a prelude to large-scale volcanic activity, including "supervolcanic" activity and caldera formation.
  • 1.8K
  • 29 Sep 2022
Topic Review
Messerschmitt Me 410
The Messerschmitt Me 410 Hornisse (Hornet) was a German heavy fighter and Schnellbomber used by the Luftwaffe during World War II. Though an incremental improvement of the Me 210, it had a new wing plan, longer fuselage and engines of greater power. The changes were significant enough for the aircraft to be renamed the Me 410.
  • 1.8K
  • 27 Oct 2022
Topic Review
The Lean Blowout Prediction Techniques
The lean blowout is the most critical issue in lean premixed gas turbine combustion. Decades of research into LBO prediction methods have yielded promising results. Predictions can be classified into five categories based on methodology: semi-empirical model, numerical simulation, hybrid, experimental, and data-driven model.
  • 1.8K
  • 30 Nov 2022
Topic Review
Status of Health Estimation Methods
As the backup power supply of power plants and substations, Valve Regulated Lead Acid (VRLA) batteries are the last safety guarantee for the safe and reliable operation of power systems, and the batteries status of health（SOH）directly affects the stability and safety of power system equipment. In recent years, due to the aging and failure of VRLA batteries, some serious safety accidents have been caused, so it is very necessary to accurately evaluate the health of batteries.
  • 1.8K
  • 21 Mar 2023
Topic Review Peer Reviewed
Gamification in Education
Gamification, or gameful design, refers to the strategic application of game design principles, mechanics, and elements into non-game environments. It is often facilitated using digital platforms, aiming to solve problems, increase engagement, and motivate individuals towards their goals. The technique fosters a gameful and interactive experience, enhancing perceived autonomy, competence, and relatedness among users. With roots in fields like education, business, marketing, and services, gamification is a versatile tool that serves to enrich user experience and create value in a multitude of settings. The widespread impact of gamification across various sectors has transformed traditional methods of engagement, notably in education.
  • 1.8K
  • 11 Oct 2023
Topic Review
Endocrine Disrupting Chemicals
Endocrine-disrupting chemicals (EDCs) are exogenous substances able to mimic or to interfere with the endocrine system, thus altering key biological processes such as organ development, reproduction, immunity, metabolism and behavior. High concentrations of EDCs are found in several everyday products including plastic bottles and food containers and they could be easily absorbed by dietary intake. In recent years, considerable interest has been raised regarding the biological effects of EDCs, particularly Bisphenol A (BPA) and phthalates, on human pregnancy and fetal development. Several evidence obtained on in vitro and animal models as well as by epidemiologic and population studies strongly indicated that endocrine disruptors could negatively impact fetal and placental health by interfering with the embryonic developing epigenome, thus establishing disease paths into adulthood. Moreover, EDCs could cause and/or contribute to the onset of severe gestational conditions as Preeclampsia (PE), Fetal Growth Restriction (FGR) and gestational diabetes in pregnancy, as well as obesity, diabetes and cardiovascular complications in reproductive age. Therefore, despite contrasting data being present in the literature, endocrine disruptors must be considered as a therapeutic target. Future actions aimed at reducing or eliminating EDC exposure during the perinatal period are mandatory to guarantee pregnancy success and preserve fetal and adult health.
  • 1.8K
  • 27 Oct 2020
Topic Review
Organoids and Aging
The biology of aging is focused on the identification of novel pathways that regulate the underlying processes of aging to develop interventions aimed at delaying the onset and progression of chronic diseases to extend lifespan. However, the research on the aging field has been conducted mainly in animal models, yeast, Caenorhabditis elegans, and cell cultures. Thus, it is unclear to what extent this knowledge is transferable to humans since they might not reflect the complexity of aging in people. An organoid culture is an in vitro 3D cell-culture technology that reproduces the physiological and cellular composition of the tissues and/or organs. This technology is being used in the cancer field to predict the response of a patient-derived tumor to a certain drug or treatment serving as patient stratification and drug-guidance approaches. Modeling aging with patient-derived organoids has a tremendous potential as a preclinical model tool to discover new biomarkers of aging, to predict adverse outcomes during aging, and to design personalized approaches for the prevention and treatment of aging-related diseases and geriatric syndromes. This could represent a novel approach to study chronological and/or biological aging, paving the way to personalized interventions targeting the biology of aging.
  • 1.8K
  • 19 Oct 2021
Topic Review
Water-Soluble Organic Matter
Inspired by studies on outdoor organic aerosols (OA), recent studies discusses and prioritizes issues related to indoor water-soluble OA and their effects on human health, providing a basis for future research in the field. The following three main topics are addressed: (1) what is known about the origin, mass contribution, and health effects of water-soluble organic matter (WSOM) in outdoor air particles; (2) the current state-of-the-art on the WSOM in indoor air particles, the main challenges and opportunities for its chemical characterization and cytotoxicity evaluation; and (3) why the aerosol WSOM should be considered in future indoor air quality studies.
  • 1.8K
  • 08 Nov 2021
Topic Review
Microsoft Jet Database Engine
The Microsoft Jet Database Engine (also Microsoft JET Engine or simply Jet) is a database engine on which several Microsoft products have been built. The first version of Jet was developed in 1992, consisting of three modules which could be used to manipulate a database. JET stands for Joint Engine Technology. Microsoft Access and Visual Basic use or have used Jet as their underlying database engine. However, it has been superseded for general use, first by Microsoft Desktop Engine (MSDE), then later by SQL Server Express. For larger database needs, Jet databases can be upgraded (or, in Microsoft parlance, "up-sized") to Microsoft's flagship SQL Server database product. A five billion record MS Jet (Red) database with compression and encryption turned on requires about one terabyte of disk storage space. It comprises typically hundreds of *.mdb files.
  • 1.8K
  • 04 Nov 2022
Topic Review
Body Weight and Metabolic Rate Changes in Narcolepsy
Narcolepsy is a known auto-immune disease that presents mainly in the teenage years with irresistible sleep attacks. Patients with narcolepsy, especially NT1, have been found to have a high prevalence of obesity and other metabolic derangements. Compared to controls, patients with narcolepsy are more likely to be obese and have higher BMIs and waist circumferences. According to recent research, weight gain in narcolepsy patients may be higher during the disease's outset. Furthermore, the available data did not show any appreciable alterations in the levels of CSF melanin-concentrating hormone, plasma and CSF leptin, or serum growth hormone in relation to weight gain. Other mechanisms have been proposed, including a reduction in sympathetic tone, hormonal changes, changes in eating behavior and physical activity, and genetic predisposition. The association between increased body mass index and narcolepsy is well-recognized; the relationship between narcolepsy and other metabolic measures, such as body fat/muscle distribution and metabolic rate independent of BMI, is not well documented, and the available evidence is inconsistent. Future longitudinal studies with larger sample sizes are needed to assess BMR in patients with narcolepsy under a standard protocol at the outset of narcolepsy, with regular follow-up.
  • 1.8K
  • 01 Dec 2022
Topic Review
Secondary Metabolites Based-Plant Origin
Natural products are compounds produced by living organisms and can be divided into two main categories: primary (PMs) and secondary metabolites (SMs). Plant PMs are crucial for plant growth and reproduction since they are directly involved in living cell processes, whereas plant SMs are organic substances directly involved in plant defense and resistance. SMs are divided into three main groups: terpenoids, phenolics and nitrogen-containing compounds. The SMs contain a variety of biological capabilities that can be used as flavoring agents, food additives, plant-disease control, strengthen plant defenses against herbivores and, additionally, it can help plant cells to be better adapted to the physiological stress response. 
  • 1.8K
  • 28 Feb 2023
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