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Topic Review
Flavivirus Infection
The flaviviruses are important human pathogens, and a deeper understanding of the virus–host cell interaction is required to identify cellular targets that can be used as therapeutic candidates. Flaviviruses hijack several cellular functions, such as exosome-mediated cell communication during infection, which is modulated by the delivery of the exosomal cargo of pro- or antiviral molecules to the receiving host cells. Therefore, to study the role of exosomes during flavivirus infections is essential to identify molecular factors that may contribute to the development of new strategies to block viral infections. This review explores the implications of exosomes in flavivirus dissemination and transmission from the vector to human host cells, as well as their involvement in the host immune response. Although several studies have been performed to identify and characterize cellular and viral molecules released in exosomes, the role of these components in viral pathogenesis is unclear. Further studies will determine the balance between protective and harmful exosomes secreted by flavivirus infected cells, the characteristics and components that distinguish them both, and how they could be a factor that determines the infection outcome.
  • 1.8K
  • 29 Jul 2020
Topic Review
Cross-Sectoral Digital Platform and Innovation Ecosystem Development
A cross-sectoral ecosystem is considered to be a mechanism for the cross-sectoral interaction of an unlimited number of actors of a certain technological sector of the economy in a platform-based single digital circuit that provides digital tools and services to ensure accelerated growth and reduce costs through synergy from multilateral interaction based on common rules and principles of self-government, digital transparency, networking, and equality for all participants.
  • 1.8K
  • 12 Nov 2021
Topic Review
Olive Oil Industry and Related Waste Management
The production of olive oil involves the sustainable management of the waste produced along the entire production chain. This entry examines the developments regarding cultivation techniques, production technologies, and waste management, highlighting the goals to be achieved and the most reasonable prospects. 
  • 1.8K
  • 19 Jan 2022
Topic Review
Coastal Motor Boat
During the First World War, following a suggestion from three junior officers of the Harwich destroyer force that small motor boats carrying a torpedo might be capable of travelling over the protective minefields and attacking ships of the Imperial German Navy at anchor in their bases, the Admiralty gave tentative approval to the idea and, in the summer of 1915, produced a Staff Requirement requesting designs for a Coastal Motor Boat for service in the North Sea. These boats were expected to have a high speed, making use of the lightweight and powerful petrol engines then available. The speed of the boat when fully loaded was to be at least 30 knots (56 km/h) and sufficient fuel was to be carried to give a considerable radius of action. They were to be armed in a variety of ways, with torpedoes, depth charges or for laying mines. Secondary armament would have been provided by light machine guns, such as the Lewis gun. The weight of a fully loaded boat, complete with 18-inch (450 mm) torpedo, was to not exceed the weight of the 30-foot (9.1 m) long motor boat then carried in the davits of a light cruiser, i.e. 4.5 tons. The CMBs were designed by Thornycroft, who had experience in small fast boats. Engines were not proper maritime internal combustion engines (as these were in short supply) but adapted aircraft engines from firms such as Sunbeam and Napier.
  • 1.8K
  • 10 Oct 2022
Topic Review
Physical Layer Authentication in Wireless Networks
The physical layer security of wireless networks is becoming increasingly important because of the rapid development of wireless communications and the increasing security threats. In addition, because of the open nature of the wireless channel, authentication is a critical issue in wireless communications. Physical layer authentication (PLA) is based on distinctive features to provide information-theory security and low complexity.
  • 1.8K
  • 15 Mar 2023
Topic Review
Recent Advances of Wearable Sweat-Sensing Devices
A sweat-sensing device requires a wearable device for the temporary attachment of its main components, including sensors, sweat collection devices, and electronic devices to the body’s skin region.
  • 1.8K
  • 21 Oct 2022
Topic Review
Beta2-Microglobulin
Beta2-microglobulin (B2M) is a key component of major histocompatibility complex class I molecules, which aid cytotoxic T-lymphocyte (CTL) immune response. B2M also plays an important role in innate defense and does not only function as an adjuvant for CTL response. 
  • 1.8K
  • 26 Jul 2021
Topic Review
Sustainable Supplier Selection and Criteria
Sustainable supplier selection (SSS) is gaining popularity as a practical method to supply chain sustainability among academics and practitioners. In addition to balancing economic, social, and environmental factors, the emergence of the COVID-19 pandemic has affected the selection of long-term suppliers to ensure sustainable supply chains, recover better from the pandemic and effectively respond to any future unprecedented crises.
  • 1.8K
  • 23 May 2022
Topic Review
Fluorescent Probes in Cellulo Recognitions of Alkaline Phosphatases
Alkaline phosphatase (ALP) is one of the vital phospho-ester bond cleaving biocatalysts that has inevitable significance in cellular systems, viz., early-stage osteoblast differentiation, cell integrity in tissues, bone mineralization, cancer biomarker, liver dysfunction, cellular osmotic pressure, protein folding and many more. Variation from optimal levels of ALP in intra and extracellular fluids can cause severe diseases, including death. Due to these reasons, ALP is considered as a vital biomarker for various preclinical and medical diagnosis. Fluorescence image-based diagnosis is the most widely used method, owing to its simplicity, robustness, non-invasive properties and excellent spatio-temporal resolution (up to the nM/pM level), as compared to conventional analytical techniques, such as the electroanalytical method, nuclear magnetic resonance (NMR) and high-performance liquid chromatography (HPLC). Most of the reviews reported for ALP’s recognition in the literature scarcely explain the structurally related, photophysical and biophysical parameters; and the sub-cellular localizations. Considering these facts, in order to enhance the opto-analytical parameters of fluorescence-based diagnostic materials at the cellular level, herein we have systematically documented recent developments in the opto-analytical capabilities of quencher-free probes for ALP, used in in vitro (biological buffers) to in cellulo conditions, along with in vivo models. 
  • 1.8K
  • 03 Sep 2022
Topic Review
Suwa Daimyōjin Ekotoba
The Suwa Daimyōjin Ekotoba (諏方大明神画詞 or 諏訪大明神絵詞 "Illustrated Record of Suwa Daimyōjin (Shrine)"), also known as Suwa Daimyōjin Go-engi Shidai (諏訪大明神御縁起次第 "Order of Legends (Engi) of Suwa Daimyōjin (Shrine)") or Suwa(-sha) Engi Emaki (諏方(社)縁起絵巻 "Illustrated Legends of Suwa (Shrine)"), was a twelve (originally ten) volume set of emakimono or painted handscrolls completed in 1356 (Enbun 1), during the Nanboku-chō period. Originally describing and depicting legends concerning the Suwa Grand Shrine in Shinano Province (modern-day Nagano Prefecture) and its deity as well as its various religious festivals as performed during the Middle Ages, the original scrolls containing the illustrations were eventually lost, with only the text being preserved in various manuscripts.
  • 1.8K
  • 20 Oct 2022
Topic Review
Mitigating Shuttle Effect in Lithium–Sulfur Batteries by Separators
Lithium–sulfur (Li-S) batteries are considered one of the most promising energy storage systems due to their high theoretical capacity, high theoretical capacity density, and low cost. However, challenges such as poor conductivity of sulfur (S) elements in active materials, the “shuttle effect” caused by lithium polysulfide, and the growth of lithium dendrites impede the commercial development of Li-S batteries. As a crucial component of the battery, the separator plays a vital role in mitigating the shuttle effect caused by polysulfide. Traditional polypropylene, polyethylene, and polyimide separators are constrained by their inherent limitations, rendering them unsuitable for direct application in lithium–sulfur batteries. Therefore, there is an urgent need for the development of novel separators. 
  • 1.8K
  • 19 Dec 2023
Topic Review
Exploration and Use of Lithium in Oman
Oman has huge potential for lithium exploitation and production, considering the enormous quantities of spodumene and seawater salt with high-grade lithium available, developing efficient regulations and rules to protect investors’ rights, and reducing the environmental risks associated with the production and recycling of lithium-ion batteries. 
  • 1.8K
  • 29 Jan 2024
Topic Review
White-tailed Mongoose
The White-tailed Mongoose (Ichneumia albicauda) is a captivating carnivorous mammal native to the African continent, distinguished by its striking white-tipped tail and sleek, slender physique. Inhabiting a variety of habitats, from woodlands to grasslands, this elusive mongoose species plays a vital role in the ecosystems it calls home.
  • 1.8K
  • 04 Feb 2024
Topic Review
Salt in Low Back Pain and Comorbid Conditions
Low back pain is the world’s leading disability, but the etiology of the majority of low back pain is non-specific with no known cause. Moreover, overuse of opioids to treat low back pain is a widespread problem. Many global populations consume excess sodium chloride, which can lead to fluid overload in hypervolemia, and cause swelling and temporary weight gain associated with low back pain. Numerous conditions comorbid with low back pain are also potentially mediated by excessive salt intake, including migraine headache, hypertension, cardiovascular disease, venous thromboembolism, liver disease, respiratory disorders, chronic kidney disease, pregnancy complications, and multiple sclerosis.
  • 1.8K
  • 14 Mar 2024
Topic Review
Vascular Endothelial Glycocalyx
Vascular endothelial cells are a monolayer of cells that comprise the innermost layer of cells in the vascular system, including arteries, veins, and capillaries, and serve a barrier function for the blood vessels surrounding all organs and in direct contact with the blood flowing through the vascular lumen.
  • 1.8K
  • 30 Dec 2020
Topic Review
Mitochondrial Uncoupling Proteins
The accumulation of oxidative damage to DNA and other biomolecules done by reactive oxygen species (ROS) plays an important role in the etiology of aging and age-related diseases such as type 2 diabetes mellitus (T2D), atherosclerosis, and neurodegenerative disorders. Mitochondrial DNA (mtDNA) is especially sensitive to oxidative stress. Mitochondrial dysfunction resulting from the accumulation of mtDNA damage impairs normal cellular function and leads to a bioenergetic crisis that accelerates aging and associated diseases.
  • 1.8K
  • 09 Aug 2022
Topic Review
Remote Sensing Data Fusion
With the growth of satellite and airborne-based platforms, remote sensing is increasing attention in the last decades. Everyday, sensors acquire data with different modalities and several resolutions. Leveraging on their complementary properties is a key scientific challenge, usually called remote sensing data fusion.
  • 1.8K
  • 22 Feb 2021
Topic Review
Aesthetical Evaluation with Stochastic Analysis
Stochastic calculus is used for the objective evaluation of the variability present in aesthetic attributes of paintings and landscapes.
  • 1.8K
  • 24 Nov 2020
Topic Review
Very Low-Calorie Ketogenic Diet for Hypercortisolism Comorbidities Treatment
A very low-calorie ketogenic diet (VLCKD) is characterized by low daily caloric intake (less than 800 kcal/day), low carbohydrate intake (<50 g/day) and normoproteic (1–1.5 g of protein/kg of ideal body weight) contents. It induces a significant weight loss and an improvement in lipid parameters, blood pressure, glycaemic indices and insulin sensitivity in patients with obesity and type 2 diabetes mellitus. Cushing’s syndrome (CS) is characterized by an endogenous or exogenous excess of glucocorticoids and shows many comorbidities including cardiovascular disease, obesity, type 2 diabetes mellitus and lipid disorders. 
  • 1.8K
  • 22 Jun 2022
Topic Review
Relativizer
In linguistics, a relativizer (abbreviated REL) is a type of conjunction that introduces a relative clause. For example, in English, the conjunction that may be considered a relativizer in a sentence such as "I have one that you can use." Relativizers do not appear, at least overtly, in all languages; even in languages that do have overt or pronounced relativizers, they do not necessarily appear all of the time. For these reasons it has been suggested that in some cases, a "zero relativizer" may be present, meaning that a relativizer is implied in the grammar but is not actually realized in speech or writing. For example, the word that can be omitted in the above English example, producing "I have one you can use", using (on this analysis) a zero relativizer.
  • 1.8K
  • 09 Oct 2022
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