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Topic Review
International Space Station Maintenance
Since construction started, the International Space Station (ISS) programme has had to deal with several maintenance issues, unexpected problems and failures. These incidents have affected the assembly timeline, led to periods of reduced capabilities of the station and in some cases could have forced the crew to abandon the space station for safety reasons, had these problems not been resolved.
  • 2.0K
  • 02 Nov 2022
Topic Review
Blackbird
Blackbird (formerly named FORscene) is an integrated internet video platform, video editing software, covering non-linear editing and publishing for broadcast, web and mobile. Designed by Blackbird plc to allow collaborative editing of video at resolutions of up to 540p and up to 60 frames per second on bandwidths as low as 2MBit/s, it is capable of video logging, reviewing, publishing and hosting through HD and 4K to UHD quality from original sources. The system is implemented as a mobile app for Android and iOS devices, a Java applet and a pure JavaScript web application as part of its user interface. The latter runs on platforms without application installation, codec installation, or machine configuration and has Web 2.0 features. Blackbird won the Royal Television Society's award for Technology in the post-production process in December 2005.
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  • 02 Nov 2022
Topic Review
Gene Disease Database
In bioinformatics, a Gene Disease Database is a systematized collection of data, typically structured to model aspects of reality, in a way to comprehend the underlying mechanisms of complex diseases, by understanding multiple composite interactions between phenotype-genotype relationships and gene-disease mechanisms. Gene Disease Databases integrate human gene-disease associations from various expert curated databases and text mining derived associations including Mendelian, complex and environmental diseases.
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  • 21 Nov 2022
Topic Review
Construction Risks Due to Fast-Track Activity Overlapping
Concurrent engineering through overlapping of activities (i.e., fast-tracking) has been used as a schedule acceleration technique. Fast-track construction projects are generally recognized as riskier and subject to risks arising due to the concurrency of work.
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  • 01 Dec 2023
Topic Review
Electrochemical Glucose Sensors Based on 2D Materials
Diabetes is a health disorder that necessitates constant blood glucose monitoring. The industry is always interested in creating novel glucose sensor devices because of the great demand for low-cost, quick, and precise means of monitoring blood glucose levels. Electrochemical glucose sensors, among others, have been developed and are now frequently used in clinical research. Nonetheless, despite the substantial obstacles, these electrochemical glucose sensors face numerous challenges. Because of their excellent stability, vast surface area, and low cost, various types of 2D materials have been employed to produce enzymatic and nonenzymatic glucose sensing applications. 
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  • 11 Jul 2022
Topic Review
Multi-Addressed Fiber Bragg Structures
The entry presents the concept of Multi-Addressed Fiber Bragg Structures (MAFBS) and their usage in Microwave Photonic Sensor Systems (MPSS). The theory of MAFBS is the logical evolution of the theory of Addressed Fiber Bragg Structures (AFBS), which implement a microwave-photonic tecnique for their interrogation. The MAFBS is a special type of Fiber Bragg Grating (FBG), the reflection spectrum of which has three (or more) narrow notches. The frequencies of narrow notches are located in infrared range of electromagnetic spectrum, while differences between them – in microwave frequency range. All cross-differences between optical frequencies of single MAFBS are called address frequencies set. When the additive optical response from a single MAFBS, passing through optical filter with oblique frequency response, is received by a photodetector, the complex electrical signal, which consists of all cross-frequency beatings of all optical frequencies, is taken at its output. This complex electrical signal at the photodetector’s output contains enough information to determine the central frequency shift of the MAFBS.
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  • 29 Oct 2020
Topic Review
Skeletal Muscle
Skeletal muscle is composed of multinucleated, mature muscle cells (myofibers) responsible for contraction, and a resident pool of mononucleated muscle cell precursors (MCPs), that are maintained in a quiescent state in homeostatic conditions. Skeletal muscle is remarkable in its ability to adapt to mechanical constraints, a property referred as muscle plasticity and mediated by both MCPs and myofibers. This review summarizes recent insights into the mechanisms underlying nuclear force transmission in MCPs and myofibers. 
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  • 11 Oct 2021
Topic Review
Interactions of SARS-CoV-2 & Variants with Cellular Components
Given the global scale of the COVID-19 pandemic and the health emergency it has caused, it is crucial to understand the impact of SARS-CoV-2 and its mutations. Here, we comprehensively review SARS-CoV-2 interactions with host cells, describe SARS-CoV-2 variants, assess impact of their protein mutations and enumerate databases with SARS-CoV-2 host-pathogen interaction data. 
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  • 24 Nov 2021
Topic Review
Anabolic Steroids and COVID-19 Infection
Anabolic androgenic steroids (AASs) are synthetic analogs of testosterone that can affect the immune system. Bodybuilders and sportsmen are at risk of abusing AASs. The findings suggest that the use of AASs could be an underlying risk factor for COVID-19 severity. 
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  • 21 Jan 2022
Topic Review
Helicobacter Pylori-Induced Gastric Infections
Helicobacter pylori is the first formally recognized bacterial carcinogen and the most important single digestive pathogen responsible for the induction of gastroduodenal diseases such as gastritis, peptic ulcer, and, finally, gastric neoplasia. The recently reported high rates of antimicrobial drug resistance hamper the current therapies of H. pylori, with therapeutic failure reaching up to 40% of patients.
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  • 27 Jul 2022
Topic Review
Finn River (County Fermanagh and County Monaghan)
The Finn River (Irish: An Fhinn or Abhainn na Finne), also known as the River Finn, is a small river that flows through parts of County Fermanagh and County Monaghan in the south of Ulster, the northern province in Ireland. Part of the river forms the boundary between County Fermanagh and County Monaghan, thus forming a short part of the border between Northern Ireland and the Republic of Ireland. Two very short stretches of the river, just north of Redhills and at Castle Saunderson, near Belturbet, also form part of the boundary between County Fermanagh and County Cavan. Parts of the river flow entirely within County Fermanagh, while other parts of the river flow entirely within County Monaghan. The Finn River should not be confused with the better known and much longer River Finn in County Donegal in the west of Ulster. The Finn River rises on the slopes of Slieve Beagh in the south-east of County Fermanagh, rising to the north of Roslea, a village also located in south-east Fermanagh. It initially flows in a southerly direction, meandering around both Rough Hill and Gola, two neighbouring townlands in the north-west of County Monaghan that are a short distance north-east of Roslea. The river then flows back into Fermanagh, skirting around the north-western, western and southern edges of Roslea and along the western edge of Spring Grove Forest, crossing back into County Monaghan beside New Bridge. At a place between New Bridge and Aghafin House, the river meanders around a sharp bend, flowing in a south-easterly direction for almost two miles, entirely within County Monaghan, between the townland of Aghafin, just north-east of Clones, and the townland of Nook, just south-east of Stonebridge. Thereafter, the river mainly flows in a south-westerly direction, all the way to its mouth on Upper Lough Erne. The river flows through Stonebridge and Analore, two hamlets in West Monaghan. It flows very close to Ballynure House, a now ruined Late Georgian residence just outside Analore. The Finn flows to the east, and then to the south, of Clones, the main town in West Monaghan. The river flows just to the north and north-west of the Hilton Park Demesne, near the village of Scotshouse, also in West Monaghan. The Finn flows through Wattlebridge, a hamlet in the south-east of County Fermanagh, then enters Upper Lough Erne nearby, entering the lough directly opposite Derrykerrib (Irish: Doire Ceirbe), an island and townland also in the south-east of County Fermanagh. The river flows into a narrow channel of the lough at this place, where the townland of Edergool in County Fermanagh meets the townland of Castlesaunderson Demesne, where Castle Saunderson is located, in County Cavan. Thus, half of the river's mouth is in County Fermanagh, while the other half is in County Cavan. The river's mouth, which is at the edge of the Castle Saunderson Demesne, is also very near the Lanesborough Demesne, a former demesne in the townland of Quivvy on the County Cavan shore of Upper Lough Erne. The Lanesborough Demesne, near Belturbet, is directly opposite the north-western shore of Derrykerrib Island. Traditionally, the Finn River was considered navigable for most of the year by certain types of river boat, from its mouth upstream as far as Cumber Bridge in the townland of Coolnalong (Irish: Cúil na Long), a bridge located between Scotshouse and Clones. The river meanders significantly throughout most of its course.
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  • 06 Oct 2022
Topic Review
Ryu-Takayanagi Conjecture
The Ryu-Takayanagi conjecture is a conjecture within holography that posits a quantitative relationship between the entanglement entropy of a conformal field theory and the geometry of an associated Anti-de Sitter spacetime . The formula characterizes "holographic screens" in the bulk; that is, it specifies which regions of the bulk geometry are "responsible to particular information in the dual CFT". The conjecture is named after Shinsei Ryu and Tadashi Takayanagi, who jointly published the result in 2006. As a result, the authors were awarded the 2015 New Horizons in Physics Prize for "fundamental ideas about entropy in quantum field theory and quantum gravity". The formula was generalized to a covariant form in 2007.
  • 2.0K
  • 12 Oct 2022
Topic Review
Nitrogenase
Nitrogenase defines the familty of enzymes that catalyze the reduction of N2 (molecular nitrogen) to NH3 (ammonia). It is the only enzyme family which can realize this process of nitrogen fization. 
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  • 19 Feb 2021
Topic Review
Drives of Urban Village Redevelopment
Urban village redevelopment generally refers to the demolition and rehabilitation of urban village buildings, involving several complicated processes, including urban space rebuilding, land ownership transformation, land value increment, and spatial benefit redistribution, which have attracted serious attention from the academic community in the past decades. At least three main processes from demand, supply and state interventions perspectives have driven urban village redevelopment in China.
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  • 21 Apr 2022
Topic Review
Dietary Recommendations for Twin Pregnancy
Recommendations for nutrition and the use of dietary supplements for pregnant women are updated on regular basis but it remains to be seen to what extent they may be applicable in twin pregnancies. Over the past 30 years, there has been a considerable increase in the number of multiple pregnancies worldwide, which mainly applies to dizygotic pregnancies. In the USA, in 2009 compared to the 1980s, the number of twin pregnancies increased by 76%; the situation was similar in Australia (66%). A multiple pregnancy is associated with an increased risk of its abnormal course. This mostly applies to pre-eclampsia, hypertension, diabetes, iron-deficiency anemia and pre-term birth that affects 50–60% of twin pregnancies. 
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  • 26 Apr 2022
Topic Review
Adenosine-to-Inosine RNA Editing
Adenosine-to-inosine RNA editing is a system of post-transcriptional modification widely distributed in metazoans which is catalyzed by ADAR enzymes and occurs mostly in double-stranded RNA (dsRNA) before splicing. This type of RNA editing changes the genetic code, as inosine generally pairs with cytosine in contrast to adenosine, and this expectably modulates RNA splicing.
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  • 20 May 2022
Topic Review
Quartz Crystal Microbalances' Electrode Shape and Mass Sensitivity
A quartz crystal microbalance (QCM) is a typical acoustic transducer that undergoes a frequency shift due to changes in the mass of its surface. Its high sensitivity, robustness, small size design, and digital output have led to its widespread development for application in the fields of chemistry, physics, biology, medicine, and surface science. Mass sensitivity is one of the vital parameters and forms the basis for quantitative analysis using QCMs.
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  • 13 Jul 2022
Topic Review
HA Filler-Induced Vascular Occlusion
Biocompatible hyaluronic acid (HA, hyaluronan) gel implants have altered the therapeutic landscape of surgery and medicine, fostering an array of innovative products that include viscosurgical aids, synovial supplements, and drug-eluting nanomaterials. However, it is perhaps the explosive growth in the cosmetic applications of injectable dermal fillers that has captured the brightest spotlight, emerging as the dominant modality in plastic surgery and aesthetic medicine. The popularity surge with which injectable HA fillers have risen to in vogue status has also brought a concomitant increase in the incidence of once-rare iatrogenic vaso-occlusive injuries ranging from disfiguring facial skin necrosis to disabling neuro-ophthalmological sequelae. As researchers' understanding of the pathophysiology of these injuries has evolved, supplemented by more than a century of astute observations, the formulation of novel therapeutic and preventative strategies has permitted the amelioration of this burdensome complication.
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  • 07 Sep 2022
Topic Review
Perspective Projection Distortion
This page is about graphical perspective projection, specifically about distortion Perspective projection distortion is the mechanism that permits a draftsman or artist to produce linear perspective. It is accomplished by a geometric protocol that exhibits the inevitable distortion of three-dimensional space when “projected," i.e., drawn, on a two-dimensional surface. The words projected/projection here refer to the use of graphics’ lines in the protocol to simulate light ray traces from a Station Point (a supposed observer´s location) to the edges and corners of an object in space, creating thereby or by their extension, an image at the lines’ points of intersection with a Projection Plane. No type of projection can perfectly map the imagery of three dimensional space onto a projection plane because of the image's (mapped on the retina-sphere) undevelopability. This is a distortion of the drawing in itself called perspective projection distortion, and refers to the difference between the drawing and the way the objects depicted on it would look if it was real, but there is another distortion caused by the difference between the location of the supposed observer situated for the drawing process and the location of the real observer of the drawing. These two distortions exist simultaneously. In the special case — and the only instance — in which perspective imagery appears affected only by the perspective projection distortion, the real observer must view the perspective imagery from precisely the supposed station point of the perspective. Real human vision and perspective projection should (unless it is otherwise desired) look the same. The difference should be imperceptible. The base to rate the quality of the perspective projection is the real vision and the difference between them is the perspective projection distortion. Normal human vision should not be considered to present any distortion unless a disturbing factor is involved. Distortion in human vision appears when there is a visual problem involved. The use of lenses can also cause, modify or avoid these distortions. In photography a lens may magnify distortion.
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  • 21 Oct 2022
Topic Review
Demand Side Management
Demand Side Management (DSM) is a cost-effective approach to managing electricity networks, aimed at reducing capacity requirements and costs, increasing the penetration of renewable generation, and reducing power system emissions.
  • 2.0K
  • 20 Jul 2023
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