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Topic Review
Electric Mobility in Portugal
In recent years, the growing concern for air quality has led to the development of sustainable vehicles to replace conventional internal combustion engine (ICE) vehicles. Currently, the most widespread technology in Europe and Portugal is that of Battery Electric Vehicles (BEV) or plug-in HEV (PHEV) electric cars, but hydrogen-based transport has also shown significant growth in the commercialization of Fuel Cell Electric Vehicles (FCEV) and in the development of new infrastructural schemes. In the current panorama of EV, particular attention should be paid to hydrogen technology, i.e., FCEVs, which is potentially a valid alternative to BEVs and can also be hybrid (FCHEV) and plug-in hybrid (FCPHEV). Several sources cited show a positive trend of hydrogen in the transport sector, identifying a growing trend in the expansion of hydrogen infrastructure, although at this time, it is still at an early stage of development
  • 2.0K
  • 06 Dec 2021
Topic Review
Tumor Lysis Syndrome
Tumor lysis syndrome (TLS) is a common cause of acute kidney injury in patients with malignancies, and it is a frequent condition for which the nephrologist is consulted in the case of the hospitalized oncological patient. Recognizing the patients at risk of developing TLS is essential, and so is the prophylactic treatment. The initiation of treatment for TLS is a medical emergency that must be addressed in a multidisciplinary team (oncologist, nephrologist, critical care physician) in order to reduce the risk of death and that of chronic renal impairment. TLS can occur spontaneously in the case of high tumor burden or may be caused by the initiation of highly efficient anti-tumor therapies, such as chemotherapy, radiation therapy, dexamethasone, monoclonal antibodies, CAR-T therapy, or hematopoietic stem cell transplantation. It is caused by lysis of tumor cells and the release of cellular components in the circulation, resulting in electrolytes and metabolic disturbances that can lead to organ dysfunction and even death. 
  • 2.0K
  • 08 Aug 2022
Topic Review
Biomedical Applications of Metal Organic Frameworks
Metal-organic frameworks (MOFs) , or metal-organic frameworks, are a new form of a porous coordination polymer. Novel materials have been developed because of technological advancements combined with material research. MOFs technology has been investigated for biomedical applications in this line. 
  • 2.0K
  • 14 Nov 2022
Topic Review
Chartered Institute of Personnel and Development
The Chartered Institute of Personnel and Development (CIPD) is a professional association for human resource management professionals. It is headquartered in Wimbledon, London, England. The organisation was founded in 1913 - it is the world's oldest association in its field and has over 145,000 members internationally working across private, public and voluntary sectors. Peter Cheese was announced in June 2012 as CIPD's new CEO from July 2012.
  • 2.0K
  • 21 Nov 2022
Topic Review
A Thermo-Catalytic Pyrolysis of Polystyrene Waste Review
Global polystyrene (PS) production has been influenced by the lightness and heat resistance this material offers in different applications, such as construction and packaging. However, population growth and the lack of PS recycling lead to a large waste generation, affecting the environment. Pyrolysis has been recognized as an effective recycling method, converting PS waste into valuable products in the chemical industry. The conversion of PS into a liquid with high aromatic content (84.75% of styrene) can be achieved by pyrolysis. In addition, PS favors the production of liquid fuel when subjected to co-pyrolysis with biomass, improving its properties such as viscosity and energy content. 
  • 2.0K
  • 12 Apr 2023
Topic Review
Photodynamic Therapy: Principles and Reaction Mechanisms
Photodynamic therapy (PDT) is a two-stage treatment that implies the use of light energy, oxygen, and light-activated compounds (photosensitizers) to elicit cancerous and precancerous cell death after light activation (phototoxicity). The biophysical, bioengineering aspects and its combinations with other strategies are highlighted herein, both conceptually and as they are currently applied clinically. Advancements of PDT with the use of nanotechnology are further explored, including quantum dots as innovative photosensitizers or energy donors as well as the combination of PDT with radiotherapy and immunotherapy as future promising cancer treatments. Finally, the potential significance of organoids as physiologically relevant models for PDT has been emphasized.
  • 2.0K
  • 26 Jan 2024
Topic Review
Articular Cartilage
Articular cartilage is a load-bearing connective tissue that has a low self-repair potential. There are high demands placed on articular hyaline cartilage in the organism, mainly mechanical flexibility, load-bearing capacity, and the ability to reduce friction. The function of the cartilage in joints is to ensure low friction and the ability to distribute the weight load acting in the joint. An articular cartilage defect can persist without healing, or if it extends into the blood-filled subchondrium, then it is replaced by cartilage tissue that does not have suitable strength properties.
  • 2.0K
  • 17 Jan 2024
Topic Review
Montology
"Montology" is the holistic, integrative and transdisciplinary science of mountains, inclusive of physical, social, theoretical and empirical disciplines, as well as humanities and arts associated with mountainscapes.
  • 2.0K
  • 29 Oct 2020
Topic Review
Botrytis Cnerea and Powdery Mildew
Synthetic controls of crop pathogens are increasingly associated with harm to the environment and human health, and pathogen resistance. Pesticide residues in crops can also act as non-tariff trade barriers. There is therefore a strong imperative to develop biologically based and natural product (NP) biofungicides as more sustainable alternatives for crop pathogen control. We demonstrate the field efficacy, over multiple seasons, of NP biofungicides, NP1 (based on anhydrous milk fat) and NP2 (based on soybean oil), on two major diseases of winegrapes—Botrytis bunch rot (Botrytis) and powdery mildew (PM). The NPs were integrated into a season-long integrated disease management programme that has produced chemical-residue-free wines. Efficacies for Botrytis control on three different varieties were: 63–97% on Chardonnay, 0–96% for Sauvignon Blanc and 46–58% on Riesling; with 65–98% PM control on Chardonnay and Riesling. NP2 exhibited the significant control of Botrytis latent infections, making it a viable alternative to mid-season synthetic fungicides. Disease control was significantly better than the untreated control and usually as efficacious as the synthetic fungicide treatment(s). Yields and wine quality in NP-treated crops were normally equivalent to those in the synthetic fungicide treatments. The results indicate that NP-mediated disease control of Botrytis and powdery mildew can be obtained in the vineyard, without synthetic fungicide input.
  • 2.0K
  • 12 Mar 2021
Topic Review
Lipid-Based Nanoparticles for Encapsulation of Anticancer Alkaloids
Alkaloids are natural products that possess numerous pharmacological activities and have been exploited effectively to treat cancer. However, the clinically approved anticancer alkaloids are generally limited by serious side effects due to their lack of specificity to cancer cells, indiscriminate tissue distribution and toxic formulation excipients. Lipid-based nanoparticles represent the most effective drug delivery system concerning clinical translation owing to their unique appealing characteristics for drug delivery.
  • 2.0K
  • 11 Nov 2021
Topic Review
Ultrasound in Medial Epicondylalgia and Medial Elbow Pain
Medial epicondylalgia (ME), commonly known as “the golfer’s elbow”, typically develops in individuals who perform repetitive forearm movements and weight-bearing activities. It accounts for up to 20% of all epicondylitis cases and is most prevalent in particular sports and occupations.
  • 2.0K
  • 18 Aug 2022
Topic Review
Kapala
A kapala (Sanskrit for "skull") or skullcup is a cup made from a human skull and used as a ritual implement (bowl) in both Hindu Tantra and Buddhist Tantra (Vajrayana). Especially in Tibet, they are often carved or elaborately mounted with precious metals and jewels.
  • 2.0K
  • 14 Nov 2022
Topic Review
Telecollaboration
Virtual exchange is a type of education program that uses technology to allow geographically-separated people to interact and communicate. This type of activity is most often situated in educational programs (but is also found in some youth organizations) in order to increase mutual understanding, global citizenship, digital literacies, and language learning. Models of virtual exchange are also known as telecollaboration, online intercultural exchange, globally networked teaching and learning, collaborative online international learning (COIL). Non-profit organizations such as Soliya (founded by Lucas Welch) and the Sharing Perspectives Foundation have designed and implement virtual exchange programs in partnership with universities and youth organizations. In 2017 the European Commission published a feasibility study into virtual exchange and in 2018 the Erasmus+ Virtual Exchange project was launched in Europe and Southern Mediterranean countries. Educational institutions such as State University of New York's COIL Center and DePaul University use virtual exchange in higher education curricula to connect young people globally with a primary mission to help them grow in their understanding of each other's contexts (society, government, education, religion, environment, gender issues, etc.).
  • 2.0K
  • 25 Nov 2022
Topic Review
Peptide Hormones
Small peptides are important signaling molecules that coordinate comprehensive intercellular communication in numerous aspects of developmental processes in plants.
  • 2.0K
  • 08 Jan 2021
Topic Review
Mass Spectrometry Imaging
Mass spectrometry imaging (MSI) or imaging mass spectrometry (IMS) is a promising analytical method to determine and visualize the spatial distribution of specific chemical compositions by their molecular weights or m/z values. MSI is basically a two-dimensional analysis method that can detect intact molecules within tissues or tissue sections without necessitating extraction, purification, and separation.
  • 2.0K
  • 30 Oct 2020
Topic Review
C Dynamics in Mangrove Forests
Mangrove forest is an important coastal ecosystems for blue carbon. Thus, understanding the carbon dynamic in mangrove forests will help the management the ecosystem with climate changes. many research studies have been quantified the potential C storage in mangrove soil to be about 500 Mg C ha−1. However, mangrove also lost about 43.8 Kg CO2-eq ha-1 yr-1 due to its CO2 and CH4 emissions.
  • 2.0K
  • 28 Oct 2020
Topic Review
Phage Applications against Biofilms
Biofilms are clusters of bacteria that live in association with surfaces, attached to other bacterial cells and to the surface by an extracellular polymeric matrix. Biofilms are capable of adhering to a wide variety of surfaces, both biotic and abiotic, including human tissues, medical devices, and other materials, representing a major threat causing infectious diseases and economic losses. Unfortunately, current antibiotics and common disinfectants have shown limited ability to remove biofilms adequately. Here, phage-based treatments are proposed as promising alternatives for biofilm eradication, including phage therapy, phage-derived enzymes, genetically modified phages, and phages in combination with antibiotics.
  • 2.0K
  • 05 Nov 2020
Topic Review
Adult Hippocampal Neurogenesis
Newborn neurons in the adult hippocampus are regulated by many intrinsic and extrinsic cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult neurogenesis, which this review discusses as one reason why psychiatric diseases, such as major depression, develop after long-term stress exposure. In reverse, adult neurogenesis has been suggested to protect against stress-induced major depression, and hence, could serve as a resilience mechanism.
  • 2.0K
  • 08 Sep 2021
Topic Review
Importance of Digitalization in the Construction Industry
The construction industry is among the least digitized industries, and the lack of innovation in construction project management practices has led to decreases in productivity. The European Directives for Public Procurement are pushing the entire construction supply chain towards more radical digital transformations over the next years, and project managers are left with the difficult task to harness ICT for the involvement and management of project stakeholders. This entry is based on the article "Realizing the Need for Digital Transformation of Stakeholder Management: A Systematic Review in the Construction Industry" recently published in the Sustainability journal. 
  • 2.0K
  • 06 Dec 2021
Topic Review
Pumpkin (Cucurbita sp.)
Pumpkin is a well-known multifunctional ingredient in the diet, full of nutrients, and has opened new vistas for scientists during the past years. The fruit of pumpkin including the flesh, seed, and peel are a rich source of primary and secondary metabolites, including proteins, carbohydrates, monounsaturated fatty acids, polyunsaturated fatty acids, carotenoids, tocopherols, tryptophan, delta-7-sterols, and many other phytochemicals.
  • 2.0K
  • 06 Jun 2022
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