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Topic Review
TDP-43 Role in Chromatin Remodeling and Transcription
TDP-43 gained momentum in the neurodegeneration field when it was first discovered that almost all amyotrophic lateral sclerosis (ALS) cases and as many as half of frontotemporal dementia (FTD) cases present pathological ubiquitinated inclusions of TDP-43. Its involvement in chromatin silencing and nuclear/cytoplasmic shuttling constitute convergent key findings from several biological screens, and several crucial epigenetic factors appear to be able to modify TDP-43-induced degeneration. TDP-43 activity at the chromatin level and its implication in the regulation of DNA transcription and stability -such as DNA repair and regulation of retrotransposons activity- are further supported by a continuously growing amount of studies.
  • 2.1K
  • 19 Sep 2023
Topic Review
Organobromine Flame Retardant Synergists
Organobromine flame retardants have been well-established for many years but because of environmental concerns have been under significant pressures to reduce their usage. However, these retardants are most always used in the presence of synergists, primarily those based on antimony compounds such as antimony III oxide, which also is associated with toxicological issues. This entry compares this with current available and potentially more environmentally sustainable synergists such as the zinc stannates and the more recently studied zinc tungstate, both of which also offer smoke suppressing properties.
  • 2.1K
  • 06 Nov 2020
Topic Review
Therapeutic Application of Betalains
Anthocyanins, betalains, riboflavin, carotenoids, chlorophylls and caramel are the basic natural food colorants used in modern food manufacture. Betalains, which are composed of red–violet betacyanin and yellow betaxanthins, are water-soluble pigments that color flowers and fruits. Betalains are pigments primarily produced by plants of the order Caryophyllales. Because of their anti-inflammatory, cognitive impairment, anticancer and anti-hepatitis properties, betalains are useful as pharmaceutical agents and dietary supplements. Betalains also exhibit antimicrobial and antimalarial effects, and as an example, betalain-rich Amaranthus spinosus displays prominent antimalarial activity. Studies also confirmed the antidiabetic effect of betalains, which reduced glycemia by 40% without causing weight loss or liver impairment. These findings show that betalain colorants may be a promising alternative to the synthetic dyes currently used as food additives
  • 2.1K
  • 21 Oct 2020
Topic Review
Cementitious Composites Containing Polyethylene Fibers
Polyethylene (PE) is an important polymeric material which is widely used in civil engineering. Recently, engineered cementitious composites (ECCs) have adopted PE fibers in structural repairing. ECC with polyethylene fibers (PE-ECC) has excellent tensile properties, ductility, strain-hardening behavior, thermal performance and durability.
  • 2.1K
  • 01 Dec 2020
Topic Review
Carbonic Anhydrase Inhibitors and Epilepsy
Carbonic anhydrases (CAs) are a group of ubiquitously expressed metalloenzymes that catalyze the reversible hydration/dehydration of CO2/HCO3. Thus, they are involved in those physiological and pathological processes in which cellular pH buffering plays a relevant role. The inhibition of CAs has pharmacologic applications for several diseases.
  • 2.1K
  • 02 Nov 2021
Topic Review
React (Web Framework)
React (also known as React.js or ReactJS) is an open-source JavaScript library for building user interfaces. It is maintained by Facebook and a community of individual developers and companies. React can be used as a base in the development of single-page or mobile applications. However, React is only concerned with rendering data to the DOM, and so creating React applications usually requires the use of additional libraries for state management and routing. Redux and React Router are respective examples of such libraries.
  • 2.1K
  • 10 Oct 2022
Topic Review
Options Strategy
Option strategies are the simultaneous, and often mixed, buying or selling of one or more options that differ in one or more of the options' variables. Call options, simply known as calls, give the buyer a right to buy a particular stock at that option's strike price. Conversely, put options, simply known as puts, give the buyer the right to sell a particular stock at the option's strike price. This is often done to gain exposure to a specific type of opportunity or risk while eliminating other risks as part of a trading strategy. A very straightforward strategy might simply be the buying or selling of a single option, however option strategies often refer to a combination of simultaneous buying and or selling of options. Options strategies allow traders to profit from movements in the underlying assets based on market sentiment (i.e., bullish, bearish or neutral). In the case of neutral strategies, they can be further classified into those that are bullish on volatility, measured by the lowercase Greek letter sigma (σ), and those that are bearish on volatility. Traders can also profit off time decay, measured by the uppercase Greek letter theta (Θ), when the stock market has low volatility. The option positions used can be long and/or short positions in calls and puts.
  • 2.1K
  • 17 Nov 2022
Biography
Allan Wilson
Allan Charles Wilson (18 October 1934 – 21 July 1991) was a Professor of Biochemistry at the University of California, Berkeley, a pioneer in the use of molecular approaches to understand evolutionary change and reconstruct phylogenies, and a revolutionary contributor to the study of human evolution. He was one of the most controversial figures in post-war biology; his work attracted a great d
  • 2.1K
  • 18 Nov 2022
Topic Review
Lipid Rafts
Lipid rafts are dynamic and shifting assemblies of sphingolipids, cholesterol, glycosphingolipids, and proteins forming platforms or lipid microdomains for the organization and dynamic contact of molecules involved in several molecular and cellular processes such as ligand affinity, effector specificity, signal transduction, membrane sorting, and receptor trafficking and recycling.
  • 2.1K
  • 25 Feb 2021
Topic Review
Spectroscopic Techniques for Dental Materials
The presented work focuses on the application of spectroscopic methods, such as Infrared Spectroscopy (IR), Fourier Transform Infrared Spectroscopy (FT-IR), Raman spectroscopy, Ultraviolet and Visible Spectroscopy (UV-Vis), X-ray spectroscopy, and Mass Spectrometry (MS), which are widely employed in the investigation of the surface properties of dental materials.
  • 2.1K
  • 03 Jun 2021
Topic Review
Asian Carp, an Alternative Material for Surimi Production
Asian carp is a general designation for grass carp, silver carp, bighead carp, and black carp. These fish species belong to the family Cyprinidae. In 2018, more than 18.5 million tons of Asian carp were produced globally. Asian carp can be used for producing surimi, a stabilized myofibrillar protein concentrate that can be made into a wide variety of products such as imitation crab sticks, fish balls, fish cakes, fish tofu, and fish sausage. Surimi is usually made from marine fish, but Asian carp have been widely used for surimi production in China. The quality of surimi is affected by various factors, including the processing methods and food additives, such as polysaccharides, protein, salt, and cryoprotectant. With an impending shortage of marine fish due to overfishing and depletion of fish stocks, Asian carp have a potential to serve as an alternative raw material for surimi products thanks to their high abundancy, less emissions of greenhouse gases from farming, desirable flesh color, and sufficient gel forming ability.
  • 2.1K
  • 06 Jun 2022
Topic Review
Ammonium Nitrate Disasters
When heated, ammonium nitrate decomposes non-explosively into gases including oxygen; however, it can be induced to decompose explosively by detonation. Large stockpiles of the material can be a major fire risk due to their supporting oxidation, and may also detonate, as happened in the Texas City disaster of 1947, which led to major changes in the regulations for storage and handling. There are two major classes of incidents resulting in explosions: In the first case, the explosion happens by the mechanism of shock to detonation transition. The initiation happens by an explosive charge going off in the mass, by the detonation of a shell thrown into the mass, or by detonation of an explosive mixture in contact with the mass. The examples are Kriewald, Morgan, Oppau, Tessenderlo, and Traskwood. In the second case, the explosion results from a fire that spreads into the ammonium nitrate (AN) itself (Texas City, Brest, Tianjin), or to a mixture of an ammonium nitrate with a combustible material during the fire. The fire must be confined at least to a degree for successful transition from a fire to an explosion (a phenomenon known as "deflagration to detonation transition", or DDT). Pure, compact AN is stable and very difficult to initiate. However, there are numerous cases when even impure AN did not explode in a fire. Ammonium nitrate decomposes in temperatures above 210 °C (410 °F). Pure AN is stable and will stop decomposing once the heat source is removed, but when catalysts are present, the reaction can become self-sustaining (known as self-sustaining decomposition, or SSD). This is a well-known hazard with some types of NPK fertilizers and is responsible for the loss of several cargo ships.
  • 2.1K
  • 28 Oct 2022
Topic Review
Peppermint Linux OS
Peppermint Linux OS is a cloud-centric OS based on Lubuntu, a derivative of the Ubuntu Linux operating system that uses the LXDE desktop environment. Peppermint's developers have written about their principles of providing a familiar environment for newcomers to Linux, which requires relatively low hardware resources to run.
  • 2.1K
  • 03 Nov 2022
Topic Review
Design and Synthesis of Polyphosphodiesters
Polyacids containing –P(O)(OH)– fragment in the polymer backbone, or polyphosphodiesters (PPDEs), hold a special place among natural and synthetic polymers. The structural similarity of PPDEs to natural nucleic and teichoic acids, biocompatibility of PPDEs and their mimicking to biomolecules providing the ‘stealth effect’, high bone mineral affinity of PPDEs, and adjustable hydrolytic stability of PPDEs are the basis for various biomedical, industrial and household applications. Actual synthetic approaches to PPDEs are based on incredibly rich chemistry of organic phosphates and phosphonates, and include modern techniques such as catalytic ring-opening polymerization (ROP), acyclic diene metathesis (ADMET) polycondensation, and others.
  • 2.1K
  • 09 Jan 2023
Topic Review
Integration of NOMA-Based VLC with Emerging Technologies
Visible light communication (VLC), a high data rate communication technology, has proven its stature as a promising complementary to its radio frequency (RF) counterpart. VLC is a cost-effective, energy-efficient, and secure technology that exploits the current infrastructure, specifically within indoor and underwater environments. Non-orthogonal multiple access (NOMA) has been considered an effective technique to circumvent these shortcomings. The NOMA scheme has emerged as a revolutionary paradigm to address the shortcomings of VLC systems.
  • 2.1K
  • 15 Mar 2023
Topic Review
Bacillus amyloliquefaciens
Bacillus amyloliquefaciens, a Gram-positive bacterium, has emerged as a versatile microorganism with significant applications in various fields, including industry, medicine, and agriculture.
  • 2.1K
  • 16 Nov 2023
Topic Review
Organoboron Compounds
The unique electron deficiency and coordination property of boron led to a wide range of applications in chemistry, energy research, materials science and the life sciences. The use of boron-containing compounds as pharmaceutical agents has a long history, and recent developments have produced encouraging strides. Boron agents have been used for both radiotherapy and chemotherapy. In radiotherapy, boron neutron capture therapy (BNCT) has been investigated to treat various types of tumors, such as glioblastoma multiforme (GBM) of brain, head and neck tumors, etc. Boron agents playing essential roles in such treatments and other well-established areas have been discussed elsewhere. Organoboron compounds used to treat various diseases besides tumor treatments through BNCT technology have also marked an important milestone. Following the clinical introduction of bortezomib as an anti-cancer agent, benzoxaborole drugs, tavaborole and crisaborole, have been approved for clinical use in the treatments of onychomycosis and atopic dermatitis. Some heterocyclic organoboron compounds represent potentially promising candidates for anti-infective drugs.
  • 2.1K
  • 25 Jun 2021
Topic Review
Application of Sol–Gels for Treatment of Gynaecological Conditions
Approaches for effective and sustained drug delivery to the female reproductive tract (FRT) for treating a range of gynaecological conditions remain limited. The development of versatile delivery platforms, such as soluble gels (sol–gels) coupled with applicators/devices, holds considerable therapeutic potential for gynaecological conditions. Sol–gel systems, which undergo solution-to-gel transition, triggered by physiological conditions such as changes in temperature, pH, or ion composition, offer advantages of both solution- and gel-based drug formulations. Furthermore, they have potential to be used as a suitable drug delivery vehicle for other novel drug formulations, including micro- and nano-particulate systems, enabling the delivery of drug molecules of diverse physicochemical character. Hence, such systems are are of profound significance in delivering the drugs to various parts of FRT for optimal treatment of various gynecological conditions which was not achievable using conventional drug delivery technologies.
  • 2.1K
  • 24 Feb 2022
Topic Review
Child Waste Workers' Health Sufferings in South Asia
Child labor remains a health hazard, affecting the mental, physical, and emotional well-being of children. Children engage in waste management through various channels while constantly working to create a healthier and cleaner environment and exposing themselves to numerous health risks. 
  • 2.1K
  • 01 Aug 2022
Topic Review
Weddell Island
Weddell Island (Spanish: Isla San José) is one of the Falkland Islands in the South Atlantic, lying off the southwest extremity of West Falkland. It is situated 1,545 km (960 mi) west-northwest of South Georgia Island, 1,165 km (724 mi) north of Livingston Island, 606 km (377 mi) northeast of Cape Horn, 358 km (222 mi) northeast of Isla de los Estados, and 510 km (320 mi) east of the Atlantic entrance to Magellan Strait. With an area of 265.8 km2 (102.6 sq mi) Weddell is the third largest island in the archipelago after East Falkland and West Falkland, and one of the largest private islands in the world. It has only one inhabited location, Weddell Settlement, with a single digit population engaged in sheep farming and tourism services. The island offers walks to wildlife watching sites and scenery destinations including some spectacular landscapes featuring the famous Falklands stone runs. Weddell is both an Important Plant Area and a priority Key Biodiversity Area. It is a remote place, infrequently visited by a resupply ship and occasionally by private yachts, accessible by air with a short (some 200 km (120 mi)) if expensive flight from the Falklands capital, Stanley.
  • 2.1K
  • 02 Nov 2022
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