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Topic Review
Arboviruses in Australia
In excess of 75 arboviruses have been identified in Australia, some of which are now well established as causative agents of debilitating diseases. These include Ross River virus, Barmah Forest virus, and Murray Valley encephalitis virus, each of which may be detected by both antibody-based recognition and molecular typing. For most of the remaining arboviruses that may be associated with pathology in humans, routine tests are not available to diagnose infection. A number of these so-called ‘neglected’ or ‘orphan’ arboviruses are considered likely to have infected humans at a regular rate for decades. Some may be associated with undifferentiated febrile illness — fever, the cause of which is not obvious — for which around half of all cases each year remain undiagnosed. Ongoing research aims to better understand the distribution, epidemiology, and transmission ecology of these mosquito-transmitted viruses that are currently unique to Australia.
  • 2.2K
  • 22 Apr 2022
Topic Review
Homi
Homi (Korean: 호미), also known as a Korean hand plow, is a short-handled traditional farming tool used by Koreans. It is a farming tool that removes grasses from paddies and fields. It is also used when plowing a rice field, planting seeds, plowing up soil, and digging potatoes in fields. It is a farming tool similar to the hoe. It is an important extension of agriculture from the ancient times because the homi was excavated in the Bronze Age historic site of the Pyeongnam Mangsan Daepyeong-ri and the early Iron Age historic site of Yangpyong, Gyeonggi Province. Homi is distributed nationwide, but they are characterized by locality. In other words, homi is classified into Plowshare-shaped(보습형), Sickle-shaped(낫형), and Triangle-shaped(세모형) depending on the natural conditions of the local area and the characteristics of agricultural management.
  • 2.2K
  • 26 Oct 2022
Topic Review
RNA World Hypothesis
The RNA world hypothesis proposes that RNA was the first life-form on earth, later developing a cell membrane around it and becoming the first prokaryotic cell.
  • 2.2K
  • 07 Nov 2022
Topic Review
Smart Energy for a Smart City
Smart Energy is a key element of a Smart City concept and understanding the current state and prospective developments of Smart Energy approaches is essential for the effective and efficient energy supply for the needs of the exponentially growing energy demands of contemporary cities. 
  • 2.2K
  • 05 Dec 2022
Topic Review
Composting
Composting is the most adaptable and fruitful method for managing biodegradable solid wastes; it is a crucial agricultural practice that contributes to recycling farm and agricultural wastes. Composting is profitable for various plant, animal, and synthetic wastes, from residential bins to large corporations. Composting and agricultural waste management (AWM) practices flourish in developing countries, especially Pakistan.
  • 2.2K
  • 16 Mar 2023
Topic Review
Mitochondrial Dysfunction
Mitochondrial dysfunction results in a series of defective cellular events, including decreased adenosine triphosphate (ATP) production, enhanced reactive oxygen species (ROS) output, and altered proteastasis and cellular quality control. An enhanced output of ROS may damage mitochondrial components, such as mitochondrial DNA and elements of the electron transport chain, resulting in the loss of proper electrochemical gradient across the mitochondrial inner membrane and an ensuing shutdown of mitochondrial energy production. Neurons have an increased demand for ATP and oxygen, and thus are more prone to damage induced by mitochondrial dysfunction. Mitochondrial dysfunction, damaged electron transport chains, altered membrane permeability and Ca2+ homeostasis, and impaired mitochondrial defense systems induced by oxidative stress, are pathological changes involved in neurodegenerative disorders. A growing body of evidence suggests that the use of antioxidants could stabilize mitochondria and thus may be suitable for preventing neuronal loss. Numerous natural products exhibit the potential to counter oxidative stress and mitochondrial dysfunction; however, science is still looking for a breakthrough in the treatment of neurodegenerative disorders. β-caryophyllene is a bicyclic sesquiterpene, and an active principle of essential oils derived from a large number of spices and food plants. As a selective cannabinoid receptor 2 (CB2) agonist, several studies have reported it as possessing numerous pharmacological activities such as antibacterial (e.g., Helicobacter pylori), antioxidant, anti-inflammatory, analgesic (e.g., neuropathic pain), anti-neurodegenerative and anticancer properties. The present review mainly focuses on the potential of β-caryophyllene in reducing oxidative stress and mitochondrial dysfunction, and its possible links with neuroprotection. 
  • 2.2K
  • 29 Apr 2021
Topic Review
Skin Substitutes
The skin plays an important role in the maintenance of the human's body physiological homeostasis. It acts as a coverage that protects against infective microorganism or biomechanical impacts. Skin is also implied in thermal regulation and fluid balance. However, skin can suffer several damages that impede normal wound-healing responses and lead to chronic wounds. Since the use of autografts, allografts, and xenografts present source limitations and intense rejection associated problems, bioengineered artificial skin substitutes (BASS) have emerged as a promising solution to address these problems. The advances that have been produced on tissue engineering techniques have enabled improving and developing new arising skin substitutes. Despite this, currently available skin substitutes have many drawbacks, and an ideal skin substitute has not been developed yet. The translation of cell‐based arising skin substitutes to clinical application represents one of the critical challenges on tissue engineering and it has to be overcome with the aim of offering each patient the more efficient therapy that fits with his clinical case and allows him having a good quality of life.
  • 2.2K
  • 19 Dec 2020
Topic Review
Phenolic Compounds
Phenolic compounds are phytochemicals with functions in pigmentation, astringency, protection against ultraviolet rays and antioxidant activity, being widely found in natural sources such as fruits, teas, spices, wine and honey. These compounds have received much attention in recent decades due to evidence related to positive health effects, such as anti-inflammatory, antimicrobial, antithrombotic, vasodilatory and cardioprotective activity, contributing to the improvement in metabolic markers associated with diabetes, hypertension and obesity.
  • 2.2K
  • 30 Jun 2021
Topic Review
Carbon-Based Composites
Carbon-based composites are materials in which a primary component in the form of a carbon structure or structures (graphene, carbon nanotubes, mesoporous carbon, etc.) and usually an inorganic phase or phases are combined into one system. Such a material is expected to exhibit additive or synergetic interfacial effects resulting in enhanced properties, such as reactivity in catalytic or electrocatalytic reactions.
  • 2.2K
  • 14 Dec 2021
Topic Review
Four Recommended Asian Vegetables in Europe
Carotenoids, anthocyanins, flavonoids, and other phenolic compounds in vegetables may prevent and counter many common diseases such as high blood pressure, diabetes, cancer, vision loss, heart disease, and several intestinal disorders. Increasing longevity, along with an aging population in Europe, has caused serious concerns about diet-related chronic diseases such as obesity, diabetes, cardiovascular diseases, and certain cancers. The European market for fresh Asian vegetables is expected to expand across the EU member states, and the introduction of new vegetables has enormous potential. 
  • 2.2K
  • 23 Dec 2021
Topic Review
Babylon
Babylon is a computer dictionary and translation program developed by the Israeli company Babylon Software Ltd. based in the city of Or Yehuda. The company was established in 1997 by the Israeli entrepreneur Amnon Ovadia. Its IPO took place ten years later. It is considered a part of Israel's Download Valley, a cluster of software companies monetizing "free" software downloads through adware. Babylon includes in-house proprietary dictionaries, as well as community-created dictionaries and glossaries. It is a tool used for translation and conversion of currencies, measurements and time, and for obtaining other contextual information. The program also uses a text-to-speech agent, so users hear the proper pronunciation of words and text. Babylon has developed 36 English-based proprietary dictionaries in 21 languages. In 2008–2009, Babylon reported earnings of 50 million NIS through its collaboration with Google. Between 2010 and 2013, Babylon became infamous for demonstrating questionable behavior typical of malware: A Babylon Toolbar bundled with Babylon and other software, has been widely identified as a browser hijacker that is very easy to install inadvertently and unnecessarily difficult to remove. This eventually led to Google terminating its agreement with Babylon Ltd. in 2013.
  • 2.2K
  • 08 Oct 2022
Topic Review
Partial Area Under the ROC Curve (PAUC)
The Partial Area Under the ROC Curve (pAUC) is a metric for the performance of binary classifier. It is computed based on the receiver operating characteristic (ROC) curve that illustrates the diagnostic ability of a given binary classifier system as its discrimination threshold is varied. The ROC curve is created by plotting the true positive rate (TPR) against the false positive rate (FPR) at various threshold settings.The area under the ROC curve (AUC) is often used to summarize in a single number the diagnostic ability of the classifier. The AUC is simply defined as the area of the ROC space that lies below the ROC curve. However, in the ROC space there are regions where the values of FPR or TPR are unacceptable or not viable in practice. For instance, the region where FPR is greater than 0.8 involves that more than 80% of negative subjects are incorrectly classified as positives: this is unacceptable in many real cases. As a consequence, the AUC computed in the entire ROC space (i.e., with both FPR and TPR ranging from 0 to 1) can provide misleading indications. To overcome this limitation of AUC, it was proposed to compute the area under the ROC curve in the area of the ROC space that corresponds to interesting (i.e., practically viable or acceptable) values of FPR and TPR.
  • 2.2K
  • 21 Oct 2022
Topic Review
Boron Used in Lithium Batteries Electrolytes
Boron and boron compounds have been extensively studied together in the history and development of lithium batteries, which are crucial to decarbonization in the automotive industry and beyond. As early as the year 2000, lithium bis(oxalato)borate, also known as LiBOB, was first reported for synthesis and use in electrolytes of LIBs. Because of the merits of being halide-free and more thermally stable than LiPF6, LiBOB has been proven beneficial either as a direct replacement for LiPF6 or as an electrolyte additive (2 wt%) in a nickel cobalt aluminum (NCA)—graphite system.
  • 2.2K
  • 03 Nov 2022
Topic Review
Yoga Improve the Athletes' Sports Performance
Yoga is a very popular trendy sport all over the world. Since its establishment and promotion, yoga has mostly been practiced in social clubs and studios, often being performed during optional courses in colleges. Basic yoga instruction is generally absent in middle schools.
  • 2.2K
  • 05 Feb 2024
Topic Review
Probiotics in Poultry Nutrition
Probiotics are live bacteria, fungi, or yeasts that supplement the gastrointestinal flora and help to maintain a healthy digestive system, thereby promoting the growth performance and overall health of poultry.
  • 2.2K
  • 06 Nov 2020
Topic Review
Imaging Findings of Mass-Forming Intrahepatic Cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy, with mass-forming growth pattern being the most common. The typical imaging appearance of mass-forming ICC (mICC) consists of irregular ring enhancement in the arterial phase followed by the progressive central enhancement on portal venous and delayed phases. However, atypical imaging presentation in the form of hypervascular mICC might also be seen, which can be attributed to distinct pathological characteristics. Ancillary imaging features such as lobular shape, capsular retraction, segmental biliary dilatation, and vascular encasement favor the diagnosis of mICC.
  • 2.2K
  • 07 May 2022
Topic Review
CTCF and Its Partners in 3D Genome
The 3D genome organization and its dynamic modulate genome function, playing a pivotal role in cell differentiation and development. CCCTC-binding factor (CTCF) and cohesin, acting as the core architectural components involved in chromatin looping and genome folding, can also recruit other protein or RNA partners to fine-tune genome structure during development. Moreover, systematic screening for partners of CTCF has been performed through high-throughput approaches. In particular, several novel protein and RNA partners, such as BHLHE40, WIZ, MAZ, Aire, MyoD, YY1, ZNF143, and Jpx, have been identified, and these partners are mostly implicated in transcriptional regulation and chromatin remodeling, offering a unique opportunity for dissecting their roles in higher-order chromatin organization by collaborating with CTCF and cohesin.
  • 2.2K
  • 26 Aug 2022
Topic Review
COVID-19 Treatment
The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has engulfed the world, affecting more than 180 countries. As a result, there has been considerable economic distress globally and a significant loss of life. Sadly, the vulnerable and immunocompromised in our societies seem to be more susceptible to severe COVID-19 complications. Notably, there are several significant risk factors for severe COVID-19 infection. These include the presence of poor nutritional status and pre-existing noncommunicable diseases (NCDs) such as diabetes mellitus, chronic lung diseases, cardiovascular diseases (CVD), obesity, and various other diseases that render the patient immunocompromised. These diseases are characterized by systemic inflammation, which may be a common feature of these NCDs, affecting patient outcomes against COVID-19. As a result, various antiviral treatments and anti-inflammatory agents are under investigation for their potential therapeutic value. The section presented below originates from the following article [1].
  • 2.2K
  • 06 Nov 2020
Topic Review
PET Biomarkers in Mitochondrial Dysfunction
There is a need to disentangle the etiological puzzle of age-related neurodegenerative diseases, whose clinical phenotypes arise from known, and as yet unknown, pathways that can act distinctly or in concert. Enhanced sub-phenotyping and the identification of in vivo biomarker-driven signature profiles could improve the stratification of patients into clinical trials and, potentially, help to drive the treatment landscape towards the precision medicine paradigm. The rapidly growing field of neuroimaging offers valuable tools to investigate disease pathophysiology and molecular pathways in humans, with the potential to capture the whole disease course starting from preclinical stages. Positron emission tomography (PET) combines the advantages of a versatile imaging technique with the ability to quantify, to nanomolar sensitivity, molecular targets in vivo. There is an increasing body of literature implicating dysfunction of mitochondria and endoplasmic reticulum dynamics, energy metabolism and oxidative stress within the molecular paradigm of age-related neurodegenerative diseases. The development of novel PET radioligands enables the in vivo investigation of mitochondrial and ER dysfunction in age-related neurodegenerative diseases.
  • 2.2K
  • 21 Feb 2021
Topic Review
Tapered Optical Fiber Configurations
Understanding environmental information is necessary for functions correlated with human activities to improve healthcare quality and reduce ecological risk. Tapered optical fibers reduce some limitations of such devices and can be considerably more responsive to fluorescence and absorption properties changes.
  • 2.2K
  • 05 Aug 2021
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