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Topic Review
An Overview of PDE4 Inhibitors in Clinical Trials
Since the early 1980s, phosphodiesterase 4 (PDE4) has been an attractive target for the treatment of inflammation-based diseases. Several scientific advancements, by both academia and pharmaceutical companies, have enabled the identification of many synthetic ligands for this target, along with the acquisition of precise information on biological requirements and linked therapeutic opportunities. The transition from pre-clinical to clinical phase was not easy for the majority of these compounds, mainly due to their significant side effects, and it took almost thirty years for a PDE4 inhibitor to become a drug i.e., Roflumilast, used in the clinics for the treatment of chronic obstructive pulmonary disease. Three additional compounds have reached the market: Crisaborole for atopic dermatitis, Apremilast for psoriatic arthritis and Ibudilast for Krabbe disease. 
  • 2.3K
  • 31 Aug 2022
Topic Review
Composite Repairs
Composite repairs. Composite materials are used in a wide range of applications in aerospace, marine, automotive, surface transport and sports equipment markets. Damage to composite components is not always visible to the naked eye and the extent of damage is best determined for structural components by suitable Non Destructive Test (NDT) methods. The concept for composite repair of composite or metallic structures is simple. The bonded repair reduces stresses in the damaged region and keeps the cracks from opening and therefore from growing.
  • 2.3K
  • 11 Oct 2022
Topic Review
Emotional Exhaustion
Emotional exhaustion is a chronic state of physical and emotional depletion that results from excessive job, personal demands, and/or continuous stress. It describes a feeling of being emotionally overextended and exhausted by one's work. It is manifested by both physical fatigue and a sense of feeling psychologically and emotionally "drained".
  • 2.3K
  • 14 Oct 2022
Topic Review
Optical Switch
An optical switch is a device that selectively switches optical signals from one channel to another. The switching can be temporal or spatial. The former is known as an optical (time-domain) switch or an optical modulator, while the latter is called an optical space switch or an optical router. In general, optical modulators and routers can be made from each other.
  • 2.3K
  • 17 Oct 2022
Topic Review
List of Aircraft (G)
This is a list of aircraft in alphabetical order beginning with 'G'.
  • 2.3K
  • 25 Oct 2022
Topic Review
Control and Upgradation of Indoor Air Quality
Due to increasing health and environmental issues, indoor air quality (IAQ) has garnered much research attention with regard to incorporating advanced clean air technologies. Various physicochemical air treatments have been used to monitor, control, and manage air contaminants, such as monitoring devices (gas sensors and internet of things-based systems), filtration (mechanical and electrical), adsorption, UV disinfection, UV photocatalysts, a non-thermal plasma approach, air conditioning systems, and green technologies (green plants and algae).
  • 2.3K
  • 24 Feb 2023
Topic Review
Electric Vehicle Battery Supply Chain
Electric vehicles (EVs) have been garnering wide attention over conventional fossil fuel-based vehicles due to the serious concerns of environmental pollution and crude oil depletion.
  • 2.3K
  • 30 Jun 2023
Topic Review
Social-Ecological Transformability
Transformability is increasingly promoted as a way of moving societies toward more sustainable futures in the era of the Anthropocene, mostly because the concept of resilience has fallen short in many instances where impacts on social-ecological systems are continuous, varied, and usually unknown. While such transformations can play a crucial role in improving the sustainability of social-ecological systems, they may lead to unexpected and undesirable outcomes. 
  • 2.3K
  • 19 Nov 2020
Topic Review
Leader—Member Exchange (LMX) Theory
The LMX theory was first described as “Vertical Dyad Linkage” (VDL). Graen and Uhl-Bien (1995) argued that the LMX theory consists of four stages, wherein each stage is related to and builds upon the previous stages. Leader–member exchange (LMX) theorists argue that leaders in the organization should give more responsibility to their followers, delegate powers, support the sharing of work-related knowledge, and allow participation in decision-making processes. LMX theory is a psychological process variable and plays an intermediary role between transformational leadership and knowledge management. 
  • 2.3K
  • 16 Sep 2021
Topic Review
Conventional PCI
Conventional PCI, often shortened to PCI, is a local computer bus for attaching hardware devices in a computer. PCI is an abbreviation for Peripheral Component Interconnect and is part of the PCI Local Bus standard. The PCI bus supports the functions found on a processor bus but in a standardized format that is independent of any particular processor's native bus. Devices connected to the PCI bus appear to a bus master to be connected directly to its own bus and are assigned addresses in the processor's address space. It is a parallel bus, synchronous to a single bus clock. Attached devices can take either the form of an integrated circuit fitted onto the motherboard itself (called a planar device in the PCI specification) or an expansion card that fits into a slot. The PCI Local Bus was first implemented in IBM PC compatibles, where it displaced the combination of several slow ISA slots and one fast VESA Local Bus slot as the bus configuration. It has subsequently been adopted for other computer types. Typical PCI cards used in PCs include: network cards, sound cards, modems, extra ports such as USB or serial, TV tuner cards and disk controllers. PCI video cards replaced ISA and VESA cards until growing bandwidth requirements outgrew the capabilities of PCI. The preferred interface for video cards then became AGP, itself a superset of PCI, before giving way to PCI Express. The first version of PCI found in retail desktop computers was a 32-bit bus using a 33 MHz bus clock and 5 V signalling, although the PCI 1.0 standard provided for a 64-bit variant as well. These have one locating notch in the card. Version 2.0 of the PCI standard introduced 3.3 V slots, physically distinguished by a flipped physical connector to prevent accidental insertion of 5 V cards. Universal cards, which can operate on either voltage, have two notches. Version 2.1 of the PCI standard introduced optional 66 MHz operation. A server-oriented variant of PCI, called PCI-X (PCI Extended) operated at frequencies up to 133 MHz for PCI-X 1.0 and up to 533 MHz for PCI-X 2.0. An internal connector for laptop cards, called Mini PCI, was introduced in version 2.2 of the PCI specification. The PCI bus was also adopted for an external laptop connector standard – the CardBus. The first PCI specification was developed by Intel, but subsequent development of the standard became the responsibility of the PCI Special Interest Group (PCI-SIG). Conventional PCI and PCI-X are sometimes called Parallel PCI in order to distinguish them technologically from their more recent successor PCI Express, which adopted a serial, lane-based architecture. PCI's heyday in the desktop computer market was approximately 1995–2005. PCI and PCI-X have become obsolete for most purposes; however, they are still common on modern desktops for the purposes of backwards compatibility and the low relative cost to produce. Many kinds of devices previously available on PCI expansion cards are now commonly integrated onto motherboards or available in USB and PCI Express versions.
  • 2.3K
  • 27 Oct 2022
Topic Review
Electric Gates
An electric gate is an entrance gate which can be opened and closed via an electric powered mechanism.
  • 2.3K
  • 08 Nov 2022
Topic Review
Sacca-kiriya
Sacca-kiriyā (Pāli; Sanskrit: satya-kriya, but more often: satyādhiṣṭhāna), is a solemn declaration of truth, expressed in ritual speech. Most often found in Buddhism, it can be an utterance with regard to one's own virtue, or with regard to a certain fact, followed by a command or resolution. Such a statement is believed to effect a wonder-working power that can benefit oneself and others, depending on the truthfulness of the person making the statement. The sacca-kiriyā is a motif found in the stories of the Buddhist Pali Canon and its commentaries, as well as in post-canonical works such as the Milindapañhā and the Avadānas. In these stories it is found usually as a blessing, but sometimes as a curse. The motif can also be found in Hindu and Jain texts. The sacca-kiriyā presumes a moral force of truth that is operating in the world, and is stronger than gods or humans. Although sacca-kiriyā often refer to characteristics of the Buddha, the Buddhist teaching, and the monastic community, it can also refer to facts with regard to natural phenomena, such as the sun or the moon. Some scholars believe that the effectiveness of a sacca-kiriyā as portrayed in stories depends on virtue and good character, whereas other scholars understand the sacca-kiriyā to be merely about speaking according to facts. Scholars theorize that the sacca-kiriyā is an ancient belief that precedes Buddhism, but was used in Buddhism as a teaching device to explain Buddhist ethics and other teachings. The principles underlying the sacca-kiriyā have also been connected with Mahatma Gandhi's ideal of non-violent resistance, and many other aspects of Asian culture and religious life.
  • 2.3K
  • 16 Nov 2022
Topic Review
Compounds Involved in Bitterness and Astringency of Pulses
Despite the many advantages of pulses, they are characterised by off-flavours that limit their consumption. Off-notes, bitterness and astringency contribute to negative perceptions of pulses. Several hypotheses have assumed that non-volatile compounds, including saponins, phenolic compounds, and alkaloids, are responsible for pulse bitterness and astringency.
  • 2.3K
  • 20 Apr 2023
Topic Review
AI-Driven Sentiment Analysis of Amazon Reviews Using BERT
Understanding customer emotions and preferences is paramount for success in the dynamic product design landscape. The pre-trained Bidirectional Encoder Representation from Transformers (BERT) model and the Text-to-Text Transfer Transformer (T5) are deployed to predict customer emotions. These models were trained on synthetically generated and manually labeled datasets to detect the specific features from review data, then sentiment analysis was performed to classify the data into positive, negative, and neutral reviews concerning their aspects. 
  • 2.3K
  • 17 Feb 2024
Topic Review
Surface Modification of Bacterial Cellulose
The surface of bacterial cellulose was successively modified by copper and zinc oxide nanoparticles using direct current (DC) magnetron sputtering and radio frequency (RF) reactive sputter coating techniques. The target materials, copper and zinc, were 99.99% pure and used in the presence of argon (Ar) gas, while zinc nanoparticles were sputtered in the presence of oxygen gas to make zinc oxide nanoparticles. The as-prepared bacterial cellulose/copper/zinc oxide nanocomposite has good ultraviolet resistance, anti-static and antibacterial characteristics. The surface morphology and chemical compositionof the nanocomposite were examined by X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) and energy-dispersive X-ray spectroscopic (EDS) techniques. The prepared bacterial cellulose/copper/zinc oxide nanocomposite illustrates excellent ultraviolet resistance (T.UVA%; 0.16 ± 0.02, T.UVB%; 0.07 ± 0.01, ultraviolet protection factor (UPF); 1850.33 ± 2.12), antistatic behavior (S.H.P; 51.50 ± 4.10, I.E. V; 349.33 ± 6.02) and antibacterial behavior (Escherichia coli; 98.45%, Staphylococcus aureus; 98.11%). Our nanocomposite prepared by sputter coating method could be a promising and effective candidate for ultraviolet resistance, antistatic and antibacterial in term of functional, technical, medical and in many daily life applications.  
  • 2.3K
  • 01 Nov 2020
Topic Review
Hydrogenosome
Hydrogenosome is a kind of membrane-bound organelle that widely exists in some evolutionarily distant protozoa and fungi, such as trichomonas, anaerobic fungi, endoamoeba and microsporidia. These microorganisms are anaerobic or microanaerobic, and they do not have mitochondria. Instead, they rely on the hydrogenosome, a kind of mitochondrion-related organelles (MROs), to metabolize organic matter under anoxic conditions, producing ATP to maintain their metabolism and growth.
  • 2.3K
  • 06 Apr 2022
Topic Review
Ford Maverick (1970)
The Ford Maverick is a compact car manufactured and marketed by Ford for model years 1970–1977 in the United States, originally as a two-door sedan employing a rear-wheel drive platform original to the 1960 Falcon — and subsequently as a four-door sedan on the same platform. The Maverick was also manufactured in Venezuela, Canada, Mexico, and from 1970 to 1979, in Brazil. The name "maverick" was derived from the word for unbranded range animals, and the car's nameplate was stylized to resemble the head of Longhorn cattle.
  • 2.3K
  • 19 Oct 2022
Topic Review
Ron Suskind
Ronald Steven "Ron" Suskind (born November 20, 1959) is an American journalist, author, and filmmaker. He was the senior national affairs writer for The Wall Street Journal from 1993 to 2000, where he won the 1995 Pulitzer Prize for Feature Writing for articles that became the starting point for his first book, A Hope in the Unseen. His other books include The Price of Loyalty, The One Percent Doctrine, The Way of the World, Confidence Men, and his memoir Life, Animated: A Story of Sidekicks, Heroes, and Autism, from which he made an Emmy Award-winning, Academy Award-nominated feature documentary. Suskind has written about the George W. Bush Administration, the Barack Obama Administration, and related issues of the United States' use of power.
  • 2.3K
  • 08 Dec 2022
Topic Review
Nanoencapsulation of Essential Oils
Essential oils (EOs) are complex mixtures of volatile and semi-volatile organic compounds that originate from different plant tissues, including flowers, buds, leaves and bark. According to their chemical composition, EOs have a characteristic aroma and present a wide spectrum of applications. However, EOs are unstable and easily degradable if not protected from external factors such as oxidation, heat and light. Therefore, there is growing interest in the encapsulation of EOs, since polymeric nanocarriers serve as a barrier between the oil and the environment. In this context, nanoencapsulation seems to be an interesting approach as it not only prevents the exposure and degradation of EOs and their bioactive constituents by creating a physical barrier, but it also facilitates their controlled release, thus resulting in greater bioavailability and efficiency.
  • 2.3K
  • 20 Dec 2022
Topic Review
Chelating Ability of Plant Polyphenols
Many studies have widely examined the effects of dietary polyphenols on human health. Polyphenols are well known for their antioxidant properties and for their chelating abilities, by which they can be potentially employed in cases of pathological conditions, such as iron overload. The iron-binding abilities of dietary polyphenols can be important in inflammatory/immunomodulatory responses, especially involving macrophages and dendritic cells, and they also might contribute to reshape the gut microbiota into a healthy profile. As the axes “polyphenol–iron metabolism–inflammatory responses” and “polyphenol–iron availability–gut microbiota” have not been very well explored so far, there is the need for further investigation to exploit such a potential to prevent or counteract pathological conditions.
  • 2.3K
  • 16 Mar 2023
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