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Topic Review
Bacteria–Cancer Interface
Epidemiological evidence reveal a very close association of malignancies with chronic inflammation as a result of persistent bacterial infection. Recently, more studies have provided experimental evidence for an etiological role of bacterial factors disposing infected tissue towards carcinoma. When healthy cells accumulate genomic insults resulting in DNA damage, they may sustain proliferative signalling, resist apoptotic signals, evade growth suppressors, enable replicative immortality, and induce angiogenesis, thus boosting active invasion and metastasis.
  • 702
  • 26 Oct 2021
Topic Review
Composition and Metabolic Activity of Gut Microbiota
The gut microbiota comprises species from all three domains of life (bacteria, archaea, and eukaryotes) as well as viruses, with each human individual harbouring a unique combination of constituent species. 
  • 701
  • 25 May 2023
Topic Review
Role of Microbiota-Modified Bile Acids in Neurodegenerative Diseases
Bile acids (BAs) are amphiphilic steroidal molecules generated from cholesterol in the liver and facilitate the digestion and absorption of fat-soluble substances in the gut. Some BAs in the intestine are modified by the gut microbiota. Because BAs are modified in a variety of ways by different types of bacteria present in the gut microbiota, changes in the gut microbiota can affect the metabolism of BAs in the host. Although most BAs absorbed from the gut are transferred to the liver, some are transferred to the systemic circulation. Furthermore, BAs have also been detected in the brain and are thought to migrate into the brain through the systemic circulation. Although BAs are known to affect a variety of physiological functions by acting as ligands for various nuclear and cell-surface receptors, BAs have also been found to act on mitochondria and autophagy in the cell. 
  • 700
  • 21 Apr 2023
Topic Review
Non-Aflatoxigenic Aspergillus flavus Control Aflatoxins
Aflatoxins (AFs) are carcinogenic compounds causing liver cancer in humans and animals. Several methodologies have been developed to control AF contamination, yet; they are usually expensive and unfriendly to the environment. Consequently, interest in biocontrol agents has increased, as they are convenient, advanced, and friendly to the environment. Using non-aflatoxigenic strains of A. flavus (AF−) as biocontrol agents is the most promising method to control AFs’ contamination in cereal crops. 
  • 697
  • 23 Jun 2021
Topic Review
Phototherapy-Based Treatment for Sexually Transmitted Infections
Phototherapy (PT) is a major therapeutic approach based on the controlled administration of light in the visible, near infrared, or UV spectrum, with or without the application of an external photosensitizer. New therapeutic strategies are urgently needed to overcome drawbacks in the treatment of some infections, particularly sexually transmitted infections (STI). STIs are easily spread by the transmission of various bacteria, viruses, and parasites with some of the infections being incurable or even lethal, leading to a serious impact on reproductive health worldwide.
  • 696
  • 20 Jul 2022
Topic Review
Strategies for the Control of Biofilms
Biofilm formation in healthcare is an issue of considerable concern, as it results in increased morbidity and mortality, imposing a significant financial burden on the healthcare system. Biofilms are highly resistant to conventional antimicrobial therapies and lead to persistent infections. Hence, there is a high demand for novel strategies other than conventional antibiotic therapies to control biofilm-based infections. There are two approaches which have been employed so far to control biofilm formation in healthcare settings: one is the development of biofilm inhibitors based on the understanding of the molecular mechanism of biofilm formation, and the other is to modify the biomaterials which are used in medical devices to prevent biofilm formation.
  • 696
  • 22 May 2023
Topic Review
Gut Microbiota and Bipolar Disorder
The gut microbiota is the set of microorganisms that colonize the gastrointestinal tract of living creatures, establishing a bidirectional symbiotic relationship that is essential for maintaining homeostasis, for their growth and digestive processes.
  • 690
  • 18 Apr 2021
Topic Review
Aurora A Kinase
Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene. Aurora A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation. Aurora A is activated by one or more phosphorylations and its activity peaks during the G2 phase to M phase transition in the cell cycle.
  • 690
  • 07 Oct 2022
Topic Review
Bacteria and Their Association with Plants
The salinization of soils is a growing agricultural concern worldwide. Irrigation practices, drought, and climate change are leading to elevated salinity levels in many regions, resulting in reduced crop yields. However, there is potential for a solution in the microbiome of halophytes, which are naturally salt-tolerant plants. These plants harbor a salt-tolerant microbiome in their rhizosphere (around roots) and endosphere (within plant tissue). These bacteria may play a significant role in conferring salt tolerance to the host plants. 
  • 690
  • 12 Dec 2023
Topic Review
BolA Function and Regulation
The BolA-like protein family is widespread among prokaryotes and eukaryotes. BolA was originally described in E. coli as a gene induced in the stationary phase and in stress conditions. The BolA overexpression makes cells spherical. It was characterized as a transcription factor modulating cellular processes such as cell permeability, biofilm production, motility, and flagella assembly. BolA is important in the switch between motile and sedentary lifestyles having connections with the signaling molecule c-di-GMP. BolA was considered a virulence factor in pathogens such as Salmonella Typhimurium and Klebsiella pneumoniae and it promotes bacterial survival when facing stresses due to host defenses. 
  • 688
  • 15 Mar 2023
Topic Review
Antibacterial Dendrimers Research Need Improvements
Antimicrobial resistance, based on the built-in abilities of bacteria to nullify the activity of current antibiotics, leaves a growing number of bacterial infections untreatable. The development of novel agents able to interact with the external layers of bacteria, causing irreparable damage, without the need to interact with processes or substances vital for the bacterium but subjected to mutation, is a recent approach to address this issue. In this contest, natural cationic antimicrobial peptides (CAMPs), able to kill bacteria by non-specific detrimental interaction with the negative bacterial membranes, have inspired the syntesis of cationic polymers which proved to be promising solutions. Only recently, also dendrimers were considered suitable macromolecules for the preparation of more advanced cationic biomimetic nanoparticles, able to harmonize the typical properties of dendrimers, including nanosize, mono-dispersion, long-term stability, high functionality, and the non-specific mechanism of action of CAMPs. As reviewed in an article available on Nanomaterials at https://www.mdpi.com/2079-4991/10/10/2022/htm#, different types of cationic dendrimers which showed considerable antibacterial effects have been synthetized and studied in the last decade, but only few structures, such as PAMAM and peptides-based ones have been extensively investigated. Moreover, despite the very promising results deriving from the evaluations of the different cationic dendrimers, these devices require further studies and more rationalized investigations. In this new entry, we have reviewed the cationic dendrimers and their antibacterial effects, which until now have only been minimally studied. In addition, we have allowed ourselves to express our considerations on how the case studies reported in the last decade regarding the different types of cationic dendrimers should be improved.
  • 687
  • 19 Jan 2021
Topic Review
Sanitizing Hatching Eggs with Essential Oils
Increased meat and egg production leads to concomitant changes in poultry practices, including the indiscriminate use of formaldehyde to sanitize hatching eggs. Although this sanitizer aids in the increase in poultry production, its toxic potential for man and for avian embryos represents an obstacle to its long-term use.
  • 682
  • 24 Aug 2023
Topic Review
Pseudomonas aeruginosa Infections
Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which causes many severe acute and chronic infections with high morbidity, and mortality rates as high as 40%. What makes P. aeruginosa a particularly challenging pathogen is its high intrinsic and acquired resistance to many of the available antibiotics. 
  • 680
  • 12 Jan 2023
Topic Review
Lyme Borreliosis
The diagnosis of Lyme borreliosis is based on two-tier testing using an ELISA and Western blot. About 5–10% of patients report persistent symptoms of unknown etiology after treatment, resulting in substantial difficulties in further diagnostic workup.
  • 678
  • 22 May 2023
Topic Review
Gut and Reproductive Tract Microbiota
Pregnancy is characterized by maternal adaptations that are necessary to create a welcoming and hospitable environment for the fetus. Studies have highlighted how the microbiota modulates several networks in humans through complex molecular interactions and how dysbiosis (de-fined as quantitative and qualitative alterations of the microbiota communities) is related to human pathologies including gynecological diseases.
  • 677
  • 18 Mar 2021
Topic Review
The Urinary Microbiome
The recent discovery of the urinary microbiome bolstered the notion that microbes might play a role in bladder cancer. Although microbial involvement in bladder neoplastic transformation and metastatic progression, except schistosomiasis, has not been established, accumulating research suggests that dysbiosis of the urinary microbiome can produce a chronically inflammatory urothelial microenvironment and lead to bladder cancer.
  • 677
  • 30 Sep 2022
Topic Review
Approach for Molecular Diagnosis of Periprosthetic Joint Infections
Periprosthetic joint infections (PJIs) represent some of the most challenging complications whose incidence will consequently rise in proportion to surgeries. The manifestation and evaluation of physical findings such as acute local inflammation, fever, and wound drainage, may correlate to the presence of PJIs; indeed, these clinical manifestation are of great value in raising the suspicion of PJIs. 
  • 676
  • 23 Aug 2022
Topic Review
Host Factors Affect the Gut Microbiome
Living organisms in nature exist as communities of various species, interacting closely with each other. Microbial organisms are also present as heterogeneous populations. Microbial organisms frequently appear as a dense mixture of various species to interact with each other in nature.
  • 674
  • 29 Mar 2022
Topic Review
Microbe Interactions within the Skin Microbiome
The skin is the largest human organ and is responsible for many important functions, such as temperature regulation, water transport, and protection from external insults. It is colonized by several microorganisms that interact with each other and with the host, shaping the microbial structure and community dynamics. Through these interactions, the skin microbiota can inhibit pathogens through several mechanisms such as the production of bacteriocins, proteases, phenol soluble modulins (PSMs), and fermentation. Furthermore, these commensals can produce molecules with antivirulence activity, reducing the potential of these pathogens to adhere to and invade human tissues. Microorganisms of the skin microbiota are also able to sense molecules from the environment and shape their behavior in response to these signals through the modulation of gene expression. 
  • 674
  • 29 Jan 2024
Topic Review
Cyclomodulins and Some Microbial Metabolites in Bacterial Microecology
A number of bacteria that colonize the human body produce toxins and effectors that cause changes in the eukaryotic cell cycle—cyclomodulins and low-molecular-weight compounds such as butyrate, lactic acid, and secondary bile acids. Cyclomodulins and metabolites are necessary for bacteria as adaptation factors—which are influenced by direct selection—to the ecological niches of the host. In the process of establishing two-way communication with the macroorganism, these compounds cause limited damage to the host, despite their ability to disrupt key processes in eukaryotic cells, which can lead to pathological changes. Possible negative consequences of cyclomodulin and metabolite actions include their potential role in carcinogenesis, in particular, with the ability to cause DNA damage, increase genome instability, and interfere with cancer-associated regulatory pathways.
  • 671
  • 13 Oct 2022
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