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Topic Review
Melatonin Protects Mitochondria and Adenosine Triphosphate Production
Melatonin (N-acetyl-5-methoxytryptamine) is a ubiquitous, mitochondria-targeted molecule present in all tested eukarya and bacteria. In March 2022, the first discovery of the serotonin N-acetyltransferase (SNAT) gene—responsible for the penultimate formation of N-acetylserotonin (NAS) before its final conversion into melatonin — in archaea further consolidates the status of melatonin as a regulator of biomolecular condensates in all three domains of life in the cellular empire. RNA viruses including SARS-CoV-2 contain proteins with intrinsically disordered regions that undergo liquid-liquid phase separation (LLPS). Liquid-liquid phase separation (LLPS) of these proteins form membraneless condensates that act as “viral factories” to facilitate and enhance replication. Phase separation of the SARS-CoV-2 nucleocapsid (N) protein is associated with mitochondrial dysfunction and rewiring of energy production away from oxidative phosphorylation (OXPHOS) to favor aerobic glycolysis in cytoplasm. Increased adenosine triphosphate (ATP) in cytoplasm supports viral replication. Melatonin protects mitochondria from damage, maintains adequate levels to disassemble “viral factories”, and prevents suppression of host antiviral immune responses by inhibiting nucleocapsid phase separation via antioxidant-dependent and -independent means.
  • 5.9K
  • 05 Sep 2022
Topic Review
Processing of Cereals and Derived-By-Products
Cereals have been one of the major food resources for human diets and animal feed for thousands of years, and a large quantity of by-products is generated throughout the entire processing food chain, from farm to fork. These by-products mostly consist of the germ and outer layers (bran) derived from dry and wet milling of the grains, of the brewers’ spent grain generated in the brewing industry, or comprise other types obtained from the breadmaking and starch production industries. Cereal processing by-products are an excellent low-cost source of various compounds such as dietary fibres, proteins, carbohydrates and sugars, minerals and antioxidants (such as polyphenols and vitamins), among others. Often, they are downgraded and end up as waste or, in the best case, are used as animal feed or fertilizers. With the increase in world population coupled with the growing awareness about environmental sustainability and healthy life-styles and well-being, the interest of the industry and the global market to provide novel, sustainable and innovative solutions for the management of cereal-based by-products is also growing rapidly.
  • 5.9K
  • 15 Sep 2020
Topic Review
Traditional Najd Architecture
The research focuses on the architectural typologies and the architectural elements of the cultural heritage in the Najd region. Najd is the great central plateau of Saudi Arabia, of which Riyadh is the most important city and the capital. The contribution leads the architects to rethink the constructive and aesthetic approach in designing and constructing new architectures without forgetting the culture and historical context of reference. The expressiveness of architectural language in terms of the formal and aesthetic approach is a feature that should not be secondary in contemporary buildings. The surface, texture, form, representation, and expression should prevail over aesthetic purposes in architecture.
  • 5.9K
  • 19 Jun 2023
Topic Review
Toyota Allion
The Toyota Allion (Japanese: トヨタ・アリオン, Toyota Arion) and its twin the Toyota Premio (Japanese: トヨタ・プレミオ, Toyota Puremio) are sedans sold in Japan since 2001 by Toyota. The sedans are designated as a compact car by Japanese dimension regulations and the exterior dimensions do not change with periodic updates. The Allion replaced the Carina, a model that first appeared in 1970. The Carina ED, a four-door hardtop coupe that appeared in 1985, was replaced by the Brevis, which was briefly available with the Allion until 2007. Unlike Toyota's other vehicles, the Allion and Premio are not exported, and are exclusively sold in Japan only. The Premio is the successor of the Corona which first appeared in 1957. The Corona EXiV, a four-door hardtop coupe that appeared in 1989, was replaced by the Progrès, which was also briefly available with the Premio until 2007. The Allion is exclusive to Japanese Toyota dealerships Toyota Store as a smaller companion to the Crown, while the Premio is exclusive to Toyopet Store locations, as a smaller companion to the Mark X. Both cars are related to the Avensis, which is an imported five-door liftback from Europe, available at all Japanese dealership locations. The Camry, which is the largest car exclusive to Toyota Corolla Store locations, is slightly larger, and based on appearance packages, offers the same luxury or performance features found in the Allion or Premio. The name "Allion" is created based on the phrase "all-in-one", while "Premio" is a play on words for "premium". Mechanically, they are identical to the Avensis which is exported new internationally as well as sold in Japan. The Allion/Premio are only offered as 4-door sedans, while the Avensis is available only as a five-door liftback. The first generation Premio is an upscale, luxurious sedan in comparison to the Allion, which has a more youthful, sporting nature. Wood trim and chrome accents gives the Premio an elegant look while the Allion considered to be a sporty or executive type car. Appearance modification options made for the first generation Allion are not made or marketed for the Premio. The second generation cars share the interior appearances and optional equipment, with exterior visual differences. Three options packages are offered with the three different engines offered, coupled with the choice of front- or four-wheel drive, thereby giving Japanese buyers options as to which annual road tax obligation they are willing to pay.
  • 5.9K
  • 30 Nov 2022
Topic Review
Curcumin's Structure and Biological Properties
Curcumin, a natural polyphenolic compound derived from the South Asian turmeric plant (Curcuma longa), has well-characterized antioxidant, anti-inflammatory, anti-protein-aggregate, and anticancer properties.
  • 5.9K
  • 06 Nov 2020
Topic Review
Bias Temperature Instability of MOSFETs
CMOS technology dominates the semiconductor industry, and the reliability of MOSFETs is a key issue. Negative bias temperature instability (NBTI) and positive bias temperature instability (PBTI) mainly degrade the performance of pMOSFETs and nMOSFETs, respectively. 
  • 5.9K
  • 13 May 2022
Topic Review
Frogs in Culture
Frogs play a variety of roles in culture, appearing in folklore and fairy tales such as the Brothers Grimm story of The Frog Prince. In ancient Egypt and Mesopotamia, frogs symbolized fertility, while in classical antiquity, the Greeks and Romans associated frogs with fertility, harmony, and licentiousness. Frogs are the subjects of fables attributed to Aesop, of proverbs in various cultures, and of art. Frog characters such as Kermit the frog and Pepe the Frog feature in popular culture. They are eaten in some parts of the world including France. In Australia, a fondant dessert is known as frog cake.
  • 5.9K
  • 27 Nov 2022
Topic Review
New Energy Vehicles in China
This article will talk about the market of new energy vehicles in China and why the government supports it.The stock of new energy vehicles in China is the world's largest, with cumulative sales of 5.5 million units through December 2020. These figures include passenger cars and heavy-duty commercial vehicles such buses and sanitation trucks, and only accounts for vehicles manufactured in the country. Of these, there were 4.9 million new energy vehicles in use at the end of 2020, accounting for 1.75% of all vehicles in circulation in China. The Chinese government uses the term new energy vehicles (NEVs) to designate plug-in electric vehicles eligible for public subsidies, and includes only battery electric vehicles (BEVs), plug-in hybrid electric vehicles (PHEVs) and fuel cell electric vehicles (FCEV). Sales of new energy vehicles since 2011 passed the 500,000 unit milestone in March 2016, and the 1 million mark in early 2017, both, excluding imports. Cumulative sales of new energy passenger cars achieved the 500,000 unit milestone in September 2016, and 1 million by the end of 2017. Domestically produced passenger cars account for 96% of new energy car sales in China. (As of December 2020), China had the largest stock of highway legal plug-in passenger cars with over 4.5 million units, 42% of the global plug-in car fleet in use. China also dominates the plug-in light commercial vehicle and electric bus deployment, with its stock reaching over 500,000 buses in 2019, 98% of the global stock, and 247,500 electric light commercial vehicles, 65% of the global fleet. In addition, the country also leads sales of medium- and heavy duty electric trucks, with over 12,000 trucks sold, and nearly all battery electric. China has been the world's best-selling plug-in electric passenger car market for five years running, from 2015 to 2019, with annual sales rising from more than 207,000 plug-in passenger cars in 2015, to 579,000 in 2017, and just over  million units both in 2018 and 2019. A particular feature of the Chinese passenger plug-in market is the dominance of small entry level vehicles, in 2015 representing 87% of total pure electric car sales, while 96% of total plug-in hybrid car sales were in the compact segment. BYD Auto ended 2015 as the world's best selling manufacturer of highway legal light-duty plug-in electric vehicles, and for a second year running was the world's top selling plug-in car manufacturer with over 100,000 units delivered in 2016. During 2016 BYD became the world's all-time second largest plug-in electric passenger car manufacturer after the Renault-Nissan Alliance. The BYD Qin was the top selling new energy passenger car for two years in a row, 2014 and 2015. The BYD Tang was the best selling plug-in passenger car in 2016. Until December 2016, the Qin ranked as the all-time top selling plug-in electric car in the country with 68,655 units sold since its inception. The BAIC EC-Series all-electric city car was the top selling plug-in car in 2017, and with 78,079 units sold, it also listed as world's top selling plug-in car in 2017. The government's political support for the adoption of electric vehicles has four goals, to create a world-leading industry that would produce jobs and exports; energy security to reduce its oil dependence which comes from the Middle East; to reduce urban air pollution; and to reduce its carbon emissions. In June 2012 the State Council of China published a plan to develop the domestic energy-saving and new energy vehicle industry. The plan set a sales target of 500,000 new energy vehicles by 2015 and 5 million by 2020. As sales of new energy vehicles were slower than expected, in September 2013, the central government introduced a subsidy scheme providing a maximum of US$9,800 toward the purchase of an all-electric passenger vehicle and up to US$81,600 for an electric bus.
  • 5.9K
  • 01 Dec 2022
Topic Review
New Seismotectonic Atlas of Greece
Integration and harmonization of the most recent seismological, geological, tectonic, geophysical and geodetic datasets, with the aim of capturing the potential of ground deformation towards a more reliable evaluation of seismic risk at a national level.
  • 5.9K
  • 20 Nov 2020
Topic Review
Time Synchronization
Time (or clock) synchronization is a large and vital field of research, as synchronization is a precondition for many applications. A few example applications are distributed data acquisition, distributed databases, and real-time communication.
  • 5.9K
  • 08 Dec 2020
Topic Review
Microsoft Visual C
Microsoft Visual C++ (often abbreviated to MSVC) is an integrated development environment (IDE) product from Microsoft for the C, C++, and C++/CLI programming languages. MSVC is proprietary software; it was originally a standalone product but later became a part of Visual Studio and made available in both trialware and freeware forms. It features tools for developing and debugging C++ code, especially code written for the Windows API, DirectX and .NET. Many applications require redistributable Visual C++ runtime library packages to function correctly. These packages are often installed independently of applications, allowing multiple applications to make use of the package while only having to install it once. These Visual C++ redistributable and runtime packages are mostly installed for standard libraries that many applications use.
  • 5.9K
  • 11 Oct 2022
Topic Review
Grade Retention
Grade retention is a strategy for the remediation of learning or developmental delays. Students who cannot keep up with their peers or do not meet a predefined level repeat the same grade once again and by doing so have an extra year to get at the level that is needed to successfully manage the next grade. There are considerable doubts as regards the usefulness and effectiveness of retaining grades. Studies conclude that in the short term retaining grades may have a positive effect on academic achievement, but that this gain disappears in the longer term.
  • 5.9K
  • 30 Oct 2020
Biography
Sabrina Gonzalez Pasterski
Sabrina Gonzalez Pasterski (born June 3, 1993) is an American theoretical physicist from Chicago who studies high energy physics.[1] She describes herself as "a proud first-generation Cuban-American & Chicago Public Schools alumna."[2] She completed her undergraduate studies at the Massachusetts Institute of Technology (MIT), earned her PhD from Harvard University and is a rising PCTS Postdoctor
  • 5.9K
  • 12 Dec 2022
Topic Review
Microbes as Biofertilizers
Biofertilizers are a promising alternative to chemical fertilizers and gaining importance for attaining sustainable agriculture.
  • 5.9K
  • 18 Mar 2021
Topic Review
Dinosaur Behavior
Dinosaur behavior is difficult for paleontologists to study since much of paleontology is dependent solely on the physical remains of ancient life. However, trace fossils and paleopathology can give insight into dinosaur behavior. Interpretations of dinosaur behavior are generally based on the pose of body fossils and their habitat, computer simulations of their biomechanics, and comparisons with modern animals in similar ecological niches. As such, the current understanding of dinosaur behavior relies on speculation, and will likely remain controversial for the foreseeable future. However, there is general agreement that some behaviors which are common in crocodiles and birds, dinosaurs' closest living relatives, were also common among dinosaurs. Gregarious behavior was common in many dinosaur species. Dinosaurs may have congregated in herds for defense, for migratory purposes, or to provide protection for their young. There is evidence that many types of dinosaurs, including various theropods, sauropods, ankylosaurians, ornithopods, and ceratopsians, formed aggregations of immature individuals. Nests and eggs have been found for most major groups of dinosaurs, and it appears likely that dinosaurs communicated with their young, in a manner similar to modern birds and crocodiles. The crests and frills of some dinosaurs, like the marginocephalians, theropods and lambeosaurines, may have been too fragile to be used for active defense, and so they were likely used for sexual or aggressive displays, though little is known about dinosaur mating and territorialism. Most dinosaurs seem to have relied on land-based locomotion. A good understanding of how dinosaurs moved on the ground is key to models of dinosaur behavior; the science of biomechanics, in particular, has provided significant insight in this area. For example, studies of the forces exerted by muscles and gravity on dinosaurs' skeletal structure have investigated how fast dinosaurs could run, whether diplodocids could create sonic booms via whip-like tail snapping, and whether sauropods could float.
  • 5.9K
  • 31 Oct 2022
Topic Review
Food Marketing
It would seem important to analyse the relationships between food marketing and consumer choice, highlighting the role of brands in these frameworks. For this purpose, a literature review was carried out considering 147 documents from Scopus database for the topics of search “food marketing” and“choices” (search performed on 16 October 2020). As main insights, it is worth highlighting that the main issues addressed by the literature, concerning food marketing and consumer choices, are the following: economic theory; label and packaging; marketing strategies; agriculture and food industry; market segments; social dimensions; brand and branding. In turn, food marketing heavily conditions consumer choices; however, these related instruments are better manipulated by larger companies. In addition, this entry highlights that bigger companies have dominant positions in these markets which are not always beneficial to the consumers’ objectives.
  • 5.9K
  • 07 May 2021
Topic Review
Christian Views on Hell
In Christian theology, Hell is the place or state into which, by God's definitive judgment, unrepentant sinners pass in the general judgment, or, as some Christians believe, immediately after death (particular judgment). Its character is inferred from teaching in the biblical texts, some of which, interpreted literally, have given rise to the popular idea of Hell. Theologians today generally see Hell as the logical consequence of using free will to reject union with God and, because God will not force conformity, it is not incompatible with God's justice and mercy. Different Hebrew and Greek words are translated as "Hell" in most English-language Bibles. These words include: "Sheol" in the Hebrew Bible, and "Hades" in the New Testament. Many modern versions, such as the New International Version, translate Sheol as "grave" and simply transliterate "Hades". It is generally agreed that both sheol and hades do not typically refer to the place of eternal punishment, but to the grave, the temporary abode of the dead, the underworld. "Gehenna" in the New Testament, where it is described as a place where both soul and body could be destroyed (Matthew 10:28) in "unquenchable fire" (Mark 9:43). The word is translated as either "Hell" or "Hell fire" in many English versions. Gehenna was a physical location outside the city walls where they burned garbage and where lepers and outcasts were sent, hence the weeping and gnashing of teeth. The Greek verb ταρταρῶ (tartarō, derived from Tartarus), which occurs once in the New Testament (in 2 Peter 2:4), is almost always translated by a phrase such as "thrown down to hell". A few translations render it as "Tartarus"; of this term, the Holman Christian Standard Bible states: "Tartarus is a Greek name for a subterranean place of divine punishment lower than Hades."
  • 5.8K
  • 18 Oct 2022
Topic Review
Phenomenology
Phenomenology (from Greek φαινόμενον, phainómenon "that which appears" and λόγος, lógos "study") is the philosophical study of the structures of experience and consciousness. As a philosophical movement it was founded in the early years of the 20th century by Edmund Husserl and was later expanded upon by a circle of his followers at the universities of Göttingen and Munich in Germany . It then spread to France , the United States , and elsewhere, often in contexts far removed from Husserl's early work. Phenomenology is not a unified movement; rather, the works of different authors share a 'family resemblance' but with many significant differences. Gabriella Farina states:Phenomenology, in Husserl's conception, is primarily concerned with the systematic reflection on and study of the structures of consciousness and the phenomena that appear in acts of consciousness. Phenomenology can be clearly differentiated from the Cartesian method of analysis which sees the world as objects, sets of objects, and objects acting and reacting upon one another. Husserl's conception of phenomenology has been criticized and developed not only by him but also by students and colleagues such as Edith Stein, Max Scheler, Roman Ingarden, and Dietrich von Hildebrand, by existentialists such as Nicolai Hartmann, Gabriel Marcel, Maurice Merleau-Ponty, and Jean-Paul Sartre, by hermeneutic philosophers such as Martin Heidegger, Hans-Georg Gadamer, and Paul Ricoeur, by later French philosophers such as Jean-Luc Marion, Michel Henry, Emmanuel Levinas, and Jacques Derrida, by sociologists such as Alfred Schütz and Eric Voegelin, and by Christian philosophers, such as Dallas Willard.
  • 5.8K
  • 28 Nov 2022
Topic Review
Virus Elimination in Plants
Virus elimination from plants is mostly based on the in vitro culture of isolated meristem, and in addition thermotherapy, chemotherapy, electrotherapy, and cryotherapy can also be applied. Treatments can result in low rate of survival, inhibited growth, incomplete development, or abnormal morphology.  The rate of destruction depends on the genotypes and physiological condition of plants. There are several ways to decrease the harmful effect of treatments. 
  • 5.8K
  • 31 May 2021
Topic Review
Edge Couplers
Silicon photonics has drawn increasing attention since recent decades and is promising to act as a key technology for future daily applications due to its various merits including ultra-low cost, high integration density owing to the high refractive index of silicon and compatibility with current semiconductor fabrication process. Optical interconnects is an important issue in silicon photonic integrated circuits to transmit light and fiber-to-chip optical interconnects is vital in application scenarios like data centers and optical transmission systems. There are mainly two categories of fiber-to-chip optical coupling, that is off-plane coupling and in-plane coupling. Grating couplers work under the former category while edge couplers function as in-plane coupling. In this paper, we mainly focus on edge couplers in silicon photonic integrated circuits. We deliver an introduction to the research background, operation mechanism and design principles of silicon photonic edge couplers. The state-of-the-art of edge couplers is reviewed according to different configurations as to the device structure, identifying the performance, fabrication feasibility and applications. In addition, a brief comparison between edge couplers and grating couplers is conducted. Packaging issue is also discussed and several prospective techniques for further improvements of edge couplers are proposed.
  • 5.8K
  • 27 Oct 2020
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