Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Subcritical-Water Extraction of Natural Products
Subcritical water refers to high-temperature and high-pressure water, but below water's critical point of 374 °C and 218 atm. A unique and useful characteristic of subcritical water is that its polarity can be dramatically decreased with increasing temperature. Therefore, subcritical water can behave similarly to methanol or ethanol. This makes subcritical water a green extraction fluid used for a variety of organic species. 
  • 2.4K
  • 09 Jul 2021
Topic Review
Melanin Transfer Models
Skin pigmentation ensures efficient photoprotection and relies on the pigment melanin, which is produced by epidermal melanocytes and transferred to surrounding keratinocytes. While the molecular mechanisms of melanin synthesis and transport in melanocytes are now well characterized, much less is known about melanin transfer and processing within keratinocytes.
  • 2.4K
  • 02 Aug 2023
Topic Review
Panjab Digital Library
The Panjab Digital Library is a voluntary organization digitizing and preserving the cultural heritage of Panjab since 2003. With over 45 million digitized pages, it is the biggest resource of digital material on Panjab. There are many historically significant documents stored and made available online. Its scope covers Sikh and Punjabi culture. The library funded by The Nanakshahi Trust was launched online in August 2009. Its base office is located at Chandigarh, India. The library's mission is to locate, digitize, preserve, collect and make accessible the accumulated wisdom of the Panjab region, without distinction as to script, language, religion, nationality, or other physical condition.
  • 2.4K
  • 03 Nov 2022
Topic Review
Firmware
In computing, firmware is a specific class of computer software that provides the low-level control for a device's specific hardware. Firmware, such as the BIOS of a personal computer, may contain basic functions of a device, and may provide hardware abstraction services to higher-level software such as operating systems. For less complex devices, firmware may act as the device's complete operating system, performing all control, monitoring and data manipulation functions. Typical examples of devices containing firmware are embedded systems, home and personal-use appliances, computers, and computer peripherals. Firmware is held in non-volatile memory devices such as ROM, EPROM, EEPROM, and Flash memory. Updating firmware requires ROM integrated circuits to be physically replaced, or EPROM or flash memory to be reprogrammed through a special procedure. Some firmware memory devices are permanently installed and cannot be changed after manufacture. Common reasons for updating firmware include fixing bugs or adding features to the device.
  • 2.4K
  • 29 Sep 2022
Topic Review
Choline
Choline is an essential micronutrient with a pivotal role in several metabolic pathways contributing to liver, neurological, and hematological homeostasis. Although choline is commonly administered to improve physical performance, its effects on muscle are still unclear. Our scoping review elucidates and summarizes thecrucial role of choline in modulating muscle fat metabolism, muscle proteins homeostasis, and themodulation of inflammation and autophagy.
  • 2.4K
  • 28 Jul 2020
Topic Review
The Autophagic Pathway
Autophagy is a catabolic pathway that accounts for degradation and recycling of cellular components to extend cell survival under stress conditions. In addition to this prominent role, recent evidence indicates that autophagy is crucially involved in the regulation of the inflammatory response, a tightly controlled process aimed at clearing the inflammatory stimulus and restoring tissue homeostasis. To be efficient and beneficial to the host, inflammation should be controlled by a resolution program, since uncontrolled inflammation is the underlying cause of many pathologies. Resolution of inflammation is an active process mediated by a variety of mediators, including the so-called specialized pro-resolving lipid mediators (SPMs), a family of endogenous lipid autacoids known to regulate leukocyte infiltration and activities, and counterbalance cytokine production. Recently, regulation of autophagic mechanisms by these mediators has emerged, uncovering unappreciated connections between inflammation resolution and autophagy. Here, we summarize mechanisms of autophagy and resolution, focusing on the contribution of autophagy in sustaining paradigmatic examples of chronic inflammatory disorders. Then, we discuss the evidence that SPMs can restore dysregulated autophagy, hypothesizing that resolution of inflammation could represent an innovative approach to modulate autophagy and its impact on the inflammatory response.
  • 2.4K
  • 09 Nov 2020
Topic Review
GaN-Based LEDs: Modeling and Simulation
Light-emitting diodes (LEDs) based on Gallium Nitride (GaN) have been revolutionizing various applications in lighting, displays, biotechnology, and other fields. Many theoretical models have been developed for GaN-LED simulation, analysis, and design optimization, including carrier transport models, quantum well recombination models, and light extraction models. The overview below is a strongly abbreviated version of Ref. [1].
  • 2.4K
  • 17 Dec 2020
Topic Review
Aneuploidy
Aneuploidy is the presence of an abnormal number of chromosomes in a cell, for example a human cell having 45 or 47 chromosomes instead of the usual 46. It does not include a difference of one or more complete sets of chromosomes. A cell with any number of complete chromosome sets is called a euploid cell. An extra or missing chromosome is a common cause of some genetic disorders. Some cancer cells also have abnormal numbers of chromosomes. About 68% of human solid tumors are aneuploid. Aneuploidy originates during cell division when the chromosomes do not separate properly between the two cells (nondisjunction). Most cases of aneuploidy in the autosomes result in miscarriage, and the most common extra autosomal chromosomes among live births are 21, 18 and 13. Chromosome abnormalities are detected in 1 of 160 live human births. Autosomal aneuploidy is more dangerous than sex chromosome aneuploidy, as autosomal aneuploidy is almost always lethal to embryos that cease developing because of it.
  • 2.4K
  • 09 Nov 2022
Topic Review
α-Synuclein Aggregation in Treatment of Parkinson’s Disease
Parkinson’s disease, the second most common neurodegenerative disorder worldwide, is characterized by the accumulation of protein deposits in the dopaminergic neurons. These deposits are primarily composed of aggregated forms of α-Synuclein (α-Syn). PD is a complex pathology initially associated with motor deficiencies, as a result of an acute neuronal loss in substantia nigra pars compacta (SNc), with a significant dopaminergic (DA) impairment.
  • 2.4K
  • 31 Mar 2023
Topic Review
Context-Based and Adaptive Cybersecurity Risk Management Framework
Organizations are faced with a variety of cyber-threats and are possibly challenged by a wide range of cyber-attacks of varying frequency, complexity, and impact. However, they can do something to prevent, or at least mitigate, these cyber-attacks by first understanding and addressing their common problems regarding cybersecurity culture, developing a cyber-risk management plan, and devising a more proactive and collaborative approach that is suitable according to their organization context.
  • 2.4K
  • 09 Jun 2023
Topic Review
Magnetic Guiding
Magnetic guidance is understood as a remote, untethered and contact-free control of the movements of an object via magnetic interactions. The movements should happen on arbitrary trajectories inside a container caused by an external device. The concept of remote magnetic guiding is developed from the underlying physics for bijective force generation over the inner volume of magnet systems. This concept can equally be implemented by electro- or permanent magnets. 
  • 2.4K
  • 07 Dec 2021
Topic Review
Anatomical Variations of the External Jugular Vein
The external jugular vein (EJV) descends superficially to the sternocleidomastoid muscle and drains into the subclavian vein after penetrating the deep cervical fascia. Numerous morphological possibilities of the EJV could occur and should be carefully interpreted. These include fenestrations and double fenestrations, true or false duplications, triplication, absence, aberrant origin or course, bifurcation, or the internal jugular vein termination of the EJV. 
  • 2.4K
  • 31 Mar 2023
Topic Review
Processes for Obtaining Syngas and Hydrogen
The growing demand for high-quality chemical products has already stimulated an increased interest in the conversion of hydrocarbon gases (natural gas, methane, biogas) into motor fuels and high value-added chemical products, as well as into hydrogen, which is increasingly in demand on the market. The conversion of natural gas into hydrogen and syngas is still the most complex and costly stage of modern gas chemical processes, the low efficiency of which hinders the development of modern gas chemistry. 
  • 2.4K
  • 14 Apr 2023
Topic Review
Chemoresistance in Breast Cancers
Despite the leaps and bounds in achieving success in the management and treatment of breast cancers through surgery, chemotherapy, and radiotherapy, breast cancer remains the most frequently occurring cancer in women and the most common cause of cancer-related deaths among women. Systemic therapeutic approaches, such as chemotherapy, although beneficial in treating and curing breast cancer subjects with localized breast tumors, tend to fail in metastatic cases of the disease due to (a) an acquired resistance to the chemotherapeutic drug and (b) the development of intrinsic resistance to therapy. The existence of cancer stem cells (CSCs) plays a crucial role in both acquired and intrinsic chemoresistance. CSCs are less abundant than terminally differentiated cancer cells and confer chemoresistance through a unique altered metabolism and capability to evade the immune response system. Furthermore, CSCs possess active DNA repair systems, transporters that support multidrug resistance (MDR), advanced detoxification processes, and the ability to self-renew and differentiate into tumor progenitor cells, thereby supporting cancer invasion, metastasis, and recurrence/relapse. Hence, current research is focusing on targeting CSCs to overcome resistance and improve the efficacy of the treatment and management of breast cancer. Studies revealed that metformin (1, 1-dimethylbiguanide), a widely used anti-hyperglycemic agent, sensitizes tumor response to various chemotherapeutic drugs. Metformin selectively targets CSCs and improves the hypoxic microenvironment, suppresses the tumor metastasis and inflammation, as well as regulates the metabolic programming, induces apoptosis, and reverses epithelial–mesenchymal transition and MDR. Here, we discuss cancer (breast cancer) and chemoresistance, the molecular mechanisms of chemoresistance in breast cancers, and metformin as a chemo-sensitizing/re-sensitizing agent, with a particular focus on breast CSCs as a critical contributing factor to acquired and intrinsic chemoresistance. The review outlines the prospects and directions for a better understanding and re-purposing of metformin as an anti-cancer/chemo-sensitizing drug in the treatment of breast cancer. It intends to provide a rationale for the use of metformin as a combinatory therapy in a clinical setting.
  • 2.4K
  • 15 Sep 2020
Topic Review
Phosphogypsum
Phosphogypsum is an almost unused by-product of phosphate fertilizer production, which includes several valuable components—calcium sulphates and rare-earth elements such as silicon, iron, titanium, magnesium, aluminum, and manganese, as well as toxic elements such as heavy metals and others.
  • 2.4K
  • 25 Feb 2021
Topic Review
Nutrition of Indian Millets
Millets are termed as “yesterday’s coarse grains and today’s nutri-cereals.” Millets are considered to be “future crops” as they are resistant to most of the pests and diseases and adapt well to the harsh environment of the arid and semi-arid regions of Asia and Africa. 
  • 2.4K
  • 28 Feb 2022
Topic Review
Non-Pharmacological Options in Atherosclerosis
Atherosclerosis remains the leading cause of mortality and morbidity worldwide characterized by the deposition of lipids and fibrous elements in the form of atheroma plaques in vascular areas which are hemodynamically overloaded. Atherosclerotic cardiovascular disease is the leading cause of death and disability. Prolonged survival with chronic disease explains why the prevalence, burden, and costs of the disease remain high. Given these issues, aggressive treatment should be started at the first indication and continued over several years, along with the reduction in disease risk factors such as visceral adiposity, dyslipidemia, hypertension, and diabetes.
  • 2.4K
  • 04 Oct 2022
Topic Review
Endocytosis in Health and Disease
Endocytosis is a mechanistic process, associated with internalization of the extracellular materials such as microbes, cellular components, nutrients, or macromolecules. Conventionally, eukaryotic cells use the endocytosis process for the absorption of molecules and secretion of signaling transmitters (hormones and cytokines) to maintain cellular homeostasis. Endocytosis machinery is a well-conserved physiological process in lower to higher organisms, which has been frequently acquired for cellular defense, immune responses, uptake, and energy metabolism. 
  • 2.4K
  • 13 Feb 2023
Topic Review
Reaction Mechanism of Olefins
Light olefins (C2-C4) are important C-building blocks which are currently used to produce a variety of chemicals, such as elastomers, medicines, cosmetics, detergents, solvents, etc. They can be produced by steam cracking, fluid catalytic cracking of naphtha, direct/indirect conversion of synthesis gas (CO + H2) or by hydrogenation of CO2 using H2 from renovable energy sources. However, the catalytic production of light olefins from CO2 is difficult due to the chemical inactivity of CO2 molecule, the high C-C coupling barrier and the necesity to limit the formation of C-C bond and methane. Therefore, the catalysts required for this reaction must to be multifunctional and have an optimized amount of active sites. 
  • 2.4K
  • 29 Nov 2021
Topic Review
Chenopodium quinoa (Willd.) Diseases
The journey of the Andean crop quinoa (Chenopodium quinoa Willd.) to unfamiliar environments and the combination of higher temperatures, sudden changes in weather, intense precipitation, and reduced water in the soil has increased the risk of observing new and emerging diseases associated with this crop. Several diseases of quinoa have been reported in the last decade. These include Ascochyta caulina, Cercospora cf. chenopodii, Colletotrichum nigrum, C. truncatum, and Pseudomonas syringae. The taxonomy of other diseases remains unclear or is characterized primarily at the genus level. Symptoms, microscopy, and pathogenicity, supported by molecular tools, constitute accurate plant disease diagnostics in the 21st century. This review aims to compile the existing information and make accurate associations between specific symptoms and causal agents of disease. In addition, we place an emphasis on downy mildew and its phenotyping, as it continues to be the most economically important and studied disease affecting quinoa worldwide. 
  • 2.4K
  • 29 Jun 2021
  • Page
  • of
  • 2799
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback