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Topic Review
Cyclin-Dependent Kinase 4/6 Inhibitors in the Tumor Microenvironment
Cancer is characterized by persistent cell proliferation driven by aberrant cell cycle regulation and stimulation of cyclin-dependent kinases (CDKs). A very intriguing and potential approach for the development of antitumor medicines is the suppression of CDKs that lead to induction of apoptosis and cell cycle arrest. The shift of the cell cycle from the G0/G1 phase to the S phase, which is characterized by active transcription and synthesis, depends on the development of the cyclin D-CDK4/6 complex. A precise balance between anticancer activity and general toxicity is demonstrated by CDK inhibitors, which can specifically block CDK4/6 and control the cell cycle by reducing the G1 to S phase transition. 
  • 2.4K
  • 08 Feb 2023
Topic Review
Nanoparticles in Lung Cancer Treatment
Lung cancer is managed using conventional therapies, including chemotherapy, radiation therapy, or a combination of both. Each of these therapies has its own limitations, such as the indiscriminate killing of normal as well as cancer cells, the solubility of the chemotherapeutic drugs, rapid clearance of the drugs from circulation before reaching the tumor site, the resistance of cancer cells to radiation, and over-sensitization of normal cells to radiation. Other treatment modalities include gene therapy, immunological checkpoint inhibitors, drug repurposing, and in situ cryo-immune engineering (ICIE) strategy. Nanotechnology has come to the rescue to overcome many shortfalls of conventional therapies.
  • 2.4K
  • 06 Jul 2023
Topic Review
Cooling Methods for Standard and Floating PV Panels
Energy and water poverty are two main challenges of the modern world. Most developing and underdeveloped countries need more efficient electricity-producing sources to overcome the problem of potable water evaporation. At the same time, the traditional way to produce energy/electricity is also responsible for polluting the environment and damaging the ecosystem. Notably, many techniques have been used around the globe, such as a photovoltaic (PV) cooling (active, passive, and combined) process to reduce the working temperature of the PV panels (up to 60 °C) to improve the system efficiency. For floating photovoltaic (FPV), water cooling is mainly responsible for reducing the panel temperature to enhance the production capacity of the PV panels, while the system efficiency can increase up to around 30%. 
  • 2.4K
  • 12 Dec 2023
Topic Review
Soiling of Pig Pens
The soiling of pig pens has important implications for animal welfare, health, workload, and environmental emissions of pig farming. This excerpt provides an overview of the historical reasons behind current production systems, of pen soiling prevalence and its importance. Possible strategies and specific suggestions on how to address pen soiling in current systems are described, based on an extensive review on pigs’ normal eliminatory behaviour.
  • 2.4K
  • 16 Nov 2020
Topic Review
Employee’s MOB and Firm’s IMM
A successful organization depends primarily on employees' effort, attitude, behavior, and interaction. All these factors are employee-related and play a critical role in accomplishing the organization’s strategy. Scholars have confirmed that employees’ attitudes and behaviors positively influence a firm’s accounting measures and stock returns. Therefore, it is crucial for a firm to entice employees to engage in market orientation behavior (MOB) to attain sustainable competitive advantages and excel at business performance. In the early 1970s, Kotler introduced internal marketing and suggested that a firm should market to its employees before marketing to its customers. Soon after the emergence of this concept, firms began to view jobs as products and employees as internal customers. To be successful, a business must retain talented and competent employees; internal marketing can help businesses resolve this issue. Internal marketing is regarded as a model component of service marketing management and a measurable scale for empirical research.
  • 2.4K
  • 29 Jun 2021
Topic Review
Gender Dysphoria
Gender dysphoria (GD) is the distress a person feels due to a mismatch between their gender identity—their personal sense of their own gender—and their sex assigned at birth. The diagnostic label gender identity disorder (GID) was used until 2013 with the release of the DSM-5. The condition was renamed to remove the stigma associated with the term disorder. People with gender dysphoria commonly identify as transgender. Gender nonconformity is not the same thing as gender dysphoria and does not always lead to dysphoria or distress. According to the American Psychiatric Association, the critical element of gender dysphoria is "clinically significant distress". The causes of gender dysphoria are unknown but a gender identity likely reflects genetic and biological, environmental, and cultural factors. Treatment for gender dysphoria may include supporting the individual's gender expression or their desire for hormone therapy or surgery. Treatment may also include counseling or psychotherapy. Some researchers and transgender people support declassification of the condition because they say the diagnosis pathologizes gender variance and reinforces the binary model of gender.
  • 2.4K
  • 17 Oct 2022
Topic Review Peer Reviewed
Oleaginous Red Yeasts: Concomitant Producers of Triacylglycerides and Carotenoids
Oleaginous red yeast species are colourful (usually having orange-pink-red hues) single cell microorganisms capable of producing valuable bioproducts including triacylglycerides (TAGs) for biodiesel and carotenoids for nutraceuticals. The name “oleaginous yeasts” is conferred based on their ability to synthesize and accumulate TAGs to over 20% of their dry cell weight. Their colours are indicative of the presence of the major carotenoids present in them.
  • 2.4K
  • 19 Apr 2023
Topic Review
Metal Organic Frameworks Supported on Graphene Oxide
Nanotechnology is one of the most active research fields in materials science. Metal-organic frameworks (MOFs) have the benefits of having a sizable specific surface area, extremely high porosity, changeable pore size, post-synthesis modification, and extreme thermal stability. Graphene oxide (GO) has attracted significant research interest due to its similar surface area to MOFs. Furthermore, oxygen-containing groups presented in graphene oxide offer the unique processing and handling advantages of amphiphilicity and dispersion in water. MOF-based GO has attracted attention due to its resemblance to metal ions and organic binding linkers. It has sparked great interest in the past few years due to its distinct characteristics and higher performance compared to MOFs or GO alone. 
  • 2.4K
  • 20 Oct 2023
Topic Review
Treatment of the Lips Using a CO2 Laser
A number of studies have recently demonstrated the effectiveness of CO2 laser irradiation for the repair and regeneration of scar tissue from injuries or surgical wounds. However, such studies of the oral mucosa are highly limited. Previous studies using CO2 laser irradiation have indicated that two factors contribute to esthetic healing, namely, artificial scabs, which are a coagulated and carbonized blood layer formed on the wound surface, and photobiomodulation therapy (PBMT) for suppressing wound scarring and promoting wound healing. 
  • 2.4K
  • 06 Dec 2023
Topic Review
Milk Bioactive Compounds
The milk fat fraction is a rich source of nutrients and bioactive factors. This fraction is composed of milk fat globules (MFGs) surrounded by the milk fat globule membrane (MFGM). In this review we revise the literature that deals two minor topics that characterize the milk fat fraction. The first topic is the MFGM proteome, which has several bioactive properties and shows similarities and variations among species and phases of lactation. The second topic is the content of essential nutrients among MFGs and MFGM, named minerals and lipophilic vitamins, in order to assess the nutrifunctional role of the milk fat fraction. 
  • 2.4K
  • 29 Apr 2021
Topic Review
Shallow Marine Sediments
Geological structure changes, including deformations and ruptures, developed in shallow marine sediments are well recognized but were not systematically reviewed in previous studies. These structures, generally developed at a depth less than 1000 m below seafloor, are considered to play a significant role in the migration, accumulation, and emission of hydrocarbon gases and fluids, and the formation of gas hydrates, and they are also taken as critical factors affecting carbon balance in the marine environment.
  • 2.3K
  • 25 Apr 2021
Topic Review
Bambara Groundnut
Currently, the global agricultural system is focused on a limited number of crop species, thereby presenting a threat to food security and supply, especially with predicted global climate change conditions. The importance of ‘underutilized’ crop species in meeting the world’s demand for food has been duly recognized by research communities, governments and policy makers worldwide. The development of underutilized crops, with their vast genetic resources and beneficial traits, may be a useful step towards solving food security challenges by offering a multifaceted agricultural system that includes additional important food resources. Bambara groundnut is among the beneficial underutilized crop species that may have a positive impact on global food security through organized and well-coordinated multidimensional breeding programs. The excessive degrees of allelic difference in Bambara groundnut germplasm could be exploited in breeding activities to develop new varieties. It is important to match recognized breeding objectives with documented diversity in order to significantly improve breeding. 
  • 2.3K
  • 08 Jun 2021
Topic Review
Diagonal Earlobe Crease
Diagonal earlobe crease is a wrinkle extending obliquely from the tragus towards the border of the earlobe. It was firstly described by Frank in 1973 in the New England Journal of Medicine in a case series of patients with coronary artery disease. Since then, there have been many reports published regarding its association mainly with atherosclerosis, especially coronary artery disease.
  • 2.3K
  • 22 Sep 2021
Topic Review
Forest Connectivity
Forest connectivity is critical for the long-term persistence and range shifts of forest-dependent species. In the face of contemporary climate change, the climate connectivity of forested areas is one of the most important factors that determine species’ ability to track suitable climate niches. Climate connectivity is defined as the degree to which a landscape allows species to shift their ranges to suitable habitats that are the same or cooler than their current habitats as the climate warms. Improving climate connectivity is both a necessary action and a viable solution to reduce the likelihood of local extinctions and biodiversity loss. This is particularly urgent considering the rapid rate of climate change, which is expected to cause large shifts in the distributions of species in European forests.
  • 2.3K
  • 28 Jul 2021
Topic Review
Effect of Licorice in Different Diseases
There are more than 30 species of Glycyrrhiza genus extensively spread worldwide. It was the most prescribed herb in Ancient Egyptian, Roman, Greek, East China, and the West from the Former Han era. There are various beneficial effects of licorice root extracts, such as treating throat infections, tuberculosis, respiratory, liver diseases, antibacterial, anti-inflammatory, and immunodeficiency. On the other hand, traditional medicines are getting the attraction to treat many diseases. Therefore, it is vital to screen the medicinal plants to find the potential of new compounds to treat chronic diseases such as respiratory, cardiovascular, anticancer, hepatoprotective, etc.
  • 2.3K
  • 07 Jan 2022
Topic Review
Catalytic Mechanism of Photocatalysts Based on GCN Heterogeneous
In the current world situation, population and industrial growth have become major problems for energy and environmental concerns. Extremely noxious pollutants such as heavy metal ions, dyes, antibiotics, phenols, and pesticides in water are the main causes behind deprived water quality leading to inadequate access to clean water. In this connection, graphite carbon nitride (GCN or g-C3N4) a nonmetallic polymeric material has been utilized extensively as a visible-light-responsive photocatalyst for a variety of environmental applications.
  • 2.3K
  • 16 Jun 2022
Topic Review
Loyalty
Loyalty, in general use, is a devotion and faithfulness to a nation, cause, philosophy, country, group, or person. Philosophers disagree on what can be an object of loyalty, as some argue that loyalty is strictly interpersonal and only another human being can be the object of loyalty. The definition of loyalty in law and political science is the fidelity of an individual to a nation, either one's nation of birth, or one's declared home nation by oath (naturalization).
  • 2.3K
  • 09 Oct 2022
Topic Review
Bit Manipulation Instruction Set
Bit manipulation instructions sets (BMI sets) are extensions to the x86 instruction set architecture for microprocessors from Intel and AMD. The purpose of these instruction sets is to improve the speed of bit manipulation. All the instructions in these sets are non-SIMD and operate only on general-purpose registers. There are two sets published by Intel: BMI (here referred to as BMI1) and BMI2; they were both introduced with the Haswell microarchitecture. Another two sets were published by AMD: ABM (Advanced Bit Manipulation, which is also a subset of SSE4a implemented by Intel as part of SSE4.2 and BMI1), and TBM (Trailing Bit Manipulation, an extension introduced with Piledriver-based processors as an extension to BMI1, but dropped again in Zen-based processors).
  • 2.3K
  • 17 Oct 2022
Topic Review
Addiction
Addiction is a biopsychosocial disorder characterized by compulsive engagement in rewarding stimuli despite adverse consequences. Despite the involvement of a number of psychosocial factors, a biological process—one that is induced by repeated exposure to an addictive stimulus—is the core pathology that drives the development and maintenance of an addiction, according to the "brain disease model" of addiction. However, some scholars who study addiction argue that the brain disease model is incomplete and misleading. The brain disease model posits that addiction is a disorder of the brain's reward system which arises through transcriptional and epigenetic mechanisms and develops over time from chronically high levels of exposure to an addictive stimulus (e.g., eating food, the use of cocaine, engagement in sexual activity, participation in high-thrill cultural activities such as gambling, etc.). DeltaFosB (ΔFosB), a gene transcription factor, is a critical component and common factor in the development of virtually all forms of behavioral and drug addictions. Two decades of research into ΔFosB's role in addiction have demonstrated that addiction arises, and the associated compulsive behavior intensifies or attenuates, along with the overexpression of ΔFosB in the D1-type medium spiny neurons of the nucleus accumbens. Due to the causal relationship between ΔFosB expression and addictions, it is used preclinically as an addiction biomarker. ΔFosB expression in these neurons directly and positively regulates drug self-administration and reward sensitization through positive reinforcement, while decreasing sensitivity to aversion.[note 1] Addiction exacts an "astoundingly high financial and human toll" on individuals and society as a whole. In the United States, the total economic cost to society is greater than that of all types of diabetes and all cancers combined. These costs arise from the direct adverse effects of drugs and associated healthcare costs (e.g., emergency medical services and outpatient and inpatient care), long-term complications (e.g., lung cancer from smoking tobacco products, liver cirrhosis and dementia from chronic alcohol consumption, and meth mouth from methamphetamine use), the loss of productivity and associated welfare costs, fatal and non-fatal accidents (e.g., traffic collisions), suicides, homicides, and incarceration, among others. Classic hallmarks of addiction include impaired control over substances or behavior, preoccupation with substance or behavior, and continued use despite consequences. Habits and patterns associated with addiction are typically characterized by immediate gratification (short-term reward), coupled with delayed deleterious effects (long-term costs). The etymology of addiction through-out history has been often misunderstood and has taken on various meanings associated with the word. An example is the usage of the word during the Early Modern period. ‘Addiction’ at the time, meant to ‘attach’ to something, giving it both positive and negative connotations. The object of this attachment could be characterised as “good or bad”.,however, the meaning of addiction during this period was mostly associated with positivity and goodness. During the highly religious era, it was seen as a way of “devoting oneself to another”. Modern research on addiction has led to a better understanding of the disease with research studies on the topic dating back to 1875, specifically on morphine addiction. This furthered the understanding of addiction being a medical condition. It wasn’t until the 19th century that addiction was seen and acknowledged as a disease, being both a medical and mental illness. Today, addiction is understood as a disease that negatively impacts those who are diagnosed, most commonly associated with drug and alcohol abuse. The understanding of addiction has changed through-out history, which has impacted, and continues to impact the ways it is medically treated and diagnosed. Examples of drug and behavioral addictions include alcoholism, marijuana addiction, amphetamine addiction, cocaine addiction, nicotine addiction, opioid addiction, food addiction, chocolate addiction, video game addiction, gambling addiction, and sexual addiction. The only behavioral addiction recognized by the DSM-5 and the ICD-10 is gambling addiction. With the introduction of the ICD-11 gaming addiction was appended. The term addiction is misused frequently to refer to other compulsive behaviors or disorders, particularly dependence, in news media. An important distinction between drug addiction and dependence is that drug dependence is a disorder in which cessation of drug use results in an unpleasant state of withdrawal, which can lead to further drug use. Addiction is the compulsive use of a substance or performance of a behavior that is independent of withdrawal. Addiction can occur in the absence of dependence, and dependence can occur in the absence of addiction, although the two often occur together.
  • 2.3K
  • 17 Oct 2022
Topic Review
Epstein–Barr Virus Latency
Epstein–Barr virus (EBV) is one of eight known herpesviruses with the potential to infect humans. EBV latency, and more particularly the proteins expressed during this phase of the viral cycle, is heavily implicated in EBV-mediated oncogenesis.
  • 2.3K
  • 30 Nov 2022
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