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Topic Review
GaN-Based LEDs: Modeling and Simulation
Light-emitting diodes (LEDs) based on Gallium Nitride (GaN) have been revolutionizing various applications in lighting, displays, biotechnology, and other fields. Many theoretical models have been developed for GaN-LED simulation, analysis, and design optimization, including carrier transport models, quantum well recombination models, and light extraction models. The overview below is a strongly abbreviated version of Ref. [1].
  • 2.4K
  • 17 Dec 2020
Topic Review
Battery Safety
Battery safety is a prominent concern for the deployment of electric vehicles (EVs). The battery powering an EV contains highly energetic active materials and flammable organic electrolytes. Usually, an EV battery catches fire due to its thermal runaway, either immediately at the time of the accident or can take a while to gain enough heat to ignite the battery chemicals. There are numerous battery abuse testing standards and regulations available globally. Therefore, battery manufacturers are always in dilemma to choose the safest one. Henceforth, to find the optimal outcome of these two major issues, six standards (SAE J2464:2009, GB/T 31485-2015:2015, FreedomCAR:2006, ISO 12405-3:2014, IEC 62660-2:2010, and SAND2017-6295:2017) and two regulations (UN/ECE-R100.02:2013 and GTR 20:2018), that are followed by more than fifty countries in the world, are investigated in terms of their abuse battery testing conditions (crush test).
  • 2.4K
  • 11 Nov 2021
Topic Review
Bell's Mania
Bell's mania, also known as delirious mania, refers to an acute neurobehavioral syndrome. This is usually characterized by an expeditious onset of delirium, mania, psychosis, followed by grandiosity, emotional lability, altered consciousness, hyperthermia, and in extreme cases, death. It is sometimes misdiagnosed as excited delirium (EXD) or catatonia due to the presence of overlapping symptoms. Pathophysiology studies reveal elevated dopamine levels in the neural circuit as the underlying mechanism. Psychostimulant users as well as individuals experiencing severe manic episodes are more prone to the manifestation of this condition. Management solutions such as sedation and ketamine injections have been discussed for medical professionals and individuals with the condition. Bell's mania cases are commonly reported in countries like the United States and Canada and are commonly associated with psychostimulant use and abuse.
  • 2.4K
  • 08 Nov 2022
Topic Review
Scanning Transmission Electron Microscopy
A scanning transmission electron microscope (STEM) is a type of transmission electron microscope (TEM). Pronunciation is [stɛm] or [ɛsti:i:ɛm]. As with a conventional transmission electron microscope (CTEM), images are formed by electrons passing through a sufficiently thin specimen. However, unlike CTEM, in STEM the electron beam is focused to a fine spot (with the typical spot size 0.05 – 0.2 nm) which is then scanned over the sample in a raster illumination system constructed so that the sample is illuminated at each point with the beam parallel to the optical axis. The rastering of the beam across the sample makes STEM suitable for analytical techniques such as Z-contrast annular dark-field imaging, and spectroscopic mapping by energy dispersive X-ray (EDX) spectroscopy, or electron energy loss spectroscopy (EELS). These signals can be obtained simultaneously, allowing direct correlation of images and spectroscopic data. A typical STEM is a conventional transmission electron microscope equipped with additional scanning coils, detectors, and necessary circuitry, which allows it to switch between operating as a STEM, or a CTEM; however, dedicated STEMs are also manufactured. High-resolution scanning transmission electron microscopes require exceptionally stable room environments. In order to obtain atomic resolution images in STEM, the level of vibration, temperature fluctuations, electromagnetic waves, and acoustic waves must be limited in the room housing the microscope.
  • 2.4K
  • 29 Nov 2022
Topic Review
Context-Based and Adaptive Cybersecurity Risk Management Framework
Organizations are faced with a variety of cyber-threats and are possibly challenged by a wide range of cyber-attacks of varying frequency, complexity, and impact. However, they can do something to prevent, or at least mitigate, these cyber-attacks by first understanding and addressing their common problems regarding cybersecurity culture, developing a cyber-risk management plan, and devising a more proactive and collaborative approach that is suitable according to their organization context.
  • 2.4K
  • 09 Jun 2023
Topic Review
The Autophagic Pathway
Autophagy is a catabolic pathway that accounts for degradation and recycling of cellular components to extend cell survival under stress conditions. In addition to this prominent role, recent evidence indicates that autophagy is crucially involved in the regulation of the inflammatory response, a tightly controlled process aimed at clearing the inflammatory stimulus and restoring tissue homeostasis. To be efficient and beneficial to the host, inflammation should be controlled by a resolution program, since uncontrolled inflammation is the underlying cause of many pathologies. Resolution of inflammation is an active process mediated by a variety of mediators, including the so-called specialized pro-resolving lipid mediators (SPMs), a family of endogenous lipid autacoids known to regulate leukocyte infiltration and activities, and counterbalance cytokine production. Recently, regulation of autophagic mechanisms by these mediators has emerged, uncovering unappreciated connections between inflammation resolution and autophagy. Here, we summarize mechanisms of autophagy and resolution, focusing on the contribution of autophagy in sustaining paradigmatic examples of chronic inflammatory disorders. Then, we discuss the evidence that SPMs can restore dysregulated autophagy, hypothesizing that resolution of inflammation could represent an innovative approach to modulate autophagy and its impact on the inflammatory response.
  • 2.4K
  • 09 Nov 2020
Topic Review
Nutrition of Indian Millets
Millets are termed as “yesterday’s coarse grains and today’s nutri-cereals.” Millets are considered to be “future crops” as they are resistant to most of the pests and diseases and adapt well to the harsh environment of the arid and semi-arid regions of Asia and Africa. 
  • 2.4K
  • 28 Feb 2022
Topic Review
Zinc Deficiency
Zinc deficiency is defined either as insufficient zinc to meet the needs of the body, or as a serum zinc level below the normal range. However, since a decrease in the serum concentration is only detectable after long-term or severe depletion, serum zinc is not a reliable biomarker for zinc status. Common symptoms include increased rates of diarrhea. Zinc deficiency affects the skin and gastrointestinal tract; brain and central nervous system, immune, skeletal, and reproductive systems. Zinc deficiency in humans is caused by reduced dietary intake, inadequate absorption, increased loss, or increased body system use. The most common cause is reduced dietary intake. In the U.S., the Recommended Dietary Allowance (RDA) is 8 mg/day for women and 11 mg/day for men. The highest concentration of dietary zinc is found in oysters, meat, beans, and nuts. Increasing the amount of zinc in the soil and thus in crops and animals is an effective preventive measure. Zinc deficiency may affect up to 2 billion people worldwide.
  • 2.4K
  • 27 Oct 2022
Topic Review
The Medicinal Chemistry of Artificial Nucleic Acids
Nucleic acids play a central role in human biology, making them suitable and attractive tools for therapeutic applications. While conventional drugs generally target proteins and induce transient therapeutic effects, nucleic acid medicines can achieve long-lasting or curative effects by targeting the genetic bases of diseases.
  • 2.4K
  • 05 Aug 2022
Topic Review
Atopic Dermatitis (AD)
The skin harbors a huge number of different microorganisms such as bacteria, fungi and viruses, and it acts as a protective shield to prevent the invasion of pathogens and to maintain the health of the commensal microbiota. Several studies, in fact, have shown the importance of the skin microbiota for healthy skin. This balance can be altered by intrinsic and extrinsic factors, leading to the development of skin disease, such as acne vulgaris (AV), atopic dermatitis (AD) and rosacea (RS).
  • 2.4K
  • 27 Oct 2022
Topic Review
Dragon C2+
SpaceX COTS Demo Flight 2 (COTS 2), also known as Dragon C2+, was the second test-flight for SpaceX's uncrewed Cargo Dragon spacecraft, launched on the third flight of the company's two-stage Falcon 9 launch vehicle. The flight was performed under a funded agreement from NASA as the second Dragon demonstration mission in the Commercial Orbital Transportation Services (COTS) program. The purpose of the COTS program is to develop and demonstrate commercial sources for cargo re-supply of the International Space Station (ISS). The Dragon C2+ spacecraft was the first American vehicle to visit the ISS since the end of the Space Shuttle program. It was also the first commercial spacecraft to rendezvous and berth with another spacecraft. Initially, the objectives of the C2+ mission were to have been accomplished by two separate missions; Dragon C2 would have carried out a fly-by of the ISS, practiced rendezvous maneuvers and communications with the station, before returning to Earth. A second mission, Dragon C3, would have been the first mission to berth with the station. In July 2011, NASA gave tentative approval to combine the objectives of the two missions. In December 2011, NASA formally approved the merger of the COTS 2 and 3 missions into the Dragon C2+ flight. There were several launch delays, the last one occurring on 19 May 2012, due to a launch abort during the last second before liftoff. Dragon C2+ successfully launched from Cape Canaveral on 22 May 2012. During the mission's first three days all of the COTS 2 objectives were successfully completed. The mission's COTS 3 phase began on 25 May when Dragon rendezvoused again with the ISS and then was successfully captured using the Canadarm2. It was berthed to the station later that day, using the robotic arm. Dragon stayed for almost six days during which the astronauts unloaded cargo, and then reloaded Dragon with Earth-bound cargo. On 31 May, Dragon unberthed from the ISS, its capsule landed in the Pacific Ocean off the California coast and was recovered. All the objectives of the mission were successfully completed, and the Falcon 9-Dragon system became certified to start regular cargo delivery missions to the ISS under the Commercial Resupply Services program.
  • 2.4K
  • 04 Nov 2022
Topic Review
Blood-Brain Barrier: Functionalised Chitosan
The major impediment to the delivery of therapeutics to the brain is the presence of the blood-brain barrier (BBB). The BBB allows for the entrance of essential nutrients while excluding harmful substances, including most therapeutic agents; hence, brain disorders, especially tumors, are very difficult to treat. Chitosan is a well-researched polymer that offers advantageous biological and chemical properties, such as mucoadhesion and ease of functionalization. Chitosan-based nanocarriers (CsNCs) establish ionic interactions with the endothelial cells, facilitating the crossing of drugs through the BBB by adsorptive mediated transcytosis. This process is further enhanced by modifications of the structure of chitosan, owing to the presence of reactive amino and hydroxyl groups. Finally, by permanently binding ligands or molecules, such as antibodies or lipids, CsNCs have shown a boosted passage through the BBB, in both in vivo and in vitro studies which will be discussed in this review.
  • 2.4K
  • 21 Nov 2020
Topic Review
Bacterial Biopolymer
Biopolymers are polymers being synthesized by living organisms with the help of enzymes that connects the building blocks like sugars, hydroxyl fatty acids, and amino acids to produce molecules with high molecular weight.
  • 2.4K
  • 30 Apr 2021
Topic Review
Pyrolysis Technology
Pyrolysis technology is a thermo-chemical route for converting biomass to many useful products (biochar, bio-oil, and combustible pyrolysis gases). The composition and relative product yield depend on the pyrolysis technology adopted. 
  • 2.4K
  • 24 Oct 2021
Topic Review
Lactobacillus reuteri
At the turn of the 20th century, L. reuteri was recorded in scientific classifications of lactic acid bacteria.
  • 2.4K
  • 12 Oct 2022
Topic Review
Taupo Volcanic Zone
The Taupō Volcanic Zone (TVZ) is a volcanic area in the North Island of New Zealand that has been active for the past two million years and is still highly active. Mount Ruapehu marks its south-western end and the zone runs north-eastward through the Taupo and Rotorua areas and offshore into the Bay of Plenty. It is part of the larger Central Volcanic Region that extends further westward through the western Bay of Plenty to the eastern side of the Coromandel Peninsula and has been active for four million years. The Taupo Volcanic Zone is widening east–west at the rate of about 8 mm per year. It is named after Lake Taupo, the flooded caldera of the largest volcano in the zone, the Taupo Volcano.
  • 2.4K
  • 24 Oct 2022
Topic Review
Aneuploidy
Aneuploidy is the presence of an abnormal number of chromosomes in a cell, for example a human cell having 45 or 47 chromosomes instead of the usual 46. It does not include a difference of one or more complete sets of chromosomes. A cell with any number of complete chromosome sets is called a euploid cell. An extra or missing chromosome is a common cause of some genetic disorders. Some cancer cells also have abnormal numbers of chromosomes. About 68% of human solid tumors are aneuploid. Aneuploidy originates during cell division when the chromosomes do not separate properly between the two cells (nondisjunction). Most cases of aneuploidy in the autosomes result in miscarriage, and the most common extra autosomal chromosomes among live births are 21, 18 and 13. Chromosome abnormalities are detected in 1 of 160 live human births. Autosomal aneuploidy is more dangerous than sex chromosome aneuploidy, as autosomal aneuploidy is almost always lethal to embryos that cease developing because of it.
  • 2.4K
  • 09 Nov 2022
Topic Review
Acetylation
Acetylation, also known as acetylation or acetylation, refers to the chemical reaction of adding an acetyl functional group to an organic compound. Conversely, the reaction in which the acetyl group is removed is called deacetylation or deacetylation. Acetylation of proteins is a post-translational modification.
  • 2.4K
  • 16 Nov 2022
Topic Review
Staphylococcal Infection
A staphylococcal infection or staph infection is an infection caused by members of the Staphylococcus genus of bacteria. These bacteria commonly inhabit the skin and nose where they are innocuous, but may enter the body through cuts or abrasions which may be nearly invisible. Once inside the body, the bacteria may spread to a number of body systems and organs, including the heart, where the toxins produced by the bacteria may cause cardiac arrest. Once the bacterium has been identified as the cause of the illness, treatment is often in the form of antibiotics and, where possible, drainage of the infected area. However, many strains of this bacterium have become antibiotic resistant; for those with these kinds of infection, the body's own immune system is the only defense against the disease. If that system is weakened or compromised, the disease may progress rapidly. Anyone can contract staph, but pregnant women, children, and people with chronic diseases or who are immuno-deficient are often more susceptible to contracting an infection.
  • 2.4K
  • 28 Nov 2022
Topic Review
Guided Biofilm Therapy
Guided biofilm therapy (GBT) is a new regimen where there is a sequential removal of plaque and calculus by initially detecting it with a disclosing agent followed by the usage of air abrasive powder for the removal of plaque and stains. Finally, the subgingival plaque and calculus are removed with a specialized nozzle and (if required) eventually scaling with a specialized tip is performed.
  • 2.4K
  • 05 Jan 2022
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