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Topic Review
Molecules from Mexican Hypoglycemic Plants
Like in many developing countries, in Mexico, the use of medicinal plants is a common practice. Based on our own field experience, there are at least 800 plants used for treating diabetes nowadays. Thus, their investigation is essential. The molecules isolated from Mexican hypoglycemic plants, including their source and target tested, are worth studying. In the last few years, some researchers have focused on the study of Mexican hypoglycemic plants. Herewith we provide a review of the 86 active compounds belonging to different classes of natural products, that have been isolated from Mexican Hypoglycemic plants.
  • 1.2K
  • 27 Oct 2020
Topic Review
Glucose Metabolism in Thyroid Cancer
Metabolism is a series of life-sustaining chemical reactions in organisms, providing energy required for cellular processes and building blocks for cellular constituents of proteins, lipids, carbohydrates and nucleic acids. Cancer cells frequently reprogram their metabolic behaviors to adapt their rapid proliferation and altered tumor microenvironments.
  • 1.2K
  • 08 Dec 2022
Topic Review
Circadian Clock
Most living organisms in both the plant and animal kingdoms have evolved processes to stay in tune with the alternation of day and night, and to optimize their physiology as a function of light supply. In mammals, a circadian clock relying on feedback loops between key transcription factors will thus control the temporally regulated pattern of expression of most genes. Modern ways of life have highly altered the synchronization of human activities with their circadian clocks. The circadian clock orchestrates most physiological events in living organisms and its deregulation in association with modern ways of life correlates with the rise of multiple pathologies in humans. 
  • 1.2K
  • 23 Aug 2022
Topic Review
Steroidogenesis, Oxidative Stress and Male Hypogonadism
Steroid sex hormones are classified as androgens, estrogens, and progestogens. Although all three classes are important in male and female physiology, androgens are associated with "musculisation" effects and are considered primarily male sex hormones. Androgens have diverse functions in muscle physiology, lean body mass, the regulation of adipose tissue, bone density, neurocognitive regulation, and spermatogenesis, male reproductive and sexual function.
  • 1.2K
  • 29 Mar 2022
Topic Review
Insulin-Like Growth Factor-1
This article details the critical roles that insulin-like growth factor-1 and its receptor insulin-like growth factor-1 receptor (GFR1) play in maintaining bone homeostasis and how exposure of bone cells to microgravity affects the function of these growth factors. 
  • 1.2K
  • 14 Jul 2020
Topic Review
LIN28-let-7-ARID3B Pathway
Placental disorders are a major cause of pregnancy loss in humans, and 40%–60% of embryos are lost between fertilization and birth. Successful embryo implantation and placental development requires rapid proliferation, invasion, and migration of trophoblast cells. In recent years, microRNAs (miRNAs) have emerged as key regulators of molecular pathways involved in trophoblast function. A miRNA binds its target mRNA in the 3ʹ-untranslated region (3ʹ-UTR), causing its degradation or translational repression. Lethal-7 (let-7) miRNAs induce cell differentiation and reduce cell proliferation by targeting proliferation-associated genes. The oncoprotein LIN28 represses the biogenesis of mature let-7 miRNAs. Proliferating cells have high LIN28 and low let-7 miRNAs, whereas differentiating cells have low LIN28 and high let-7 miRNAs. In placenta, low LIN28 and high let-7 miRNAs can lead to reduced proliferation of trophoblast cells, resulting in abnormal placental development. In trophoblast cells, let-7 miRNAs reduce the expression of proliferation factors either directly by binding their mRNA in 3ʹ-UTR or indirectly by targeting the -rich interaction domain (ARID)3B complex, a transcription-activating complex comprised of ARID3A, ARID3B, and histone demethylase 4C (KDM4C). In this review, we discuss regulation of trophoblast function by miRNAs, focusing on the role of LIN28-let-7-ARID3B pathway in placental development.
  • 1.2K
  • 27 Oct 2020
Topic Review
Nitric Oxide in Different Cancer Types
Nitric oxide (NO) is a short-lived, ubiquitous signaling molecule that affects numerous critical functions in the body. There are markedly conflicting findings in the literature regarding the bimodal effects of NO in carcinogenesis and tumor progression, which has important consequences for treatment. 
  • 1.1K
  • 16 Jan 2023
Topic Review
Obesity and Respiratory Infections
Obesity has become a major metabolic disorder due to a combination of genetic, nutritional, and environmental factors. Energy balance in the body is sustained by regulating food intake and energy expenditure. Excessive calorie consumption and/or inadequate energy expenditure result in the accumulation of excess body fat, which eventually leads to an obese phenotype. Obesity has long been linked to increased susceptibility and severity of infectious diseases of the respiratory tract. Studies have shown that Body Mass Index (BMI) is linked to worse outcomes and increased severity of respiratory tract infections, such as non-allergic rhinitis and influenza-like illness. During the 2009 H1N1 pandemic and the ongoing SARS-CoV-2 (COVID-19) pandemic, obesity also became a significant risk factor for severe illness and higher mortality.
  • 1.1K
  • 27 Feb 2023
Topic Review
2-Hydroxybutyric Acid for Insulin Resistance
Diabetes mellitus type 2 (T2D), commonly known as non-insulin-dependent diabetes mellitus (NIDDM) is responsible for up to 95% of diabetic cases worldwide. It is defined as a chronic condition characterized by the loss and/or dysfunction of β-cells and insulin resistance (IR) in effector tissues, which is immediately recognized by an increase in glucose levels in the bloodstream, i.e., hyperglycemia.
  • 1.1K
  • 15 Dec 2021
Topic Review
Ketone Bodies and SIRT1
Ketone bodies (KBs) and Sirtuin-1 (SIRT1) have received increasing attention over the past two decades given their pivotal function in a variety of biological contexts, including transcriptional regulation, cell cycle progression, inflammation, metabolism, neurological and cardiovascular physiology, and cancer. As a consequence, the modulation of KBs and SIRT1 is considered a promising therapeutic option for many diseases.
  • 1.1K
  • 22 Feb 2023
Topic Review
Sex-Specific SARS-CoV-2 Mortality
COVID-19 shows a sex-dependent epidemiology. This letter aims to point out some molecular mechanisms which could explain this gender-related difference. Such knownledge may be useful for the future management of COVID-19 patients.
  • 1.1K
  • 02 Nov 2020
Topic Review
Anti-Cancer Effects of Atrial Natriuretic Peptides
The atrial natriuretic peptide (ANP), a cardiovascular hormone, plays a pivotal role in the homeostatic control of blood pressure, electrolytes, and water balance and is approved to treat congestive heart failure. In addition, there is a growing realization that ANPs might be related to immune response and tumor growth. The anti-inflammatory and immune-modulatory effects of ANPs in the tissue microenvironment are mediated through autocrine or paracrine mechanisms, which further suppress tumorigenesis. In cancers, ANPs show anti-proliferative effects through several molecular pathways. Furthermore, ANPs attenuate the side effects of cancer therapy. Therefore, ANPs act on several hallmarks of cancer, such as inflammation, angiogenesis, sustained tumor growth, and metastasis. 
  • 1.1K
  • 12 Oct 2022
Topic Review
Low Carbohydrate Diet
Low-carbohydrate diets are increasingly used to help patients with obesity and type 2 diabetes. We sought to provide an overview of the evidence for this treatment approach, considering the epidemiology and pathophysiology of obesity and diabetes in terms of carbohydrate excess. We describe the mechanistic basis for the clinical benefits associated with nutritional ketosis and identify areas of practice where the evidence base could be improved. 
  • 1.1K
  • 28 Oct 2020
Topic Review
RAS Dysregulation and COVID-19
Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a critical agent responsible for the pandemic coronavirus disease 2019 (COVID-19). The most harmful clinical feature of COVID-19 patients is the upper airway infection leading to severe pneumonia associated with acute respiratory distress syndrome (ARDS). The critical functional receptor for SARS-CoV-2 infection is angiotensin-converting enzyme 2 (ACE2), which belongs to the renin–angiotensin system (RAS) in humans. ACE2 is part of the non-classical RAS axis that counteract the harmful actions of the classical RAS axis. The balance of the classical ad non-classical RAS could be altered in COVID-19 patients.
  • 1.1K
  • 09 Nov 2020
Topic Review
Prebiotic Potential of Dietary Beans and Pulses
Dietary pulses, including dry beans, lentils, chickpeas, and dry peas, have the highest proportion of fiber among different legume cultivars and are inexpensive, easily accessible, and have a long shelf-life. The inclusion of pulses in regular dietary patterns is an easy and effective solution for achieving recommended fiber intake and maintaining a healthier gut and overall health. Dietary pulses-derived resistant starch (RS) is a relatively less explored prebiotic ingredient. Several in vitro and preclinical studies have elucidated the crucial role of RS in fostering and shaping the gut microbiota composition towards homeostasis thereby improving host metabolic health. 
  • 1.1K
  • 05 May 2022
Topic Review
The Glycerolipid/NEFA Cycle
Lipotoxicity and glucotoxicity emerged as established mechanisms participating in the pathophysiology of obesity-related type 2 diabetes in general, and in the loss of β-cell function in particular. Glycerolipid/free fatty acid cycle as a protective pathway mediating active storage and recruitment of lipids.
  • 1.1K
  • 29 Mar 2022
Topic Review
Growth hormon Central regulate metabolism
Growth hormone (GH) is secreted by the pituitary gland, and in addition to its classical functions of regulating height, protein synthesis, tissue growth, and cell proliferation, GH exerts profound effects on metabolism. In this regard, GH stimulates lipolysis in white adipose tissue and antago-nizes insulin’s effects on glycemic control. During the last decade, a wide distribution of GH-responsive neurons were identified in numerous brain areas, especially in hypothalamic nu-clei, that control metabolism. The specific role of GH action in different neuronal populations is now starting to be uncovered, and so far, it indicates that the brain is an important target of GH for the regulation of food intake, energy expenditure, and glycemia and neuroendocrine changes, particularly in response to different forms of metabolic stress such as glucoprivation, food re-striction, and physical exercise.
  • 1.1K
  • 10 Feb 2021
Topic Review
White Fat Browning Associate with Obesity
Obesity is negatively associated with the increase in social productivity and endangers people’s health. It is caused by the excessive energy consumption as well as the collection and an excessive level of triglycerides and lipids, which are stored in adipocytes.  Studying the signal transduction pathways of the white fat browning might provide novel ideas for the treatment of obesity and alleviation of obesity-related glucose and lipid metabolism disorders.
  • 1.1K
  • 26 Jul 2022
Topic Review
RONS and Myokines in Skeletal Muscle Glucose Uptake
The skeletal muscle is the largest organ in the body that performs different functions, including those related to the movement of the body such as stability, equilibrium, and locomotion; vital functions such as breathing; and those associated with the maintenance of metabolic homeostasis, in which the generation and expenditure of energy and heat production are critical. The adequate interplay of these functions leads to the maintenance of life in organisms. Glucose is essential in metabolism since it is one of the main substrates that produces ATP, the key molecule that transfers energy during chemical reactions in organisms. To produce ATP, glucose needs to be transported from the extracellular space into the cytosol of the cell. This process is called glucose uptake, and it is critical in skeletal muscle since it provides enough glucose to the cell to produce ATP and satisfy the high demand for energy of the skeletal muscle. Glucose uptake in skeletal muscle tissue is a process mainly regulated by insulin, which is a hormone synthesized in the pancreas and released into the blood stream, where it is transported until it binds to specific insulin receptors that are anchored at the plasma membrane of skeletal muscle cells.
  • 1.1K
  • 23 Dec 2022
Topic Review
Liquid–Liquid Phase Separation in Metabolic Diseases
Liquid–liquid phase separation (LLPS) is a reversible and dynamical biophysical process where homogeneous biomacromolecules spontaneously de-mix into two coexisting liquid phases (a condensed phase and a dilute phase) through transient multivalent macromolecular interactions.
  • 1.1K
  • 10 Oct 2022
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