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Topic Review
Pathogenesis of Urinary Tract Infections
Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, occurring in both community and healthcare settings. Although the clinical symptoms of UTIs are heterogeneous and range from uncomplicated (uUTIs) to complicated (cUTIs), most UTIs are usually treated empirically. Bacteria are the main causative agents of these infections, although more rarely, other microorganisms, such as fungi and some viruses, have been reported to be responsible for UTIs.
  • 3.0K
  • 21 Jun 2023
Topic Review
Exosomes
Exosomes are lipid bilayer particles released from cells into their surrounding environment. These vesicles are mediators of near and long-distance intercellular communication and affect various aspects of cell biology. In addition to their biological function, they play an increasingly important role both in diagnosis and as therapeutic agents.
  • 3.0K
  • 20 Jan 2021
Topic Review
Water-Driven Music
Water-driven music technology has been one of the primary sources of human leisure from prehistoric times up until the present. Water powered, along with air pressure organs, have been used throughout history. One of them was an organ of fountains located inside a formal garden. 
  • 3.0K
  • 22 Feb 2021
Topic Review
Green Taxes in Africa
Environmental or green taxation has been increasingly seen as a productive economic instrument to generate incentives to stimulate more environmentally friendly consumption and production choices and trends. Growing attention to environmental challenges such as the lack of optimum, effective, and responsible usage of natural resources, health concerns from the use of some energy resources, environmental degradation, and climate change have driven the implementation of green taxes. These taxes have been used by various countries, regions and continents on variegated areas and driven by an array of motives. The African continent has also put in place environmental taxes as evidenced in various countries.
  • 3.0K
  • 28 Sep 2022
Topic Review
Hobbes's Moral and Political Philosophy
Thomas Hobbes’s moral and political philosophy is constructed around the basic premise of social and political order, explaining how humans should live in peace under a sovereign power so as to avoid conflict within the ‘state of nature’. Hobbes’s moral philosophy and political philosophy are significantly intertwined; his moral thought is based around ideas of human nature, which determine the interactions that make up his political philosophy.  Hobbes’s moral philosophy therefore provides justification for, and informs, the theories of sovereignty and the state of nature that underpin his political philosophy. In utilising methods of deductive reasoning and motion science, Hobbes examines human emotion, reason and knowledge to construct his ideas of human nature (moral philosophy). This methodology critically influences his politics, determining the interactions of conflict (in the state of nature) which necessitate the creation of a politically authoritative State to ensure the maintenance of peace and cooperation. This method is used and developed in works such as The Elements of Law (1640), De Cive (1642), Leviathan (1651) and Behemoth (1681).
  • 3.0K
  • 30 Sep 2022
Topic Review
Herfindahl Index
The Herfindahl index (also known as Herfindahl–Hirschman Index, HHI, or sometimes HHI-score) is a measure of the size of firms in relation to the industry and an indicator of the amount of competition among them. Named after economists Orris C. Herfindahl and Albert O. Hirschman, it is an economic concept widely applied in competition law, antitrust and also technology management. It is defined as the sum of the squares of the market shares of the firms within the industry (sometimes limited to the 50 largest firms), where the market shares are expressed as fractions. The result is proportional to the average market share, weighted by market share. As such, it can range from 0 to 1.0, moving from a huge number of very small firms to a single monopolistic producer. Increases in the Herfindahl index generally indicate a decrease in competition and an increase of market power, whereas decreases indicate the opposite. Alternatively, if whole percentages are used, the index ranges from 0 to 10,000 "points". For example, an index of .25 is the same as 2,500 points. The major benefit of the Herfindahl index in relationship to such measures as the concentration ratio is that it gives more weight to larger firms. The measure is essentially equivalent to the Simpson diversity index, which is a diversity index used in ecology; the inverse participation ratio (IPR) in physics; and the effective number of parties index in politics.
  • 3.0K
  • 19 Oct 2022
Topic Review
Genomics Improve Abiotic Stress Tolerance in Tomato Plant
Solanum lycopersicum L. (Solanaceae), generally known as tomato, is one of the most significant fruits that are nutritionally classified as a vegetable. It contains carotenoids (lycopene and carotene), phenolic compounds (flavonoids), vitamins (ascorbic acid, -tocopherol, vitamin A), glycoalkaloids (tomatine), and phytosterols (-sitosterol, campesterol, and stigmasterol).
  • 3.0K
  • 21 Apr 2023
Topic Review
The Flavonoid Biosynthesis Network in Plants
Flavonoids have long been a major focus of research into secondary metabolism. We present a systematic summary of what is known of the flavonoid biosynthetic pathway in plants, presenting a model of flavonoid biosynthesis that includes eight branches (stilbene, aurone, flavone, isoflavone, flavonol, phlobaphene, proanthocyanidin, and anthocyanin biosynthesis) and four important intermediate metabolites (chalcone, flavanone, dihydroflavonol, and leucoanthocyanidin). 
  • 3.0K
  • 23 Dec 2021
Topic Review
DNA-Based Biosensors
Due to superior biocompatibility, thermal stability, and alternative functionalization, deoxyribonucleic acid (DNA) is becoming a fascinating biological material used for biosensing. It is widely acknowledged that DNA and its assembly structure can be applied for detecting specific targets, including nucleic acids, proteins, metal ions, and small biological molecules. With the development of DNA nanotechnology, dynamic networks based on DNA hybridization can be used to amplify the signals of biosensors.
  • 3.0K
  • 07 Apr 2022
Topic Review
Eurypterus
Eurypterus (/jʊəˈrɪptərəs/ yoo-RIP-tər-əs) is an extinct genus of eurypterid, a group of organisms commonly called "sea scorpions". The genus lived during the Silurian period, from around 432 to 418 million years ago. Eurypterus is by far the most well-studied and well-known eurypterid. Eurypterus fossil specimens probably represent more than 95% of all known eurypterid specimens. There are fifteen species belonging to the genus Eurypterus, the most common of which is E. remipes, the first eurypterid fossil discovered and the state fossil of New York. Members of Eurypterus averaged at about 13 to 23 cm (5 to 9 in) in length, but the largest individual discovered was estimated to be 60 cm (24 in) long. They all possessed spine-bearing appendages and a large paddle they used for swimming. They were generalist species, equally likely to engage in predation or scavenging.
  • 3.0K
  • 09 Nov 2022
Topic Review
Abiraterone
Abiraterone, also known as abiraterone acetate and sold under the brand name Zytiga among others, is a medication used to treat prostate cancer. Specifically it is used together with corticosteroid for metastatic castration-resistant prostate cancer (mCRPC) and metastatic high-risk castration-sensitive prostate cancer (mCSPC). It should either be used following removal of the testicles or along with a gonadotropin-releasing hormone (GnRH) analog. It is taken by mouth. Common side effects include tiredness, vomiting, headache, joint pain, high blood pressure, swelling, low blood potassium, high blood sugar, hot flashes, diarrhea, and cough. Other severe side effects may include liver failure and adrenocortical insufficiency. In males who partners can become pregnant, birth control is recommended. Supplied as abiraterone acetate it is converted in the body to abiraterone. Abiraterone works by suppressing the production of androgens – specifically it inhibits CYP17A1 – and thereby decreases the production of testosterone. In doing so, it prevents the effects of these hormones in prostate cancer. Abiraterone was described in 1995, and approved for medical use in the United States and Europe in 2011. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. In the United Kingdom it costs the NHS £2,735 a month as of 2018. In the United States this amount costs US$3,276 as of 2019. The medication is marketed widely throughout the world.
  • 3.0K
  • 14 Nov 2022
Biography
Brian Krzanich
Brian Matthew Krzanich (born May 9, 1960) is the former chief executive officer (CEO) of Intel. He joined the company as an engineer in 1982, and served as chief operating officer before being promoted to CEO. As CEO, Krzanich was credited for diversifying Intel's product offerings and workforce. Krzanich has served on the Deere & Co. and Semiconductor Industry Association boards, as well as the
  • 3.0K
  • 05 Dec 2022
Topic Review
Machine Learning in Mechanical Design and Optimization
Machine learning, by definition, refers to the development of knowledge by computers using input data. Mechanical engineering is a strong area for this technology. Older machine builders have gained significant knowledge through several case studies and efficient workflows. This creates the opportunity to approach new projects, to be able to either use their technical knowledge with familiar elements that have already been discovered or use their experience to learn and adapt to new challenges. Newcomers to the field learn in this way and gather their effectiveness and knowledge; when it comes to learning, engineering is one of the areas where much of the learning takes place at work. How well it pays depends on the ability to collect and process information.
  • 3.0K
  • 15 Jun 2023
Topic Review
Genus Cordyline
Cordyline species have a long history in traditional medicine as a basis of treatment for various ailments such as a bloody cough, dysentery, and a high fever. There are about 26 accepted species names in this genus distributed worldwide, including C. fruticosa, C. autralis, C. stricta, C. cannifolia, and C. dracaenosides. 
  • 3.0K
  • 19 Dec 2023
Topic Review
Sodium Glucose Co-transporter 2 Inhibitors
Sodium glucose co-transporter 2 (SGLT2) inhibitors are effective antihyperglycemic agents by inhibiting glucose reabsorption in the proximal tubule of the kidney. 
  • 3.0K
  • 09 Mar 2021
Topic Review
Spirulina and its Health Benefits
Spirulina is a kind of blue-green algae (BGA) that is multicellular, filamentous, and prokaryotic. It is also known as a cyanobacterium. It is classified within the phylum known as blue-green algae. Despite the fact that it includes a high concentration of nutrients, such as proteins, vitamins, minerals, and fatty acids—in particular, the necessary omega-3 fatty acids and omega-6 fatty acids—the percentage of total fat and cholesterol that can be found in these algae is substantially lower when compared to other food sources.
  • 3.0K
  • 20 Sep 2022
Topic Review
Aggression
Aggression is overt or covert, often harmful, social interaction with the intention of inflicting damage or other harm upon another individual. It may occur either reactively or without provocation. In humans, aggression can be caused by various triggers, from frustration due to blocked goals to feeling disrespected. Human aggression can be classified into direct and indirect aggression; whilst the former is characterized by physical or verbal behavior intended to cause harm to someone, the latter is characterized by behavior intended to harm the social relations of an individual or group. In definitions commonly used in the social sciences and behavioral sciences, aggression is an action or response by an individual that delivers something unpleasant to another person. Some definitions include that the individual must intend to harm another person. In an interdisciplinary perspective, aggression is regarded as “an ensemble of mechanism formed during the course of evolution in order to assert oneself, relatives or friends against others, to gain or to defend resources (ultimate causes) by harmful damaging means [...] These mechanisms are often motivated by emotions like fear, frustration, anger, feelings of stress, dominance or pleasure (proximate causes) [...] Sometimes aggressive behavior serves as a stress relief or a subjective feeling of power." Predatory or defensive behavior between members of different species may not be considered aggression in the same sense. Aggression can take a variety of forms, which may be expressed physically, or communicated verbally or non-verbally: including anti-predator aggression, defensive aggression (fear-induced), predatory aggression, dominance aggression, inter-male aggression, resident-intruder aggression, maternal aggression, species-specific aggression, sex-related aggression, territorial aggression, isolation-induced aggression, irritable aggression, and brain-stimulation-induced aggression (hypothalamus). There are two subtypes of human aggression: (1) controlled-instrumental subtype (purposeful or goal-oriented); and (2) reactive-impulsive subtype (often elicits uncontrollable actions that are inappropriate or undesirable). Aggression differs from what is commonly called assertiveness, although the terms are often used interchangeably among laypeople (as in phrases such as "an aggressive salesperson").
  • 3.0K
  • 10 Nov 2022
Topic Review
Exercise and Cartilage Regeneration Therapy
In response to exercise, articular chondrocytes increase their production of glycosaminoglycans, bone morphogenic proteins, and anti-inflammatory cytokines and decrease their production of proinflammatory cytokines and matrix-degrading metalloproteinases. These changes are associated with improvements in cartilage organization and reductions in cartilage degeneration. Studies in humans indicate that exercise enhances joint recruitment of bone marrow-derived mesenchymal stem cells and upregulates their expression of osteogenic and chondrogenic genes, osteogenic microRNAs, and osteogenic growth factors. Rodent experiments demonstrate that exercise enhances the osteogenic potential of bone marrow-derived mesenchymal stem cells while diminishing their adipogenic potential, and that exercise done after stem cell implantation may benefit stem cell transplant viability. Physical exercise also exerts a beneficial effect on the skeletal system by decreasing immune cell production of osteoclastogenic cytokines interleukin-1β, tumor necrosis factor-α, and interferon-γ, while increasing their production of antiosteoclastogenic cytokines interleukin-10 and transforming growth factor-β.
  • 3.0K
  • 28 Jan 2021
Topic Review
Electrical Transcription
Electrical transcriptions are special phonograph recordings made exclusively for radio broadcasting, which were widely used during the 'Golden Age of Radio', wherein, they provided material—from station-identification jingles and commercials to full-length programs—for use by local stations, affiliates of one of the radio networks. Physically, electrical transcriptions look much like long-playing records that were popular for decades. They differ from consumer-oriented recordings, however, in that they were "distributed to radio stations for the purpose of broadcast, and not for sale to the public.... The ET had higher quality audio than was available on consumer records" largely because they had less surface noise than commercial recordings,
  • 3.0K
  • 01 Oct 2022
Topic Review
Electrospinning Process of Electrospun Fibers
Electrospinning is a simple and versatile method to generate nanofibers. Remarkable progress has been made in the development of the electrospinning process. The production of nanofibers is affected by many parameters, which influence the final material properties. Electrospun fibers have a wide range of applications, such as energy storage devices and biomedical scaffolds.
  • 3.0K
  • 24 Aug 2023
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