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Topic Review
Clinical Manifestations of Arthropod Bites
Arthropod blood feeders are vectors of several human pathogenic agents, including viruses (e.g., yellow fever, chikungunya, dengue fever), parasites (e.g., malaria, leishmaniasis, lymphatic filariasis...), or bacteria (e.g., plague...). Besides their role as a vector of pathogens, their biting activities cause a nuisance to humans. We document herein, clinical symptoms associated with the biting of ten clusters of hematophagous arthropods, including mosquitoes, biting midges and sandflies, lice, ticks, tsetse flies, blackflies, horse flies, fleas, triatomine and bed bugs. Within the framework of clinical history and entomo-epidemiological information, we propose a  discriminative key that can be helpful for practicing physicians in identifying hematophagous arthropods biting humans and delivering treatment for the associated clinical disorders.
  • 3.2K
  • 04 Jun 2020
Topic Review
Use of Glucagon-Like Peptide-1
Glucagon-like peptide-1 (GLP-1) is a human incretin hormone derived from the proglucagon molecule. GLP-1 receptor agonists are frequently used to treat type 2 diabetes mellitus and obesity. However, the hormone affects the liver, pancreas, brain, fat cells, heart, and gastrointestinal tract. The results showed that GLP-1 agonists can benefit defined off-medication motor scores in Parkinson’s Disease and improve emotional well-being. In Alzheimer’s disease, GLP-1 analogs can improve the brain’s glucose metabolism by improving glucose transport across the blood–brain barrier. In depression, the analogs can improve quality of life and depression scales. GLP-1 analogs can also have a role in treating chemical dependency, inhibiting dopaminergic release in the brain’s reward centers, decreasing withdrawal effects and relapses. These medications can also improve lipotoxicity by reducing visceral adiposity and decreasing liver fat deposition, reducing insulin resistance and the development of non-alcoholic fatty liver diseases. The adverse effects are primarily gastrointestinal. Therefore, GLP-1 analogs can benefit other conditions besides traditional diabetes and obesity uses.
  • 3.2K
  • 10 Jul 2022
Topic Review
Pathophysiological Mechanisms of Antipsychotic-Induced Parkinsonism
Among neurological adverse drug reactions (ADRs) in patients with schizophrenia treated with antipsychotics (APs), drug-induced parkinsonism (DIP) is the most common motility disorder caused by drugs affecting dopamine receptors. One of the causes of DIP is the disruption of neurotransmitter interactions that regulate the signaling pathways of the dopaminergic, cholinergic, GABAergic, adenosinergic, endocannabinoid, and other neurotransmitter systems.
  • 3.2K
  • 26 Aug 2022
Topic Review
Farnsworth-Munsell 100 Hue Test
The Farnsworth-Munsell 100 Hue Color Vision test is a test of the human visual system often used to test for color blindness. The system was developed by Dean Farnsworth in the 1940s and it tests the ability to isolate and arrange minute differences in various color targets with constant value and chroma that cover all the visual hues described by the Munsell color system. There are several variations of the test, one featuring 100 color hues and one featuring 15 color hues. Originally taken in an analog environment with physical hue tiles, the test is now taken from computer consoles. An accurate quantification of color vision accuracy is particularly important to designers, photographers and colorists, who all rely on accurate color vision to produce quality content.
  • 3.2K
  • 01 Dec 2022
Topic Review
Risk of Trigonelline in Coffee and Coffee By-Products
Trigonelline is a bioactive pyridine alkaloid that occurs naturally in high concentrations in coffee (up to 7.2 g/kg) and coffee by-products (up to 62.6 g/kg) such as coffee leaves, flowers, cherry husks or pulp, parchment, silver skin, and spent grounds. In the past, coffee by-products were mostly considered waste and discarded. However, the use of coffee by-products as food has attracted interest because of their economic and nutritional value and the environmental benefits of sustainable resource use. Their authorization as so-called novel foods in the European Union may lead to increased oral exposure of the general population to trigonelline. 
  • 3.2K
  • 21 Apr 2023
Topic Review
Antibody Conjugated Polymeric Nanoparticles
Nanoparticles (NPs) are promising drug delivery systems (DDS) for identifying and treating cancer. Active targeting NPs can be generated by conjugation with ligands that bind overexpressed or mutant cell surface receptors on target cells that are poorly or not even expressed on normal cells. Receptor-mediated endocytosis of the NPs occurs and the drug is released inside the cell or in the surrounding tissue due to the bystander effect. Antibodies are the most frequently used ligands to actively target tumor cells. In this context, antibody-based therapies have been extensively used in HER2+ breast cancer.
  • 3.2K
  • 29 Oct 2020
Topic Review
Liquid Crystal Aided Nanotechnology/Nanoscience
The research field of liquid crystals and their applications is recently changing from being largely focused on display applications and optical shutter elements in various fields, to quite novel and diverse applications in the area of nanotechnology and nanoscience. Functional nanoparticles, such as ferroelectric and magnetic particles, have recently been used to a significant extent to modify the physical properties of liquid crystals. Also, intriguing photonic functionalities can be realized by adding nanoparticles such as quantum dots, metal particles, semiconductors, etc. into liquid crystals. The self-organization of liquid crystal molecules is exploited to used as order templates to orient nanoparticles. Similarly, anisodiametric nanoparticles such as rods, nanotubes and flakes are shown to form lyotropic liquid crystal phases in the presence of isotropic host solvents at a certain concentration.
  • 3.2K
  • 27 Oct 2020
Topic Review
Abandoned Croplands in South Africa
There is no standardised definition of agricultural land abandonment; however, a simple definition is the cessation of agricultural activities on a given surface of land. The term agricultural land abandonment is inclusive of land previously used for crops, vegetables, fruit trees, and cultivated and natural pastures. Other agricultural land abandonment studies specifically focus on crops, hence terms such as cropland abandonment, formerly arable lands, and old arable lands or fields are used. Others specify that for the land to qualify as abandoned, it should not be used for any other activity such as urbanisation or afforestation. Therefore, in the context of the rural areas of Africa wherein the cessation of cropping the land is used for grazing, the definition of cropland abandonment suffices. Baxter and Calvert define cropland abandonment as a process of withdrawing cropland from active agricultural production without a plan for crop cultivation in the immediate future. The cessation is usually due to a decline in economic viability even after changes in farming practices. Cessation results in natural succession wherein grasses, shrubs, and trees colonise former cropping lands; it can also result in land degradation. In the former homeland communal areas of South Africa, where the main agricultural activity involves cropping and livestock production, by default if the land is not used for cropping it turns into a grazing area. The same trend of abandoned cropping lands being used for grazing was also reported in Botswana. Therefore, the definition of abandoned cropping land is land mainly used for grazing. The areas are sometimes also called old fields, fallow, or idle fields. Some have turned to be secondary grasslands.
  • 3.2K
  • 25 May 2022
Topic Review
Doom WAD
Doom WAD is the default format of package files for the video game Doom and its sequel Doom II: Hell on Earth, that contain sprites, levels, and game data. WAD stands for Where's All the Data? Immediately after its release in 1993, Doom attracted a sizeable following of players who created their own mods for WAD files—packages containing levels, graphics, and other game data—and played a vital part in spawning the mod-making culture which is now commonplace for first-person shooter games. Thousands of WADs have been created for Doom, ranging from single custom levels to full original games; most of these can be freely downloaded over the Internet. Several WADs have also been released commercially, and for some people the WAD-making hobby became a gateway to a professional career as a level designer. There are two types of WADs: IWADs (internal WADs) and PWADs (patch WADs). IWADs contain the data necessary to load the game, while PWADs contain additional data, such as new character sprites, as necessary for custom levels.
  • 3.2K
  • 13 Oct 2022
Topic Review
Islamic Funeral
Funerals in Islam (called Janazah in Arabic) follow fairly specific rites, though they are subject to regional interpretation and variation in custom. In all cases, however, sharia (Islamic religious law) calls for burial of the body as soon as possible, preceded by a simple ritual involving bathing and shrouding the body, followed by salah (prayer). Burial is usual within 24 hours of death to protect the living from any sanitary issues, except in the case of a person killed in battle or when foul play is suspected; in those cases it is important to determine cause of death before burial. Cremation of the body is forbidden.
  • 3.2K
  • 09 Nov 2022
Topic Review
Public Health Evolution in Liberia
Over the past two centuries since its independence in 1847, Liberia has made significant progress in building an integrated public health system designed to serve its population. Despite a prolonged period of civil conflict (1990–2003) and the emergence of the 2014–2016 Ebola Virus Disease (EVD) that crippled its already weakened health system, Liberia was able to re-emerge, making significant strides and gains in rebuilding and strengthening its health infrastructure and systems. Lessons learnt from the EVD epidemic have led to developments such as the newly established National Public Health Institute of Liberia (NPHIL) and several tertiary public health institutions to meet the growing demands of a skilled workforce equipped to combat existing and emerging health problems and/crisis, including informing the more recent COVID-19 response.
  • 3.2K
  • 29 Dec 2022
Topic Review
Health Benefits of Indigenous Durian
Durian (Durio zibethinus Murr.) is an energy-dense seasonal tropical fruit grown in Southeast Asia. It is one of the most expensive fruits in the region. It has a creamy texture and a sweet-bitter taste. The unique durian flavour is attributable to the presence of fat, sugar, and volatile compounds such as esters and sulphur-containing compounds such as thioacetals, thioesters, and thiolanes, as well as alcohols.
  • 3.2K
  • 06 Jul 2021
Topic Review
Pollution of Polyethylene Terephthalate Water Bottles
According to studies on global plastic manufacturing and the resulting pollution, plastic wastes have been identified as a serious environmental concern. The impact of plastic garbage on marine species, humans, and the environment is a source of public concern, necessitating the need to save ecosystems and the lives that depend on them. Polyethylene terephthalate (PET) water bottles have a significant carbon footprint and represent tremendous waste. In the United Arab Emirates (UAE), PET water bottles are widely utilized, with yearly consumption reaching 450 water bottles per person. 
  • 3.2K
  • 27 Apr 2022
Topic Review
Ice Crystal
Most of the aquatic products are caught from distant seas which make them prone to deterioration and quality losses. One of the main strategies that can be used to increase shelf life and maintain product quality is freezing. During freezing, however, the ice crystals formed may considerably impact the cellular integrity, resulting in loss and degradation of food quality.
  • 3.2K
  • 07 Feb 2021
Topic Review
Eudragit® Based Copolymer for Smart Healthcare
Eudragit, synthesized by radical polymerization, is used for enteric coating, precise temporal release, and targeting the entire gastrointestinal system. Evonik Healthcare Germany offers different grades of Eudragit. The ratio of methacrylic acid to its methacrylate-based monomers used in the polymerization reaction defines the final product’s characteristics and consequently its potential range of applications.
  • 3.2K
  • 22 May 2023
Topic Review
Spinal-Deformities and Advancement in Corrective-Orthoses
Spinal deformity is an abnormality in the spinal curves and can seriously affect the activities of daily life. The conventional way to treat spinal deformities, such as scoliosis, kyphosis, and spondylolisthesis, is to use spinal orthoses (braces). Braces have been used for centuries to apply corrective forces to the spine to treat spinal deformities or to stabilize the spine during postoperative rehabilitation. Braces have not modernized with advancements in technology, and very few braces are equipped with smart sensory design and active actuation. There is a need to enable the orthotists, ergonomics practitioners, and developers to incorporate new technologies into the passive field of bracing. 
  • 3.2K
  • 30 Jan 2021
Topic Review
Hypobaric Hypoxia and Heart
Under hypobaric hypoxia contidition, the principal impact on humans is due to the low atmospheric pressure  and the subsequent proportional decrease in partial oxygen pressure (PO2)  in the inspired air, generating a reduction in the bioavailability of oxygen in organs, tissues and cells at high altitude.
  • 3.2K
  • 27 Oct 2020
Topic Review
Cardiolipin
Cardiolipin (IUPAC name 1,3-bis(sn-3’-phosphatidyl)-sn-glycerol) is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid composition. It can also be found in the membranes of most bacteria. The name "cardiolipin" is derived from the fact that it was first found in animal hearts. It was first isolated from beef heart in the early 1940s. In mammalian cells, but also in plant cells, cardiolipin (CL) is found almost exclusively in the inner mitochondrial membrane, where it is essential for the optimal function of numerous enzymes that are involved in mitochondrial energy metabolism.
  • 3.2K
  • 28 Sep 2022
Topic Review
Lories and Lorikeets
Lories and lorikeets (tribe Loriini) are small to medium-sized arboreal parrots characterized by their specialized brush-tipped tongues for feeding on nectar of various blossoms and soft fruits, preferably berries. The species form a monophyletic group within the parrot family Psittacidae. Traditionally, they were considered a separate subfamily (Loriinae) from the other subfamily (Psittacinae) based on the specialized characteristics, but recent molecular and morphological studies show that the group is positioned in the middle of various other groups. They are widely distributed throughout the Australasian region, including south-eastern Asia, Polynesia, Papua New Guinea, Timor Leste and Australia , and the majority have very brightly coloured plumage.
  • 3.2K
  • 21 Oct 2022
Topic Review
Astrophotography
Astrophotography, also known as astronomical imaging, is the photography or imaging of astronomical objects, celestial events, or areas of the night sky. The first photograph of an astronomical object (the Moon) was taken in 1840, but it was not until the late 19th century that advances in technology allowed for detailed stellar photography. Besides being able to record the details of extended objects such as the Moon, Sun, and planets, modern astrophotography has the ability to image objects invisible to the human eye such as dim stars, nebulae, and galaxies. This is done by long time exposure since both film and digital cameras can accumulate and sum photons over these long periods of time. Photography using extended exposure-times revolutionized the field of professional astronomical research, recording hundreds of thousands of new stars, and nebulae invisible to the human eye. Specialized and ever-larger optical telescopes were constructed as essentially big cameras to record images on photographic plates. Astrophotography had an early role in sky surveys and star classification but over time it has given way to more sophisticated equipment and techniques designed for specific fields of scientific research, with image sensors becoming just one of many forms of sensor. Today, astrophotography is mostly a subdiscipline in amateur astronomy, usually seeking aesthetically pleasing images rather than scientific data. Amateurs use a wide range of special equipment and techniques.
  • 3.2K
  • 22 Nov 2022
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