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Topic Review
Hypobaric Hypoxia and Heart
Under hypobaric hypoxia contidition, the principal impact on humans is due to the low atmospheric pressure  and the subsequent proportional decrease in partial oxygen pressure (PO2)  in the inspired air, generating a reduction in the bioavailability of oxygen in organs, tissues and cells at high altitude.
  • 3.3K
  • 27 Oct 2020
Topic Review
Turn (Geometry)
A turn is a unit of plane angle measurement equal to 2π radians, 360 degrees or 400 gradians. A turn is also referred to as a cycle (abbreviated cyc), revolution (abbreviated rev), complete rotation (abbreviated rot) or full circle. Subdivisions of a turn include half turns, quarter turns, centiturns, milliturns, points, etc.
  • 3.3K
  • 22 Nov 2022
Topic Review
Implementation of Lutetium-177 Therapy
Peptide receptor radionuclide therapy (PRRT) using Lutetium-177 (177Lu) based radiopharmaceuticals has emerged as a therapeutic area in the field of nuclear medicine and oncology, allowing for personalized medicine. Since the first market authorization in 2018 of [¹⁷⁷Lu]Lu-DOTATATE (Lutathera®) targeting somatostatin receptor type 2 in the treatment of gastroenteropancreatic neuroendocrine tumors, intensive research has led to transfer innovative 177Lu containing pharmaceuticals to the clinic.
  • 3.3K
  • 04 May 2023
Topic Review
Advanced Combustion for Improving Thermal Efficiency
Improving thermal efficiency and reducing carbon emissions are the permanent themes for internal combustion (IC) engines. Improving thermal efficiency and reducing fuel consumption and greenhouse gas (GHG) emissions motivate the technological progress of the automobile and engine industry.
  • 3.3K
  • 14 Sep 2022
Topic Review
Electrochemical Impedance Spectroscopy
Electrochemical impedance spectroscopy is finding increasing use in electrochemical sensors and biosensors, both in their characterisation, including during successive phases of sensor construction, and in application as a quantitative determination technique.
  • 3.3K
  • 28 Apr 2022
Topic Review
Surfaces on Sprint Performance
The main function of a sport surface is to ensure safety and adequate player performance during physical exercise practice. 
  • 3.3K
  • 29 Apr 2021
Topic Review
TECAR Therapy, High-Intensity Laser Therapy, Manual Therapy
It has been estimated that between 30 and 50 per cent of all injuries that take place throughout participation in a sport are the consequence of soft tissue injuries, and muscle injuries are the primary cause of physical disability. Due to the produced effects, manual therapy combined with high-intensity laser therapy (Hilt) or capacitive and resistive electrical transfer (TECAR) therapy, or even all three therapies used in a treatment plan, can provide optimal muscle recovery in a shorter time; therefore, the use of combined and not isolated recovery procedures is a better alternative in muscle recovery.
  • 3.3K
  • 27 Oct 2022
Topic Review
Space Shuttle Launch Countdown
The launch of Space Shuttle missions was governed by a countdown. Two clocks were maintained, the unofficial, but sometimes mentioned, L (launch) clock represented the time remaining before the scheduled launch in real time, and the more often referred to T (test) clock included several built-in holds where additional verifications were made. Built-in holds were extended if mission parameters allowed for additional checks or to correct issues. Launches of the Space Shuttle to the International Space Station did not allow for holds to be extended due to the launch window which was limited to no more than 10 minutes due to the 90 minute orbit period of the station and speed of Earth's rotation (913.6 miles per hour (1,470.3 km/h) at the Kennedy Space Center), which puts the launch pads 1,000 miles (1,600 km) east of the station on its next orbit.
  • 3.3K
  • 22 Nov 2022
Topic Review
ESG Measurement
Investors are currently obliged to take environment, social, and governance (ESG) issues into consideration as part of their fiduciary duty. As such, it becomes increasingly important to identify sustainable investments that also hold financial value. A sector where this is especially underdeveloped is real estate.
  • 3.3K
  • 01 Apr 2021
Topic Review
Indoor Positioning
The indoor positioning system (IPS) is becoming increasing important in accurately determining the locations of objects by the utilization of micro-electro-mechanical-systems (MEMS) involving smartphone sensors, embedded sources, mapping localizations, and wireless communication networks. 
  • 3.3K
  • 14 Jan 2021
Topic Review
Doom WAD
Doom WAD is the default format of package files for the video game Doom and its sequel Doom II: Hell on Earth, that contain sprites, levels, and game data. WAD stands for Where's All the Data? Immediately after its release in 1993, Doom attracted a sizeable following of players who created their own mods for WAD files—packages containing levels, graphics, and other game data—and played a vital part in spawning the mod-making culture which is now commonplace for first-person shooter games. Thousands of WADs have been created for Doom, ranging from single custom levels to full original games; most of these can be freely downloaded over the Internet. Several WADs have also been released commercially, and for some people the WAD-making hobby became a gateway to a professional career as a level designer. There are two types of WADs: IWADs (internal WADs) and PWADs (patch WADs). IWADs contain the data necessary to load the game, while PWADs contain additional data, such as new character sprites, as necessary for custom levels.
  • 3.3K
  • 13 Oct 2022
Topic Review
El Toro Loco (Truck)
El Toro Loco (Spanish for "The Crazy Bull") is a monster truck currently racing in the Monster Jam series. It is currently driven by Kayla Blood. Other drivers of have included Dan Rodoni, Aaron Basl, Ryan Huffaker, Joey Parnell, Chris Baker, and Nathan Weenk. It features one of the first 3-D body shells, with horns sticking out of the roof. This body was originally designed for Bulldozer, and was found a second use for El Toro Loco. As El Toro Loco has increased in popularity, it has become the primary truck for the body style.
  • 3.3K
  • 31 Oct 2022
Topic Review
Turbulence Simulation Approaches
Turbulent flow can be numerically resolved with different levels of accuracy. Many numerical approaches for solving turbulence have been proposed, such as the Reynolds-Averaged Navier–Stokes (RANS), the Large Eddy Simulation (LES), and Direct Numerical Simulation (DNS) approaches. Among these numerical methods, the RANS approach, specifically the Eddy Viscosity Model (EVM), is widely used for calculating turbulent flows thanks to its relatively high accuracy in predicting the mean flow features and its more limited computational demands. However, this approach suffers from several weaknesses, e.g., compromised accuracy and uncertainties due to assumptions in the model construction and insufficient incorporation of the fluid physics. In the LES approach, the whole eddy range is separated into two parts, namely, the large-scale eddy and subgrid-scale (SGS) eddy. The former can be directly resolved, while the latter is computed using the SGS model. As the computing power rapidly increases, this approach is extensively used to study turbulence physics and to resolve low-to-medium Reynolds number flows.
  • 3.3K
  • 13 Sep 2021
Topic Review
Pathophysiological Mechanisms of Antipsychotic-Induced Parkinsonism
Among neurological adverse drug reactions (ADRs) in patients with schizophrenia treated with antipsychotics (APs), drug-induced parkinsonism (DIP) is the most common motility disorder caused by drugs affecting dopamine receptors. One of the causes of DIP is the disruption of neurotransmitter interactions that regulate the signaling pathways of the dopaminergic, cholinergic, GABAergic, adenosinergic, endocannabinoid, and other neurotransmitter systems.
  • 3.3K
  • 26 Aug 2022
Topic Review
LINPACK Benchmarks
The LINPACK Benchmarks are a measure of a system's floating-point computing power. Introduced by Jack Dongarra, they measure how fast a computer solves a dense n by n system of linear equations Ax = b, which is a common task in engineering. The latest version of these benchmarks is used to build the TOP500 list, ranking the world's most powerful supercomputers. The aim is to approximate how fast a computer will perform when solving real problems. It is a simplification, since no single computational task can reflect the overall performance of a computer system. Nevertheless, the LINPACK benchmark performance can provide a good correction over the peak performance provided by the manufacturer. The peak performance is the maximal theoretical performance a computer can achieve, calculated as the machine's frequency, in cycles per second, times the number of operations per cycle it can perform. The actual performance will always be lower than the peak performance. The performance of a computer is a complex issue that depends on many interconnected variables. The performance measured by the LINPACK benchmark consists of the number of 64-bit floating-point operations, generally additions and multiplications, a computer can perform per second, also known as FLOPS. However, a computer's performance when running actual applications is likely to be far behind the maximal performance it achieves running the appropriate LINPACK benchmark. The name of these benchmarks comes from the LINPACK package, a collection of algebra Fortran subroutines widely used in the 1980s, and initially tightly linked to the LINPACK benchmark. The LINPACK package has since been replaced by other libraries.
  • 3.3K
  • 02 Dec 2022
Topic Review
Grey Water
Grey water (also spelled gray water in the United States) or sullage refers to wastewater generated in households or office buildings from streams without fecal contamination, i.e., all streams except for the wastewater from toilets. Sources of grey water include sinks, showers, baths, washing machines or dishwashers. As grey water contains fewer pathogens than domestic wastewater, it is generally safer to handle and easier to treat and reuse onsite for toilet flushing, landscape or crop irrigation, and other non-potable uses. The application of grey water reuse in urban water systems provides substantial benefits for both the water supply subsystem, by reducing the demand for fresh clean water, and the wastewater subsystems by reducing the amount of wastewater required to be conveyed and treated. Treated grey water has many uses, for example, toilet flushing or irrigation.
  • 3.3K
  • 04 Nov 2022
Topic Review
Pathophysiology of Therapy-Related Acute Myeloid Leukemia
Therapy-related acute myeloid leukemia (t-AML) is one of the most serious long-term complications of cancer chemotherapy. Various cytotoxic agents and exposure to ionizing radiation can lead to the development of t-AML, which is usually associated with adverse genetic changes and a poor prognosis. 
  • 3.3K
  • 11 Apr 2023
Topic Review
Pyocyanin
Pyocyanin is a blue pigment synthesized by about 95% of the strains of Pseudomonas aeruginosa.
  • 3.3K
  • 02 Mar 2021
Topic Review
Short Code
Short codes, or short numbers, are short digit sequences, significantly shorter than telephone numbers, that are used to address messages in the Multimedia Messaging System (MMS) and short message service (SMS) systems of mobile network operators. In addition to messaging, they may be used in abbreviated dialing. Short codes are designed to be easier to read and remember than telephone numbers. Short codes are unique to each operator at the technological level. Even so, providers generally have agreements to avoid overlaps. In some countries, such as the United States, some classes of numbers are inter-operator (used by multiple providers or carriers, U.S. inter-operator numbers are called common short codes). Short codes are widely used for value-added services such as charity donations, mobile services, ordering ringtones, and television program voting. Messages sent to a short code can be billed at a higher rate than a standard SMS and may even subscribe a customer to a recurring monthly service that will be added to the customer's mobile phone bill until the user texts, for example, the word "STOP" to terminate the service.
  • 3.3K
  • 10 Nov 2022
Topic Review
Potential Effects of Fasting in SARS-CoV-2 Infection
Intermittent fasting is a potential complementary therapy to vaccination and antiviral therapies that not only impacts chronic disease risk but also has good evidence of an impact on infectious diseases such as COVID-19. Intermittent fasting should improve the immune response of and reduce acute hyperinflammation for unvaccinated people, strengthen immunity between vaccinations for vaccinated people, and prolong the length of time a vaccinated person can go before receiving a subsequent booster dose of the SARS-CoV-2 vaccine. A set of at least 10 biological mechanisms may be impacted by intermittent fasting in the human physiological response to SARS-CoV-2 that may reduce the severity of COVID-19 outcomes. For example, by boosting autophagy, fasting may aid the immune system to identify silently infected cells via increased degradation of viral proteins and through antigen presentation to natural killer cells and cytotoxic T cells. Intermittent fasting may also provide a constellation of mechanisms that empower a damaged human immune system to repair itself and to hunt down residual SARS-CoV-2 virus that is hiding from it in the context of both acute infection and post-acute sequelae of COVID-19. Furthermore, fasting adds no financial cost to a care plan and, when practiced safely, is available to most adults regardless of education, income, location, or ancestry. Clinical trials of intermittent fasting for reduction of COVID-19 severity are needed.
  • 3.3K
  • 06 Jan 2023
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