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Topic Review
Natural Compounds as Ferroptosis Inducers
Ferroptosis is classified as a non-canonical cell death mechanism. To date, several natural compounds have been discovered to induce ferroptosis in different cancer models.
  • 3.3K
  • 25 Feb 2021
Topic Review
Vitamin D in Long COVID-19
Coronavirus disease 2019 (COVID-19) has quickly become a global pandemic. Reports from different parts of the world indicate that a significant proportion of people who have recovered from COVID-19 are suffering from various health problems collectively referred to as “long COVID-19”. Common symptoms include fatigue, shortness of breath, cough, joint pain, chest pain, muscle aches, headaches, and so on. Vitamin D is an immunomodulatory hormone with proven efficacy against various upper respiratory tract infections. Vitamin D can inhibit hyperinflammatory reactions and accelerate the healing process in the affected areas, especially in lung tissue. Moreover, vitamin D deficiency has been associated with the severity and mortality of COVID-19 cases, with a high prevalence of hypovitaminosis D found in patients with COVID-19 and acute respiratory failure. However, no evidence has been found to support a role of vitamin D supplementation in reducing symptoms of long-COVID-19. On the other hand, having a higher vitamin D level before SARS-CoV-2 infection or raising it rapidly at the first symptoms of infection can significantly reduce the risk and severity of COVID-19.
  • 3.3K
  • 29 Apr 2022
Topic Review
Luxury Yacht
A Luxury yacht (also super-yacht, large yacht and mega-yacht) is a very expensive, privately owned, professionally crewed sailing or motor yacht. There is no industry-wide standard for the difference between super-yacht and mega-yacht. The only legal distinction is between yachts above 24 metres (79 ft) and below, as in some countries those above 24 meters must have a permanent crew onboard. This term began to appear at the beginning of the 20th century, when wealthy individuals constructed large private yachts for personal pleasure, such as Charles Henry Fletcher's Jemima F. III, at 111 feet, the largest motor-powered yacht in the world in 1908. More examples of early luxury motor yachts include the Cox & King yachts, Charles L. Seabury and Company's yachts, M/Y (motor yacht) Christina O, and M/Y Savarona.
  • 3.3K
  • 21 Nov 2022
Topic Review
Social Movement
A social movement is a collective, organized effort by individuals or groups to bring about social, political, economic, or cultural change. These movements typically mobilize around specific issues, grievances, or ideals, aiming to challenge existing power structures, advocate for reforms, or promote alternative visions of society. Social movements employ a variety of tactics, including protests, demonstrations, advocacy campaigns, and grassroots organizing, to raise awareness, mobilize support, and effectuate social transformation.
  • 3.3K
  • 26 Jan 2024
Topic Review
Laser Melting Deposition
Ceramics and ceramic-reinforced metal matrix composites (CMMCs) demonstrate high wear resistance, excellent chemical inertness, and exceptional properties at elevated temperatures. These characteristics are suitable for their utilization in biomedical, aerospace, electronics, and other high-end engineering industries. The aforementioned performances make them difficult to fabricate via conventional manufacturing methods, requiring high costs and energy consumption. To overcome these issues, laser additive manufacturing (LAM) techniques, with high-power laser beams, were developed and extensively employed for processing ceramics and ceramic-reinforced CMMCs-based coatings. In respect to other LAM processes, laser melting deposition (LMD) excels in several aspects, such as high coating efficiency and lower labor cost. Nevertheless, difficulties such as poor bonding between coating and substrate, cracking, and reduced toughness are still encountered in some LMD coatings.
  • 3.3K
  • 24 Mar 2021
Topic Review
Sunflower Seeds, Oil and Oilcake
Ample amounts of by-products are generated from the oil industry. Among them, sunflower oilcakes have the potential to be used for human consumption, thus achieving the concept of sustainability and circular economy. Sunflower oil contains principally oleic (19.81%) and linoleic (64.35%) acids, which cannot be synthetized by humans and need to be assimilated through a diet. Sunflower seeds are very nutritive (33.85% proteins and 65.42% lipids and 18 mineral elements). Due to the rich content of lipids, they are principally used as a source of vegetable oil. Compared to seeds, sunflower oilcakes are richer in fibers (31.88% and 12.64% for samples in form of pellets and cake, respectively) and proteins (20.15% and 21.60%), with a balanced amino acids profile. The remaining oil (15.77% and 14.16%) is abundant in unsaturated fatty acids (95.59% and 92.12%). The comparison between the three products showed the presence of valuable components that makes them suitable for healthy diets with an adequate intake of nutrients and other bioactive compounds with benefic effects.
  • 3.3K
  • 07 Dec 2021
Topic Review
Analysis of Phytic Acid
Phytate is a six-fold dihydrogenphosphate ester of myo‑inositol or cis-1,2,3,5-trans-4,6-cyclohexanehexol which is the most abundant of nine possible isomers of inositol (Ins). Myo-orientation is also found in the case of phytic acid, which is due to the fact that the maximal number (i.e., five out of six) of phosphate groups are present in thermodynamically stabilized equatorial position. However, the molecule can be inverted from equatorial (1a5e) to the axial (5a1e) orientation between pH 9.0 and pH 9.5.
  • 3.3K
  • 18 Jan 2021
Topic Review
Nikolaas Tinbergen
Nikolaas "Niko" Tinbergen FRS (/ˈtɪnbɜːrɡən/; Dutch: [ˈnikoːlaːs ˈnikoː ˈtɪnbɛrɣən]; 15 April 1907 – 21 December 1988) was a Dutch biologist and ornithologist who shared the 1973 Nobel Prize in Physiology or Medicine with Karl von Frisch and Konrad Lorenz for their discoveries concerning organization and elicitation of individual and social behavior patterns in animals. He is regarded as one of the founders of modern ethology, the study of animal behavior. In 1951, he published The Study of Instinct, an influential book on animal behaviour. In the 1960s, he collaborated with filmmaker Hugh Falkus on a series of wildlife films, including The Riddle of the Rook (1972) and Signals for Survival (1969), which won the Italia prize in that year and the American blue ribbon in 1971.
  • 3.3K
  • 04 Oct 2022
Topic Review
Timoshenko Beam Theory
The Timoshenko beam theory was developed by Stephen Timoshenko early in the 20th century. The model takes into account shear deformation and rotational bending effects, making it suitable for describing the behaviour of thick beams, sandwich composite beams, or beams subject to high-frequency excitation when the wavelength approaches the thickness of the beam. The resulting equation is of 4th order but, unlike Euler–Bernoulli beam theory, there is also a second-order partial derivative present. Physically, taking into account the added mechanisms of deformation effectively lowers the stiffness of the beam, while the result is a larger deflection under a static load and lower predicted eigenfrequencies for a given set of boundary conditions. The latter effect is more noticeable for higher frequencies as the wavelength becomes shorter (in principle comparable to the height of the beam or shorter), and thus the distance between opposing shear forces decreases. If the shear modulus of the beam material approaches infinity—and thus the beam becomes rigid in shear—and if rotational inertia effects are neglected, Timoshenko beam theory converges towards ordinary beam theory.
  • 3.3K
  • 15 Nov 2022
Topic Review
Epoch (Reference Date)
In the fields of chronology and periodization, an epoch is an instant in time chosen as the origin of a particular era. The "epoch" then serves as a reference point from which time is measured. Time measurement units are counted from the epoch so that the date and time of events can be specified unambiguously. Events taking place before the epoch can be dated by counting negatively from the epoch, though in pragmatic periodization practice, epochs are defined for the past, and another epoch is used to start the next era, therefore serving as the ending of the older preceding era. The whole purpose and criteria of such definitions are to clarify and co-ordinate scholarship about a period, at times, across disciplines. Epochs are generally chosen to be convenient or significant by a consensus of the time scale's initial users, or by authoritarian fiat. The epoch moment or date is usually defined by a specific clear event, condition, or criterion—the epoch event or epoch criterion—from which the period or era or age is usually characterized or described.
  • 3.3K
  • 28 Oct 2022
Topic Review
Silicon Field Effect Transistors (FET)
Highly sensitive and selective gas and volatile organic compound (VOC) sensor platforms with fast response and recovery kinetics are in high demand for environmental health monitoring, industry, and medical diagnostics. Among the various categories of gas sensors studied to date, field effect transistors (FETs) have proved to be an extremely efficient platform due to their miniaturized form factor, high sensitivity, and ultra-low power consumption. Despite the advent of various kinds of new materials, silicon (Si) still enjoys the advantages of excellent and reproducible electronic properties and compatibility with complementary metal–oxide–semiconductor (CMOS) technologies for integrated multiplexing and signal processing.
  • 3.3K
  • 26 Oct 2021
Topic Review
Minerals’ Role in Human Nutrition
Micronutrients such as selenium, fluoride, zinc, iron, and manganese are minerals that are crucial for many body homeostatic processes supplied at low levels. The importance of these micronutrients starts early in the human life cycle and continues across its different stages.
  • 3.3K
  • 02 Nov 2021
Topic Review
Stepwells as Sustainable Water Management Structures
Stepwells were one such effective water management technologies used in India. Stepwells were constructed based on their geographical and topographical suitability, which revealed socio-cultural behaviors and beliefs.
  • 3.3K
  • 28 Sep 2022
Topic Review
Socialist Party USA
The Socialist Party USA, officially the Socialist Party of the United States of America (SPUSA), is a multi-tendency democratic socialist party in the United States . The SPUSA was founded in 1973 as a successor to the Socialist Party of America, which had been renamed Social Democrats, USA a year before. The party is officially committed to multi-tendency democratic socialism. Along with its predecessor, the Socialist Party USA has received varying degrees of support when its candidates have competed against those from the Republican and Democratic parties. The SPUSA advocates for complete independence from the Democratic Party. Self-described as opposing all forms of oppression, specifically capitalism and authoritarian forms of communism, the party advocates for the creation of a "radical democracy that places people's lives under their own control—a non-racist, classless, feminist, socialist society [... in which] the people own and control the means of production and distribution through democratically-controlled public agencies, cooperatives, or other collective groups [...] full employment is realized for everyone who wants to work [...] workers have the right to form unions freely, and to strike and engage in other forms of job actions [...] production of society is used for the benefit of all humanity, not for the private profit of a few". Headquartered at the A.J. Muste Institute, the SPUSA's National Office is located at 168 Canal Street in the Chinatown neighborhood of New York City. The party has four chartered state organizations in California, Michigan, Maine and New Jersey as well as twenty eight chartered locals throughout the country. In October 2015, the Socialist Party USA nominated Mimi Soltysik for President and Angela Nicole Walker for Vice President.
  • 3.3K
  • 15 Nov 2022
Topic Review
Gas-Sensing Characteristics of Metal Oxide Semiconductor Sensors
The sensing characteristics of metal oxide semiconductors (MOSs) depend on the carrier concentration, which is relevant to the working temperature. The characteristic parameters commonly used to measure gas-sensing performance include optimal working temperature, sensitivity, selectivity, stability, repeatability, response and recovery time, and the lowest detection limits.
  • 3.3K
  • 29 Jun 2022
Topic Review
2010s in Political History
2010s political history refers to significant political and societal historical events of the 2010s, presented as a historical overview in narrative format.
  • 3.3K
  • 04 Nov 2022
Topic Review
Sotai
Sotai or Sotai-hō (操体法, Sōtai-hō) is a Japan ese form of muscular or movement therapy invented by Keizo Hashimoto (1897–1993), a Japanese medical doctor from Sendai. The term So-tai (操体) is actually the opposite of the Japanese word for exercise: Tai-so (体操). Dr. Hashimoto conceived Sotai as an antidote to the forceful and regimented exercises of Japan, that anyone could practice easily to restore balance and health. Sotai is different from regular exercise because it distinguishes between balanced movements that are natural and beneficial and those that are unnatural and cause strains and physical distortions. The aim of Sotai is to help the body restore and maintain its natural balance. Dr. Hashimoto developed a model of treatment based on restoring structural balance that is claimed to work with the breath and movements toward comfort (or away from pain). He developed Sotai Therapy from traditional East Asian medicine (acupuncture, moxibustion, bone setting (Sekkotsu), Seitai Jutsu) in concert with his knowledge of modern medicine. Sotai Therapy is intended to be a method of neuromuscular reeducation and unwinding muscular holding patterns. According practitioners, Sotai Therapy balances the nervous and muscular systems. Its central principle is backtracking movement or "reverse-motion" treatment. The idea is that structural distortions can be returned to a more normal condition by moving the body in the comfortable direction. Using the effects of an isometric contraction followed by a sudden relaxation (post-isometric relaxation) can normalise the strained condition.
  • 3.3K
  • 21 Nov 2022
Topic Review
Basic Principles of Atomic Force Microscopy
Visualization of biomedical samples in their native environments at the microscopic scale is crucial for studying fundamental principles and discovering biomedical systems with complex interaction. The study of dynamic biological processes requires a microscope system with multiple modalities, high spatial/temporal resolution, large imaging ranges, versatile imaging environments and ideally in-situ manipulation capabilities. Development of new Atomic Force Microscopy (AFM) capabilities has made it such a powerful tool for biological and biomedical research. 
  • 3.3K
  • 15 Dec 2022
Topic Review Peer Reviewed
Effects of High Hydrostatic Pressure on Fungal Spores and Plant Bioactive Compounds
Fungi, and their spores, are responsible for the spoilage of several foods and plants and are susceptible to contamination with mycotoxins, which have associated health hazards. In this context, proper methodologies for inactivating such fungi and controlling mycotoxin production are critical. High-pressure processing (HPP) has recently become popular as a nonthermal alternative to conventional thermal pasteurization processes. Even though HPP can effectively eliminate some fungal spores, some species, such as those from the genera Byssochlamys, Talaromyces, and Aspergillus, are quite resistant to this treatment. Additionally, high pressure can also be used as a cold extraction technique for bioactive compounds from medicinal plants and other matrices (termed high pressure-assisted extraction, HPE). With this method, safe use for food, cosmetic, and pharmaceutical applications is guaranteed. This method simultaneously works (depending on the applied pressure level) as an extraction technique and induces the pasteurization effect on the extracts. This encyclopedia entry aims to highlight the effects of nonthermal HPP on fungal spores, the prevalence of mycotoxins in plant materials and how high pressure can be used as an extraction technique to produce high-value cold pasteurized extracts with biological activity.
  • 3.3K
  • 18 Oct 2022
Topic Review
Satellite Geodesy
Satellite geodesy is geodesy by means of artificial satellites — the measurement of the form and dimensions of Earth, the location of objects on its surface and the figure of the Earth's gravity field by means of artificial satellite techniques. It belongs to the broader field of space geodesy. Traditional astronomical geodesy is not commonly considered a part of satellite geodesy, although there is considerable overlap between the techniques. The main goals of satellite geodesy are: Satellite geodetic data and methods can be applied to diverse fields such as navigation, hydrography, oceanography and geophysics. Satellite geodesy relies heavily on orbital mechanics.
  • 3.3K
  • 24 Oct 2022
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