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Topic Review
Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is an advanced technique that uses minimum fragmented ions from complex molecules for mass spectrometry (MS) analysis (tissue profiling by mass spectrometry). It is able to analyze spatially resolved tissue or tumor sections at the molecular level. It has become a valuable tool for tumor and tissue imaging, due to its ease of operation and high mass resolution, but it still has vast room for development in the instrumentation of larger proteins in some tissues. 
  • 1.4K
  • 23 Mar 2022
Topic Review
Colistin Resistance in Bacteria
Colistin is an old polypeptide antibiotic of the group E, discovered in 1947 by Y. Koyama from Paenibacillus polymyxa subspecies colistinus cultures. It is a bactericidal, narrow-spectrum molecule directed against most GNB, but ineffective against Gram-positive bacteria, anaerobic bacteria, and mycoplasmas.
  • 1.4K
  • 21 Mar 2021
Topic Review
Host Defense and Pathogenesis in Staphylococcus aureus
Staphylococcus aureus is a versatile pathogen known to cause hospital- and community-acquired, foodborne, and zoonotic infections. As a multi-faceted pathogen, it is essential to consolidate the knowledge on its pathogenesis, including the mechanisms of virulence regulation, development of antimicrobial resistance and biofilm formation, to make it more amenable to classical and novel therapeutic strategies such as those based on nanomaterials.
  • 1.4K
  • 08 Feb 2023
Topic Review
Resuscitation of Viable but Nonculturable Bacteria
The viable but nonculturable (VBNC) state is a survival strategy for bacteria when encountered with unfavorable conditions. Under favorable environments such as nutrient supplementation, external stress elimination, or supplementation with resuscitation-promoting substances, bacteria will recover from the VBNC state, which is termed “resuscitation”.
  • 1.4K
  • 03 Jan 2023
Topic Review
Paracoccidioidomycosis
Paracoccidioidomycosis (PCM) is systemic mycosis caused by fungi of the genus Paracoccidioides. This disease is endemic in Latin America that mainly affects workers in rural areas and causes some degree of disability for working-age people. For people who develop symptoms, PCM usually affects the  lungs, skin, mucous membranes, lymph nodes, and internal organs. Paracoccidioides spp. are thermally dimorphic fungi that present infective mycelia at 25 °C and differentiate into pathogenic yeast forms at 37 °C. 
  • 1.4K
  • 14 Mar 2021
Topic Review
Africa Vaccine Technology Transfer
The rampant spread of the COVID-19 infection poses a grave and formidable challenge to global healthcare, with particular concern to the inhabitants of the African continent. In response to these pressing concerns, different strategies have been employed to combat the emergence of this insidious disease, encompassing crucial measures such as physical distancing, the utilization of face masks, meticulous hand hygiene, and widespread vaccination campaigns.
  • 1.4K
  • 15 Sep 2023
Topic Review
Gut-Brain Axis in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a complex behavioral syndrome that is characterized by speech and language disorders, intellectual impairment, learning and motor dysfunctions. Several genetic and environmental factors are suspected to affect the ASD phenotype including air pollution, exposure to pesticides, maternal infections, inflammatory conditions, dietary factors or consumption of antibiotics during pregnancy.  Many children with ASD shows abnormalities in gastrointestinal (GI) physiology, including increased intestinal permeability, overall microbiota alterations, and gut infection. Moreover, they are “picky eaters” and the existence of specific sensory patterns in ASD patients could represent one of the main aspects in hampering feeding. GI disorders are associated with an altered composition of the gut microbiota. Gut microbiome is able to communicate with brain activities through microbiota-derived signaling molecules, immune mediators, gut hormones as well as vagal and spinal afferent neurons. Since the diet induces changes in the intestinal microbiota and in the production of molecules, such as the SCFA, we wanted to investigate the role that nutritional intervention can have on GI microbiota composition and thus on its influence on behavior, GI symptoms and microbiota composition and report which are the beneficial effect on ASD condition.
  • 1.4K
  • 23 Nov 2021
Topic Review
The STEC–MFG Association
Shiga toxin-producing Escherichia coli (STEC) are zoonotic Gram-negative bacteria. While raw milk cheese consumption is healthful, contamination with pathogens such as STEC can occur due to poor hygiene practices at the farm level. STEC infections cause mild to serious symptoms in humans. The raw milk cheese-making process concentrates certain milk macromolecules such as proteins and milk fat globules (MFGs), allowing the intrinsic beneficial and pathogenic microflora to continue to thrive. MFGs are surrounded by a biological membrane, the milk fat globule membrane (MFGM), which has a globally positive health effect, including inhibition of pathogen adhesion.
  • 1.4K
  • 22 Apr 2022
Topic Review
Antimicrobial Resistance of VBNC Bacteria
 Antimicrobial Resistance of VBNC Bacteria means the bacteria that enter the viable but non-culturable (VBNC) state, either through unfavorable environmental conditions or through potentially lethal stress, lose their ability to grow on standard enrichment media, but show a drastically increased tolerance against antimicrobials including antibiotics.
  • 1.4K
  • 16 Feb 2021
Topic Review
Fermentative Foods
Fermented foods identify cultures and civilizations. History, climate and the particulars of local production of raw materials have urged humanity to exploit various pathways of fermentation to produce a wide variety of traditional edible products which represent adaptations to specific conditions.
  • 1.4K
  • 28 Sep 2021
Topic Review
Drug-Resistance of Candida glabrata
Candida glabrata is a yeast of increasing medical relevance, particularly in critically ill patients. It is the second most isolated Candida species associated with invasive candidiasis (IC) behind C. albicans. The attributed higher incidence is primarily due to an increase in the acquired immunodeficiency syndrome (AIDS) population, cancer, and diabetic patients. The elderly population and the frequent use of indwelling medical devices are also predisposing factors.
  • 1.4K
  • 30 Aug 2021
Topic Review
Pandemrix
Pandemrix is an influenza vaccine for influenza pandemics, such as the 2009 flu pandemic. The vaccine was developed by GlaxoSmithKline (GSK) and patented in September 2006. The vaccine was one of the H1N1 vaccines approved for use by the European Commission in September 2009, upon the recommendations of the European Medicines Agency (EMEA). The vaccine is only approved for use when an H1N1 influenza pandemic has been officially declared by the World Health Organization (WHO) or European Union (EU). The vaccine was initially developed as a pandemic mock-up vaccine using an H5N1 strain. Pandemrix was found to be associated with an increased risk of narcolepsy following investigations by Swedish and Finnish health authorities and had higher rates of adverse events than other vaccines for H1N1. This resulted in several legal cases. Stanford University studies suggested that narcolepsy is an autoimmune disease and that it appears to be triggered by upper airway respiratory infections.
  • 1.4K
  • 06 Oct 2022
Topic Review
Quorum-Sensing Inhibitors from Probiotics
Experience-based knowledge has shown that bacteria can communicate with each other through a cell-density-dependent mechanism called quorum sensing (QS). QS controls specific bacterial phenotypes, such as sporulation, virulence and pathogenesis, the production of degrading enzymes, bioluminescence, swarming motility, and biofilm formation. The expression of these phenotypes in food spoiling and pathogenic bacteria, which may occur in food, can have dramatic consequences on food production, the economy, and health.
  • 1.4K
  • 23 Dec 2022
Topic Review
Antimicrobial Peptides Synergy with Vancomycin
There is an urgent and imminent need to develop new antimicrobials to fight against antibiotic-resistant bacterial and fungal strains. In this study, a checkerboard method was used to evaluate the synergistic effects of the antimicrobial peptide P-113 and its bulky non-nature amino acid substituted derivatives with vancomycin against vancomycin-resistant Enterococcus faecium, Staphylococcus aureus, and wild-type Escherichia coli. Boron-dipyrro-methene (BODIPY) labeled vancomycin was used to characterize the interactions between the peptides, vancomycin, and bacterial strains. Moreover, neutralization of antibiotic-induced releasing of lipopolysaccharide (LPS) from E. coli by the peptides was obtained. Among these peptides, Bip-P-113 demonstrated the best minimal inhibitory concentrations (MICs), antibiotics synergism, bacterial membrane permeabilization, and supernatant LPS neutralizing activities against the bacteria studied. These results could help in developing antimicrobial peptides that have synergistic activity with large size glycopeptides such as vancomycin in therapeutic applications.
  • 1.4K
  • 29 Oct 2020
Topic Review
Antarctic cryptoendolithic communities
The Antarctic cryptoendolithic communities are self-supporting assemblages of phototrophic and heterotrophic microorganisms, including bacteria, Cyanobacteria, Chlorophyta and both free-living and lichen-forming fungi. These are among the most stress-resistant organisms known to date, constantly living to the edge of their physiological adaptability.
  • 1.4K
  • 27 Oct 2020
Topic Review
Prebiotics for Pregnancy and Its Complications
The term “prebiotics” was first coined by professors Emeritus Marcel Roberfroid and Glenn Gibson in a 1995 publication, where they explained the selective growth of colonic bifidobacterials boosted by the intact fibrous oligosaccharide inulin. They explained prebiotics as “nondigestible food ingredients that beneficially affect the host by selectively stimulating the growth and/or activity of one or a limited number of bacterial species already resident in the colon, and thus attempt to improve host health”.
  • 1.4K
  • 22 Mar 2023
Topic Review
Genital Tract Microbiome of Cattle
The term microbiota refers to the entire population of microorganisms that colonizes a particular location and includes not just bacteria, but also other microbes such as fungi, archaea, viruses, and protozoans. Cows have bacteria inhabiting the uterus even before calving and establish a unique endometrial microbiome within 20 min of calving where the microbiome is similar between cows that develop metritis and cows without endometritis until at least the second day postpartum.
  • 1.4K
  • 23 Feb 2022
Topic Review
Phage-Bacteria Interactions
With the increasing global threat of antibiotic resistance, there is an urgent need to develop new effective therapies to tackle antibiotic-resistant bacterial infections. Bacteriophage therapy is considered as a possible alternative over antibiotics to treat antibiotic-resistant bacteria. Bacteria can evolve resistance towards bacteriophages through antiphage defense mechanisms, which is a major limitation of phage therapy. The antiphage mechanisms target the phage life cycle, including adsorption, the injection of DNA, synthesis, the assembly of phage particles, and the release of progeny virions.
  • 1.4K
  • 21 Jul 2022
Topic Review
Pathogenicity and Immunogenicity of Adenovirus
Adenovirus is formed of an icosahedral protein shell measuring 90 nm and harboring linear double-stranded DNA (dsDNA) that belongs to the genus Mastadenovirus of the Adenoviridae family. Most people have been infected by adenovirus, leading to lifelong immunity.
  • 1.4K
  • 26 Oct 2022
Topic Review
Neisseria gonorrhoeae
Neisseria gonorrhoeae is a Gram-negative diplococcus which causes the sexually transmitted infection (STI) gonorrhea.
  • 1.4K
  • 24 Feb 2021
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