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Topic Review
HEK293 Cell Line
The HEK293 cell line has earned its place as a producer of biotherapeutics. In addition to its ease of growth in serum-free suspension culture and its amenability to transfection, this cell line’s most important attribute is its human origin, which makes it suitable to produce biologics intended for human use. At the present time, the growth and production properties of the HEK293 cell line are inferior to those of non-human cell lines, such as the Chinese hamster ovary (CHO) and the murine myeloma NSO cell lines. However, the modification of genes involved in cellular processes, such as cell proliferation, apoptosis, metabolism, glycosylation, secretion, and protein folding, in addition to bioprocess, media, and vector optimization, have greatly improved the performance of this cell line.
  • 4.0K
  • 07 Jul 2021
Topic Review
Chinese Information Operations and Information Warfare
Informatized warfare of China is the implementation of information warfare (IW) within the Chinese military. Laid out in the Chinese Defence White Paper of 2008, informatized warfare includes the utilization of information-based weapons and forces, including battlefield management systems, precision-strike capabilities, and technology-assisted command and control (C4ISR). However, some media and analyst report also uses the term to describe the political and espionage effort from the Chinese state.
  • 4.0K
  • 14 Oct 2022
Topic Review
Thyroid and Heart
The thyroid–heart relationship has a long and articulated history of its own, a history that encompasses physiological and pathophysiological knowledge. Molecular biology studies, in an experimental context, have highlighted the extraordinary dialogue that exists among the two systems in the field of cardioprotection, which is an extremely important area for the treatment of cardiac diseases in both acute and chronic phases. In addition, in the last few years, several studies have been carried out on the prognostic impact of alterations in thyroid function, including subclinical ones, in heart disease, in particular in heart failure and acute myocardial infarction, with evidence of a negative prognostic impact of these and, therefore, with the suggestion to treat these alterations in order to prevent cardiac events, such as death.  A comprehensive summary of the heart–thyroid relationship is provided.
  • 4.0K
  • 03 Jan 2024
Topic Review
Epidemiology of Plague
Globally about 600 cases of plague are reported a year. In 2017 and November 2019 the countries with the most cases include the Democratic Republic of the Congo, Madagascar , and Peru. Local outbreaks of the plague are grouped into three plague pandemics, whereby the respective start and end dates and the assignment of some outbreaks to either pandemic are still subject to discussion. The pandemics were: However, the late medieval Black Death (roughly 1331 to 1353) is sometimes seen not as the start of the second, but as the end of the first pandemic – in that case, the first pandemic ended in around 1353, and the second pandemic's start would be about 1361. Also various end dates of the second pandemic are given in the literature, ranging from about 1840 to 1890.
  • 4.0K
  • 29 Nov 2022
Topic Review Peer Reviewed
Numerical Solution of Desiccation Cracks in Clayey Soils
This entry presents the theoretical fundamentals, the mathematical formulation, and the numerical solution for the problem of desiccation cracks in clayey soils. The formulation uses two stress state variables (total stress and suction) and results in a non-symmetric and nonlinear system of transient partial differential equations. A release node algorithm technique is proposed to simulate cracking, and the strategy to implement it in the hydromechanical framework is explained in detail. This general framework was validated with experimental results, and several numerical examples were published at international conferences and in journal papers.
  • 4.0K
  • 25 May 2022
Topic Review
Jump Scare
A jump scare (often shortened to jumpscare) is a technique often used in horror films, haunted attractions, video games, and Internet screamers, intended to scare the audience by surprising them with an abrupt change in image or event, usually co-occurring with a frightening sound, mostly loud screaming. Common in film since the 1980s, the jump scare has been described as "one of the most basic building blocks of horror movies". Jump scares can surprise the viewer by appearing at a point in the film where the soundtrack is quiet and the viewer is not expecting anything alarming to happen, or can be the sudden payoff to a long period of suspense. Some critics have described jump scares as a lazy way to frighten viewers, and believe that the horror genre has undergone a decline in recent years following an over-reliance on the trope, establishing it as a cliché of modern horror films.
  • 4.0K
  • 11 Oct 2022
Topic Review
Mode-locking
Mode-locking is a technique in optics by which a laser can be made to produce pulses of light of extremely short duration, on the order of picoseconds (10−12 s) or femtoseconds (10−15 s). A laser operated in this way is sometimes referred to as a femtosecond laser, for example in modern refractive surgery. The basis of the technique is to induce a fixed-phase relationship between the longitudinal modes of the laser's resonant cavity. Constructive interference between these modes can cause the laser light to be produced as a train of pulses. The laser is then said to be 'phase-locked' or 'mode-locked'.
  • 4.0K
  • 03 Nov 2022
Topic Review
Sustainable Manufacturability of Archimedes Screw Turbines
Archimedes screw turbines are considered a new technology in small- or microscale hydropower. The Archimedes screw turbines is a hydroturbine that is geometrically modeled after Archimedean screws, which are machines historically used to pump water to higher elevations. Archimedes screw turbines are easy and practical to operate compared with other turbines. It is considered a fish-friendly turbine due to the geometric structure of the screw-shaped turbine that allows fish to swim in between them.
  • 4.0K
  • 30 Jan 2023
Topic Review
Inositol Hexaphosphate (IP6)
Multiple human health-beneficial effects have been related to highly phosphorylated inositol hexaphosphate (IP6). This naturally occurring carbohydrate and its parent compound, myo-inositol (Ins), are abundantly present in plants, particularly in certain high-fiber diets, but also in mammalian cells, where they regulate important cellular functions. However, the striking and broad-spectrum anticancer activity of IP6, consistently demonstrated in different experimental models, has been in a spotlight of the scientific community dealing with the nutrition and cancer during the last several decades. First experiments were performed in colon cancer 30 years ago. Since then, it has been shown that IP6 reduces cell proliferation, induces apoptosis and differentiation of malignant cells with reversion to normal phenotype, affecting several critical molecular targets. Enhanced immunity and antioxidant properties also contribute to the tumor cell destruction. Although Ins possesses a modest anticancer potential, the best anticancer results were obtained from the combination of IP6 + Ins.
  • 4.0K
  • 07 Jan 2021
Topic Review
Mount Tai
Mount Tai (Chinese: 泰山; pinyin: Tài Shān) is a mountain of historical and cultural significance located north of the city of Tai'an, it is the highest point in Shandong province, China. The tallest peak is the Jade Emperor Peak (simplified Chinese: 玉皇顶; traditional Chinese: 玉皇頂; pinyin: Yùhuáng Dǐng), which is commonly reported as being 1,545 meters (5,069 ft) tall, but is officially described by the PRC government as 1,532.7 meters (5,029 ft) tall. Mount Tai is known as the eastern mountain of the Sacred Mountains of China. It is associated with sunrise, birth, and renewal, and is often regarded the foremost of the five. Mount Tai has been a place of worship for at least 3,000 years and served as one of the most important ceremonial centers of China during large portions of this period. Because of its sacred importance and dramatic landscape, Promulgated by UNESCO as a Mixed Cultural and Natural Heritage in 1987. And it meets 7 of the 10 evaluation standards of World Heritage, and is listed as the World Heritage that meets the most standards along with the Tasmanian Wilderness World Heritage Area in Australia. An Earthquake or thunderstorm occurred in Mount Tai in 1831 BC or 1652 BC, also known as Mount Tai earthquake. First seen in "Bamboo Annals". At present, it is recognized by most scholars as the first recorded earthquake in Chinese history.
  • 4.0K
  • 10 Nov 2022
Topic Review
Flybuys (Australia)
flybuys is an Australia n loyalty program owned and operated by Coles, with the main participating retail outlets being Coles Supermarkets, Coles Express, Kmart, Liquorland, First Choice Liquor and Target stores. It is one of Australia's largest loyalty programs, with over 10 million flybuys cardholders in over 5.5 million Australian households. Members earn points from household consumer purchases (and through credit card use) and subsequently exchange points for gift cards, merchandise, flights and other rewards.
  • 4.0K
  • 02 Dec 2022
Topic Review
Metal-Organic Frameworks in CO2 Cycloaddition with Epoxides
The level of carbon dioxide in the atmosphere is growing rapidly due to fossil fuel combustion processes, heavy oil, coal, oil shelter, and exhausts from automobiles for energy generation, which lead to depletion of the ozone layer and consequently result in global warming. The realization of a carbon-neutral environment is the main focus of science and academic researchers of today. Several processes were employed to minimize carbon dioxide in the air, some of which include the utilization of non-fossil sources of energy like solar, nuclear, and biomass-based fuels. Consequently, these sources were reported to have a relatively high cost of production and maintenance. The applications of both homogeneous and heterogeneous processes in carbon capture and storage were investigated in recent years and the focus now is on the conversion of CO2 into useful chemicals and compounds. It was established that CO2 can undergo cycloaddition reaction with epoxides under the influence of special catalysts to give cyclic carbonates, which can be used as value-added chemicals at a different level of pharmaceutical and industrial applications. Among the various catalysts studied for this reaction, metal-organic frameworks are now on the frontline as a potential catalyst due to their special features and easy synthesis. Several metal-organic framework (MOF)-based catalysts were studied for their application in transforming CO2 to organic carbonates using epoxides. Here, we report some recent studies of porous MOF materials and an in-depth discussion of two repeatedly used metal-organic frameworks as a catalyst in the conversion of CO2 to organic carbonates
  • 4.0K
  • 25 Nov 2021
Topic Review
Arhat
In Buddhism, an arhat (Sanskrit) or arahant (Pali) is one who has gained insight into the true nature of existence and has achieved nirvana. Mahayana Buddhist traditions have used the term for people far advanced along the path of Enlightenment, but who may not have reached full Buddhahood. The understanding of the concept has changed over the centuries, and varies between different schools of Buddhism and different regions. A range of views on the attainment of arhats existed in the early Buddhist schools. The Sarvāstivāda, Kāśyapīya, Mahāsāṃghika, Ekavyāvahārika, Lokottaravāda, Bahuśrutīya, Prajñaptivāda, and Caitika schools all regarded arhats as imperfect in their attainments compared to buddhas. Mahayana Buddhist teachings urge followers to take up the path of a bodhisattva, and to not fall back to the level of arhats and śrāvakas. The arhats, or at least the senior arhats, came to be widely regarded by Theravada buddhists as "moving beyond the state of personal freedom to join the Bodhisattva enterprise in their own way". Mahayana Buddhism regarded a group of Eighteen Arhats (with names and personalities) as awaiting the return of the Buddha as Maitreya, while other groupings of 6, 8, 16, 100, and 500 also appear in tradition and Buddhist art, especially in East Asia called luohan or lohan. They may be seen as the Buddhist equivalents of the Christian saint, apostles or early disciples and leaders of the faith.
  • 4.0K
  • 28 Nov 2022
Topic Review
Integration of Blockchain Technology with Cloud Computing
Blockchain technology’s desirable characteristics are decentralization, integrity, immutability, verification, fault tolerance, anonymity, audibility, and transparency. There are many benefits of blockchain technology concerning cloud computing, including those associated with business data handling, privacy, and encryption. 
  • 4.0K
  • 29 Nov 2022
Topic Review
Treating Delusional Disorder with Antipsychotics
Delusional disorder (DD) has been considered a treatment-resistant disorder, with antipsychotics acknowledged as the best. It is possible that the discovery of the right drug could turn treatment resistance into treatment response.
  • 4.0K
  • 29 Dec 2022
Topic Review
Monotreme
Monotremes (/ˈmɒnətriːmz/) are prototherian mammals of the order Monotremata. They are one of the three groups of living mammals, along with placentals (Eutheria) and marsupials (Metatheria). Monotremes are typified by structural differences in their brains, jaws, digestive tract, reproductive tract, and other body parts, compared to the more common mammalian types. In addition, they lay eggs rather than bearing live young, but, like all mammals, the female monotremes nurse their young with milk. Monotremes have been considered members of Australosphenida, a clade that contains extinct mammals from the Jurassic and Cretaceous of Madagascar, South America, and Australia, though this is disputed. The only surviving examples of monotremes are all indigenous to Australia and New Guinea, although there is evidence that they were once more widespread, as Monotrematum is known from the Paleocene of South America. The extant monotreme species are the platypus and four species of echidnas. There is currently some debate regarding monotreme taxonomy. The name monotreme derives from the Greek words μονός (monós 'single') and τρῆμα (trêma 'hole'), referring to the cloaca.
  • 4.0K
  • 28 Nov 2022
Topic Review
High-Purity Quartz Processing Technology
Quartz deposits are widely dispersed in nature, but the presence of ore bodies capable of yielding high-purity quartz is exceedingly rare. As a result, the effective purification and processing of high-purity quartz from natural siliceous materials has emerged as a prominent area of research within the non-metallic mineral processing field.
  • 4.0K
  • 12 Dec 2023
Topic Review
Bio-Preservation of Bread
Bread is a food that is commonly recognized as a very convenient type of food, but it is also easily prone to microbial attack. As a result of bread spoilage, a significant economic loss occurs to both consumers and producers. The bakery industry has sought to identify treatments that make bread safe and with an extended shelf-life to address this economic and safety concern, including replacing harmful chemical preservatives. New frontiers, on the other hand, have recently been explored. Alternative methods of bread preservation, such as microbial fermentation, utilization of plant and animal derivatives, nanofibers, and other innovative technologies, have yielded promising results. 
  • 4.0K
  • 29 Mar 2022
Topic Review
Electrochemical Glucose Sensing
The research field of glucose biosensing has shown remarkable growth and development since the first reported enzyme electrode in 1962. Extensive research on various immobilization methods and the improvement of electron transfer efficiency between the enzyme and the electrode have led to the development of various sensing platforms that have been constantly evolving with the invention of advanced nanostructures and their nano-composites. Examples of such nanomaterials or composites include gold nanoparticles, carbon nanotubes, carbon/graphene quantum dots and chitosan hydrogel composites, all of which have been exploited due to their contributions as components of a biosensor either for improving the immobilization process or for their electrocatalytic activity towards glucose. This review aims to summarize the evolution of the biosensing aspect of these glucose sensors in terms of the various generations and recent trends based on the use of applied nanostructures for glucose detection in the presence and absence of the enzyme.
  • 4.0K
  • 13 Nov 2020
Topic Review
Web Search Engine
A web search engine or Internet search engine is a software system that is designed to carry out web search (Internet search), which means to search the World Wide Web in a systematic way for particular information specified in a textual web search query. The search results are generally presented in a line of results, often referred to as search engine results pages (SERPs). The information may be a mix of links to web pages, images, videos, infographics, articles, research papers, and other types of files. Some search engines also mine data available in databases or open directories. Unlike web directories, which are maintained only by human editors, search engines also maintain real-time information by running an algorithm on a web crawler. Internet content that is not capable of being searched by a web search engine is generally described as the deep web.
  • 4.0K
  • 19 Oct 2022
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