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Topic Review
Rhinovirus
Rhinoviruses (RVs) are non-enveloped positive sense RNA viruses with a lifecycle fully contained within the cytoplasm. Despite decades of study, the details of how RVs exit the infected cell are still unclear. Current literature strongly suggests a role for necroptosis and/or autophagy in RV release, with the caveat that all the literature is based on RV-A and RV-B strains, with no studies to date examining the interaction of RV-C strains with cell death pathways.
  • 4.1K
  • 15 Jun 2021
Topic Review
Background on Computing Paradigms
General overview of the different mentioned paradigms needs to be provided in order to be oriented in the computing field. For clarity and consistency, each paradigm is carefully discussed concisely in the oncoming text. The reason for discussing each of these paradigms is to have an overview that will guide the understanding of the research goal for this entry, which is primarily the information security and privacy aspects for each paradigm.
  • 4.1K
  • 25 Feb 2022
Topic Review
Blairism
In British politics, Blairism is the political ideology of the former leader of the Labour Party and Prime Minister Tony Blair and those that follow him. It entered the New Penguin English Dictionary in 2000. Proponents of Blairism are referred to as Blairites.
  • 4.1K
  • 18 Oct 2022
Topic Review
Springfield Armory XDM
The Springfield Armory XDM (X-Treme Duty, the M is for the match grade barrel and match grade trigger) are a series of semi-automatic pistols that are polymer-framed and striker-fired. They closely resemble their predecessor, the HS2000 pistol (most widely known in the United States as Springfield Armory XD). Manufactured in the city of Karlovac, Croatia by HS Produkt (formerly I.M. Metal), the Springfield Armory XDM is the marketing name for the firearm, which is licensed and sold in the United States by Springfield Armory, Inc..
  • 4.1K
  • 25 Oct 2022
Topic Review Peer Reviewed
Joanna I of Anjou (1343–1382)
Joanna I of Anjou (1325–1382), countess of Provence and the fourth sovereign of the Angevin dynasty in south Italy (since 1343), became the heir to the throne of the Kingdom of Sicily, succeeding her grandfather King Robert “the Wise” (1277–1343). The public and official images of the queen and the “symbolic” representations of her power, commissioned by her or by her entourage, contributed to create a new standard in the cultural references of the Angevin iconographic tradition aiming to assimilate models shared by the European ruling class. In particular, the following works of art and architecture will be analyzed: the queen’s portraits carved on the front slabs of royal sepulchers (namely those of her mother Mary of Valois and of Robert of Anjou) and on the liturgical furnishings in the church of Santa Chiara in Naples; the images painted in numerous illuminated manuscripts, in the chapter house of the friars in the Franciscan convent of Santa Chiara in Naples, in the lunette of the church in the Charterhouse of Capri. The church of the Incoronata in Naples does not show, at the present time, any portrait of the queen or explicit reference to Joanna as a patron. However, it is considered the highest symbolic image of her queenship. 
  • 4.1K
  • 13 Apr 2022
Topic Review Peer Reviewed
The “Pink Tax” and Gender Price Disparity in Personal Care
The “Pink Tax” refers to charging higher prices for products and services marketed primarily to women compared to similar or identical items targeted at men, despite comparable production costs. This research uses Unilever as a case study to focus on the impact of the Pink Tax on women’s purchasing power, particularly within the personal care industry. The study provides a comprehensive overview of the Pink Tax’s evolution, key research findings, public responses, and regulatory measures to address this issue. By synthesising existing research and case studies, this paper highlights the economic burden imposed on women and the reinforcement of gender stereotypes through market practices. The study underscores the need for equitable pricing mechanisms and informed consumer advocacy to rectify the economic disparities exacerbated by the Pink Tax.
  • 4.1K
  • 27 Aug 2024
Topic Review
NRF2
Nuclear factor erythroid 2‐related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification. NRF2 activation renders cells resistant to chemical carcinogens and inflammatory challenges. In addition to antioxidant responses, NRF2 is involved in other cellular processes, including metabolism and inflammation, and its functions are beyond the originally envisioned. NRF2 activity is tightly regulated through a complex transcriptional and post-translational network that enables it to orchestrate the cell’s response and adaptation to various pathological stressors for the homeostasis maintenance. Elevated or decreased NRF2 activity by pharmacological and genetic manipulations of NRF2 activation is associated with many metabolism- or inflammation-related diseases. Emerging evidence shows that NRF2 lies at the center of a complex regulatory network and establishes NRF2 as a truly pleiotropic transcription factor. Here we summarize the complex regulatory network of NRF2 activity and its roles in metabolic reprogramming, unfolded protein response, proteostatsis, autophagy, mitochondrial biogenesis, inflammation, and immunity.
  • 4.1K
  • 17 Jul 2020
Topic Review
Sex and Sexuality in Autism Spectrum Disorders
Autism spectrum disorder (ASD) consists of a set of permanent neurodevelopmental conditions, which are studded with social and communication differences, limited interests, and repetitive behaviors. Individuals with ASD have difficulty reading eye gestures and expressions, and may also have stereotyped or repetitive language, excessive adherence to routines, fixed interests, and rigid thinking. The relationship difficulties resulting from ASD do not allow individuals to relate adequately to others, leading to unwanted sexual contact, social isolation, and mental health disorders.
  • 4.1K
  • 14 Nov 2022
Topic Review
Anthocyanidins and Anthocyanins
Anthocyanidins are colored molecules having medium-size and belonging to the class of flavonoids.
  • 4.1K
  • 24 May 2021
Topic Review
Methyl Iodide
Methyl iodide, also called iodomethane, and commonly abbreviated "MeI", is the chemical compound with the formula CH3I. It is a dense, colorless, volatile liquid. In terms of chemical structure, it is related to methane by replacement of one hydrogen atom by an atom of iodine. It is naturally emitted by rice plantations in small amounts. It is also produced in vast quantities estimated to be greater than 214,000 tons annually by algae and kelp in the world's temperate oceans, and in lesser amounts on land by terrestrial fungi and bacteria. It is used in organic synthesis as a source of methyl groups.
  • 4.1K
  • 01 Nov 2022
Topic Review
EPR (Nuclear Reactor)
The EPR is a third generation pressurised water reactor (PWR) design. It has been designed and developed mainly by Framatome (part of Areva between 2001 and 2017) and Électricité de France (EDF) in France, and Siemens in Germany. In Europe this reactor design was called European Pressurised Reactor, and the internationalised name was Evolutionary Power Reactor, but it is now simply named EPR. The first two EPR units, at Olkiluoto in Finland and Flamanville in France, are both facing costly construction delays (to at least 2019). Construction commenced on two Chinese units at Taishan in 2009 and 2010. Taishan 1 achieved criticality on 6 June 2018. Taishan 2 is expected to begin operation in 2019. Two units at Hinkley Point in the United Kingdom received final approval in September 2016 and are expected to be completed by 2025. EDF has acknowledged severe difficulties in building the EPR design. In September 2015 EDF stated that the design of a "New Model" EPR was being worked on, which will be easier and cheaper to build.
  • 4.1K
  • 15 Nov 2022
Topic Review
Embodied 'Basic' Emotions in Chinese and English Language
References to the body are one feature shared across languages, particularly when describing the mental processes of emotion, reflecting the embodiment of an emotional experience. Embodied emotion concepts encompass these categorized outcomes of bidirectional brain–body interactions yet can be differentiated further into afferent or interoceptive and efferent or autonomic processes. Between languages, a comparison of emotion words indicates the dominance of afferent or interoceptive processes in how embodied emotions are conceptualized in Chinese, while efferent or autonomic processes feature more commonly in English. Correspondingly, in linguistic expressions of emotion, Chinese-speaking people are biased toward being more receptive, reflective, and adaptive, whereas native English speakers may tend to be more reactive, proactive, and interactive. 
  • 4.1K
  • 05 Aug 2022
Topic Review
Inertial Confinement Fusion
Inertial confinement fusion (ICF) is a type of fusion energy research that attempts to initiate nuclear fusion reactions by heating and compressing a fuel target, typically in the form of a pellet that most often contains a mixture of deuterium and tritium. Typical fuel pellets are about the size of a pinhead and contain around 10 milligrams of fuel. To compress and heat the fuel, energy is delivered to the outer layer of the target using high-energy beams of laser light, electrons or ions, although for a variety of reasons, almost all ICF devices (As of 2015) have used lasers. The heated outer layer explodes outward, producing a reaction force against the remainder of the target, accelerating it inwards, compressing the target. This process is designed to create shock waves that travel inward through the target. A sufficiently powerful set of shock waves can compress and heat the fuel at the center so much that fusion reactions occur. ICF is one of two major branches of fusion energy research, the other being magnetic confinement fusion. When it was first proposed in the early 1970s, ICF appeared to be a practical approach to power production and the field flourished. Experiments during the 1970s and '80s demonstrated that the efficiency of these devices was much lower than expected, and reaching ignition would not be easy. Throughout the 1980s and '90s, many experiments were conducted in order to understand the complex interaction of high-intensity laser light and plasma. These led to the design of newer machines, much larger, that would finally reach ignition energies. The largest operational ICF experiment is the National Ignition Facility (NIF) in the US, designed using the decades-long experience of earlier experiments. Like those earlier experiments, however, NIF has failed to reach ignition and is, as of 2015, generating about ​1⁄3 of the required energy levels.
  • 4.1K
  • 29 Sep 2022
Topic Review
Network Intrusion Detection Systems Using Artificial Intelligence/Machine Learning
The rapid growth of the Internet and communications has resulted in a huge increase in transmitted data. These data are coveted by attackers and they continuously create novel attacks to steal or corrupt these data. The growth of these attacks is an issue for the security of systems and represents one of the biggest challenges for intrusion detection. An intrusion detection system (IDS) is a tool that helps to detect intrusions by inspecting the network traffic. Although many researchers have studied and created new IDS solutions, IDS still needs improving in order to have good detection accuracy while reducing false alarm rates. 
  • 4.1K
  • 23 Dec 2022
Topic Review
Smart Materials
The introduction of smart materials (SMs) will become increasingly relevant as biomedical technologies progress. Smart materials sense and respond to external stimuli (e.g., chemical, electrical, mechanical, or magnetic signals) or environmental circumstances (e.g., temperature, illuminance, acidity, or humidity), and provide versatile platforms for studying various biological processes because of the numerous analogies between smart materials and biological systems. 
  • 4.1K
  • 07 Jul 2023
Topic Review
Levels-of-Processing Effect
The levels-of-processing effect, identified by Fergus I. M. Craik and Robert S. Lockhart in 1972, describes memory recall of stimuli as a function of the depth of mental processing. Deeper levels of analysis produce more elaborate, longer-lasting, and stronger memory traces than shallow levels of analysis. Depth of processing falls on a shallow to deep continuum. Shallow processing (e.g., processing based on phonemic and orthographic components) leads to a fragile memory trace that is susceptible to rapid decay. Conversely, deep processing (e.g., semantic processing) results in a more durable memory trace. This theory contradicts the multi-store Atkinson-Shiffrin memory model which represents memory strength as being continuously variable, the assumption being that rehearsal always improves long-term memory. They argued that rehearsal that consists simply of repeating previous analyses (maintenance rehearsal) doesn't enhance long-term memory. In a study from 1975 (Craik and Tulving) participants were given a list of 60 words. Each word was presented along with three questions. The participant had to answer one of them. Those three questions were in one of three categories. One category of questions was about how the word was presented visually ("Is the word shown in italics?"). The second category of questions was about the phonemic qualities of the word ("Does the word begin with the sound 'bee'?"). The third category of questions was presented so that the reader was forced to think about the word within a certain context. ("Can you meet one in the street [a friend]"?) The result of this study showed that the words which contained deep processing (the latter) were remembered better.
  • 4.1K
  • 25 Oct 2022
Topic Review
Content-Control Software
Content-control software, commonly referred to as an Internet filter, is software that restricts or controls the content an Internet user is capable to access, especially when utilised to restrict material delivered over the Internet via the Web, Email, or other means. Content-control software determines what content will be available or be blocked. Such restrictions can be applied at various levels: a government can attempt to apply them nationwide (see Internet censorship), or they can, for example, be applied by an ISP to its clients, by an employer to its personnel, by a school to its students, by a library to its visitors, by a parent to a child's computer, or by an individual user to their own computer. The motive is often to prevent access to content which the computer's owner(s) or other authorities may consider objectionable. When imposed without the consent of the user, content control can be characterised as a form of internet censorship. Some content-control software includes time control functions that empowers parents to set the amount of time that child may spend accessing the Internet or playing games or other computer activities. In some countries, such software is ubiquitous. In Cuba, if a computer user at a government-controlled Internet cafe types certain words, the word processor or web browser is automatically closed, and a "state security" warning is given.
  • 4.1K
  • 08 Nov 2022
Topic Review
Methanol to Gasoline (MTG)
The MTG (Methanol to Gasoline) process allows us to transform methanol into hydrocarbons within the range of gasoline boiling points.
  • 4.1K
  • 04 Mar 2022
Topic Review
Action
In physics, action is a numerical value describing how a physical system has changed over time. Action is significant because the equations of motion of the system can be derived through the principle of stationary action. In the simple case of a single particle moving with a specified velocity, the action is the momentum of the particle times the distance it moves, added up along its path, or equivalently, twice its kinetic energy times the length of time for which it has that amount of energy, added up over the period of time under consideration. For more complicated systems, all such quantities are added together. More formally, action is a mathematical functional which takes the trajectory, also called path or history, of the system as its argument and has a real number as its result. Generally, the action takes different values for different paths. Action has dimensions of energy × time or momentum × length, and its SI unit is joule-second (like the Planck constant h).
  • 4.1K
  • 25 Nov 2022
Topic Review
Multi-Dimensional Concept of Sustainable Development and Urban Governance
Modern cities bear the entire burden and responsibility of operationalizing the concept of sustainable development, since they are the ones that represent the greatest threat to its implementation. The sustainability of cities largely depends on the form of public governance and decision making; in fact, this interdependence is a prerequisite for all the relevant progress in sustainable development that many European cities strive to achieve. An approach to governance in European cities that has proven to be the most effective in achieving urban sustainability is an integrated one, as it encompasses the coordination, cooperation and integration of sectoral policies and the participation of different actors at all levels of governance.
  • 4.1K
  • 16 Jun 2023
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