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Topic Review
Development of Therapeutic Monoclonal Antibodies
We provide an overview of the challenges and advancements in the development of therapeutic monoclonal antibodies and antibody products.
  • 4.2K
  • 21 Sep 2021
Topic Review
Kerala School of Astronomy and Mathematics
The Kerala School of Astronomy and Mathematics was a school of mathematics and astronomy founded by Madhava of Sangamagrama in Kerala, India, which included among its members: Parameshvara, Neelakanta Somayaji, Jyeshtadeva, Achyuta Pisharati, Melpathur Narayana Bhattathiri and Achyuta Panikkar. The school flourished between the 14th and 16th centuries and the original discoveries of the school seems to have ended with Narayana Bhattathiri (1559–1632). In attempting to solve astronomical problems, the Kerala school independently discovered a number of important mathematical concepts. Their most important results—series expansion for trigonometric functions—were described in Sanskrit verse in a book by Neelakanta called Tantrasangraha, and again in a commentary on this work, called Tantrasangraha-vakhya, of unknown authorship. The theorems were stated without proof, but proofs for the series for sine, cosine, and inverse tangent were provided a century later in the work Yuktibhasa (c. 1500 – c. 1610), written in Malayalam, by Jyesthadeva, and also in a commentary on Tantrasangraha. Their work, completed two centuries before the invention of calculus in Europe, provided what is now considered the first example of a power series (apart from geometric series). However, they did not formulate a systematic theory of differentiation and integration, nor is there any direct evidence of their results being transmitted outside Kerala.
  • 4.2K
  • 07 Oct 2022
Topic Review
Lymphatic Drainage of Renal Tissues
Acute kidney injury (AKI), especially if recurring, represents a risk factor for future chronic kidney disease. In intensive care units, increased intra-abdominal pressure is well-recognized as a significant contributor to AKI. Renal interstitial pressure changes synchronously to renal perfusion pressure. The renal parenchyma is primarily drained by the urine conducting and renal venous system. The renal lymphatic system can also contribute to renal compartment syndrome, the functional changes in the lymphatic flow was not investigated in connection with pneumo-peritoneum.
  • 4.2K
  • 17 May 2022
Topic Review
Depersonalization Disorder
Depersonalization disorder (DPD), also known as depersonalization/derealization disorder (DPDR), is a mental disorder in which the person has persistent or recurrent feelings of depersonalization or derealization. Depersonalization is described as feeling disconnected or detached from one's self. Individuals experiencing depersonalization may report feeling as if they are an outside observer of their own thoughts or body, and often report feeling a loss of control over their thoughts or actions. In some cases, individuals may be unable to accept their reflection as their own, or they may have out-of-body experiences. Derealization is described as detachment from one's surroundings. Individuals experiencing derealization may report perceiving the world around them as foggy, dreamlike/surreal, or visually distorted. In addition to these depersonalization-derealization disorder symptoms, the inner turmoil created by the disorder can result in depression, self-harm, low self-esteem, phobias, panic attacks, and suicide. It can also cause a variety of physical symptoms, including chest pain, blurry vision, visual snow, nausea, and the sensation of pins and needles in one's arms or legs. Depersonalization-derealization disorder is thought to be caused largely by interpersonal trauma such as childhood abuse. Triggers may include significant stress, panic attacks, and drug use. Studies suggest a uniform syndrome for chronic depersonalization/derealization regardless of whether drugs or an anxiety disorder is the precipitant. It is unclear whether genetics plays a role; however, there are many neurochemical and hormonal changes in individuals with depersonalization disorder. The disorder is typically associated with cognitive disruptions in early perceptual and attentional processes. Diagnostic criteria for depersonalization-derealization disorder include persistent or recurrent feelings of detachment from one's mental or bodily processes or from one's surroundings. A diagnosis is made when the dissociation is persistent and interferes with the social or occupational functions of daily life. However, accurate descriptions of the symptoms are hard to provide due to the subjective nature of depersonalization and derealization and persons' ambiguous use of language when describing these episodes. In the DSM-5, it was combined with derealization disorder and renamed "depersonalization/derealization disorder" ("DDPD"). In the DSM-5, it remains classified as a dissociative disorder, while the ICD-10 calls it "depersonalization-derealization syndrome" and classifies it as a neurotic disorder. Although the disorder is an alteration in the subjective experience of reality, it is not a form of psychosis, as the person is able to distinguish between their own internal experiences and the objective reality of the outside world. During episodic and continuous depersonalization, the person can distinguish between reality and fantasy and the grasp on reality remains stable at all times. While depersonalization-derealization disorder was once considered rare, lifetime experiences with it occur in about 1–2% of the general population. The chronic form of the disorder has a reported prevalence of 0.8 to 1.9%. While brief episodes of depersonalization or derealization can be common in the general population, the disorder is only diagnosed when these symptoms cause substantial distress or impair social, occupational, or other important areas of functioning.
  • 4.2K
  • 23 Nov 2022
Topic Review
Ultra-processed Foods
Ultra-processed foods were first defined by Dr. Carlos Monteiro in 2009 through the NOVA classification. Briefly, they are characterized in their formulation by the addition of cosmetic ingredients and/or additives for mainly industrial use - and having undergone an excessive processing  - to imitate, exacerbate, mask or restore sensory properties (aroma, texture, taste and color). It can also be very denaturing technological processes directly applied to the food (cooking-extrusion, puffing, etc.). They are food and drink products that have undergone specified types of food processing, usually by transnational and other very large 'Big food' corporations. These foods are designed to be 'convenient, eaten on the go, hyperpalatable and appealing to consumers, and, most importantly, the most profitable segment of Big Food companies’ portfolios because of these foods’ low-cost ingredients'. The NOVA-derived Siga score propose a complementary definition more focused ont the degradation of the food/ingredient matrix effect: "An ultra-processed food is characterized by the presence in its list of ingredients of at least one substance that is itself ultra-processed, called a marker of ultra-processing (MUP). These MUPs are obtained by synthesis, or by a succession of physical, chemical and/or biological processes applied to natural raw materials and which lead to a strong degradation compared to their original matrix".
  • 4.2K
  • 29 Oct 2020
Topic Review
Greenwashing in Corporate Social Responsibility
Corporate social responsibility (CSR) has emerged as a pivotal area of focus, with an increasing number of companies prioritizing its integration into their operational strategies.
  • 4.2K
  • 20 Nov 2023
Topic Review
White Hole
White holes are regions of space-time that although matter may come out, no matter is able to enter; or in other words, they have gravitational features opposite to those of black holes. White holes exist in the solutions to Einstein's general theory of relativity and the maximal extension of the Schwarzschild metric. The term "white hole" was coined by Soviet cosmologist Igor Novikov in 1965 after his theorization on the existence.
  • 4.2K
  • 15 Oct 2023
Topic Review
Xanthones
Xanthone is an aromatic oxygenated heterocyclic molecule, with a dibenzo-γ-pirone scaffold, known as 9H-xanthen-9-one, with the molecular formula of C13H8O2.
  • 4.2K
  • 23 Feb 2021
Topic Review
May 12: China’s Devastating Earthquake (2008 Sichuan Earthquake)
On May 12, 2008, at 14:28 local time, a catastrophic magnitude 8.0 (Mw) earthquake struck Wenchuan County in Sichuan Province, China (USGS, 2008). Known as the Great Sichuan Earthquake or Wenchuan Earthquake, it was the deadliest seismic event in China since the 1976 Tangshan Earthquake, with an official death toll of 69,227, over 374,000 injured, and 17,923 missing (Chinese Government, 2008). The disaster caused $125 billion (USD) in economic losses (World Bank, 2009), displaced 4.8 million people, and triggered long-term social, political, and environmental consequences.
  • 4.2K
  • 08 May 2025
Topic Review Peer Reviewed
Digital Literacy and Electronic Business
Digital literacy is a term that traditionally describes the extent to which a person is able to use interactive digital devices for living and working, such as computers and smartphones, as well as services delivered through these devices. The advent of the digital society at large and electronic business, specifically in the past decades, has broadened the use of digital devices beyond the isolated uses of working and simple communication; this advent has created digital ecosystems in which workers and consumers are embedded to various degrees, such as social media platforms or integrated shopping and media platforms. This embedding implies that a traditional, narrow notion of digital literacy needs to be extended and made more precise. For this purpose, we use the related notions of digital dexterity, digital proficiency and digital awareness. The term digital dexterity describes the extent to which an individual can handle or operate digital devices or services from a physical perspective. The term digital proficiency describes the extent to which an individual can use digital means to effectively and efficiently facilitate their living and working. The term digital awareness describes the extent to which individuals can understand what their position in digital ecosystems is, including the opportunities and threats of participating in these ecosystems. Digital literacy in the modern, broad interpretation is then the combination of digital dexterity, digital proficiency and digital awareness.
  • 4.2K
  • 13 Apr 2022
Topic Review
Ursus (Genus)
Ursus is a genus in the family Ursidae (bears) that includes the widely distributed brown bear, the polar bear, the American black bear, and the Asian black bear. The name is derived from the Latin ursus, meaning bear.
  • 4.2K
  • 01 Dec 2022
Topic Review
Green Chemistry Education
An important goal for sustainability education is to learn negotiation, problem solving and decision-making skills through discussions about ecological, social, economic, and ethical principles concerning local and global responsibility in their own life. Through memorable, experiential, and active processes, students learn to discuss their own value selection and to evaluate phenomena and sources of information critically. In this article, we aim to identify suitable pedagogical approaches to teaching and learning green chemistry among college students and preservice teachers by examining the teaching methods that have been used to promote green chemistry education (GCE) and how these methods have supported green chemistry learning (GCL).
  • 4.2K
  • 11 Nov 2020
Topic Review
Bone Tissues
Osseous tissue is a kind of hard connective tissue, which is also composed of cells, fibers and matrix. The fibers are bone glue fibers (the same as collagen fibers), and the matrix contains a large amount of solid inorganic salts.
  • 4.2K
  • 13 Sep 2021
Topic Review
Skin Stem Cells and Wound Healing
The human skin is a necessary organ for survival; therefore, its integrity and uncompromised function are essential. Normally, skin wounds can heal without problem; however, some diseases or extensive damage may delay or prevent healing. Skin stem cells (SSCs) are heavily involved in the healing process, as they can replace, restore, and regenerate the epidermal cells that may have been lost, damaged, or have become pathologically dysfunctional. However, non-healing wounds represent a serious and life-threatening scenario that may require advanced therapeutic strategies that may involve the use of stem cell allografts.
  • 4.2K
  • 26 Oct 2021
Topic Review
Ascribed Status
Ascribed status refers to the social position or rank assigned to an individual at birth or through inherent characteristics beyond their control, such as gender, race, or family background. Unlike achieved status, which is earned through individual effort or accomplishments, ascribed status shapes one's identity and societal roles independent of personal merit or achievement. These predetermined attributes often influence an individual's opportunities, privileges, and interactions within society.
  • 4.2K
  • 02 Feb 2024
Topic Review
Biological Melatonin versus Synthetic Melatonin
Melatonin dietary supplements are widely consumed worldwide, with developed countries as the largest consumers, with an estimated annual growth rate of approximately 10% until 2027, mainly in developing countries. The wide use of melatonin against sleep disorders and particular problems, such as jet lag, has been added to other applications, such as anti-aging, anti-stress, immune system activation, anticancer, and others, which have triggered its use, normally without a prescription. The chemical industry currently covers 100% of the needs of the melatonin market.
  • 4.2K
  • 18 Apr 2023
Topic Review
Business System Planning
Business systems planning (BSP) is a method of analyzing, defining and designing the information architecture of organizations. It was introduced by IBM for internal use only in 1981, although initial work on BSP began during the early 1970s. BSP was later sold to organizations. It is a complex method dealing with interconnected data, processes, strategies, aims and organizational departments. BSP was a new approach to IA; its goals are to: The result of a BSP project is a technology roadmap aligning investments and business strategy. BSP comprises 15 steps, which are classified into three sections by function.
  • 4.2K
  • 08 Oct 2022
Topic Review
Online Reviews
Online reviews, also referred to as electronic word of mouth (eWOM) or user-generated content (UGC), are all similar concepts with minor differences. eWOM is all electronic communications between producers and consumers and between consumers themselves: emails, websites, consumer review sites, blogs, virtual communities, chat rooms, newsgroups, and instant messaging. UGC is data generated online by consumers, e.g., text (consumer reviews and blogs) and picture data.
  • 4.2K
  • 09 Dec 2020
Topic Review
Sourdough Bread Fermentation and Probiotics
Sourdough fermentation is an ancient technique to ferment cereal flour that improves bread quality, bringing nutritional and health benefits. The fermented dough has a complex microbiome composed mainly of lactic acid bacteria and yeasts. During fermentation, the production of metabolites and chemical reactions occurs, giving the product unique characteristics and high sensory quality. Mastery of fermentation allows gluten levels to adjust, delay starch digestibility, and increase the bio-accessibility of vitamins and minerals. 
  • 4.2K
  • 27 Feb 2023
Topic Review
Zinc Complexes as Anticancer Agents
The search for anticancer metal-based drugs alternative to platinum derivatives could not exclude zinc derivatives due to the importance of this metal for the correct functioning of the human body. Zinc, the second most abundant trace element in the human body, is one of the most important micro-elements essential for human physiology. Its ubiquity in thousands of proteins and enzymes is related to its chemical features, in particular, its lack of redox activity and its ability to support different coordination geometries and to promote fast ligands exchange. Analogously to other trace elements, the impairment of its homeostasis can lead to various diseases and in some cases can be also related to cancer development. However, zinc complexes generally exert lower toxicity in comparison to other metal-based drugs and many zinc derivatives have been proposed as antitumor agents. Among them zinc complexes  comprising  N-donor ligands have been surveyed and analyzed. 
  • 4.2K
  • 22 Dec 2020
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