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Topic Review
Essential-thrombocythemia and Acquired von-Willebrand Syndrome
Over the past decade, new insights have emerged on the pathophysiology of essential thrombocythemia (ET), its clinical management, and associated thrombohemostatic disturbances. Here, we review the latest diagnostic and risk stratification modalities of ET and its therapeutics. Moreover, we discuss the clinical evidence-based benefits, deriving from major clinical trials, of using cytoreductive therapy and antiplatelet agents to lower the risk of fatal vascular events. Also, we focus on the condition of extreme thrombocytosis (>1000 × 109/L) and bleeding risk, the development and pathogenesis of acquired von Willebrand syndrome, and the clinical approach to this paradoxical scenario in ET.
  • 4.3K
  • 20 Oct 2020
Topic Review
Resveratrol and Human Skin Lightening
Resveratrol is a polyphenol compound found in many edible plants such as Vitis vinifera, and its inhibitory effects on the catalytic activity, gene expression, and posttranslational modifications of tyrosinase, a key enzyme in the melanin biosynthetic pathway, provide a mechanistic basis for its antimelanogenic effects seen in melanocytic cells, three-dimensionally reconstituted skin models, and in vivo animal models. Recent clinical studies have supported the efficacy of resveratrol and its analogs, such as resveratryl triacetate (RTA) and resveratryl triglycolate (RTG), in human skin lightening. These findings suggest that resveratrol and its analogs are potentially useful as skin lightening agents in cosmetics.
  • 4.3K
  • 29 Jul 2021
Topic Review
Sustainability Performance & Sustainable Banking
In the light of Agenda 2030 awareness of sustainability is steadily growing all over the world. Devastating phenomena like pandemics (Sustainable Development Goal 3 (SDGs—Agenda 2030)), poverty (Sustainable Development Goal 1 (SDGs—Agenda 2030)) as well as climate change (Sustainable Development Goal 13 (SDGs—Agenda 2030)) threaten humanity, calling for more sustainable solutions. Although economic growth (Sustainable Development Goal 8 (SDGs—Agenda 2030)) is one of the principal goals for a sustainable future, little research has been devoted to the interface of corporate social responsibility (CSR) and sustainability and their contribution to the financial sector, in view of sustainable banking. Even fewer are the studies concerning sustainable banking in Greece. This paper attempts a comparative overview of sustainability integration into businesses, focusing on the banking industry. The current theoretical analysis initially provides an extended review of the CSR and sustainability concepts, which is followed by a comprehensive analysis of non-financial disclosures (NFDs) and their business value, providing some evidence from Greece. 
  • 4.3K
  • 15 Jun 2021
Topic Review
Powered Hang Glider
A foot-launched powered hang glider (FLPHG), also called powered harness, nanolight, or hangmotor, is a powered hang glider harness with a motor and propeller in pusher configuration. An ordinary hang glider is used for its wing and control frame, and the pilot can foot-launch from a hill or from flat ground, needing a length of about a football field to get airborne, or much less if there is an oncoming breeze and no obstacles.
  • 4.3K
  • 04 Nov 2022
Topic Review
Cairo Declaration on Human Rights in Islam
The Cairo Declaration on Human Rights in Islam (CDHRI) is a declaration of the member states of the Organisation of Islamic Cooperation (OIC) adopted in Cairo, Egypt, on 5 August 1990, (Conference of Foreign Ministers, 9–14 Muharram 1411H in the Islamic calendar) which provides an overview on the Islamic perspective on human rights, and affirms Islamic sharia as its sole source. CDHRI declares its purpose to be "general guidance for Member States [of the OIC] in the field of human rights". This declaration is widely acknowledged as an Islamic response to the United Nations' Universal Declaration of Human Rights (UDHR), adopted in 1948. It guarantees some, but not all, of the UDHR and serves as a living document of human rights guidelines prescribed for all members of the OIC to follow, but restricts them explicitly to the limits set by the sharia. Because of this limit, the CDHRI has been criticized as an attempt to shield OIC member states from international criticism for human rights violations, as well as for failing to guarantee freedom of religion, justifying corporal punishment and allowing discrimination against non-Muslims and women.
  • 4.3K
  • 18 Oct 2022
Topic Review
Capillary-Driven Flow Microfluidics
Point-of-care (POC) or near-patient testing allows clinicians to accurately achieve real-time diagnostic results performed at or near to the patient site. The outlook of POC devices is to provide quicker analyses that can lead to well-informed clinical decisions and hence improve the health of patients at the point-of-need. Microfluidics plays an important role in the development of POC devices. However, requirements of handling expertise, pumping systems and complex fluidic controls make the technology unaffordable to the current healthcare systems in the world. In recent years, capillary-driven flow microfluidics has emerged as an attractive microfluidic-based technology to overcome these limitations by offering robust, cost-effective and simple-to-operate devices. The internal wall of the microchannels can be pre-coated with reagents, and by merely dipping the device into the patient sample, the sample can be loaded into the microchannel driven by capillary forces and can be detected via handheld or smartphone-based detectors. The capabilities of capillary-driven flow devices have not been fully exploited in developing POC diagnostics, especially for antimicrobial resistance studies in clinical settings. The purpose of this review is to open up this field of microfluidics to the ever-expanding microfluidic-based scientific community.
  • 4.3K
  • 24 Jul 2020
Topic Review
Energy-Saving and Sustainable Building Systems
Generally, energy used in a building can be accrued in various ways and a statistical process can be used for studying the building’s overall performance and minimizing the energy requirement of the building. Different statistical models are used to interpret the real-world data in terms of individual theory to develop energy-efficient buildings. Underfloor air distribution, double-glazed windows, use of highly efficient electric motors and variable speed drives may play a great role in reducing building energy consumption. In the UK, the application of double-glazed windows in commercial buildings can save 39–53% energy. The proper maintenance of a building’s central heating system can save up to 11% energy. The automatic HVAC control system can reduce up to 20% of the building’s total heating load. Proper utilization of a VSD system in motor and building performance optimization by an ANOVA tool also proved instrumental in saving energy.
  • 4.3K
  • 10 Feb 2022
Topic Review
LCD Projector
An LCD projector is a type of video projector for displaying video, images or computer data on a screen or other flat surface. It is a modern equivalent of the slide projector or overhead projector. To display images, LCD (liquid-crystal display) projectors typically send light from a metal-halide lamp through a prism or series of dichroic filters that separates light to three polysilicon panels – one each for the red, green and blue components of the video signal. As polarized light passes through the panels (combination of polarizer, LCD panel and analyzer), individual pixels can be opened to allow light to pass or closed to block the light. The combination of open and closed pixels can produce a wide range of colors and shades in the projected image. Metal-halide lamps are used because they output an ideal color temperature and a broad spectrum of color. These lamps also have the ability to produce an extremely large amount of light within a small area; current projectors average about 2,000 to 15,000 American National Standards Institute (ANSI) lumens. Other technologies, such as Digital Light Processing (DLP) and liquid crystal on silicon (LCOS) are also becoming more popular in modestly priced video projection.
  • 4.3K
  • 04 Nov 2022
Topic Review
20% Project
The 20% Project is an initiative where company employees are allocated twenty-percent of their paid work time to pursue personal projects. The objective of the program is to inspire innovation in participating employees and ultimately increase company potential. The 20% Project was influenced by a comparable program, launched in 1948, by manufacturing multinational 3M which required employees to have 15% time: to dedicate up to 15 percent of their paid hours to a personal interest. Technology company Google is credited for popularising the 20% concept, with many of their current services being products of employee pet projects. Some schools have also utilized the principles of the 20% Project to foster creativity and boost productivity.
  • 4.3K
  • 25 Nov 2022
Topic Review
Cell Lysis
Cell lysis is the first step of sample preparation for nucleic acid (NA) detection. Its purpose is to release NAs from the cells by disrupting the structure of cell membranes, which are also known as phospholipid bilayer membranes or plasmalemma. As NA detection typically relies on amplification using polymerase chain reaction (PCR) or isothermal alternatives, carry-over of inhibitory agents including the reagents used for lysis needs to be avoided or minimised. While washing steps are easily implemented in a laboratory setting, for Point of Need testing, the trend is towards substitution of strong inhibitory lytic reagents for more benign alternatives to minimise processing steps and reagent use. Additionally, sustainability of the reagents and their disposal are growing concerns. Here, an overview of lysis methods is provided from the perspective of their suitability for for point of need testing.
  • 4.3K
  • 16 Nov 2023
Topic Review
Skin Lesion Datasets and Image Preprocessing
Skin lesions affect millions of people worldwide. They can be easily recognized based on their typically abnormal texture and color but are difficult to diagnose due to similar symptoms among certain types of lesions.
  • 4.3K
  • 18 Apr 2023
Topic Review
Essential Oil Standards for Lavandula angustifolia
Lavender is in the research spotlight due to its increasing economic importance, while market demand is expected to continue to grow. Among the hundreds of essential-oil-bearing plants, Lavandula angustifolia Mill. remains one of the most valuable. Due to the increasing market demand as well as the expanding use of essential oils, the development of regulations, guidelines and standards aiming to maintain a high level of quality and safety remains a priority. Exigence is necessary for ensuring that buyers are receiving what they paid for, and in addition, depending on the destination of use and industry, for ensuring the derived product quality is not adversely affected.
  • 4.3K
  • 13 Mar 2023
Topic Review
Bee Products Treat Polycystic Ovarian Syndrome-Related Infertility
Bee products, including honey, have been utilized since ancient times for nutritional and therapeutic purposes. Other bee products such as bee pollen, royal jelly, and propolis have caught a lot of attention. Being high in antioxidants and bioactive compounds, these products have established their applications in the pharmaceutical field as supplementary or alternative medicines. Polycystic ovarian syndrome (PCOS) as a hormonal disorder in which the ovaries produce an irregular quantity of androgen. Bee products, especially honey, have been used since ancient times as a safer alternative to sugar. Being rich in antioxidants, honey indirectly helps PCOS patients by lowering the risk of oxidative stress, inflammation, and type-2 diabetes.
  • 4.3K
  • 12 Apr 2023
Topic Review
Tsunami
A tsunami (Japanese: 津波) (/(t)suːˈnɑːmi, (t)sʊˈ-/ (t)soo-NAH-mee, (t)suu- pronounced [tsɯnami]) is a series of waves in a water body caused by the displacement of a large volume of water, generally in an ocean or a large lake. Earthquakes, volcanic eruptions and other underwater explosions (including detonations, landslides, glacier calvings, meteorite impacts and other disturbances) above or below water all have the potential to generate a tsunami. Unlike normal ocean waves, which are generated by wind, or tides, which are generated by the gravitational pull of the Moon and the Sun, a tsunami is generated by the displacement of water. Tsunami waves do not resemble normal undersea currents or sea waves because their wavelength is far longer. Rather than appearing as a breaking wave, a tsunami may instead initially resemble a rapidly rising tide. For this reason, it is often referred to as a tidal wave, although this usage is not favoured by the scientific community because it might give the false impression of a causal relationship between tides and tsunamis. Tsunamis generally consist of a series of waves, with periods ranging from minutes to hours, arriving in a so-called "wave train". Wave heights of tens of metres can be generated by large events. Although the impact of tsunamis is limited to coastal areas, their destructive power can be enormous, and they can affect entire ocean basins. The 2004 Indian Ocean tsunami was among the deadliest natural disasters in human history, with at least 230,000 people killed or missing in 14 countries bordering the Indian Ocean. The Ancient Greece historian Thucydides suggested in his 5th century BC History of the Peloponnesian War that tsunamis were related to submarine earthquakes, but the understanding of tsunamis remained slim until the 20th century and much remains unknown. Major areas of current research include determining why some large earthquakes do not generate tsunamis while other smaller ones do; accurately forecasting the passage of tsunamis across the oceans; and forecasting how tsunami waves interact with shorelines.
  • 4.3K
  • 02 Dec 2022
Topic Review
Hydro Generation Scheduling
The optimal generation scheduling (OGS) of hydropower units holds an important position in electric power systems, which is significantly investigated as a research issue. Hydropower has a slight social and ecological effect when compared with other types of sustainable power source. The target of long-, mid-, and short-term hydro scheduling (LMSTHS) is to optimize the power generation schedule of the accessible hydropower units, which generate maximum energy by utilizing the available potential during a specific period. Numerous traditional optimization procedures are first presented for making a solution to the LMSTHS problem. Lately, various optimization approaches, which have been assigned as a procedure based on experiences, have been executed to get the optimal solution of the generation scheduling of hydro systems. This article offers a complete survey of the implementation of various methods to get the OGS of hydro systems by examining the executed methods from various perspectives. Optimal solutions obtained by a collection of meta-heuristic optimization methods for various experience cases are established, and the presented methods are compared according to the case study, limitation of parameters, optimization techniques, and consideration of the main goal. Previous studies are mostly focused on hydro scheduling that is based on a reservoir of hydropower plants. Future study aspects are also considered, which are presented as the key issue surrounding the LMSTHS problem.
  • 4.3K
  • 25 Jan 2022
Topic Review
Agriculture 5.0 and Remote Sensing
Constant industrial innovation has made it possible that 2021 has been officially marked by the European Commission as the beginning of the era of “Industry 5.0”. In this 5th industrial revolution, RS has the potential of being one of the most important technologies for today’s agriculture. RS sprouted in the 19th century (specifically in 1858) through the use of air balloons for aerial observations. At present, it occupies a central position in precision agriculture (PA) and soil studies. It is also important to mention some of the interchangeable terms most commonly used include “precision farming”, “precision approach”, “remote sensing”, “digital farming”, “information intensive agriculture”, “smart agriculture”, “variable rate technology (VRT)”, “global navigation satellite system (GNSS) agriculture”, “farming by inch”, “site specific crop management”, “digital agriculture”, “agriculture 5.0”, etc. RS is a vast term that covers various technological systems, such as satellites, RPAs, GNSS, geographic information systems (GIS), big data analysis, the Internet of Things (IoT), the Internet of Everything (IoE), cloud computing, wireless sensors technologies (WST), decision support systems (DSS), and autonomous robots.
  • 4.3K
  • 14 Sep 2021
Topic Review
Main Cable's Construction Control Technology of Suspension Bridge
The main cable shape control confronts new challenges when a suspension bridge’s span exceeds two kilometers. As a suspension bridge’s primary load-bearing component, it is difficult to alter the alignment once the erection is completed. Hence, the accurate calculation and control of the main cable shape has significant scientific research value from various aspects. The erection error of the free cable shape will have a substantial impact on subsequent construction stages. Therefore, when erecting the main cable, it is essential to guarantee the shape’s precision to the greatest extent possible.
  • 4.3K
  • 06 Mar 2023
Topic Review Peer Reviewed
Alphonse II of Aragon (1164–1196)
Alphonse II King of Aragon (1164–1196). He was the first king of the Crown of Aragon and son of the Queen Petronila of Aragon (1157–1164) and the count of Barcelona, Ramon Berenguer IV (1137–1162). Aware of the new political reality that he embodied as King of Aragon and Count of Barcelona, Alphonse II made significant changes to his iconography. Among the most important of these is the binomial that he incorporated to his pendent seals; that is, a portrayal of Alphonse enthroned as king on the obverse and Alphonse as count and mounted on a horse on the reverse. As a known bibliophile and as a result of his desire to reorganise his chancellery following the union of various political entities, he ordered the compilation of the Liber Feudorum Maior, the folios of which demonstrate his potestas regia through their lavish iconography. He was no less innovative in his coinage, on which he included, for the first time, the image of his head wearing the crown.
  • 4.3K
  • 13 Apr 2022
Topic Review
Perceived Consumer Effectiveness and Sustainable Credence Food Attributes
While perceived consumer effectiveness has consistently been linked to socially conscious attitudes, such as sustainable consumption decisions, the concept appears to have been confounded with other related constructs in the empirical studies measuring its effects on consumer buying intentions and consumer behaviour. A sustainable food consumer evaluation is based on product values and credibility to health, origin, environment, and ethical concerns.
  • 4.3K
  • 27 May 2022
Topic Review
The Rihla
The Rihla, formal title A Masterpiece to Those Who Contemplate the Wonders of Cities and the Marvels of Travelling, is the travelogue written by Ibn Battuta, documenting his lifetime of travel and exploration, which according to his description covered about 70,000 miles. Rihla is the Arabic word for a journey or the travelogue that documents it.
  • 4.3K
  • 26 Oct 2022
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