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Topic Review
The Mechanisms of Clozapine-Induced Neutropenia
Despite its severe adverse effects, such as agranulocytosis, clozapine is the primary treatment for treatment-resistant schizophrenia. Clozapine is the gold standard for treatment-resistant schizophrenia. It was discovered over a half-century ago by researchers at Wander AG, a Swiss pharmaceutical company. After a decade, the use of clozapine began to fade away due to its alarming side effect but was re-introduced in the year 1989 for the treatment of refractory psychosis. Numerous comparative studies between clozapine and other antipsychotics have reported superior efficacy of clozapine in treatment-resistant schizophrenia.
  • 4.5K
  • 10 Nov 2021
Topic Review
Classification of Indigenous Peoples of the Americas
Classification of Indigenous peoples of the Americas is based upon cultural regions, geography, and linguistics. Anthropologists have named various cultural regions, with fluid boundaries, that are generally agreed upon with some variation. These cultural regions are broadly based upon the locations of Indigenous peoples of the Americas from early European and African contact beginning in the late 15th century. When Indigenous peoples have been forcibly removed by nation-states, they retain their original geographic classification. Some groups span multiple cultural regions.
  • 4.5K
  • 25 Oct 2022
Topic Review
Sociology of Space
The sociology of space is a sub-discipline of sociology that mostly borrows from theories developed within the discipline of geography, including the sub fields of human geography, economic geography, and feminist geography. The "sociology" of space examines the social and material constitution of spaces. It is concerned with understanding the social practices, institutional forces, and material complexity of how humans and spaces interact. The sociology of space is an inter-disciplinary area of study, drawing on various theoretical traditions including Marxism, postcolonialism, and Science and Technology Studies, and overlaps and encompasses theorists with various academic disciplines such as geography and architecture. Edward T. Hall developed the study of Proxemics which concentrates on the empirical analysis of space in psychology.
  • 4.5K
  • 03 Nov 2022
Topic Review
Middle Eastern Philosophy
Middle Eastern philosophy includes the various philosophies of the Middle East regions, including the Fertile Crescent, Iran, and Anatolia. Traditions include Ancient Egyptian philosophy, Babylonian philosophy, Jewish philosophy, Iranian/Persian philosophy, and Islamic philosophy.
  • 4.5K
  • 05 Dec 2022
Topic Review
Nuclear Symmetry Energy
Nuclear symmetry energy is a measure of the energy cost to make nuclear systems more neutron rich. It depends on the density of the system. Information about the density dependence of nuclear symmetry energy has broad ramifications on the mechanisms of supernova explosions, properties of neutron stars and gravitational waves from their mergers. It is also important for understanding properties of nuclei as well as the dynamics and products of their collisions in laboratory experiments. 
  • 4.5K
  • 03 Aug 2021
Topic Review Peer Reviewed
Cottage Culture in Finland: Development and Perspectives
This entry provides an understanding of the past, present, and future of the Finnish cottage culture to create an overall picture of its development trajectory and its terminology, e.g., villa, in this context denoting a second home. Convenient, ready-made solutions, easy maintenance, a high level of equipment, year-round use, location, and modern and simple architectural styles are important selection criteria for (summer) cottages that belonged only to the wealthy bourgeois class in the 19th century and have taken their present form with a major transformation in Finland since then. Additionally, municipal regulations and increased attention to ecological concerns are other important issues regarding the cottage today. Cottage inheritance has changed over the generations, and the tightening of building regulations and increased environmental awareness are key drivers of the future transformation of cottage culture. Moreover, the increasing demand for single-family and outdoor spaces created by social changes such as remote working, which has become widespread with the COVID-19 pandemic, will make the summer cottage lifestyle even more popular in Finland. It is thought that this entry will contribute to the continuance of the Finnish cottage culture, which is essential for the vitality of countryside municipalities, local development, national culture, and the well-being of Finnish people. 
  • 4.5K
  • 14 Apr 2022
Topic Review
Sustainable Agriculture and Biodiversity Conservation in Japan
Japan aims to be carbon-neutral by 2050 by targeting various sectors including agriculture. One of the main strategies in this sector to mitigate climate change effects is environmental conservation agriculture (ECA); however, ECA utilization remains low in most of Japan’s prefectures to this date. Japan has been active in promoting biodiversity conservation and sustainable agriculture, which is why it currently has a total of 11 Globally Important Agricultural Heritage Systems (GIAHS) designated by FAO. Japan has been proactive in preserving endangered species, such as butterflies vascular plants, and birds
  • 4.5K
  • 19 May 2022
Topic Review
Bitumen Aging and Rejuvenation Chemistry
Bitumen aging and rejuvenation include a series of chemical transformations that the material undergoes and that results in the variation of its physical characteristics.
  • 4.5K
  • 30 Jun 2021
Topic Review
Papaverine and Its Mechanism of Action
Papaverine has been proven to be a high-value opioid alkaloid in the field of therapeutics either in solitude or in combination with other metabolites/molecules. Pharmacological research has revealed that papaverine demonstrates a variety of biological activities, including activity against erectile dysfunction, postoperative vasospasms, and pulmonary vasoconstriction, as well as antiviral, cardioprotective, anti-inflammatory, anticancer, neuroprotective, and gestational actions.
  • 4.5K
  • 07 Apr 2023
Topic Review
Nematode Identification
Nematodes are non-segmented roundworms evenly distributed with various habitats ranging to approximately every ecological extremity. These are the least studied organisms despite being the most diversified group. Nematodes are the most critical equilibrium-maintaining factors, having implications on the yield and health of plants as well as well-being of animals. As a result of the lack of precise taxonomic features, nematode taxonomy remains uncertain. Morphology-based identification has proved inefficacious in identifying and exploring the diversity of nematodes, as there are insufficient morphological variations. Different molecular and new evolving methodologies have been employed to augment morphology-based approaches and bypass these difficulties with varying effectiveness. These identification techniques vary from molecular-based targeting DNA or protein-based targeting amino acid sequences to methods for image processing. High-throughput approaches such as next-generation sequencing have also been added to this league. These alternative approaches have helped to classify nematodes and enhanced the base for increased diversity and phylogeny of nematodes, thus helping to formulate increasingly more nematode bases for use as model organisms to study different hot topics about human well-being.
  • 4.5K
  • 12 Jul 2022
Topic Review
Insect Pests of Brassica oleracea
The propagation and regeneration of Brassica species has been successful using seeds and different explants like petioles, cotyledons, stems and shoot tips. Shoot regeneration and rooting of Brassica species are successfully obtained from cotyledons and hypocotyl explants. The biological cycle length of Brassica species may either differ slightly or may not differ from one species to another. For instance, the seeds of Brassica oleracea take five days to germinate after sowing at 20–25 °C while the seeds of Brassica campestries take about three to five days to germinate after sowing at 20–25 °C. The most common insect pests of economic importance to Brassica oleracea in African smallholder farmers include Plutella xylostella, Helula undalis, Pieris brassicae, Brevycoryne brassicae, Trichoplusia ni and Myzus persicae. Those insect pests infest cabbages at different stages of growth, causing huge damage and resulting into huge yield losses. The African smallholder farmers use cultural and synthetic pesticides to control those insect pests and minimize infestations. The cultural practices are environmental friendly but are ineffective to control the insect pests. Due to ineffectiveness of cultural practices, African smallholder famers use broad-spectrum synthetic pesticides to effectively control the Brassica species insect pests. The improper and misuse of synthetic pesticides result into insect pests resistance towards the insecticides applied, environmental pollution and human health threats. Insect pests such as Plutella xylostella, Hellula undalis, Brevicoryne brassicae and Myzus persicae have developed resistance to a wide range of pesticides used such as cypermethrin, parathion, decamethrin, quinalphos and lamda-cyhalothrin. Therefore, that calls for search of the alternative products which can effectively be used to control those insect pests in the field.
  • 4.5K
  • 28 Oct 2020
Topic Review
Polyenes
Polyenes were, after griseofulvin, the first fungal-specific antibiotics on the market and ever since, more than 200 polyene antifungals have been discovered, of which amphotericin B, nystatin and natamycin are most commonly used in antifungal therapy .
  • 4.5K
  • 12 Jan 2021
Topic Review
C3 to CAM Photosynthesis Transition
Global climate change and population growth are persistently posing threats to natural resources (e.g., freshwater) and agricultural production. Crassulacean acid metabolism (CAM) evolved from C3 photosynthesis as an adaptive form of photosynthesis in hot and arid regions. It features the nocturnal opening of stomata for CO2 assimilation, diurnal closure of stomata for water conservation, and high water-use efficiency.
  • 4.5K
  • 08 Sep 2023
Topic Review
Biogas
Biogas refers to a mixture of different gases produced by the breakdown of organic matter in the absence of oxygen. Biogas can be produced from raw materials such as agricultural waste, manure, municipal waste, plant material, sewage, green waste or food waste. Biogas is a renewable energy source. Biogas can be produced by anaerobic digestion with methanogen or anaerobic organisms, which digest material inside a closed system, or fermentation of biodegradable materials. This closed system is called an anaerobic digester, biodigester or a bioreactor. Biogas is primarily methane (CH4) and carbon dioxide (CO2) and may have small amounts of hydrogen sulphide (H2S), moisture and siloxanes. The gases methane, hydrogen, and carbon monoxide (CO) can be combusted or oxidized with oxygen. This energy release allows biogas to be used as a fuel; it can be used for any heating purpose, such as cooking. It can also be used in a gas engine to convert the energy in the gas into electricity and heat. Biogas can be compressed, the same way as natural gas is compressed to CNG, and used to power motor vehicles. In the United Kingdom , for example, biogas is estimated to have the potential to replace around 17% of vehicle fuel. It qualifies for renewable energy subsidies in some parts of the world. Biogas can be cleaned and upgraded to natural gas standards, when it becomes bio-methane. Biogas is considered to be a renewable resource because its production-and-use cycle is continuous, and it generates no net carbon dioxide. As the organic material grows, it is converted and used. It then regrows in a continually repeating cycle. From a carbon perspective, as much carbon dioxide is absorbed from the atmosphere in the growth of the primary bio-resource as is released, when the material is ultimately converted to energy.
  • 4.5K
  • 22 Nov 2022
Biography
Robert Barron
Robert Emmet Barron (born November 19, 1959) is an American prelate of the Roman Catholic Church currently serving as an auxiliary bishop of the Archdiocese of Los Angeles. He is the founder of the Catholic ministerial organization Word on Fire, and was the host of the TV series CATHOLICISM, an award-winning documentary about the Catholic faith, which aired on PBS. Previously, he served as recto
  • 4.5K
  • 20 Dec 2022
Topic Review
MXene
The MXenes are a kind of 2D metal carbide/nitride with an alternative atomic arrangement of Mn+1Xn (M = transition metals; X = C, N; n = 1, 2, 3, 4).
  • 4.5K
  • 23 Feb 2021
Topic Review
Performance Evaluation of the Board of Directors
Abstract:   Purpose: The objectives of this paper are to analyse both individual and overall performance evaluations of the Board of Directors as carried out by Maltese Listed Companies (MLCs) and to assess the importance of such board evaluations to small shareholders. Design/Approach/Methodology: The study was designed around semi-structured interviews with fifteen MLC representatives and seven stockbrokers, as well as questionnaires administered to twenty-nine small shareholders. Findings: The findings indicate that, while Boards of Director evaluations are carried out in MLCs, they lack the necessary formal structures that specify critical evaluation measures. Thus one may infer that those charged with the responsibility of conducting evaluations are not being well determined. By departing from the recommendations of the Maltese Corporate Governance Code on performance evaluations, MLCs have generally opted to resort to an inward and more restricted style of evaluation, doing away with external or independent parties in the process.   Practical Implications: Recommendations include the promotion of shareholder interest by enhancing their awareness of the benefits they will stand to gain from the process and by involving them more in the process. Originality/Value: The paper considers possible evaluation measures that may be aimed to enhance both shareholder and public confidence in the exercise and also other ways by which it may be improved. It thus contributes to the literature, as yet scarce, which relates to corporate governance in small states.   Keywords: Performance evaluation, corporate governance, board of directors, MLCs.   JEL code: G34. Paper type: Research article.
  • 4.5K
  • 28 May 2020
Biography
Liu Bowen
Liu Ji (July 1, 1311 – May 16, 1375),[1][2] courtesy name Bowen, better known as Liu Bowen, was a Chinese military strategist, philosopher, politician, and poet who lived in the late Yuan and early Ming dynasties. He was born in Qingtian County (present-day Wencheng County, Wenzhou, Zhejiang). He served as a key advisor to Zhu Yuanzhang (the Hongwu Emperor), the founder of the Ming dynasty, in
  • 4.5K
  • 06 Dec 2022
Topic Review
Waveguide (Electromagnetism)
In electromagnetics and communications engineering, the term waveguide may refer to any linear structure that conveys electromagnetic waves between its endpoints. However, the original and most common meaning is a hollow metal pipe used to carry radio waves. This type of waveguide is used as a transmission line mostly at microwave frequencies, for such purposes as connecting microwave transmitters and receivers to their antennas, in equipment such as microwave ovens, radar sets, satellite communications, and microwave radio links. A dielectric waveguide employs a solid dielectric rod rather than a hollow pipe. An optical fibre is a dielectric guide designed to work at optical frequencies. Transmission lines such as microstrip, coplanar waveguide, stripline or coaxial cable may also be considered to be waveguides. The electromagnetic waves in a (metal-pipe) waveguide may be imagined as travelling down the guide in a zig-zag path, being repeatedly reflected between opposite walls of the guide. For the particular case of rectangular waveguide, it is possible to base an exact analysis on this view. Propagation in a dielectric waveguide may be viewed in the same way, with the waves confined to the dielectric by total internal reflection at its surface. Some structures, such as non-radiative dielectric waveguides and the Goubau line, use both metal walls and dielectric surfaces to confine the wave.
  • 4.5K
  • 07 Oct 2022
Topic Review
Land Use and Land Cover Mapping
The volume of collected or archived geospatial data for land use and land cover (LULC) mapping including remotely sensed satellite imagery and auxiliary geospatial datasets is increasing. Innovative machine learning, deep learning algorithms, and cutting-edge cloud computing have also been developed. While new opportunities are provided by these geospatial big data and advanced computer technologies for LULC mapping, challenges also emerge for LULC mapping from using these geospatial big data.
  • 4.5K
  • 17 Oct 2022
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