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Topic Review
Probiotics in Children with Asthma
A type-2 immune response usually sustains wheezing and asthma in children. In addition, dysbiosis of digestive and respiratory tracts is detectable in patients with wheezing and asthma. Probiotics may rebalance immune response, repair dysbiosis, and mitigate airway inflammation. As a result, probiotics may prevent asthma and wheezing relapse. There is evidence that some probiotic strains may improve asthma outcomes in children.
  • 1.1K
  • 09 Jul 2022
Topic Review
Membrane-Based Direct Air Capture Application
Direct air capture (DAC) is an emerging negative CO2 emission technology that aims to introduce a feasible method for CO2 capture from the atmosphere. Unlike carbon capture from point sources, which deals with flue gas at high CO2 concentrations, carbon capture directly from the atmosphere has proved difficult due to the low CO2 concentration in ambient air. Current DAC technologies mainly consider sorbent-based systems; however, membrane technology can be considered a promising DAC approach since it provides several advantages, e.g., lower energy and operational costs, less environmental footprint, and more potential for small-scale ubiquitous installations. Several recent advancements in validating the feasibility of highly permeable gas separation membrane fabrication and system design show that membrane-based direct air capture (m-DAC) could be a complementary approach to sorbent-based DAC, e.g., as part of a hybrid system design that incorporates other DAC technologies (e.g., solvent or sorbent-based DAC). 
  • 1.1K
  • 05 Feb 2024
Topic Review
Chitosan-Coated Gold Nanoparticles
Delivery of small interfering RNA (siRNA) provides one of the most powerful strategies for downregulation of therapeutic targets. Despite the widely explored capabilities of this strategy, intracellular delivery is hindered by a lack of carriers that have high stability, low toxicity and high transfection efficiency. Here we propose a layer by layer (LBL) self-assembly method to fabricate chitosan-coated gold nanoparticles (CS-AuNPs) as a more stable and efficient siRNA delivery system. 
  • 1.1K
  • 06 Apr 2021
Topic Review
Rejuvenate Aging Cells and Tissues
Rejuvenate aging cells and tissues is strategies to delay and potentially even reverse the aging process.
  • 1.1K
  • 26 May 2021
Topic Review
Eating Timing and Obesity/Metabolic Risk
Eating is fundamental to survival. Animals choose when to eat depending on food availability. The timing of eating can synchronize different organs and tissues that are related to food digestion, absorption, or metabolism, such as the stomach, gut, liver, pancreas, or adipose tissue. Studies performed in experimental animal models suggest that food intake is a major external synchronizer of peripheral clocks. 
  • 1.1K
  • 12 Aug 2021
Topic Review
Cytokinin and Auxin in DNSO
The role of CK and auxin signalization is central to the entire process of DNSO, whereby the early stages of DNSO are dominated by auxin and the later stages by CK signaling. Taking into account the early observation by Skoog and Miller that a high auxin/CK ratio stimulates the development of roots, while a high CK/auxin ratio is favorable to the development of shoot tissue, the general need for a sequence of two regeneration media can be explained by the differences in morphogenic requirements between early and late stages of DNSO. In the early stages, a high auxin/CK ratio is required not only for the development of calli but also of lateral root-like primordia within the calli; later, a high CK/auxin ratio will be required to convert the developmental fate of these primordia into taking on a shoot identity.
  • 1.1K
  • 18 Aug 2021
Topic Review
Influenza Virus Neuraminidase and Vaccine
The influenza virus neuraminidase (NA) is primarily involved in the release of progeny viruses from infected cells—a critical role for virus replication.
  • 1.1K
  • 25 Aug 2021
Topic Review
Reprocessable Photodeformable Azobenzene Polymers
Photodeformable azobenzene (azo) polymers are a class of smart polymers that can efficiently convert light energy into mechanical power, holding great promise in various photoactuating applications. They are typically of crosslinked polymer networks with highly oriented azo mesogens embedded inside. Upon exposure to the light of appropriate wavelength, they experience dramatic order parameter change following the configuration change of the azo units. This could result in the generation and accumulation of the gradient microscopic photomechanical force in the crosslinked polymer networks, thus leading to their macroscopic deformation. Most of the presently developed photodeformable azo polymers have stable chemically crosslinked networks, which make their reprocessing impossible, thus limiting their large scale applications. To solve this problem, reprocessable photodeformable azo polymers have been recently developed by introducing dynamic crosslinking networks (including physically crosslinked and dynamic covalent bond-crosslinked ones) into their structures. In addition, some uncrosslinked photodeformable azo polymers have also been reported and constitute one special type of reprocessable photodeformable azo polymers, whose photodeformation behaviors are mainly induced by the selective reorientation of the azo moieties (become perpendicular to the polarization direction of the polarized light) under the irradiation of either polarized blue light or interfering polarized light.
  • 1.1K
  • 30 Aug 2021
Topic Review
C1q as Biomarker in ME/CFS
This study revealed high levels of circulating complement factor C1q of the participants, placing C1q as a key molecule to identify an myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) subtype/subgroup with more apparent pain symptoms.
  • 1.1K
  • 26 Nov 2021
Topic Review
Vitamin B12 Deficiency in Adults
In this entry, we focused our attention on some case reports related to the vitamin B12 deficiency associated to anemia, neurologic disorders, and hyperhomocysteinemia. B12 deficiency reversal is simply achieved by prompt therapy, even though it is not the same for several disorders.
  • 1.1K
  • 08 Oct 2021
Topic Review
Potentiality of Nanoenzymes for Cancer Treatment
Nanozyme synthesis is an innovative technology since it connects nanoparticles with biological activities and framework. Various assays have been implemented for the enzymes of proteins that also implement nanozymes, which could also have the potential for performing the catalysis of similar substrates. Due to such different functions of nanozymes, they are used for the treatment of the environment, biosensing, agents that act against microbes, cytoprotection of different cell biomolecules with management, diagnosis of diseases, etc..
  • 1.1K
  • 22 Oct 2021
Topic Review
Ferulic Acid in Animal Models of Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disease with a high incidence in the elderly. Many preclinical studies show that a natural product, ferulic acid (FA), displays neuroprotective effects in AD models. 
  • 1.1K
  • 27 Oct 2021
Topic Review
Sustainable Employability Based on the swAge-Model
Sustainable employability commonly refers to the ability of employees to participate in work and the labour market during their lifetimes. The swAge-model, a tool that helps us understand how to make working life more sustainable and healthier for all ages, can be the basis of sustainable employability.
  • 1.1K
  • 29 Dec 2021
Topic Review
FAAH, MAGL, and DAGL in Obesity Treatment
The endocannabinoid system (ECS) plays an integral role in maintaining metabolic homeostasis and may affect hunger, caloric intake, and nutrient absorption. Obesity has been associated with higher levels of the endogenous cannabinoid transmitters (endocannabinoids). Therefore, the ECS is an important target in obesity treatment. Modulating the enzymes that synthesize and degrade endocannabinoids, namely fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL), and diacylglycerol lipase (DAGL), may be a promising strategy to treat obesity.
  • 1.1K
  • 18 Jan 2022
Topic Review
Comprehensive Framework for Active Health Governance
Health policies are regarded as a governance mechanism crucial for reducing health inequity and improving overall health outcomes. However, the current literature in health policy largely focused on some specific health policy changes and their tangible outcomes, or on specific inequality of health policies in gender, age, racial, or socio-economic status, short of comprehensively responding to and addressing the shift from disease-centered to active-health-oriented. A comprehensive framework is proposed to identify the main elements of a well-defined active health governance and the interactions between these elements. The proposed framework is composed of four elements and three approaches that are dynamically interacted to achieve two active health outcomes. 
  • 1.1K
  • 21 Feb 2022
Topic Review
Benefits of Insect Pollination in Brassicaceae
Cultivated Brassicaceae attract a wide variety of pollinators. In both self-compatible and self-incompatible crop species, meta-analysis indicates that seed yield (Y), silique set (SQS), number of siliquae/plant (NSQ), and the number of seeds/silique (NSSQ) increase when plants are insect-pollinated compared to when there is no insect pollination. The weight of seeds (WS), however, increased in self-incompatible species but not in self-compatible ones as a result of insect pollination. Overall, the percentage of studies showing a positive effect of insect pollination on yield parameters was higher in self-incompatible than in self-compatible species. It was shown that the ability of self-compatible species to reproduce does not fully compensate for the loss of yield benefits in the absence of insect pollination. 
  • 1.1K
  • 31 Mar 2022
Topic Review
COVID-19 and One-Carbon Metabolism
Dysregulation of one-carbon metabolism affects a wide range of biological processes and is associated with a number of diseases, including cardiovascular disease, dementia, neural tube defects, and cancer. Accumulating evidence suggests that one-carbon metabolism plays an important role in COVID-19. The symptoms of long COVID-19 are similar to those presented by subjects suffering from vitamin B12 deficiency (pernicious anemia). The metabolism of a cell infected by the SARS-CoV-2 virus is reshaped to fulfill the need for massive viral RNA synthesis, which requires de novo purine biosynthesis involving folate and one-carbon metabolism. Many aspects of host sulfur amino acid metabolism, particularly glutathione metabolism underlying antioxidant defenses, are also taken over by the SARS-CoV-2 virus. 
  • 1.1K
  • 18 Apr 2022
Topic Review
Anemia in Pregnant Women and Children
 Globally, anemia is still a public health issue faced by people in low and high-income countries. Anemia is a condition in which a person’s hemoglobin level is less than normal (below 11 g/dL for pregnant women and children aged 6–59 months). This study gives an overview of published scientific articles related to the prevalence, nutritional indicators, and social determinants of anemia in pregnant women and children aged 6 to 59 months living in Mozambique and Portugal. 
  • 1.1K
  • 20 Apr 2022
Topic Review
Flake Graphene-Based Nanomaterial in Non-Small Lung Cancer
Lung cancer is a highly aggressive neoplasm that is now a leading cause of cancer death worldwide. One of the major approaches for killing cancer cells is related with activation of apoptotic cell death with anti-cancer drugs. Regarding lung-cancer therapy, graphene was already considered as an attractive material for screening (biosensing) or direct anti-cancer treatment.
  • 1.1K
  • 24 May 2022
Topic Review
Biosimilars
Biosimilars are recombinant DNA products that join DNA from different species and subsequently insert the hybrid DNA into a host cell, often a bacterium or mammalian cell, to express the target protein; this molecular chimera was first created by researchers from UC San Francisco and Stanford in 1972. Stanley Cohen of Stanford and Herbert Boyer of UCSF received the US patent in 1980. Boyer co-founded Genentech, Inc. in 1976. The Cohen-Boyer patents will eventually have more than 500 licensees to biotechnology and pharmaceutical companies and earn Stanford and UCSF more than USD 250 million in royalties. These patents have now expired. Biosimilars include monoclonal antibodies, cytokines, growth factors, enzymes, immunomodulators, and thrombolytics, proteins extracted from animals or microorganisms, including recombinant versions of these products (except clotting factors), and other non-vaccine therapeutic immunotherapies. Billions of patients receiving biosimilars have shown therapeutic equivalence. None of these products have shown adverse events more than the reference product, including immunogenicity responses. It is estimated that the cumulative exposure to EU-approved biosimilars was more than two billion patient treatment days in 2020, with no adverse event reporting or withdrawal from the market due to safety reasons and no biosimilar-specific adverse effects have been added to the product information.
  • 1.1K
  • 02 Aug 2022
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