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Topic Review
Dielectrophoresis Studies on Protein Albumin
Research relating to dielectrophoresis (DEP) has been progressing rapidly through time as it is a strong and controllable technique for manipulation, separation, preconcentration, and partitioning of protein. Extensive studies have been carried out on protein DEP, especially on Bovine Serum Albumin (BSA).
  • 1.1K
  • 01 Sep 2022
Topic Review
Perhapsatron
The Perhapsatron was an early fusion power device based on the pinch concept in the 1950s. Conceived by James (Jim) Tuck while working at Los Alamos National Laboratory (LANL), he whimsically named the device on the chance that it might be able to create fusion reactions. The first example was built in the winter of 1952/53, and it quickly demonstrated a series of instabilities in the plasma that plagued the pinch concept. A series of modifications followed which attempted to correct these problems, leading to the ultimate "S-4" model. None of these proved fruitful.
  • 1.1K
  • 27 Sep 2022
Topic Review
Polish–Czechoslovak Confederation
The Polish-Czechoslovak confederation, or federation, was a political concept from the time of World War II, supported by the Polish government-in-exile and, to a lesser extent, the United Kingdom and the United States . It was a revitalisation of the Międzymorze concept, proposing the creation of a federation based on Poland and Czechoslovakia. The project had less support in the Czechoslovak government-in-exile, which believed it did not need Polish support against the Soviet Union, and was eventually sunk by the growing Soviet dominance, as Joseph Stalin did not want a strong and independent federation in Europe that could threaten his designs for Eastern Europe.
  • 1.1K
  • 14 Nov 2022
Topic Review
Self-Healing of Polymeric Materials
The self-healing of damages that occur during the operation of the corresponding structures makes it possible to extend the service life of the latter, and in this case, the problem of saving non-renewable resources is simultaneously solved. Two strategies are considered: (a) creating reversible crosslinks in the thermoplastic and (b) introducing a healing agent into cracks. Bond exchange reactions in network polymers (a) proceed as a dissociative process, in which crosslinks are split into their constituent reactive fragments with subsequent regeneration, or as an associative process, the limiting stage of which is the interaction of the reactive end group and the crosslink.
  • 1.1K
  • 15 Feb 2023
Topic Review
Nanotechnology for Blood–Brain Barrier Crossing
Nanomedicine is currently focused on the design and development of nanocarriers that enhance drug delivery to the brain to address unmet clinical needs for treating neuropsychiatric disorders and neurological diseases. Polymer and lipid-based drug carriers are advantageous for delivery to the central nervous system (CNS) due to their safety profiles, drug-loading capacity, and controlled-release properties. Polymer and lipid-based nanoparticles (NPs) are reported to penetrate the blood–brain barrier (BBB) and have been extensively assessed in in vitro and animal models of glioblastoma, epilepsy, and neurodegenerative disease. Since approval by the Food and Drug Administration (FDA) of intranasal esketamine for treatment of major depressive disorder, intranasal administration has emerged as an attractive route to bypass the BBB for drug delivery to the CNS. NPs can be specifically designed for intranasal administration by tailoring their size and coating with mucoadhesive agents or other moieties that promote transport across the nasal mucosa.
  • 1.1K
  • 28 Feb 2023
Topic Review
Local and Systemic Effects of Porphyromonas gingivalis Infection
Porphyromonas gingivalis, a gram-negative anaerobe, is a leading etiological agent in periodontitis. This infectious pathogen can induce a dysbiotic, proinflammatory state within the oral cavity by disrupting commensal interactions between the host and oral microbiota. It is advantageous for P. gingivalis to avoid complete host immunosuppression, as inflammation-induced tissue damage provides essential nutrients necessary for robust bacterial proliferation. When it gains access to circulation, P. gingivalis is able to infect a variety of cells, further triggering a variety of inflammatory and hemostatic responses. Among these is the activation of platelets and neutrophils. Neutrophil responses to P. gingivalis, particularly in the presence of activated platelets, include the release of strongly thrombogenic extracellular DNA traps (NETs). Consequently, this pathogen has the capacity not only to promote localized tissue destructiion of the gums but may also trigger some thromboinflammatory processes.
  • 1.1K
  • 24 Mar 2023
Topic Review
Biomacromolecules for Wound Dressings
Biomacromolecules are particularly promising for the fabrication of novel, more effective antimicrobial wound dressings.
  • 1.1K
  • 31 Mar 2023
Topic Review
Under-Expanded Jets in Advanced Propulsion Systems
The current ongoing rise in environmental pollution is leading research efforts toward the adoption of propulsion systems powered by gaseous fuels like hydrogen, methane, e-fuels, etc. Although gaseous fuels have been used in several types of propulsion systems, there are still many aspects that can be improved and require further study. For this reason, researchers considered it important to provide a review of the latest research topics, with a particular focus on the injection process. In advanced engine systems, fuel supply is achieved via enhanced direct injection into the combustion chamber. The latter involves the presence of under-expanded jets. Under-expanded jets are a particular kind of compressible flow.
  • 1.1K
  • 19 Oct 2023
Topic Review
Accurate Measurement of Urban Environments
In the field of urban environment analysis research, image segmentation technology that groups important objects in the urban landscape image in pixel units has been the subject of increased attention.
  • 1.1K
  • 10 Nov 2023
Topic Review
Pathophysiology and Treatment of Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary condition characterized by the sudden onset of respiratory failure, pulmonary edema, dysfunction of endothelial and epithelial barriers, and the activation of inflammatory cascades. Despite the increasing number of deaths attributed to ARDS, a comprehensive therapeutic approach for managing patients with ARDS remains elusive. To elucidate the pathological mechanisms underlying ARDS, numerous studies have employed various preclinical models, often utilizing lipopolysaccharide as the ARDS inducer. Accumulating evidence emphasizes the pivotal role of reactive oxygen species (ROS) in the pathophysiology of ARDS. Both preclinical and clinical investigations have asserted the potential of antioxidants in ameliorating ARDS. 
  • 1.1K
  • 13 Dec 2023
Topic Review
Nutritional Factors Associated with Dental Caries
Nutrition and dietetic care span various life stages, addressing nutritional needs and exploring factors that shape dietary habits. Globally, an alarming disproportion in food resource distribution, coupled with substandard nutritional intake, underscores profound implications for oral health. 
  • 1.1K
  • 18 Dec 2023
Topic Review
Objectivizing Measures of Post-Stroke Hand Rehabilitation through Multi-Disciplinary Scales
There is a wide variety of tools and measures for rehabilitation outcomes in post-stroke patients with impairments in the upper limb and hand, such as paralysis, paresis, flaccidity, and spasticity. However, there is a lack of general recommendations for selecting the most appropriate scales, tests, and instruments to objectively evaluate therapy outcomes. Reviews on upper limb and hand measurements reveal that clinicians’ choices of tools and methods are highly varied. Some clinicians and medical teams continue to employ non-standard and unverified metrics in their research and measurements.
  • 1.1K
  • 09 Jan 2024
Topic Review
AI Applications in Drug Discovery
The drug discovery and development process is very lengthy, highly expensive, and extremely complex in nature. Considering the time and cost constraints associated with conventional drug discovery, new methods must be found to enhance the declining efficiency of traditional approaches. Artificial intelligence (AI) has emerged as a powerful tool that harnesses anthropomorphic knowledge and provides expedited solutions to complex challenges. Advancements in AI and machine learning (ML) techniques have revolutionized their applications to drug discovery and development. 
  • 1.1K
  • 23 Feb 2024
Topic Review
Green Closed-Loop Supply Chain Response to Carbon Policies
As greenhouse gas (GHG) emissions continue to increase, governments throughout the world are under increasing pressure to enact legislation restricting emissions and implement environmental measures, such as the Kyoto Protocol and the European Union Emission Trading System.
  • 1.1K
  • 26 Mar 2024
Topic Review
Deep Learning Methods for Solving the NLI Problem
Natural language inference (NLI) is one of the most important natural language understanding (NLU) tasks. NLI expresses the ability to infer information during spoken or written communication. The NLI task concerns the determination of the entailment relation of a pair of sentences, called the premise and hypothesis. If the premise entails the hypothesis, the pair is labeled as an “entailment”. If the hypothesis contradicts the premise, the pair is labeled a “contradiction”, and if there is not enough information to infer a relationship, the pair is labeled as “neutral”.
  • 1.1K
  • 26 Apr 2024
Topic Review
The Potential of DHA as Cancer Therapy Strategies
Docosahexaenoic acid (DHA), also known as omega-3 (n-3) polyunsaturated fatty acid (PUFA), is a natural compound that has demonstrated pharmacological activity against several malignant neoplasms. Available cancer treatments cause side effects, affect healthy cells, reduce the quality of life of patients and may cause resistance to antineoplastics. For these reasons, the search for new therapies is continuous.
  • 1.1K
  • 05 May 2023
Topic Review
PPE in Designing Public Parks
Public participation exercise (PPE) is defined as citizen participation and implies the involvement of citizens in a wide range of policymaking activities. These include the determination of levels of service, budget priorities, and the acceptability of physical construction projects in order to orient government programmes toward community needs, build public support, and encourage a sense of cohesiveness within neighbourhoods.
  • 1.1K
  • 11 Nov 2021
Topic Review
Chinese Cordyceps in the Antitumor Mechanisms
Chinese Cordyceps is a valuable source of natural products with various therapeutic effects. It is rich in various active components, of which adenosine, cordycepin and polysaccharides have been confirmed with significant immunomodulatory and antitumor functions.
  • 1.1K
  • 30 Nov 2022
Topic Review
Immune Cell Trafficking across the Different CNS Barriers
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) known for the manifestation of demyelinated lesions throughout the CNS, leading to neurodegeneration. To date, not all pathological mechanisms that drive disease progression are known, but the clinical benefits of anti-CD20 therapies have put B cells in the spotlight of MS research.
  • 1.1K
  • 24 Jun 2022
Topic Review
Impact of AI on the Future of Work
Artificial Intelligence (AI) is transforming the way we work, creating new opportunities for efficiency, innovation, and growth. However, it also poses several challenges, including job displacement, skills gaps, and ethical concerns. This research explores the potential impact of AI on the future of work and discusses strategies for addressing these challenges. By embracing AI technology and investing in the development of new skills, we can create a future of work that is more productive, equitable, and sustainable.
  • 1.1K
  • 22 May 2023
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