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Topic Review
Inhibitor-Enzyme Complexes for New Anti-TB Agents
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is the most devastating human pathogen, as confirmed by the latest TB Report published in October.
  • 552
  • 23 Jan 2022
Topic Review
Phaseolus multiflorus var. albus
Phaseolus multiflorus var. albus (Leguminosae), commonly known as “white kidney bean”, is a twining perennial vine whose fruit has been used as a popular food worldwide owing to its high nutritional content, in terms of proteins, carbohydrates, fats, and vitamins.
  • 547
  • 22 Oct 2021
Topic Review
Proteasome Structure and Function in Multiple Myeloma
Multiple myeloma (MM) is an aggressive and incurable disease for most patients, characterized by periods of treatment, remission and relapse. The introduction of new classes of drugs, such as proteasome inhibitors (PIs), has improved survival outcomes in these patient populations. The proteasome is the core of the ubiquitin–proteasome system (UPS), a complex and conserved pathway involved in the control of multiple cellular processes, including cell cycle control, transcription, DNA damage repair, protein quality control and antigen presentation. 
  • 546
  • 23 Feb 2023
Topic Review
PDE4 Inhibitors
Cyclic nucleotide phosphodiesterases 4 (PDE4) are a family of enzymes which specifically promote the hydrolysis and degradation of cAMP. The inhibition of PDE4 enzymes has been widely investigated as a possible alternative strategy for the treatment of a variety of respiratory diseases, including chronic obstructive pulmonary disease and asthma, as well as psoriasis and other autoimmune disorders.
  • 545
  • 21 Jul 2023
Topic Review
Thiocoumarins
Thiocoumarins are a particular class of coumarins in which one or two of the oxygen atoms are replaced by a sulfur. They are chemically subdivided in three groups: Thiocoumarins, 2-thioxocoumarins, and dithiocoumarins.
  • 544
  • 15 Aug 2022
Topic Review
Antimicrobial Nanomaterials Based on Halloysite Clay Mineral
Bacterial infections represent one of the major causes of mortality worldwide. Over the years, several nanomaterials with antibacterial properties have been developed. In this context, clay minerals, because of their intrinsic properties, have been efficiently used as antimicrobial agents since ancient times. Halloysite nanotubes are one of the emerging nanomaterials that have found application as antimicrobial agents in several fields. 
  • 538
  • 08 Jan 2023
Topic Review
The Role of Small Molecules Containing Fluorine Atoms
The fluorine atom possesses many intrinsic properties that can be beneficial when incorporated into small molecules. These properties include the atom’s size, electronegativity, and ability to block metabolic oxidation sites. Substituents that feature fluorine and fluorine-containing groups are currently prevalent in drugs that lower cholesterol, relieve asthma, and treat anxiety disorders, as well as improve the chemical properties of various medications and imaging agents. 
  • 538
  • 27 Feb 2024
Topic Review
Supramolecular Self-Assembly of Antibiotics
Antibiotic resistance has posed a great threat to human health. The emergence of antibiotic resistance has always outpaced the development of new antibiotics, and the investment in the development of new antibiotics is diminishing. Supramolecular self-assembly of the conventional antibacterial agents has been proved to be a promising and versatile strategy to tackle the serious problem of antibiotic resistance.
  • 525
  • 14 Jul 2022
Topic Review
Caspase-1 Inhibition
The inflammatory protease caspase-1 is associated with the release of cytokines. An excessive number of cytokines (a “cytokine storm”) is a dangerous consequence of COVID-19 infection and has been indicated as being among the causes of death by COVID-19. The anti-inflammatory drug colchicine (which is reported in the literature to be a caspase-1 inhibitor) and the corticosteroid drugs, dexamethasone and methylprednisolone, are among the most effective active compounds for COVID-19 treatment.
  • 520
  • 18 Feb 2022
Topic Review
Deep Eutectic Systems as Alternative Solvents
Chemists in the medicinal chemistry field are constantly searching for alternatives towards more sustainable and eco-friendly processes for the design and synthesis of drug candidates. The pharmaceutical industry is one of the most polluting industries, having a high E-factor, which is driving the adoption of more sustainable processes not only for new drug candidates, but also in the production of well-established active pharmaceutical ingredients. Deep eutectic systems (DESs) have emerged as a greener alternative to ionic liquids, and their potential to substitute traditional organic solvents in drug discovery has raised interest among scientists. 
  • 520
  • 28 Feb 2024
Topic Review
RA and Effects of Curcumin
Rheumatoid arthritis (RA) is a widespread, chronic, autoimmune disorder affecting the joints, causing irreversible cartilage, synovium, and bone degradation. During the course of the disease, many immune and joint cells are activated, causing persistent inflammation. Immune cells including macrophages, lymphocytes, neutrophils, mast cells, natural killer cells, innate lymphoid cells, as well as synovial tissue cells, like fibroblast-like synoviocytes, chondrocytes, and osteoclasts secrete different pro-inflammatory factors, counting many cytokines, angiogenesis-stimulating molecules and others, exacerbating the ongoing condition. Curcumin is a natural polyphenol extracted from turmeric (Curcuma longa), with prominent anti-inflammatory and immunomodulatory effects. Various in vitro and in vivo studies have shown that curcumin can suppress the expression of inflammatory mediators and modulate immune cells, alleviating the course of RA, making it a promising, potential drug. 
  • 517
  • 13 Apr 2021
Topic Review
New Marine Xanthones Isolated since 2010
Xanthones are considered polyketide derivatives due to their biosynthetic precursor. They are aromatic oxygenated heterocyclic compounds with a dibenzo-γ-pyrone scaffold, known as 9H-xanthen-9-one.
  • 517
  • 27 Jun 2022
Topic Review
Phlorotannins’ Constituents in Fucales
Fucales are an order within the Phaeophyceae that include most of the common littoral seaweeds in temperate and subtropical coastal regions. Many species of this order have long been a part of human culture with applications as food, feedand remedies in folk medicine. Apart from their high nutritional value, these seaweeds are also a well-known reservoir of multiple bioactive compounds with great industrial interest. Among them, phlorotannins, a unique and diverse class of brown algae-exclusive phenolics, have gathered much attention during the last few years due to their numerous potential health benefits. However, due to their complex structural features, combined with the scarcity of standards, it poses a great challenge to the identification and characterization of these compounds, at least with the technology currently available. Nevertheless, much effort has been taken towards the elucidation of the structural features of phlorotannins, which have resulted in relevant insights into the chemistry of these compounds.
  • 512
  • 05 Jan 2023
Topic Review
Fundamentals of Rhenium-188 Radiopharmaceutical Chemistry
The β− emitter, rhenium-188 (188Re), has long been recognized as an attractive candidate for targeted cancer radionuclide therapy (TRNT). This transition metal shares chemical similarities with its congener element technetium, whose nuclear isomer technetium-99m (99mTc) is the current workhorse of diagnostic nuclear medicine. This pair of elements forms a characteristic matched pair for chemical and medical research and applications.
  • 511
  • 21 Apr 2023
Topic Review
Role of Anticancer Drug Glycoconjugates
Sugars, which are a structural element during both the synthesis of the aforementioned glycoconjugates and the preparation of polysaccharide or glycopolymer carriers of anticancer drugs, are widely distributed in nature and also constitute one of the main classes of natural compounds found in living organisms, where they perform important functions in many physiological and pathological processes. 
  • 494
  • 20 Mar 2023
Topic Review
Essential Oils as Potential Anti-Influenza Agents
Essential oils (EOs) are chemical substances, mostly produced by aromatic plants in response to stress, that have a history of medicinal use for many diseases. In the past, EOs have continued to gain more attention because of their proven therapeutic applications against the flu and other infectious diseases. Influenza (flu) is an infectious zoonotic disease that affects the lungs and their associated organs. It is a public health problem with a huge health burden, causing a seasonal outbreak every year. Occasionally, it comes as a disease pandemic with unprecedentedly high hospitalization and mortality. Influenza is managed by vaccination and antiviral drugs such as Amantadine, Rimantadine, Oseltamivir, Peramivir, Zanamivir, and Baloxavir. However, the adverse side effects of these drugs, the rapid and unlimited variabilities of influenza viruses, and the emerging resistance of new virus strains to the currently used vaccines and drugs have necessitated the need to obtain more effective anti-influenza agents.
  • 492
  • 16 Jan 2023
Topic Review
Food-Based Carbon Dots for Biomedical Applications
Thermal treatment is one of the common methods used in food processing to reduce microbial activity and control the presence of foodborne pathogens. During thermal processing, carbonization reactions are often observed in foods, which could result in the formation of carbon dots (CDs). Typical CDs are regarded as organic carbonization products with sizes less than 20 nm, exhibiting excitation-dependent fluorescence properties. They possess sp2/sp3 carbon skeletons and feature an abundance of functional groups and polymer chains within their structures. The surface of CDs is rich in hydrophilic compounds, including carboxyl, hydroxyl, and amine groups, contributing to their excellent water dispersibility.
  • 490
  • 26 Dec 2023
Topic Review
Pyrrolotriazinone
Pyrrolotriazinones, a class of azolotriazinone, are indeed a fused bicyclic compound. Pyrrolotriazinones share common properties with all nitrogen-containing heterocycles.
  • 489
  • 17 Dec 2021
Topic Review
Dietary Supplements for Weight Loss Control
The market offers supplements containing food plant-derived molecules (e.g., primary and secondary metabolites, vitamins, and fibers), microbes (probiotics), and microbial-derived fractions (postbiotics). They can control lipid and carbohydrate metabolism, reduce appetite (interacting with the central nervous system) and adipogenesis, influence intestinal microbiota activity, and increase energy expenditure. Unfortunately, the copious choice of products and different legislation on food supplements worldwide can confuse consumers.
  • 485
  • 25 Jul 2023
Topic Review
Copper-Coordinated Thiazoles and Benzothiazoles as Antimicrobial Agents
Thiazole and benzothiazole are present in different structures with interesting biological effects and are used to develop new effective antimicrobial agents. Moreover, nitrogen atoms that are present in this heterocycle allow for coordination with various metals, forming metal complexes that enhance the biological activity of organic ligands that are often used as commercial drugs.
  • 481
  • 09 May 2023
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