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Topic Review
COVID-19-Related Acute Respiratory Distress Syndrome
Lower respiratory tract invasion by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) results in widespread damage of type II alveolar and pulmonary capillary endothelial cells, disruption of the alveolar-capillary barrier, activation of coagulation, and diffuse thrombogenesis amplified by recruited monocytes and neutrophils and concurrent hypofibrinolysis. These pathobiological mechanisms are associated with a distinct form of acute respiratory distress syndrome (ARDS), characterized by relatively high lung compliance, progressively worsening hypoxemia, low potential for lung recruitment, hyperperfusion of nonaerated lung tissue, and diffuse small-vessel thrombosis.
  • 1.1K
  • 14 Oct 2022
Topic Review
PHYLIP
PHYLogeny Inference Package (PHYLIP) is a free computational phylogenetics package of programs for inferring evolutionary trees (phylogenies). It consists of 35 portable programs, i.e., the source code is written in the programming language C. As of version 3.696, it is licensed as open-source software; versions 3.695 and older were proprietary software freeware. Releases occur as source code, and as precompiled executables for many operating systems including Windows (95, 98, ME, NT, 2000, XP, Vista), Mac OS 8, Mac OS 9, OS X, Linux (Debian, Red Hat); and FreeBSD from FreeBSD.org. Full documentation is written for all the programs in the package and is included therein. The programs in the phylip package were written by Professor Joseph Felsenstein, of the Department of Genome Sciences and the Department of Biology, University of Washington, Seattle. Methods (implemented by each program) that are available in the package include parsimony, distance matrix, and likelihood methods, including bootstrapping and consensus trees. Data types that can be handled include molecular sequences, gene frequencies, restriction sites and fragments, distance matrices, and discrete characters. Each program is controlled through a menu, which asks users which options they want to set, and allows them to start the computation. The data is read into the program from a text file, which the user can prepare using any word processor or text editor (but this text file cannot be in the special format of the word processor, it must instead be in flat ASCII or text only format). Some sequence analysis programs such as the ClustalW alignment program can write data files in the PHYLIP format. Most of the programs look for the data in a file called infile . If the phylip programs do not find this file, they then ask the user to type in the file name of the data file.
  • 1.1K
  • 27 Oct 2022
Topic Review
Ethanol versus Adenosine on Emotional and Cognitive Disturbances
Binge drinking intake is the most common pattern of ethanol consumption by adolescents, which elicits emotional disturbances, mainly anxiety and depressive symptoms, as well as cognitive alterations. Ethanol exposure may act on the adenosine neuromodulation system by increasing adenosine levels, consequently increasing the activation of adenosine receptors in the brain. The adenosine modulation system is involved in the control of mood and memory behavior.
  • 1.1K
  • 14 Nov 2022
Topic Review
BFR Tanker
The Big Falcon Rocket (officially shortened to BFR) is a privately funded fully reusable launch vehicle and spacecraft system in development by SpaceX. The overall space vehicle architecture includes both launch vehicles and spacecraft, as well as ground infrastructure for rapid launch and relaunch, and zero-gravity propellant transfer technology to be deployed in low Earth orbit (LEO). The payload capacity to Earth orbit of at least 100,000 kg (220,000 lb) makes BFR a super heavy-lift launch vehicle. The first orbital flight is tentatively planned for 2020. SpaceX has been developing a super heavy-lift launch vehicle for many years, with the exact design and nomenclature of the vehicle undergoing multiple revisions over time. Before 2016, the vehicle was referred to as the Mars Colonial Transporter (MCT), though very few details about the design of the MCT were ever made public. Starting from 2016, SpaceX began sharing annual updates with the public, detailing the designs and uses of their upcoming new launch vehicle. In 2016, SpaceX CEO Elon Musk presented the vehicle at the International Astronautical Congress as the ITS launch vehicle, forming a core part of Musk's comprehensive vision for an Interplanetary Transport System (ITS). The ITS vehicle had a 12-meter (39 ft) core diameter, but was only intended for interplanetary travel. In September 2017, the design (now known as the BFR) was scaled down to 9 meters (30 ft) While the ITS had been solely aimed at Mars transit and other interplanetary uses, SpaceX pivoted to a plan that would support all SpaceX launch service provider capabilities with a single set of 9-meter vehicles: Earth orbit, lunar orbit, Interplanetary spaceflight, and potentially, even intercontinental passenger transport on Earth. In September 2018, a redesign of the second stage was announced, adding steerable canards, two radially adjustable fins also acting as landing legs, and a third leg that looks like a vertical stabilizer but has no aerodynamic function due to the special re-entry profile of the spacecraft. The launch vehicle design is dependent on the concurrent development work on the Raptor rocket engines, which are cryogenic methalox-fueled engines to be used for both stages of the BFR launch vehicle. Development on the Raptor began in 2012, leading to engine testing which began in 2016. The BFR system is intended to completely replace all of SpaceX's existing space hardware (the Falcon 9 and Falcon Heavy launch vehicles, and the Dragon spacecraft), initially aiming at the Earth-orbit launch market, but explicitly adding substantial capability to support long-duration spaceflight in the cislunar and Mars transport flight environments.
  • 1.1K
  • 23 Nov 2022
Topic Review
Valuable Biochemicals from Red Microalgae
Red microalgae represent a natural reservoir of beneficial substances with applications in different industrial sectors. They are rich in natural biomolecules known for their antihypertensive, antioxidant, antimicrobial, antiviral, anti-inflammatory, antitumor, and anticoagulant activities. Many red microalgae are a source of vitamins, minerals, photochemicals, polyunsaturated fatty acids, and a wide spectrum of polysaccharides. The content of their valuable compounds and their activities have turned red microalgae into cellular factories of special interest in food, nutraceutical, and pharmaceutical industries. 
  • 1.1K
  • 09 Dec 2022
Topic Review
Human Papillomavirus Status and the Cervicovaginal Microbiome
 Uterine cervical cancer (CC) is a complex, multistep disease primarily linked to persistent infection with high-risk human papillomavirus (HR-HPV). However, it is widely acknowledged that HR-HPV infection alone cannot account for the formation and progression of CC. Emerging evidence suggests that the cervicovaginal microbiome (CVM) also plays a significant role in HPVrelated CC. Certain bacteria, such as Fusobacterium spp., Porphyromonas, Prevotella, and Campylobacter, are currently being considered as potential microbiomarkers for HPV-positive CC. However, the composition of the CVM in CC is inconsistent; thus, further studies are needed. This review comprehensively discusses the complex interplay between HPV and the CVM in cervical carcinogenesis. It is postulated that the dynamic interaction between HPV and the CVM creates an imbalanced cervicovaginal microenvironment that triggers dysbiosis, enhances HPV persistence, and promotes cervical carcinogenesis. Moreover, this review aims to provide updated evidence on the potential role of bacteriotherapy, particularly probiotics, in the treatment of CC
  • 1.1K
  • 18 Jun 2023
Topic Review
Low-Temperature Lithium–Sulfur Batteries
The lithium–sulfur (Li-S) battery is considered to be one of the attractive candidates for breaking the limit of specific energy of lithium-ion batteries and has the potential to conquer the related energy storage market due to its advantages of low-cost, high-energy density, high theoretical specific energy, and environmental friendliness issues.
  • 1.1K
  • 20 Jun 2023
Topic Review
Promoting Mental Health at Schools Program
Promoting Mental Health at Schools (PROMEHS) is a European, school-based, universal mental health program explicitly focused on both promoting students’ mental health and preventing negative conduct by adopting a whole-school approach.
  • 1.1K
  • 26 Jun 2023
Topic Review
Recent Trends in Fermented Beverages Processing: Emerging Technologies
Since ancient times, fermentation has been one of the most utilized techniques for food preservation and for the development of natural products with functional properties at low cost. Nowadays, fermented foods and beverages are highly attractive to consumers since they are perceived as natural and potential sources of functional compounds. Research efforts conducted in this area over the years have allowed for an understanding of the main reactions occurring during fermentation related to microbial growth, enzyme activity, metabolite production, and physicochemical changes. As a result, scientists and technologists have been able to improve the fermentation process in terms of efficiency, safety, costs, and high-quality production of products.
  • 1.1K
  • 28 Jun 2023
Topic Review
Plant-Derived Smoke and Karrikin 1  Activity in Seed
Plant-derived smoke and smoke water (SW) can stimulate seed germination in numerous plants from fire-prone and fire-free areas, including cultivated plants and agricultural weeds. Smoke contains thousands of compounds; only several stimulants and inhibitors have been isolated from smoke. Among the six karrikins present in smoke, karrikin 1 (KAR1) seems to be key for the stimulating effect of smoke. The discovery and activity of highly diluted SW and KAR1 at extremely low concentrations (even at ca. 10−9 M) inducing seed germination of a wide array of horticultural and agricultural plants have created tremendous opportunities for the use of these factors in pre-sowing seed treatment through smoke- or KAR1-priming.
  • 1.1K
  • 05 Jul 2023
Topic Review
TRP Channels on the Progression of Liver Diseases
The liver serves as a vital organ with a primary metabolic function. In addition, it possesses the ability to synthesize and decompose proteins, regulate overall blood volume, eliminate toxins, and regulate immunity, all of which are crucial for maintaining normal physiological activities in the human body. 
  • 1.1K
  • 25 Aug 2023
Topic Review
Building Retrofitting Measures in Korean
Green buildings and architecture are necessary for sustainable building development. Buildings are responsible for global high-energy consumption and carbon emissions. Retrofitting measures mitigate the effect of climate change on buildings by improving their energy performance at beneficial cost-effectiveness. The most critical aspect of retrofitting is structural refurbishment, which aids in added strength, stability, and safety.
  • 1.1K
  • 08 Sep 2023
Topic Review
Continuous Spike–Waves during Slow Sleep
In the context of childhood epilepsy, the concept of continuous spike–waves during slow sleep (CSWS) includes several childhood-onset heterogeneous conditions that share electroencephalograms (EEGs) characterized by a high frequency of paroxysmal abnormalities during sleep, which have negative effects on the cognitive development and behavior of the child. These negative effects may have the characteristics of a clear regression or of a slowdown in development. Seizures are very often present, but not constantly. The above makes it clear why CSWS have been included in epileptic encephalopathies, in which, by definition, frequent EEG paroxysmal abnormalities have an unfavorable impact on cognitive functions, including socio-communicative skills, causing autistic features, even regardless of the presence of clinically overt seizures.
  • 1.1K
  • 05 Feb 2024
Topic Review
Mayer-Rokitansky-Küster-Hauser Syndrome
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a disorder that occurs in females and mainly affects the reproductive system.
  • 1.1K
  • 23 Dec 2020
Topic Review
BCOR Gene
BCL6 corepressor
  • 1.1K
  • 24 Dec 2020
Topic Review
Carpenter Syndrome
Carpenter syndrome is a condition characterized by the premature fusion of certain skull bones (craniosynostosis), abnormalities of the fingers and toes, and other developmental problems.
  • 1.1K
  • 24 Dec 2020
Topic Review
Role of TRPA1 and TRPV1
TRPA1 and TRPV1 are structurally related thermosensitive cation channels and are often co-expressed in sensory nerve endings. TRPA1 and TRPV1 can also indirectly influence some, but not all, primary taste qualities via the release of substance P and calcitonin gene-related peptide (CGRP) from trigeminal neurons and their subsequent effects on CGRP receptor expressed in Type III taste receptor cells. Here, we will review the effect of some chemesthetic agonists of TRPA1 and TRPV1 and their influence on bitter, sour, and salt taste qualities.
  • 1.1K
  • 13 Apr 2021
Topic Review
SARS-CoV-2 Variants
The emergence of SARS-CoV-2 variants have significantly impact the course of COVID-19 pandemic worldwide. They have in common a higher transmissibility, becoming dominant within populations in a short time, and an accumulation of a high number of mutations in the spike (S) protein, especially within the amino terminal domain (NTD) and the receptor binding domain (RBD) which could affect the efficacy of the current licenced vaccines. 
  • 1.1K
  • 24 May 2021
Topic Review
Tannery Wastewater
Las aguas residuales de las curtidurías son producto de un proceso de transformación de materia orgánica a materia no degradable, que requiere la adición de compuestos y aditivos que permitan dicha transformación, generando a su vez residuos altamente contaminantes no solo para la salud humana, sino también para el medio ambiente.
  • 1.1K
  • 01 Jun 2021
Topic Review
CD5/CD6 variation in autoimmunity/cancer
Pathogens are one of the main selective pressures that ancestral humans had to adapt to. Components of the immune response system have been preferential targets of natural selection in response to such pathogen-driven pressure. In turn, there is compelling evidence showing that positively selected immune gene variants conferring increased resistance to past or present infectious agents are today associated with increased risk for autoimmune or inflammatory disorders but decreased risk of cancer, the other side of the same coin. CD5 and CD6 are lymphocytic scavenger receptors at the interphase of the innate and adaptive immune responses since they are involved in both: (i) microbial-associated pattern recognition; and (ii) modulation of intracellular signals mediated by the clonotypic antigen-specific receptor present in T and B cells (TCR and BCR, respectively).
  • 1.1K
  • 02 Jun 2021
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