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Topic Review
Formulation of Nanocarrier-based Viral Vaccines
Vaccination, employing peptides, nucleic acids, and other molecules, or using pathogen-based strategies, in fact, is one of the most potent approaches in the management of viral diseases. However, the vaccine candidate requires protection from degradation and precise delivery to the target cells. This can be achieved by employing different types of drug and vaccine delivery strategies, among which, nanotechnology-based systems seem to be more promising. 
  • 1.2K
  • 25 May 2021
Topic Review
Proteins from Industrial Biowastes
A great amount of biowastes, comprising byproducts and biomass wastes, is originated yearly from the agri-food industry. These biowastes are commonly rich in proteins and polysaccharides and mainly discarded or used for animal feeding. 
  • 1.2K
  • 20 May 2021
Topic Review
BTK Targeting in Multiple Myeloma
Multiple myeloma (MM), a clonal plasma cell disorder, disrupts the bones’ hematopoiesis and microenvironment homeostasis and ability to mediate an immune response against malignant clones. Despite prominent survival improvement with newer treatment modalities since the 2000s, MM is still considered a non-curable disease. Patients experience disease recurrence episodes with clonal evolution, and with each relapse disease comes back with a more aggressive phenotype. Bruton’s Tyrosine Kinase (BTK) has been a major target for B cell clonal disorders and its role in clonal plasma cell disorders is under active investigation. BTK is a cytosolic kinase which plays a major role in the immune system and its related malignancies. The BTK pathway has been shown to provide survival for malignant clone and multiple myeloma stem cells (MMSCs). BTK also regulates the malignant clones’ interaction with the bone marrow microenvironment. Hence, BTK inhibition is a promising therapeutic strategy for MM patients
  • 1.2K
  • 08 Jun 2021
Topic Review
All-Dielectric Metasurface for Sensing Microcystin-LR
Microcystin is a kind of biotoxin widely found in freshwater bodies across the world. It is one of the indicators of water eutrophication which makes water consumption harmful to human beings. Microcystin can inhibit the production of protein phosphatase in cells and exposure to microcystin can severely damage organs, including liver, intestines, lungs, and kidneys. There are many variants of microcystin, such as MC-LR, MC-RR, and MC-YR (L, R, and Y stand for leucine, arginine, and tyrosine, respectively). Among them, MC-LR is the most common and the most toxic variant. 
  • 1.2K
  • 21 Jun 2021
Topic Review
Green Revolution Gene SD1
The green revolution gene sd1 in rice has been used for decades, but was not identified for a long time. The SD1 gene encodes the rice Gibberellin 20 oxidase-2 (GA20ox2). As such, the SD1 gene is instrumental in uncovering the molecular mechanisms underlying gibberellin biosynthesis There are ten different alleles of SD1.
  • 1.2K
  • 23 Sep 2021
Topic Review
3C Protease as Ferroptosis Inducer
Regulated cell death (RCD) is a fundamental process common to nearly all living beings and essential for the development and tissue homeostasis in animals and humans. A wide range of molecules can induce RCD including a number of viral proteolytic enzymes. To date, numerous data indicate that picornaviral 3C proteases can induce RCD. In most reported cases, these proteases induce classical caspase-dependent apoptosis. In contrast, the human hepatitis A virus 3C protease (3Cpro) has recently been shown to cause caspase-independent cell death accompanied by previously undescribed features. In the current topic the results of the study where 3Cpro-induced cell death was characterized morphologically and biochemically are presented. It was found that dead cells demonstrated necrosis-like morphological changes including permeabilization of plasma membrane, loss of mitochondrial potential, as well as mitochondria and nuclei swelling. Additionally, it was shown that 3Cpro-induced cell death was efficiently blocked by ferroptosis inhibitors and was accompanied by intense lipid peroxidation. Taken together, these results indicate that 3Cpro induces ferroptosis upon its individual expression in human cells. This is the first demonstration that a proteolytic enzyme can induce ferroptosis, the recently discovered and actively studied type of RCD.
  • 1.2K
  • 22 Sep 2021
Topic Review
Mosquito Oviposition Sites
A summary of repellent/deterrent microorganisms involved in mosquito oviposition site selection is detailed in.
  • 1.2K
  • 06 Aug 2021
Topic Review
CRISPR-Powered Microfluidics Applications
Clustered regularly interspaced short palindromic repeats (CRISPR) technology is a simple yet powerful tool for highly specific and rapid modification of DNA in a genome, which is the complete set of genetic instructions in an organism. One of the requirements for successful modification of the eukaryotic genome using the CRISPR/Cas9 system is the presence of the guide RNA (sgRNA or crRNA/duplex crRNA/tracrRNA) Cas9 protein complex and the introduction of mRNA or DNA. In therapeutic approaches, the genome of specific cells can be re-transplanted into the patient in vitro and then the host genome modified to treat any possible deficiency in genes. Nowadays, the use of microfluidic channels and chips is one of the best approaches to deliver materials and cells as it prevents many problems by accurately editing the cell and creating an opportunity for successful editing and screening of their genome. Such chips provide a suitable substrate for cell manipulation, drug screening, and exosome characterization. Furthermore, they are useful for pathogen and cancer detection because of their high throughput, low cost, flexibility, and controlled fluid or gas flow.
  • 1.2K
  • 10 Jan 2022
Topic Review
Subacute Thyroiditis and the COVID-19
Subacute thyroiditis (SAT), also known as De Quervain or granulomatous thyroiditis, is caused by a viral infection, especially (but not exclusively) of the upper respiratory tract or by post-viral inflammation. Since 2020, the entity has been listed in association with the coronavirus disease 2019 (COVID-19) infection, and since 2021 it has been related to the vaccine against the virus.
  • 1.2K
  • 02 Jun 2022
Topic Review
Assisted Reproductive Technology
The term assisted reproduction technology (ART) was introduced in the 1970s. It covers all methods that are used to assist in a successful pregnancy, where ART techniques are used to replace the biological functions connected with procreation. The Polish Society of Reproductive Medicine and Embryology (PTMRiE) and the Polish Society of Gynecologists and Obstetrics (PTGiP) recommend further optimization of ART techniques.
  • 1.2K
  • 06 May 2022
Topic Review
Yoga and Qigong for Health
Yoga and qigong are ancient mind–body practices used in the East for thousands of years to promote inner peace and mental clarity. Both share breathing techniques and slow movements and are being used as alternative/complementary approaches to the management of disease, especially chronic problems with no effective conventional treatments.
  • 1.2K
  • 08 Jul 2022
Topic Review
Effects of L-Citrulline on Physical Performance
Consumption of amino acids L-arginine (L-Arg) and L-citrulline (L-Cit) are purported to increase nitric oxide (NO) production and improve physical performance. Supplementing with L-Cit is more effective in increasing plasma L-Arg concentration than supplementing with L-Arg Clinical trials have shown relatively more favorable outcomes than not after supplementing with L-Cit and combined L-Arg and L-Cit. Administration of combined L-Arg and L-Cit may increase circulating L-Arg concentration and rapidly enhance NO bioavailability more effectively than either individual L-Arg or L-Cit, probably due to the synergistic effect of the two amino acids. Combining the two amino acids in supplements enhances performance by reducing energy expenditure, time exhaustion, and increases the power output.
  • 1.2K
  • 09 Sep 2022
Topic Review
Google Cast
Google Cast is a proprietary protocol developed by Google for playing Internet-streamed audio/video content on a compatible consumer device. The protocol is used to initiate and control playback of content on digital media players, high-definition televisions, and home audio systems using a mobile device, personal computer, or smart speaker. The protocol was first launched on July 24, 2013, to support Google's first-generation Chromecast player. The Google Cast SDK was released on February 3, 2014, allowing third parties to modify their software to support the protocol. According to Google, over 20,000 Google Cast-ready apps were available as of May 2015. Support for Google Cast has since been integrated into subsequent devices, such as the Nexus Player and other Android TV devices (such as televisions), as well as soundbars, speakers, and later models of the Chromecast. Consumer devices that natively support the protocol are marketed as Chromecast built-in. As of October 2017, over 55 million Chromecasts and Chromecast built-in devices have been sold.
  • 1.2K
  • 19 Oct 2022
Topic Review
Electrochemical  Lactate (Bio)Sensor Transduction Approaches
Monitoring of lactate is spreading from the evident clinical environment, where its role as a biomarker is notorious, to the agrifood ambit as well. In the former, lactate concentration can serve as a useful indicator of several diseases (e.g., tumour development and lactic acidosis) and a relevant value in sports performance for athletes, among others. In the latter, the spotlight is placed on the food control, bringing to the table meaningful information such as decaying product detection and stress monitoring of species. No matter what purpose is involved, electrochemical (bio)sensors stand as a solid and suitable choice.
  • 1.2K
  • 22 Nov 2022
Topic Review
Thermally Conductive 3D Aerogels Based on Carbon Nanofillers
Aerogels are perfect 3D interconnected designs with unique properties provided by tenuous networks of nanosheets or filaments; they are typically fabricated via sol–gel, freeze drying, and other phase-separating and drying techniques and possess remarkable properties, such as an extraordinarily high specific surface area, great flexibility, low density, variable tunable porosity, low dielectric constant, and low TC. Due to the abovementioned advantageous physical features, they present a large amount of promise for applications as adaptable absorbent materials and for their uses in EM shielding, thermal insulation, and wearable pressure-sensing materials, to be employed as a multifunctional aerogel material. 
  • 1.2K
  • 28 Nov 2022
Topic Review
Sparśa
Sparśa (Sanskrit; Pali: phassa) is a Sanskrit/Indian term that is translated as "contact", "touching", "sensation", "sense impression", etc. It is defined as the coming together of three factors: the sense organ, the sense object, and sense consciousness (vijnana). For example, contact (sparsha) is said to occur at the coming together of the eye organ, a visual object, and the visual sense consciousness. Sparśa is identified within the Buddhist teachings as:
  • 1.2K
  • 02 Dec 2022
Topic Review
Antibiotic Synthesis in Flow Mode
Continuous-flow chemistry has become a mainstream process and a notable trend among emerging technologies for drug synthesis. It is routinely used in academic and industrial laboratories to generate a wide variety of molecules and building blocks. The advantages it provides, in terms of safety, speed, cost efficiency and small-equipment footprint compared to analog batch processes, have been known for some time. What has become even more important is its compliance with the quality objectives that are required by drug-development protocols that integrate inline analysis and purification tools. There can be no doubt that worldwide government agencies have strongly encouraged the study and implementation of this innovative, sustainable and environmentally friendly technology.
  • 1.2K
  • 08 Feb 2023
Topic Review
Hyaluronan Structure and Physicochemical Properties
Hyaluronan (HA) is a naturally occurring non-sulfated glycosaminoglycan (GAG), cell-surface-associated biopolymer, and is the crucial component of tissue extracellular matrix (ECM). HA is a regular polymer of disaccharides composed of glucuronic acid and N-acetylglucosamine linked via alternating β-1,4 and β-1,3 glycosidic bonds.
  • 1.2K
  • 04 May 2023
Topic Review
New Pharmacotherapies in Neuropathic Pain
Neuropathic pain, which is characterized by abnormal sensory processing due to nerve damage or dysfunction, often poses challenges in finding effective and well-tolerated therapies. Traditional analgesics, such as opioids and non-steroidal anti-inflammatory drugs (NSAIDs), may provide limited relief or be associated with significant side effects. The investigation into new drug targets and emerging pharmacotherapies in neuropathic pain could be of great interest in enhancing pain management and improving patient outcomes. In the context of neuropathic pain, repurposing drugs gained attention as a promising strategy for discovering novel treatment options. Repurposing drugs for neuropathic pain offers several advantages in the drug development process.
  • 1.2K
  • 05 Jul 2023
Topic Review
Metabolite-Based Hydrogels
Minimalistic peptide- and metabolite-based supramolecular hydrogels have great potential relative to traditional polymeric hydrogels in various biomedical and technological applications. Advantages such as remarkable biodegradability, high water content, favorable mechanical properties, biocompatibility, self-healing, synthetic feasibility, low cost, easy design, biological function, remarkable injectability, and multi-responsiveness to external stimuli make supramolecular hydrogels promising candidates for drug delivery, tissue engineering, tissue regeneration, and wound healing. Non-covalent interactions such as hydrogen bonding, hydrophobic interactions, electrostatic interactions, and π–π stacking interactions play key roles in the formation of peptide- and metabolite-containing low-molecular-weight hydrogels. Peptide- and metabolite-based hydrogels display shear-thinning and immediate recovery behavior due to the involvement of weak non-covalent interactions, making them supreme models for the delivery of drug molecules. In the areas of regenerative medicine, tissue engineering, pre-clinical evaluation, and numerous other biomedical applications, peptide- and metabolite-based hydrogelators with rationally designed architectures have intriguing uses. 
  • 1.2K
  • 03 Jul 2023
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