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Topic Review
Impacts of COVID-19 on Short Food Supply Chains
Short food supply chains (SFSCs) attracted government and public support owing to their potential to mitigate some of the sustainability issues associated with the conventional globalized food supply system. The event of the coronavirus disease pandemic placed unprecedented pressure on food supply systems worldwide.
  • 1.2K
  • 17 Nov 2022
Topic Review
Hydrogels via Diels–Alder Crosslinking
The Diels–Alder (DA) reaction is a promising tool for obtaining covalently crosslinked hydrogels due to its reaction bioorthogonality, the absence of by-products, and the application of mild conditions without a catalyst. The resulting hydrogels are in demand for use in various fields of materials science and biomedicine.
  • 1.2K
  • 10 Feb 2023
Topic Review
The Analysis of Chaos-Based Metaheuristic Methods
The concept of chaos has been applied extensively in various applications with the growth of nonlinear dynamical systems that are highly sensitive to the initial state. Chaos-based algorithms can generate a large number of different search points in a short time, which can help explore the optimization area more efficiently and quickly than traditional optimization algorithms. In this regard, a new method named CSCSO is proposed to improve the shortcomings of the recently proposed Sand Cat Swarm Optimization (SCSO) algorithm with this chaos theory. This algorithm has also been tested in engineering and social science-based constrained problems. Especially in social sciences, it solves basic problems with this kind of artificial intelligence-based mechanism instead of traditional methods such as questionnaires and fieldresearch.
  • 1.2K
  • 07 Aug 2023
Topic Review
Biological Synthesis of Nanoparticles from Microalgae
Microalgae have been a source of useful compounds mainly used as food and dietary supplements. They have been used as a source of metabolites that can participate in the synthesis of several nanoparticles through inexpensive and environmentally friendly routes alternative to chemical synthesis.
  • 1.2K
  • 15 Jun 2023
Topic Review
DDoS Detection Using DL Models and Explanation Methods
With the rise of distributed denial of service (DDoS) attacks, several machine learning-based attack detection models have been used to mitigate malicious behavioral attacks. Understanding how machine learning models work is not trivial. This is particularly true for complex and nonlinear models, such as deep learning models that have high accuracy. The struggle to explain these models creates a tension between accuracy and explanation. Different methods have been used to explain deep learning models and address ambiguity issues.
  • 1.2K
  • 25 Aug 2023
Topic Review
Future of Construction Management Software Market
The global Construction Management Software Market size was valued at USD 9.67 billion in 2023 and is projected to grow from USD 10.52 billion in 2024 to USD 20.67 billion by 2031, exhibiting a CAGR of 10.12% during the forecast period. Increasing adoption of cloud-based solutions and integration of artificial intelligence and machine learning are boosting the demand of construction management software.
  • 1.2K
  • 18 Nov 2024
Topic Review
GnRH in Endometrial Cancer
Endometrial cancer (EC) is one of the most common gynecological malignancies. Gonadotropin releasing hormone (GnRH) is a decapeptide first described to be secreted by the hypothalamus to regulate pituitary gonadotropin secretion. In this systematic review, we analyze and summarize the data indicating that most EC express GnRH and its receptor (GnRH-R) as part of an autocrine system regulating proliferation, the cell cycle, and apoptosis. We analyze the available data on the expression and function of GnRH-II, its putative receptor, and its signal transduction. GnRH-I and GnRH-II agonists, and antagonists as well as cytotoxic GnRH-I analogs, have been shown to inhibit proliferation and to induce apoptosis in human EC cell lines in pre-clinical models. Treatment with conventional doses of GnRH-agonists that suppress pituitary gonadotropin secretion and ovarian estrogen production has become part of fertility preserving therapy of early EC or its pre-cancer (atypical endometrial hyperplasia). Conventional doses of GnRH-agonists had marginal activity in advanced or recurrent EC. Higher doses or more potent analogs including GnRH-II antagonists have not yet been used clinically. The cytotoxic GnRH-analog Zoptarelin Doxorubicin has shown encouraging activity in a phase II trial in patients with advanced or recurrent EC, which expressed GnRH-R. In a phase III trial in patients with EC of unknown GnRH-R expression, the cytotoxic GnRH doxorubicin conjugate was not superior to free doxorubicin. Further well-designed clinical trials exploiting the GnRH-system in EC might be useful. 
  • 1.2K
  • 18 Feb 2021
Topic Review
Friction-plate Electromagnetic Couplings
Electromagnetic clutches and brakes operate electrically, but transmit torque mechanically. This is why they used to be referred to as electro-mechanical clutches or brakes. Over the years, EM became known as electromagnetic versus electro mechanical, referring more about their actuation method versus physical operation. Since the clutches started becoming popular over 60 years ago, the variety of applications and brake and clutch designs has increased dramatically, but the basic operation remains the same. This article is about the working principles of single face friction plate clutches and brakes. In this article, clutches and brakes are referred to as (mechanical) couplings.
  • 1.2K
  • 07 Oct 2022
Topic Review
Seed Dormancy/Germination
From embryo development through seedling growth, several molecular pathways control genome stability, environmental signal transduction and the transcriptional landscape.
  • 1.2K
  • 07 Mar 2021
Topic Review
Brassinosteroid Signaling Networks
Brassinosteroids, the steroid hormones of plants, control physiological and developmental processes through its signaling pathway. The major brassinosteroid signaling network components, from the receptor to transcription factors, have been identified in the past two decades. The development of biotechnologies has driven the identification of novel brassinosteroid signaling components, even revealing several crosstalks between brassinosteroid and other plant signaling pathways.
  • 1.2K
  • 01 Dec 2020
Topic Review
COVID-19 and University Degree Programs
COVID-19, caused by a member of the coronavirus family of viruses, has spread to most countries around the world since it was first recorded in humans in China in late 2019. Closing universities and cancelling all face-to-face activities have become a COVID-19 inevitable reality in many parts of the world. Its impact on university programs, particularly to maintain academic standards and quality assurance procedures, has become significantly more challenging and complex. New ways of working digitally, to minimize disruption to daily operations, have also led to enormous anxiety and uncertainty within the student population, and meeting students’ expectations has also become significantly more difficult. 
  • 1.2K
  • 05 Feb 2021
Topic Review
OCA2 Gene
OCA2 melanosomal transmembrane protein
  • 1.2K
  • 24 Dec 2020
Topic Review
Plant Neighbor of BRCA1
Plant NBR1 is a structural homolog and functional hybrid of mammalian autophagy receptors NBR1 and p62.
  • 1.2K
  • 26 Feb 2021
Topic Review
Passive Control of Base Pressure
In the present world, passive control finds application in various areas like flow over blunt projectiles, missiles, supersonic parallel diffusers (for cruise correction), the engine of jets, static testbeds of rockets, the ports of internal combustion engines, vernier rockets, and single expansion ramp nozzle (SERN) rockets. In this study, various passive control techniques to control the base pressure and regulate the drag force are discussed. In the study, papers ranging from subsonic, sonic, and supersonic flow are discussed. Different types of passive control management techniques like cavity, ribs, dimple, static cylinder, spikes, etc., are discussed in this review article.
  • 1.2K
  • 23 Feb 2021
Topic Review
HIV-1 Capsid
HIV-1 capsid has been recognized to have an important role as a structural protein that holds the viral genome, together with viral proteins essential for viral life cycle, such as the reverse transcriptase (RT) and the integrase (IN). The reverse transcription process takes place between the cytoplasm and the nucleus of the host cell, thus the Reverse Transcription Complexes (RTCs)/Pre-integration Complexes (PICs) are hosted in intact or partial cores. Early biochemical assays failed to identify the viral CA associated to the RTC/PIC, possibly due to the stringent detergent conditions used to fractionate the cells or to isolate the viral complexes. More recently, it has been observed that some host partners of capsid, such as Nup153 and CPSF6, can only bind multimeric CA proteins organized in hexamers. Those host factors are mainly located in the nuclear compartment, suggesting the entrance of the viral CA as multimeric structure inside the nucleus. Recent data show CA complexes within the nucleus having a different morphology from the cytoplasmic ones, clearly highlighting the remodeling of the viral cores during nuclear translocation. Thus, the multimeric CA complexes lead the viral genome into the host nuclear compartment, piloting the intranuclear journey of HIV-1 in order to successfully replicate.
  • 1.2K
  • 26 Feb 2021
Topic Review
Glycosaminoglycans in Cancer Therapy
The tumor microenvironment (TME) is composed of cancerous, non-cancerous, stromal, and immune cells that are surrounded by the components of the extracellular matrix (ECM). Glycosaminoglycans (GAGs), natural biomacromolecules, essential ECM, and cell membrane components are extensively altered in cancer tissues. During disease progression, the GAG fine structure changes in a manner associated with disease evolution. Thus, changes in the GAG sulfation pattern are immediately correlated to malignant transformation. Their molecular weight, distribution, composition, and fine modifications, including sulfation, exhibit distinct alterations during cancer development. GAGs and GAG-based molecules, due to their unique properties, are suggested as promising effectors for anticancer therapy. Considering their participation in tumorigenesis, their utilization in drug development has been the focus of both industry and academic research efforts. These efforts have been developing in two main directions; (i) utilizing GAGs as targets of therapeutic strategies and (ii) employing GAGs specificity and excellent physicochemical properties for targeted delivery of cancer therapeutics.
  • 1.2K
  • 24 Mar 2021
Topic Review
Metformin Protects Livers against NASH-related-HCC
Nonalcoholic fatty liver disease (NAFLD) is strongly linked to the global epidemic of obesity and type 2 diabetes mellitus (T2DM). Notably, NAFLD can progress from the mildest form of simple steatosis to nonalcoholic steatohepatitis (NASH) that increases the risk for hepatocellular carcinoma (HCC), which is a malignancy with a dismal prognosis and rising incidence in the United States and other developed counties, possibly due to the epidemic of NAFLD. Metformin, the first-line drug for T2DM, has been suggested to reduce risks for several types of cancers including HCC and protect against NASH-related HCC, as revealed by epidemical studies on humans and preclinical studies on animal models.
  • 1.2K
  • 12 Oct 2021
Topic Review
Chronothyroidology and Chronobiology
Chronobiology is the scientific discipline which considers biological phenomena in relation to time, which assumes itself biological identity. Many physiological processes are cyclically regulated by intrinsic clocks and many pathological events show a circadian time-related occurrence. Even the pituitary–thyroid axis is under the control of a central clock, and the hormones of the pituitary–thyroid axis exhibit circadian, ultradian and circannual rhythmicity.
  • 1.2K
  • 25 May 2021
Topic Review
Proteomics, Personalized Medicine and Cancer
Cancer, a major public health issue worldwide, is the second most common cause of death. Initiatives such as the Human Genome Project (HGP) and Human Proteome Project (HPP) have greatly advanced the understanding of human health and disease, including cancer, and are supporting the current trend towards personalized/precision medicine.
  • 1.2K
  • 01 Jun 2021
Topic Review
Hallmarks of Aging in Macrophages
The skin is our largest organ and the outermost protective barrier. Its aging reflects both intrinsic and extrinsic processes resulting from the constant insults it is exposed to. Aging in the skin is accompanied by specific epigenetic modifications, accumulation of senescent cells, reduced cellular proliferation/tissue renewal, altered extracellular matrix, and a proinflammatory environment favoring undesirable conditions, including disease onset. Macrophages (Mφ) are the most abundant immune cell type in the skin and comprise a group of heterogeneous and plastic cells that are key for skin homeostasis and host defense. However, they have also been implicated in orchestrating chronic inflammation during aging. Since Mφ are related to innate and adaptive immunity, it is possible that age-modified skin Mφ promote adaptive immunity exacerbation and exhaustion, favoring the emergence of proinflammatory pathologies, such as skin cancer.
  • 1.2K
  • 10 Jun 2021
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