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Topic Review
Major Pharmacological Actions of Quercetin
Quercetin (3,3′,4′,5,7-pentahydroxy-2-phenylchromen-4-one), the major representative of the flavonoid subclass of flavonols, is derived from the Latin word “Quercetum,” meaning “Oak Forest”. It can be found in a variety of foods, including fruits and vegetables, and has been reported to be effective against a variety of viruses. 
  • 1.2K
  • 02 Feb 2023
Topic Review
Toxigenic Fusarium Species
Toxigenic Fusarium species are among the most important plant pathogens in agriculture. They may infect nearly every plant species and comprise about 300 phylospecies. The worldwide most important toxigenic species is F. graminearum producing the trichothecenes deoxynivalenol or nivalenol and the estrogenic zearalenone. Among the economically most important diseases are Fusarium head blight (FHB) of cereals, Fusarium crown rot of wheat and barley, Gibberella/Fusarium ear and stalk rot of maize. Mycotoxins are harmful to humans and animals and a great worldwide threat. The global economic losses caused by toxigenic Fusarium diseases are immense. They can only be controlled by a combination of measures including agronomic practices and resistant varieties. With genomic techniques new insights into the Fusarium-host pathosystem will be possible. 
  • 1.2K
  • 28 Mar 2023
Topic Review
Point-of-Care Ultrasound in Upper Airway Sono-Anatomy
Airway management is a common and critical procedure in acute settings, such as the Emergency Department (ED) or Intensive Care Unit (ICU) of hospitals. Many of the traditional physical examination methods have limitations in airway assessment. Point-of-care ultrasound (POCUS) has emerged as a promising tool for airway management due to its familiarity, accessibility, safety, and non-invasive nature. It can assist physicians in identifying relevant anatomy of the upper airway with objective measurements of airway parameters, and it can guide airway interventions with dynamic real-time images. To date, ultrasound has been considered highly accurate for assessment of the difficult airway, confirmation of proper endotracheal intubation, prediction of post-extubation laryngeal edema, and preparation for cricothyrotomy by identifying the cricothyroid membrane. The researchers aim to provide a comprehensive overview of the use of POCUS on upper airway sono-anatomy. In conclusion, POCUS is a valuable tool with multiple applications ranging from pre- and post-intubation management. Clinicians should consider using POCUS in conjunction with traditional exam techniques to manage the airway more efficiently in the acute setting.
  • 1.2K
  • 12 May 2023
Topic Review
Flexible Electrochromic Materials
The application potential of flexible electrochromic materials for wearable devices, smart textiles, flexible displays, electronic paper, and implantable biomedical devices is enormous. These materials offer the advantages of conformability and mechanical robustness, making them highly desirable for these applications.
  • 1.2K
  • 07 Jul 2023
Topic Review
Algorithms for Spam Detection
Spam emails have become a pervasive issue, as internet users receive increasing amounts of unwanted or fake emails. To combat this issue, automatic spam detection methods have been proposed, which aim to classify emails into spam and non-spam categories. Machine learning techniques have been utilized for this task with considerable success. 
  • 1.2K
  • 16 Oct 2023
Topic Review
Vermicompost Application in the Remediation of Soils
Vermicompost improves soil quality, increases nutrient availability, boosts crop productivity, and enhances pest and disease tolerance. It acts as an organic fertilizer, enriching the soil with essential nutrients, humic acids, growth-regulating hormones, and enzymes, improving plant nutrition, photosynthesis, and overall crop quality. Furthermore, vermicompost shows promise in mitigating soil degradation and sequestering organic carbon while demonstrating the potential for pest management, including effectiveness against pests like fall armyworm (Spodoptera frugiperda).
  • 1.2K
  • 20 Nov 2023
Topic Review
Multidrug Resistant Pseudomonas aeruginosa in Lebanon
Pseudomonas aeruginosa is a common cause of healthcare-associated infections and chronic airway diseases in non-clinical settings. P. aeruginosa is intrinsically resistant to a variety of antimicrobials and has the ability to acquire resistance to others, causing increasingly recalcitrant infections and elevating public health concerns. It is showed that the bacterium was predominant in lesions of patients on mechanical ventilation and in burn patients and those with diabetic foot infections and hematological malignancies. It is also found that carbapenem resistance in P. aeruginosa isolates in Lebanon involved both enzymatic and non-enzymatic mechanisms but depended predominantly on VIM-2 production (40.7%). Additionally, MDR P. aeruginosa was detected in animals, where a study reported the emergence of carbapenemase-producing P. aeruginosa in livestock in Lebanon.
  • 1.2K
  • 10 Jun 2022
Topic Review
Mitochondrial Metabolism and Hematopoietic Stem Cell Aging
Mitochondrial dysfunction and stem cell exhaustion are two hallmarks of aging. In the hematopoietic system, aging is linked to imbalanced immune response and reduced regenerative capacity in hematopoietic stem cells (HSCs), as well as an increased predisposition to a spectrum of diseases, including myelodysplastic syndrome and acute myeloid leukemia.
  • 1.2K
  • 20 Oct 2021
Topic Review
Gut Microbiota and Gut–Liver Axis in Liver Disease
The gut microbiota composition is important for nutrient metabolism, mucosal barrier function, immunomodulation, and defense against pathogens. Alterations in the gut microbiome can disturb the gut ecosystem. These changes may lead to the loss of beneficial bacteria or an increase in potentially pathogenic bacteria. Furthermore, these have been shown to contribute to the pathophysiology of gastrointestinal and extra-intestinal diseases. Pathologies of the liver, such as non-alcoholic liver disease, alcoholic liver disease, cirrhosis, hepatocellular carcinoma, autoimmune hepatitis, viral hepatitis, and primary sclerosing cholangitis have all been linked to changes in the gut microbiome composition.
  • 1.2K
  • 08 Jun 2022
Topic Review
Co-Inoculation of three species
The adoption of multi-species starter cultures is highly considered in modern winemaking to enhance the complexity and wine attributes. However, the valuation of strains compatibility at the industrial-scale is essential to guarantee the quality and the safety during the process. This concept is particularly important when the starter is composed of non-Saccharomyces, Saccharomyces spp. and malolactic bacteria, three organisms with dissimilar biological properties and oenological implication.
  • 1.2K
  • 28 Oct 2020
Topic Review
Androgenic Plant Families in Breeding
One of the limitations in obtaining the genetic diversity of doubled haploid (DH) lines via anther culture is the development of families of regenerants, and each family represents a clone. This work examines the results of studying this phenomenon in anther culture of alloplasmic (H. vulgare)–T. aestivum and euplasmic lines with 1RS.1BL and 7DL-7Ai translocations and hybrids between them. Parameters of androgenesis such as the number of embryo-like structures, the total number of regenerants, and the number of green regenerants per 100 anthers varied depending on the genotype. In all genotypes from embryo-like structures, predominant development of families of plantlets rather than single plantlets was found. The source of family plantlets was polyembryos. About 75% of families consisted of regenerants at the same fertility level. On average, 37.74%4% of the R0 plants were fertile. The sister DH lines of three hybrid combinations were formed from seeds of R1 plants (2n = 42) with high fertility and in the presence of wheat–alien translocations. After four years of breeding trials, the sister DH lines of three families with fungal disease resistance increased yield, and some parameters of grain quality exceeding the controls were identified as promising for breeding.
  • 1.2K
  • 29 Jun 2020
Topic Review
Small Fiber Neuropathy
Small fiber neuropathy is a condition characterized by severe pain attacks that typically begin in the feet or hands.
  • 1.2K
  • 25 Dec 2020
Topic Review
Kinetics of Carbon Nanotubes
Carbon formation on steel has recently become an active research area with several important applications, using either carbon nanotubes (CNTs) or graphene structures. The production of vertically aligned CNT (VACNT) forests with combined metals has been explored with important results. Detailed kinetics is the best approach to understand a mechanism. The growth behavior seems complex but can be simplified through the knowledge of the three more common alternative reaction mechanisms/routes.
  • 1.2K
  • 01 Feb 2021
Topic Review
Nanoparticles in Male Infertility
Advancement in the field of nanotechnology has prompted the need to elucidate the deleterious effects of nanoparticles (NPs) on reproductive health. Many studies have reported on the health safety issues related to NPs by investigating their exposure routes, deposition and toxic effects on different primary and secondary organs but few studies have focused on NPs’ deposition in reproductive organs. Noteworthy, even fewer studies have dealt with the toxic effects of NPs on reproductive indices and sperm parameters (i.e. sperm number, motility and morphology) by evaluating, for instance, the histopathology of seminiferous tubules and testosterone levels. To date, the research suggests that NPs can easily cross the blood testes barrier and, after accumulation in the testis, induce adverse effects on spermatogenesis.
  • 1.2K
  • 12 Mar 2021
Topic Review
Suprachoroidal Delivery of Therapeutic Agents
Suprachoroidal drug delivery technology has advanced rapidly and emerged as a promising administration route for a variety of therapeutic candidates, targeting multiple ocular diseases, ranging from neovascular age-related macular degeneration to choroidal melanoma. This entry summarizes the latest preclinical and clinical progress in suprachoroidal delivery of therapeutic agents, focusing on small molecule suspensions.
  • 1.2K
  • 22 Sep 2021
Topic Review
Visually Impaired People
Blind and Visually impaired people (BVIP) face a range of practical difficulties when undertaking outdoor journeys as pedestrians. Over the past decade, a variety of assistive devices have been researched and developed to help BVIP navigate more safely and independently. In addition, research in overlapping domains are addressing the problem of automatic environment interpretation using computer vision and machine learning, particularly deep learning, approaches. Our aim in this article is to present a comprehensive review of research directly in, or relevant to, assistive outdoor navigation for BVIP. We breakdown the navigation area into a series of navigation phases and tasks. We then use this structure for our systematic review of research, analysing articles, methods, datasets and current limitations by task. We also provide an overview of commercial and non-commercial navigation applications targeted at BVIP. Our review contributes to the body of knowledge by providing a comprehensive, structured analysis of work in the domain, including the state of the art, and guidance on future directions. It will support both researchers and other stakeholders in the domain to establish an informed view of research progress. 
  • 1.2K
  • 17 May 2021
Topic Review
I4.0, Servitisation, and Circular Economy
Industry 4.0 (I4.0) technologies have been highlighted in recent literature as enablers of servitisation. Simultaneously, businesses are advised to implement a circular economy (CE) to bring new opportunities. However, it is pertinent to mention that little attention has been given to assess the role of I4.0 in adopting the CE and servitisation in a fully integrated manner. This research fills this gap by developing a conceptual framework through a systematic literature review of 139 studies investigating the relationship between the I4.0, CE, and servitisation. This study identifies the impact of these variables on a firm’s operational and financial performance (revenue stream, growth, and profitability). Our research findings advocate that adopting I4.0 technologies to the business and manufacturing model enables sustainability, energy and resource efficiency while enhancing performance and offering innovative products through smart services. Thus, firms must systematically adopt I4.0 technologies to support a CE model that creates value through servitisation. This study identifies the research gaps that are unexplored for practitioners and future researchers while providing insight into the role of I4.0 in implementing CE in the servitisation business model.
  • 1.2K
  • 23 Jun 2021
Topic Review
Magnetic Nanostructures for Cancer Immunotherapy
Magnetic nanoparticles (MNPs) represent an attractive class of nanomaterials due to their unique physical and chemical features that allow them to respond specifically to magnetic fields. Among the magnetic class of materials, iron oxide-based nanoparticles are the only inorganic nanomaterials that have been approved by the Food and Drug Administration (FDA) for medical applications. Magnetic nanomaterials are particularly appealing for cancer immunotherapy due to their unique features, which include (i) the traceability of their signal by magnetic resonance imaging (MRI) or by magnetic particle imaging (MPI) techniques ; (ii) their exploitation as carriers to promote the accumulation and the efficient delivery of biotherapeutic compounds, such as genes and peptides, into a specific target cell or tissue; (iii) their ability to mediate the elimination of cancer cells through the production of a local thermo-ablative effect when exposed to an external alternating magnetic field, referred to as magnetic hyperthermia therapy (MHT); and (iv) their intrinsic immunomodulatory properties that can be harnessed to further promote or modulate the immune function.
  • 1.2K
  • 07 Jul 2021
Topic Review
Cristae Dynamics
Recent studies using fluorescence super-resolution (SR) microscopy techniques showed unexpected fast movement of cristae and CJs, collectively termed as cristae dynamics. Cristae undergo continuous cycles of membrane remodelling often assisted by the dynamics of CJs in a MICOS-dependent manner, which led to the proposal of the ‘Cristae Fission and Fusion’ (CriFF) model. The field of cristae dynamics is still in infancy, future experiments could provide better insights about the consequences of the reduced cristae or CJ dynamics in the knockouts (KOs) of the MICOS subunits and their relevance in many pathologies associated with the MICOS complex.
  • 1.2K
  • 27 Jul 2021
Topic Review
Bioactive Antimicrobial Peptides for Infected Diabetic Foot Ulcers
Diabetic foot ulcer (DFU) is a devastating complication, affecting 15% of diabetic patients and representing the leading cause of non-traumatic amputations. Notably, the risk of mixed bacterial–fungal infection is elevated and highly associated with wound necrosis and poor clinical outcomes. Antimicrobial peptides (AMPs) are endogenous peptides that are naturally abundant in several organisms, such as bacteria, amphibians and mammals. These molecules have shown broad-spectrum antimicrobial activity and some of them even have wound-healing activity, establishing themselves as ideal candidates for treating multi-kingdom infected wounds.
  • 1.2K
  • 24 Dec 2021
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